Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _3 value "Pretreatment of HCAECs with simvastatin or atorvastatin (1 and 10 microM) reduced ox-LDL-induced expression of LOX-1 as well as adhesion molecules" provenance.
- _3 value "Pretreatment of HCAECs with simvastatin or atorvastatin (1 and 10 microM) reduced ox-LDL-induced expression of LOX-1 as well as adhesion molecules" provenance.
- _3 value "Pretreatment of HCAECs with simvastatin or atorvastatin (1 and 10 microM) reduced ox-LDL-induced expression of LOX-1 as well as adhesion molecules" provenance.
- _3 value "We observed that ox-LDL (40 microg/ml) treatment up-regulated the expression of E- and P-selectins, VCAM-1 and ICAM-1 in HCAECs." provenance.
- _3 value "Treatment with TAS-103 increased the levels of both Sp1/Sp3 and Oct1 in nuclear extracts." provenance.
- _3 value "Treatment with TAS-103 increased the levels of both Sp1/Sp3 and Oct1 in nuclear extracts." provenance.
- _3 value "We have confirmed that both camptothecin and etoposide induce ATP6L promoter activity (data not shown)." provenance.
- _3 value "We have confirmed that both camptothecin and etoposide induce ATP6L promoter activity (data not shown)." provenance.
- _2 value "Table 1." provenance.
- _3 value "Table 1." provenance.
- _3 value "exercise training by obese Zucker rats leads to upregulation of ERK2 protein expression (90)" provenance.
- _3 value "muscle contractions lead to an increase in ERK1/2, isoforms of MAP kinase (39)" provenance.
- _3 value "muscle contractions lead to an increase in ERK1/2, isoforms of MAP kinase (39)" provenance.
- _4 value "It is known that LPS stimulation leads to increased activation of three subgroups of MAPKs, i.e., ERK, JNK, and p38, in murine macrophages and human monocytes (38, 39)." provenance.
- _4 value "It is known that LPS stimulation leads to increased activation of three subgroups of MAPKs, i.e., ERK, JNK, and p38, in murine macrophages and human monocytes (38, 39)." provenance.
- _4 value "It is known that LPS stimulation leads to increased activation of three subgroups of MAPKs, i.e., ERK, JNK, and p38, in murine macrophages and human monocytes (38, 39)." provenance.
- _4 value "It is known that LPS stimulation leads to increased activation of three subgroups of MAPKs, i.e., ERK, JNK, and p38, in murine macrophages and human monocytes (38, 39)." provenance.
- _6 value "cells expressing myrAkt maintained higher levels of transferrin receptor on the cell surface in the absence of IL3 than control cells these results indicate that transferrin receptor surface expression is regulated by IL3 and that myrAkt can support growth factor-independent transferrin receptor expression." provenance.
- _9 value "these results suggest that Akt-mediated increases in transporter and receptor surface expression in the absence of IL3 are dependent on mTOR activity." provenance.
- _9 value "these results suggest that Akt-mediated increases in transporter and receptor surface expression in the absence of IL3 are dependent on mTOR activity." provenance.
- _6 value "these results suggest that Akt-mediated increases in transporter and receptor surface expression in the absence of IL3 are dependent on mTOR activity." provenance.
- _5 value "These observations indicate that phosphorylation of Ser 362 and Ser 374 prime c-Fos for additional growth factor-regulated phosphorylation... ERK phosphorylates Thr 325 and Thr 331 in primed c-Fos. [Figure 2c shows the experimental results, done with ERK 1/2.]" provenance.
- _5 value "These observations indicate that phosphorylation of Ser 362 and Ser 374 prime c-Fos for additional growth factor-regulated phosphorylation... ERK phosphorylates Thr 325 and Thr 331 in primed c-Fos. [Figure 2c shows the experimental results, done with ERK 1/2.]" provenance.
- _6 value "Here we demonstrate that Tiam1, a Rac-specific GEF, preferentially associates with activated GTP-bound Ras through a Ras-binding domain. Furthermore, activated Ras and Tiam1 cooperate to cause synergistic formation of Rac-GTP in a PI(3)K-independent manner. Thus, Tiam1 can function as an effector that directly mediates Ras activation of Rac." provenance.
