Matches in Nanopublications for { ?s ?p "Treatment of hippocampal neurons with thrombopoietin (TPO) for 15 hours at concentrations as low as 10 pM, increased the spontaneous cell death rate by >60%; treatment with AG-490 (20 microM), an inhibitor of JAK2-transphosphorylation, and PD-98059 (50 microM), an inhibitor of ERK1/2, completely eliminated TPO-induced neuronal death, as did the caspase-3 inhibitor Ac-VAD-CHO (50 microM), suggesting that receptor mediated activation of JAK2 and ERK1/2 are involved in caspase-3 activation and cell death in TPO treated hippocampal neurons." ?g. }
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- _4 value "Treatment of hippocampal neurons with thrombopoietin (TPO) for 15 hours at concentrations as low as 10 pM, increased the spontaneous cell death rate by >60%; treatment with AG-490 (20 microM), an inhibitor of JAK2-transphosphorylation, and PD-98059 (50 microM), an inhibitor of ERK1/2, completely eliminated TPO-induced neuronal death, as did the caspase-3 inhibitor Ac-VAD-CHO (50 microM), suggesting that receptor mediated activation of JAK2 and ERK1/2 are involved in caspase-3 activation and cell death in TPO treated hippocampal neurons." provenance.
- _4 value "Treatment of hippocampal neurons with thrombopoietin (TPO) for 15 hours at concentrations as low as 10 pM, increased the spontaneous cell death rate by >60%; treatment with AG-490 (20 microM), an inhibitor of JAK2-transphosphorylation, and PD-98059 (50 microM), an inhibitor of ERK1/2, completely eliminated TPO-induced neuronal death, as did the caspase-3 inhibitor Ac-VAD-CHO (50 microM), suggesting that receptor mediated activation of JAK2 and ERK1/2 are involved in caspase-3 activation and cell death in TPO treated hippocampal neurons." provenance.