Matches in Nanopublications for { ?s ?p "We further demonstrated that DDR1 activated the MAPK cascade in a Ras-dependent manner. When DDR1 and either a DN mutant form of Ras (N17Ras) or Raf1 (DN-Raf-Flag), a direct downstream effector of Ras, were transiently transfected into 293T cells stimulated with collagen IV, activation levels of ERK were substantially decreased (Figure 4B). These findings demonstrated that DDR1 activates MAPK through Ras and Raf, as has been demonstrated for p53-induced MAPK activation (Lee et al., 2000)." ?g. }
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- _9 value "We further demonstrated that DDR1 activated the MAPK cascade in a Ras-dependent manner. When DDR1 and either a DN mutant form of Ras (N17Ras) or Raf1 (DN-Raf-Flag), a direct downstream effector of Ras, were transiently transfected into 293T cells stimulated with collagen IV, activation levels of ERK were substantially decreased (Figure 4B). These findings demonstrated that DDR1 activates MAPK through Ras and Raf, as has been demonstrated for p53-induced MAPK activation (Lee et al., 2000)." provenance.
- _6 value "We further demonstrated that DDR1 activated the MAPK cascade in a Ras-dependent manner. When DDR1 and either a DN mutant form of Ras (N17Ras) or Raf1 (DN-Raf-Flag), a direct downstream effector of Ras, were transiently transfected into 293T cells stimulated with collagen IV, activation levels of ERK were substantially decreased (Figure 4B). These findings demonstrated that DDR1 activates MAPK through Ras and Raf, as has been demonstrated for p53-induced MAPK activation (Lee et al., 2000)." provenance.
- _8 value "We further demonstrated that DDR1 activated the MAPK cascade in a Ras-dependent manner. When DDR1 and either a DN mutant form of Ras (N17Ras) or Raf1 (DN-Raf-Flag), a direct downstream effector of Ras, were transiently transfected into 293T cells stimulated with collagen IV, activation levels of ERK were substantially decreased (Figure 4B). These findings demonstrated that DDR1 activates MAPK through Ras and Raf, as has been demonstrated for p53-induced MAPK activation (Lee et al., 2000)." provenance.