- _6 value "Here we demonstrate that Tiam1, a Rac-specific GEF, preferentially associates with activated GTP-bound Ras through a Ras-binding domain. Furthermore, activated Ras and Tiam1 cooperate to cause synergistic formation of Rac-GTP in a PI(3)K-independent manner. Thus, Tiam1 can function as an effector that directly mediates Ras activation of Rac." provenance.
- _3 value "FSH, through its second messengers (increase in intracellular cAMP and intracellular calcium), downregulated the glypican-1 mRNA expression in Sertoli cells from 20-day-old rats." provenance.
- _3 value "Ariadne: Glutamate and NMDA, which induced the highest increase in cytosolic Ca 2+ concentration, were also the most effective agonists in stimulating eEF-2 phosphorylation" provenance.
- _4 value "OSM treatment of BAE cells enhanced the synthesis of bFGF protein as determined by ELISA assays" provenance.
- _5 value "Besides binding, HB-EGF activates HER4. For example (i) it induces tyrosine phosphorylation of HER4 in cells overexpressing this receptor and of endogenous HER4 in MDA-MB-453 cells and astrocytes; (ii) it induces association of phosphatidylinositol 3-kinase (PI3-K) activity with HER4; and (iii) it is a potent chemotactic factor for cells overexpressing HER4. " provenance.
- _4 value "Costimulation of WEHI-231 and CH31 cells with calcium ionophores and protein kinase C agonists partially mimics anti-IgM stimulation and elicits a strong up-regulation of cyclin G2 mRNA and down-regulation of cyclin D2 mRNA. we treated logarithmically growing WEHI-231, CH31, BAL-17, and CH12 cells with 7 nM PdBu in combination with 250 nM ionomycin" provenance.
- _4 value "Costimulation of WEHI-231 and CH31 cells with calcium ionophores and protein kinase C agonists partially mimics anti-IgM stimulation and elicits a strong up-regulation of cyclin G2 mRNA and down-regulation of cyclin D2 mRNA. we treated logarithmically growing WEHI-231, CH31, BAL-17, and CH12 cells with 7 nM PdBu in combination with 250 nM ionomycin" provenance.
- _3 value "Unstimulated immature B cell lines (WEHI-231 and CH31) and unstimulated or IgM B cell receptor (BCR)-stimulated mature B cell lines (BAL-17 and CH12) rapidly proliferate and express low levels of cyclin G2 mRNA. These results suggest that in murine B cells responding to growth inhibitory stimuli cyclin G2 may be a key negative regulator of cell cycle progression." provenance.
- _4 value "Adrenaline and noradrenaline, the main effectors of the sympathetic nervous system and adrenal medulla, respectively, are thought to control adiposity and energy balance through several mechanisms. They promote catabolism of triglycerides and glycogen, stimulate food intake when injected into the central nervous system, activate thermogenesis in brown adipose tissue, and regulate heat loss through modulation of peripheral vasoconstriction and piloerection. Thermogenesis in brown adipose tissue occurs in response to cold and overeating (diet induced), and there is an inverse relationship between diet-induced thermogenesis and obesity both in humans and in animal models. As a potential model for obesity, we generated mice that cannot synthesize noradrenaline or adrenaline by inactivating the gene that encodes dopamine beta-hydroxylase. These mice are cold intolerant because they have impaired peripheral vasoconstriction and are unable to induce thermogenesis in brown adipose tissue through uncoupling protein (UCP1). The mutants have increased food intake but do not become obese because their basal metabolic rate is also elevated. The unexpected increase in basal metabolic rate is not due to hyperthyroidism, compensation by the widely expressed uncoupling protein UCP2, or shivering." provenance.
- _3 value "Transforming growth factor beta (TGF-beta) causes growth arrest in most cell types" provenance.
- _3 value "Caco-2 cells treated with various doses of VitaminD3(0.05-1.0 micromolar) for 2 weeks, observed these cells showed a dose-dependent increase in CYP3A7 mRNA expression to vitaminD3 treatment." provenance.
