Matches in Nanopublications for { ?s ?p "Attempts to extend these findings in vivo, however, were initially hampered by perinatal lethality of homozygote C/EBPa null mice, which perish due to hypoglycemia secondary to a failure of hepatic gluconeogenesis [13]. Two different groups subsequently developed ways to work around this problem. One group expressed C/EBPb from the endogenous C/EBPa locus (so-called C/EBPb/b mice) [14]. This rescued the hepatic phenotype, presumably because the requirement for a C/EBP in liver is not restricted to the C/EBPa isoform. In white fat, however, C/EBPa function could not be replaced by C/EBPb, and these animals had small fat pads with reduced lipid content per cell." ?g. }
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- _4 value "Attempts to extend these findings in vivo, however, were initially hampered by perinatal lethality of homozygote C/EBPa null mice, which perish due to hypoglycemia secondary to a failure of hepatic gluconeogenesis [13]. Two different groups subsequently developed ways to work around this problem. One group expressed C/EBPb from the endogenous C/EBPa locus (so-called C/EBPb/b mice) [14]. This rescued the hepatic phenotype, presumably because the requirement for a C/EBP in liver is not restricted to the C/EBPa isoform. In white fat, however, C/EBPa function could not be replaced by C/EBPb, and these animals had small fat pads with reduced lipid content per cell." provenance.
- _4 value "Attempts to extend these findings in vivo, however, were initially hampered by perinatal lethality of homozygote C/EBPa null mice, which perish due to hypoglycemia secondary to a failure of hepatic gluconeogenesis [13]. Two different groups subsequently developed ways to work around this problem. One group expressed C/EBPb from the endogenous C/EBPa locus (so-called C/EBPb/b mice) [14]. This rescued the hepatic phenotype, presumably because the requirement for a C/EBP in liver is not restricted to the C/EBPa isoform. In white fat, however, C/EBPa function could not be replaced by C/EBPb, and these animals had small fat pads with reduced lipid content per cell." provenance.