Matches in Nanopublications for { ?s ?p "In the SR, the calcium release channel (ryanodine recpetor) and the calcium pump (sarcoerndoplasmic reticulum calcium ATPase, SERCA) are critical to the regulation of contractility. Proper contraction requires both that Ca2+ release into the cytoplasm is adequate to stimulate contraction and that Ca2+ reuptake into the SR is sufficient to permit relaxation and to replenish calcium stores. Cytoplasmic concentrations of both calcium and ATP regulate the activity of both the ryanodine receptor and SERCA. As noted above, trigger calcium opens the ryanodine receptor. Cytoplasmic calcium concentration is directly related to the number of receptors that open. A safety mechanism also exists whereby high calcium levels lead to calcium-calmodulin complex formation: this complex inhibits calcium release by decreasing the open time of the ryanodine receptor. High concentrations of ATP favor the open channel conformation, and thereby facilitate SR calcium release into the cytosol. " ?g. }
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- _5 value "In the SR, the calcium release channel (ryanodine recpetor) and the calcium pump (sarcoerndoplasmic reticulum calcium ATPase, SERCA) are critical to the regulation of contractility. Proper contraction requires both that Ca2+ release into the cytoplasm is adequate to stimulate contraction and that Ca2+ reuptake into the SR is sufficient to permit relaxation and to replenish calcium stores. Cytoplasmic concentrations of both calcium and ATP regulate the activity of both the ryanodine receptor and SERCA. As noted above, trigger calcium opens the ryanodine receptor. Cytoplasmic calcium concentration is directly related to the number of receptors that open. A safety mechanism also exists whereby high calcium levels lead to calcium-calmodulin complex formation: this complex inhibits calcium release by decreasing the open time of the ryanodine receptor. High concentrations of ATP favor the open channel conformation, and thereby facilitate SR calcium release into the cytosol. " provenance.