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- _5 value "IRF5 associates with both Myd88 and TRAF-6 and ligands for TLR4 and TLR9 promote nuclear translocation of IRF5 in a Myd88-dependent manner [61] (Figure 3). However, many of the downstream mediators of the IRF5 pathway await identification. Although IRF-5 is phosphorylated by TBK1 and IKK-i, this phosphorylation does not lead to IRF-5 nuclear translocation or activation [62]. The Myd88 activation of IRF-5..." provenance.
- _5 value "IRF5 associates with both Myd88 and TRAF-6 and ligands for TLR4 and TLR9 promote nuclear translocation of IRF5 in a Myd88-dependent manner [61] (Figure 3). However, many of the downstream mediators of the IRF5 pathway await identification. Although IRF-5 is phosphorylated by TBK1 and IKK-i, this phosphorylation does not lead to IRF-5 nuclear translocation or activation [62]. The Myd88 activation of IRF-5..." provenance.