Matches in Nanopublications for { ?s ?p "TIMP-3 expressing stable colon carcinoma cell lines display reduced tumor growth, 199 and in these cells TIMP-3 overexpression resulted in apoptosis through stabilization of TNF-a receptors on the cell surface. 200 This suggests that individual TIMPs may modulate the levels of death proteins from the cell surface, as demonstrated by findings that shedding of FAS from the cell surface is mediated by MMP-induced cleavage and is inhibited by synthetic MMP inhibitors. 201" ?g. }
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- _6 value "TIMP-3 expressing stable colon carcinoma cell lines display reduced tumor growth, 199 and in these cells TIMP-3 overexpression resulted in apoptosis through stabilization of TNF-a receptors on the cell surface. 200 This suggests that individual TIMPs may modulate the levels of death proteins from the cell surface, as demonstrated by findings that shedding of FAS from the cell surface is mediated by MMP-induced cleavage and is inhibited by synthetic MMP inhibitors. 201" provenance.