Matches in Nanopublications for { ?s ?p "agents that inhibit NF?B activation are desired, and are currently being pursued,based on strategies that seek to maintain levels of endogenous NF?B-inhibiting I?B-family proteins, by either suppressing the IkB kinases (IKKs) responsible for phosphorylation of IkBalpha (which induces its polyubiquitination) or blocking the proteolytic activity of the 26s proteasome responsible for degrading IkB following ubiquitination (Figure 2A)." ?g. }
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- _5 value "agents that inhibit NF?B activation are desired, and are currently being pursued,based on strategies that seek to maintain levels of endogenous NF?B-inhibiting I?B-family proteins, by either suppressing the IkB kinases (IKKs) responsible for phosphorylation of IkBalpha (which induces its polyubiquitination) or blocking the proteolytic activity of the 26s proteasome responsible for degrading IkB following ubiquitination (Figure 2A)." provenance.