- _2 value "During lipid infusion, muscle UDP-N-acetyl-glucosamine (UDP-GlcNAc) increased by twofold" provenance.
- _2 value "Inadequate suppression of fatty acid oxidation by insulin is a common feature of various forms of insulin resistance in humans (2, 3)" provenance.
- _3 value "Ariadne: We previously found that PGE 2 was more effective in inhibiting alpha1(I) collagen accumulation induced by transforming growth factor-beta than that induced by insulin" provenance.
- _5 value "In this light, JDP2 could be used as a general inhibitor involved in cell cycle arrest and terminal differentiation and, like Mad, may have tumor suppressor activity The in vitro interaction of JDP2 with JunB and JunD was also examined (Fig. 5C). JDP2 formed heterodimeric complexes with both proteins. The stability of the JDP2-JunB and JDP2-JunD dimers is comparable to that of the c-Jun-JDP2 dimers (Fig. 5C). These results demonstrate that JDP1 and JDP2 are indeed bona fide members of the AP-1 group that heterodimerize with c-Jun or other Jun proteins." provenance.
- _4 value "Ectopic expression and activation of GR in human osteosarcoma cell lines U2OS and SAOS2, which lack endogenous receptors, result in a G1 cell cycle arrest." provenance.
- _5 value "Erk and p38 phosphorylate MNK1 and MNK2, which stimulates their in vitro kinase activity towards a substrate, EIF-4E" provenance.
- _5 value "Erk and p38 phosphorylate MNK1 and MNK2, which stimulates their in vitro kinase activity towards a substrate, EIF-4E" provenance.
- _5 value "Erk and p38 phosphorylate MNK1 and MNK2, which stimulates their in vitro kinase activity towards a substrate, EIF-4E" provenance.
- _5 value "MKNK1 was phosphorylated and activated by ERK1 and p38 MAP kinases but not by JNK/SAPK MNK1 was activated upon stimulation of HeLa cells with 12-o-tetradecanoylphorbol-13-acetate" provenance.
- _3 value "Accelerated muscle protein degradation and increased hepatic acute phase protein synthesis are hallmarks of an inflammatory response. The cytokines IL-1, IL-6, and TNF-a are able to stimulate hepatic synthesis of acute phase proteins in vivo and in vitro (Richards et al., 1991)." provenance.
- _5 value "Modified assertion" provenance.
- _5 value "from full text - Fig 2 and 3 - ATM kinase activates c-Abl kinase. Serine-465 of c-Abl is required for tyrosine kinase activation by ionizing radiation and ATM. 3T3 cells" provenance.
- _4 value "(TPA), a PKC activator that mimics diacylglycerol function, to cultures led to a significant decrease of both basal and phenobarbital-induced ALA-S mRNA levels" provenance.
- _5 value "protein kinase C (PKC) activation negatively influences ALA-S mRNA levels" provenance.
- _8 value "Modified assertion" provenance.
- _5 value "The dominant negative forms of Ras and Rac inhibited alpha6 beta4 integrin activation of Jnk1. Alpha6 beta4 integrin activates the Rac-Jnk signaling pathway via Ras and PI3K." provenance.
- _5 value "activation of Jnk was inhibited by dominant-negative Ras and Rac1 and by the phosphoinositide 3-kinase inhibitor" provenance.
- _7 value "activation of Jnk was inhibited by dominant-negative Ras and Rac1 and by the phosphoinositide 3-kinase inhibitor" provenance.
- _6 value "activation of Jnk was inhibited by dominant-negative Ras and Rac1 and by the phosphoinositide 3-kinase inhibitor" provenance.
- _6 value "stimulation of Erk by alpha6beta4 was suppressed by dominant-negative Shc, Ras and RhoA" provenance.
- _3 value "One of sixty cytogenetically aberrant myeloid malignancies, an AML with a complex karyotype including del(5q) and del(20q), showed a hemizygous interstitial deletion of the ETV6 and CDKN1B loci." provenance.
