Matches in Nanopublications for { ?s ?p "Although cyclin E, cdk4, cdk6, p16, and p21 showed no detectable difference between WT and Hipk2?/? MEFs, the level of cyclin D1 protein was up-regulated in Hipk2?/? MEFs and keratinocytes by 2.5- and 3-fold, respectively. FROM TEXT: Given the role of HIPK2 as a transcriptional corepressor, we reasoned that an increase in cyclin D1 protein may be due to an increase in transcription of cyclin D1 in Hipk2?/? MEFs. Consistent with this, quantitative RT-PCR (qRT-PCR) showed that cyclin D1 mRNA, but not D2 or D3, was up-regulated in Hipk2?/? MEFs." ?g. }
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- _4 value "Although cyclin E, cdk4, cdk6, p16, and p21 showed no detectable difference between WT and Hipk2?/? MEFs, the level of cyclin D1 protein was up-regulated in Hipk2?/? MEFs and keratinocytes by 2.5- and 3-fold, respectively. FROM TEXT: Given the role of HIPK2 as a transcriptional corepressor, we reasoned that an increase in cyclin D1 protein may be due to an increase in transcription of cyclin D1 in Hipk2?/? MEFs. Consistent with this, quantitative RT-PCR (qRT-PCR) showed that cyclin D1 mRNA, but not D2 or D3, was up-regulated in Hipk2?/? MEFs." provenance.
- _4 value "Although cyclin E, cdk4, cdk6, p16, and p21 showed no detectable difference between WT and Hipk2?/? MEFs, the level of cyclin D1 protein was up-regulated in Hipk2?/? MEFs and keratinocytes by 2.5- and 3-fold, respectively. FROM TEXT: Given the role of HIPK2 as a transcriptional corepressor, we reasoned that an increase in cyclin D1 protein may be due to an increase in transcription of cyclin D1 in Hipk2?/? MEFs. Consistent with this, quantitative RT-PCR (qRT-PCR) showed that cyclin D1 mRNA, but not D2 or D3, was up-regulated in Hipk2?/? MEFs." provenance.