Matches in Nanopublications for { ?s ?p "Although the precise mechanism for this growth-inhibitory effect remains elusive,TGF-B is able to prevent progression through the cell cycle first by inducing expression of the cyclin kinase inhibitors p15INK4b,27 p21CIP1,28 and p27KIP1,29 which block cyclin and cyclin-dependent kinases from phosphorylating the retinoblastoma protein (Rb), thus allowing the hypophosphorylated form of Rb to bind and sequester the E2F transcription factor, and second by directly suppressing c-myc expression." ?g. }
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- _3 value "Although the precise mechanism for this growth-inhibitory effect remains elusive,TGF-B is able to prevent progression through the cell cycle first by inducing expression of the cyclin kinase inhibitors p15INK4b,27 p21CIP1,28 and p27KIP1,29 which block cyclin and cyclin-dependent kinases from phosphorylating the retinoblastoma protein (Rb), thus allowing the hypophosphorylated form of Rb to bind and sequester the E2F transcription factor, and second by directly suppressing c-myc expression." provenance.
- _3 value "Although the precise mechanism for this growth-inhibitory effect remains elusive,TGF-B is able to prevent progression through the cell cycle first by inducing expression of the cyclin kinase inhibitors p15INK4b,27 p21CIP1,28 and p27KIP1,29 which block cyclin and cyclin-dependent kinases from phosphorylating the retinoblastoma protein (Rb), thus allowing the hypophosphorylated form of Rb to bind and sequester the E2F transcription factor, and second by directly suppressing c-myc expression." provenance.