Matches in Nanopublications for { ?s ?p "Mdm2 is a negative regulator of p53, ultimately causing p53 degradation by the proteasome, whereas p53 transcriptionally upregulates Mdm2. ARF inhibits Mdm2 function. MYC activation leads to increased ARF expression (Zindy et al., 1998), resulting in increased p53 protein." ?g. }
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- _5 value "Mdm2 is a negative regulator of p53, ultimately causing p53 degradation by the proteasome, whereas p53 transcriptionally upregulates Mdm2. ARF inhibits Mdm2 function. MYC activation leads to increased ARF expression (Zindy et al., 1998), resulting in increased p53 protein." provenance.
- _4 value "Mdm2 is a negative regulator of p53, ultimately causing p53 degradation by the proteasome, whereas p53 transcriptionally upregulates Mdm2. ARF inhibits Mdm2 function. MYC activation leads to increased ARF expression (Zindy et al., 1998), resulting in increased p53 protein." provenance.