Matches in Nanopublications for { ?s ?p "A G protein-coupled chemoattractant receptor (R) activates PI3K isoforms, which converts PtdIns(4,5)P2 to PtdIns(3,4,5)P3. PI3K activation itself would lead only to a transient increase in PtdIns(3,4,5)P3 followed by a decrease in this lipid product as a result of depletion of the upstream phosphoinositide substrates, such as PtdIns(4,5)P2. Hence, PtdIns(3,4,5)P3 at the leading edge or front of the cell stimulates its own accumulation through the activation of one or more Rho GTPases (Rac, cdc42 and/or Rho), which in turn activate PI3K and increase PtdIns(3,4,5)P3 formation. " ?g. }
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- _5 value "A G protein-coupled chemoattractant receptor (R) activates PI3K isoforms, which converts PtdIns(4,5)P2 to PtdIns(3,4,5)P3. PI3K activation itself would lead only to a transient increase in PtdIns(3,4,5)P3 followed by a decrease in this lipid product as a result of depletion of the upstream phosphoinositide substrates, such as PtdIns(4,5)P2. Hence, PtdIns(3,4,5)P3 at the leading edge or front of the cell stimulates its own accumulation through the activation of one or more Rho GTPases (Rac, cdc42 and/or Rho), which in turn activate PI3K and increase PtdIns(3,4,5)P3 formation. " provenance.