Matches in Nanopublications for { ?s ?p "from full text - However, after introduction of theWTMdm2 into these cells, a strong and rapid (5 min.) phosphorylation of both ERK1p42 and ERK2p44occurred. Upon stimulation with serum instead of IGF-1, phosphorylation of ERKs increased strongly in both mock and Mdm2-transfected Mdm2 KO cells (Fig. 4A, right panel) but was stabilized by Mdm2. This suggests that serum-induced ERK activation mediated by other growth factor receptor pathways is not dependent on Mdm2. Data from three experiments are presented in Fig. 4B, which suggest that Mdm2 is important for IGF-1-induced activation of ERK1/2." ?g. }
Showing items 1 to 1 of
1
with 100 items per page.
- _7 value "from full text - However, after introduction of theWTMdm2 into these cells, a strong and rapid (5 min.) phosphorylation of both ERK1p42 and ERK2p44occurred. Upon stimulation with serum instead of IGF-1, phosphorylation of ERKs increased strongly in both mock and Mdm2-transfected Mdm2 KO cells (Fig. 4A, right panel) but was stabilized by Mdm2. This suggests that serum-induced ERK activation mediated by other growth factor receptor pathways is not dependent on Mdm2. Data from three experiments are presented in Fig. 4B, which suggest that Mdm2 is important for IGF-1-induced activation of ERK1/2." provenance.