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- assertion description "[TNF-?, hsCRP and uMCP-1 and markers of oxidative stress i.e. increased MDA and decreased GSH and FRAP in DM-CKD suggest an important role of inflammation and oxidative stress in the pathogenesis of renal damage in diabetic patients.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." provenance.