Matches in Nanopublications for { ?s ?p "To this end, several studies have been directed towards understanding and elucidating the molecular mechanisms of GSH synthesis and regulation in type II alveolar epithelial cells in response to various environmental oxidants, antioxidants and inflammatory stimuli (table 2).....The GSH redox system is crucial in maintaining intracellular GSH/GSSG homeostasis, which is critical to normal cellular physiological processes, and represents one of the most important antioxidant defence systems in lung cells [64]. This system uses GSH as a substrate in the detoxification of peroxides such as H2O2 and lipid peroxides, a reaction which involves glutathione peroxidase.This reaction generates GSSG which is then reduced to GSH by glutathione reductase in a reaction requiring the hexose monophosphate shunt pathway utilizing NADPH" ?g. }
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- _4 value "To this end, several studies have been directed towards understanding and elucidating the molecular mechanisms of GSH synthesis and regulation in type II alveolar epithelial cells in response to various environmental oxidants, antioxidants and inflammatory stimuli (table 2).....The GSH redox system is crucial in maintaining intracellular GSH/GSSG homeostasis, which is critical to normal cellular physiological processes, and represents one of the most important antioxidant defence systems in lung cells [64]. This system uses GSH as a substrate in the detoxification of peroxides such as H2O2 and lipid peroxides, a reaction which involves glutathione peroxidase.This reaction generates GSSG which is then reduced to GSH by glutathione reductase in a reaction requiring the hexose monophosphate shunt pathway utilizing NADPH" provenance.