Matches in Nanopublications for { ?s ?p "IL-18 treatment markedly increased phospho-ATF-2 (Thr71) levels in HCMEC, and this effect was blocked by the IL-18BPa/Fc chimera (Fig. 5A). Furthermore, treatment with the p38PMAPK inhibitor SB203580 strongly inhibited IL-18-mediated ATF-2 phosphorylation (Fig. 5B). Inhibition of p38MAPK also attenuated p65 phosphorylation (Fig. 5C) and NF-?B-driven reporter gene activity (Fig. 5D). Together, these results demonstrate that IL-18 induced NF-?B activation via p38MAPK activation (Fig. 5)." ?g. }
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- _5 value "IL-18 treatment markedly increased phospho-ATF-2 (Thr71) levels in HCMEC, and this effect was blocked by the IL-18BPa/Fc chimera (Fig. 5A). Furthermore, treatment with the p38PMAPK inhibitor SB203580 strongly inhibited IL-18-mediated ATF-2 phosphorylation (Fig. 5B). Inhibition of p38MAPK also attenuated p65 phosphorylation (Fig. 5C) and NF-?B-driven reporter gene activity (Fig. 5D). Together, these results demonstrate that IL-18 induced NF-?B activation via p38MAPK activation (Fig. 5)." provenance.
- _5 value "IL-18 treatment markedly increased phospho-ATF-2 (Thr71) levels in HCMEC, and this effect was blocked by the IL-18BPa/Fc chimera (Fig. 5A). Furthermore, treatment with the p38PMAPK inhibitor SB203580 strongly inhibited IL-18-mediated ATF-2 phosphorylation (Fig. 5B). Inhibition of p38MAPK also attenuated p65 phosphorylation (Fig. 5C) and NF-?B-driven reporter gene activity (Fig. 5D). Together, these results demonstrate that IL-18 induced NF-?B activation via p38MAPK activation (Fig. 5)." provenance.
- _5 value "IL-18 treatment markedly increased phospho-ATF-2 (Thr71) levels in HCMEC, and this effect was blocked by the IL-18BPa/Fc chimera (Fig. 5A). Furthermore, treatment with the p38PMAPK inhibitor SB203580 strongly inhibited IL-18-mediated ATF-2 phosphorylation (Fig. 5B). Inhibition of p38MAPK also attenuated p65 phosphorylation (Fig. 5C) and NF-?B-driven reporter gene activity (Fig. 5D). Together, these results demonstrate that IL-18 induced NF-?B activation via p38MAPK activation (Fig. 5)." provenance.