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- assertion description "[Further bioinformatic analysis of BXD phenotypes, combined with biochemical evaluation of SERT knockout mice, nominates SERT-dependent 5-HT signaling as a major determinant of midbrain iron homeostasis that, in turn, dictates iron-regulated DA phenotypes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." provenance.