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- assertion description "[ASM from patients with severe asthma shows greater proliferation and IL-6 release than in patients with nonsevere asthma, but both groups show corticosteroid insensitivity. miR-221 regulates p21(WAF1) and p27(kip1) expression levels.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." provenance.