Matches in Nanopublications for { ?s ?p "CSM-induced activation of TLR-4 has been shown to induce IRAK1 phosphorylation and TRAF6 degradation. An increase in IkB phosphorylation and degradation is also observed which ultimately leads to the translocation of NF-kB (p65) into the nucleus. The ability of cigarette smoke condensate (CSC) to activate NF-kB has also been demonstrated in another study using U937 cells. CSC has been shown to induce the activation of IKK (-a and -b) at 15 minutes post treatment, which resulted in increased phosphorylation of I?-B? at serine 32, resulting in Ik-Ba degradation and subsequent activation of NF-kB [53]." ?g. }
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- _6 value "CSM-induced activation of TLR-4 has been shown to induce IRAK1 phosphorylation and TRAF6 degradation. An increase in IkB phosphorylation and degradation is also observed which ultimately leads to the translocation of NF-kB (p65) into the nucleus. The ability of cigarette smoke condensate (CSC) to activate NF-kB has also been demonstrated in another study using U937 cells. CSC has been shown to induce the activation of IKK (-a and -b) at 15 minutes post treatment, which resulted in increased phosphorylation of I?-B? at serine 32, resulting in Ik-Ba degradation and subsequent activation of NF-kB [53]." provenance.
- _6 value "CSM-induced activation of TLR-4 has been shown to induce IRAK1 phosphorylation and TRAF6 degradation. An increase in IkB phosphorylation and degradation is also observed which ultimately leads to the translocation of NF-kB (p65) into the nucleus. The ability of cigarette smoke condensate (CSC) to activate NF-kB has also been demonstrated in another study using U937 cells. CSC has been shown to induce the activation of IKK (-a and -b) at 15 minutes post treatment, which resulted in increased phosphorylation of I?-B? at serine 32, resulting in Ik-Ba degradation and subsequent activation of NF-kB [53]." provenance.