Matches in Nanopublications for { ?s ?p "BRCA1 mRNA levels decreased rapidly after HRG treatment. This was followed by an increase in BRCA1 mRNA peaking at 12 to 16 h, and by a decrease thereafter which approached the basal level. There was lower expression of cells grown on Laminin and the lowest expression in cells grown on Collagen type 4. However when C-terminal truncated BRCA1 was overexpressed in T47D cells grown on Laminin, BRCA1 expression was restored. HRG dependent decrease in BRCA1 mRNA levels was not affected by pre-treatment of cells with ALLN (Calpain inhibitor), or lactacystin (a proteosome inhibitor). In addition an another proteosome inhibitor, PSI, had an effect on the HRG dependent BRCA1 mRNA levels compared to ALLN and lactacystin together." ?g. }
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- _4 value "BRCA1 mRNA levels decreased rapidly after HRG treatment. This was followed by an increase in BRCA1 mRNA peaking at 12 to 16 h, and by a decrease thereafter which approached the basal level. There was lower expression of cells grown on Laminin and the lowest expression in cells grown on Collagen type 4. However when C-terminal truncated BRCA1 was overexpressed in T47D cells grown on Laminin, BRCA1 expression was restored. HRG dependent decrease in BRCA1 mRNA levels was not affected by pre-treatment of cells with ALLN (Calpain inhibitor), or lactacystin (a proteosome inhibitor). In addition an another proteosome inhibitor, PSI, had an effect on the HRG dependent BRCA1 mRNA levels compared to ALLN and lactacystin together." provenance.
- _4 value "BRCA1 mRNA levels decreased rapidly after HRG treatment. This was followed by an increase in BRCA1 mRNA peaking at 12 to 16 h, and by a decrease thereafter which approached the basal level. There was lower expression of cells grown on Laminin and the lowest expression in cells grown on Collagen type 4. However when C-terminal truncated BRCA1 was overexpressed in T47D cells grown on Laminin, BRCA1 expression was restored. HRG dependent decrease in BRCA1 mRNA levels was not affected by pre-treatment of cells with ALLN (Calpain inhibitor), or lactacystin (a proteosome inhibitor). In addition an another proteosome inhibitor, PSI, had an effect on the HRG dependent BRCA1 mRNA levels compared to ALLN and lactacystin together." provenance.