Matches in Nanopublications for { ?s ?p "Using transienttransfection assays in HepG2 hepatoma cells, we demonstrated the ability of HLFalone and in synergistic combination with the D-box binding protein (DBP),another proline and acidic-rich (PAR) protein family member, to transactivatethese promoters. HLF is capable of binding to multiple sites in both the FactorVIII and Factor IX promoters. At least some of the synergistic activation of theFactor VIII promoter seen with HLF and DBP cotransfection can be attributed toincreased binding of HLF-DBP heterodimers to two Factor VIII promoter sites." ?g. }
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- _7 value "Using transienttransfection assays in HepG2 hepatoma cells, we demonstrated the ability of HLFalone and in synergistic combination with the D-box binding protein (DBP),another proline and acidic-rich (PAR) protein family member, to transactivatethese promoters. HLF is capable of binding to multiple sites in both the FactorVIII and Factor IX promoters. At least some of the synergistic activation of theFactor VIII promoter seen with HLF and DBP cotransfection can be attributed toincreased binding of HLF-DBP heterodimers to two Factor VIII promoter sites." provenance.
- _7 value "Using transienttransfection assays in HepG2 hepatoma cells, we demonstrated the ability of HLFalone and in synergistic combination with the D-box binding protein (DBP),another proline and acidic-rich (PAR) protein family member, to transactivatethese promoters. HLF is capable of binding to multiple sites in both the FactorVIII and Factor IX promoters. At least some of the synergistic activation of theFactor VIII promoter seen with HLF and DBP cotransfection can be attributed toincreased binding of HLF-DBP heterodimers to two Factor VIII promoter sites." provenance.