Matches in Nanopublications for { ?s ?p "To determine whether paracrine production of IL-6 was responsible for activating the gp130 receptor in these cell lines, conditioned medium (CM) was isolated from 11-18 cells and applied to MCF-10A cells (which do not express pSTAT3) in the absence or presence of various blocking antibodies against gp130, IL-6, IL-6?specific receptor IL-6R, and other gp130 pathway cytokines, OSM and LIF. 11-18 CM induced high levels of pSTAT3, which was inhibited by gp130, IL-6 ligand, or IL-6 receptor antibodies, but not in control IgG-, anti-OSM-, or anti-LIF antibody?treated MCF-10A cells (Figure 4B)." ?g. }
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- _4 value "To determine whether paracrine production of IL-6 was responsible for activating the gp130 receptor in these cell lines, conditioned medium (CM) was isolated from 11-18 cells and applied to MCF-10A cells (which do not express pSTAT3) in the absence or presence of various blocking antibodies against gp130, IL-6, IL-6?specific receptor IL-6R, and other gp130 pathway cytokines, OSM and LIF. 11-18 CM induced high levels of pSTAT3, which was inhibited by gp130, IL-6 ligand, or IL-6 receptor antibodies, but not in control IgG-, anti-OSM-, or anti-LIF antibody?treated MCF-10A cells (Figure 4B)." provenance.