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- assertion description "[findings suggest a two-stage model of APE/Ref-1 behaviour during malignant thyrocyte transformation: 1) simple hyperplasia and upregulation of APE/Ref-1 in the nucleus and 2) nuclear levels drop as the cell becomes progressively undifferentiated]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine." provenance.