Matches in Nanopublications for { ?s ?p "Fibrin production and deposition in tumors and during inflammation is associated with angiogenesis providing a matrix for the migration of endothelial cells [149, 173]. PAI-1 is actively expressed in fibroblasts contacting endothelial cells [174]. Such contact during angiogenesis can only occur after the degradation of the basement membrane in the process of endothelial cell migration. Tumor growth and angiogenesis are also suppressed in vivo in PAI-1 deficient mice, suggesting the potential importance of PAI-1 in tumor angiogenesis [173]. In various malignant tumors including breast cancer, the combination of high levels of uPA and PAI-1 indicates the poorest prognosis [175]. This suggests that synergic effects of PAI-1 and uPA can promote tumor angiogenesis and metastasis." ?g. }
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- _3 value "Fibrin production and deposition in tumors and during inflammation is associated with angiogenesis providing a matrix for the migration of endothelial cells [149, 173]. PAI-1 is actively expressed in fibroblasts contacting endothelial cells [174]. Such contact during angiogenesis can only occur after the degradation of the basement membrane in the process of endothelial cell migration. Tumor growth and angiogenesis are also suppressed in vivo in PAI-1 deficient mice, suggesting the potential importance of PAI-1 in tumor angiogenesis [173]. In various malignant tumors including breast cancer, the combination of high levels of uPA and PAI-1 indicates the poorest prognosis [175]. This suggests that synergic effects of PAI-1 and uPA can promote tumor angiogenesis and metastasis." provenance.
- _3 value "Fibrin production and deposition in tumors and during inflammation is associated with angiogenesis providing a matrix for the migration of endothelial cells [149, 173]. PAI-1 is actively expressed in fibroblasts contacting endothelial cells [174]. Such contact during angiogenesis can only occur after the degradation of the basement membrane in the process of endothelial cell migration. Tumor growth and angiogenesis are also suppressed in vivo in PAI-1 deficient mice, suggesting the potential importance of PAI-1 in tumor angiogenesis [173]. In various malignant tumors including breast cancer, the combination of high levels of uPA and PAI-1 indicates the poorest prognosis [175]. This suggests that synergic effects of PAI-1 and uPA can promote tumor angiogenesis and metastasis." provenance.