Matches in Nanopublications for { ?s ?p "In agreement with the role of S62 phosphorylation on reporter gene expression, the hTERT and Bmi-1 genes were repressed by IFN-? + TPA and by the Cdk2 inhibitor CVT-313 (Fig. 6D), whereas the p21 and p16Ink4A genes were strongly induced (Fig. 6E). The changes in gene expression are consistent with the ChIP results and indicate that cyclin E/Cdk2 enhances, whereas IFN-?, through the activation of p27, represses Myc-activated transcription (and vice versa for Myc-repressed transcription) of genes involved in cellular senescence. " ?g. }
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- _5 value "In agreement with the role of S62 phosphorylation on reporter gene expression, the hTERT and Bmi-1 genes were repressed by IFN-? + TPA and by the Cdk2 inhibitor CVT-313 (Fig. 6D), whereas the p21 and p16Ink4A genes were strongly induced (Fig. 6E). The changes in gene expression are consistent with the ChIP results and indicate that cyclin E/Cdk2 enhances, whereas IFN-?, through the activation of p27, represses Myc-activated transcription (and vice versa for Myc-repressed transcription) of genes involved in cellular senescence. " provenance.