- _4 value "NF-I can synergistically enhance the transactivation of HNF-1alpha or HNF-3." provenance.
- _4 value "Site-directed mutagenesis or deletion of the NF-kappa B-like site decreased the cytokine-induced activity of the promoter... We show that the NF-kappa B-like site located at-90 in the MCP-1 promoter binds to the p50/p65 heterodimer of the NF-kappa B/Rel family in IL-1 beta-stimulated human endothelial cells." provenance.
- _4 value "Modified assertion" provenance.
- _5 value "In addition, E1A can repress the activity of HBP1 via conserved region 1 sequences in a manner independent of the CBP co-activator." provenance.
- _4 value "Addition of forskolin or prostaglandin E1, agents known to elevate platelet cAMP and calcium efflux, to platelets pre-labeled with [32P]PO4 resulted in the direct phosphorylation of platelet PMCA. Similarly, addition of the catalytic subunit of protein kinase A to platelet plasma membranes resulted in a 1.4-fold stimulation of activity. Thus, the previously reported inhibition of platelet activation by elevated intracellular cAMP may be accomplished in part by stimulation of PMCA, likely resulting in a decrease in intracellular calcium. " provenance.
- _5 value "Phosphorylation of erythrocyte ghosts and purified PMCA by pp60(src) also resulted in up to 75% inhibition of Ca2+-ATPase activity, and inhibition was correlated with tyrosine phosphorylation. Sequencing of a peptide obtained after 32P labeling of purified erythrocyte PMCA in vitro showed that tyrosine 1176 of PMCA4b is phosphorylated by pp60(src). These results indicate that tyrosine phosphorylation of platelet PMCA may serve as positive feedback to inhibit PMCA and increase intracellular calcium during platelet activation." provenance.
- _3 value "Staurosporine treatment was less effective in down-regulating cyclin B1 expression in asynchronous HeLa cells at earlier time points following irradiation when compared to caffeine-treated cells." provenance.
- _4 value "Neutralizing antibodies directed against either IL-6 or gp130 blocked protein S upregulation by the IL-6/sIL-6R complex." provenance.
- _4 value "treatment of H3922 cells with OM for 72 h lowers the steady-state level of c-myc mRNA to 16% of that seen in control cells" provenance.
- _3 value "Forskolin not only inhibited activation-induced cell death and NF-kappa B activation, but also suppressed expression of Fas and Fas ligand (Fas-L)" provenance.
- _3 value "Forskolin not only inhibited activation-induced cell death and NF-kappa B activation, but also suppressed expression of Fas and Fas ligand (Fas-L)" provenance.
- _3 value "Forskolin not only inhibited activation-induced cell death and NF-kappa B activation, but also suppressed expression of Fas and Fas ligand (Fas-L)" provenance.
- _5 value "From mutations file" provenance.
- _4 value "Treatment of cells with EPO resulted in formation of SIE binding complex and Beta-CAP (Beta casein/Csn2 promoter site) binding complex.The Beta-CAP binding complex was supershifted by the anti-Stat5 antibody." provenance.
- _3 value "Modified assertion" provenance.
- _4 value "This effect could be prevented with the compound KT5720, a specific inhibitor of the cAMP-dependent protein kinase." provenance.
- _5 value "Northern blot analysis and runoff transcription assays demonstrated that the protein kinase A pathway not only stimulated the activity of the luciferase reporter construct but also the transcription of the endogenous LAP/C/EBP beta gene in different cell types." provenance.
- _3 value "ECs under cyclic strain induced a sustained elevated production of intracellular superoxide. ECs under strain or pretreated with either H2O2 or xanthine oxidase/hypoxanthine induced MCP-1 expression." provenance.
- _2 value "ECs under cyclic strain induced a sustained elevated production of intracellular superoxide. ECs under strain or pretreated with either H2O2 or xanthine oxidase/hypoxanthine induced MCP-1 expression." provenance.
- _6 value "To examine directly the role of MKP-1 in the regulation of these protein kinases in vivo, we established a U937 cell line that conditionally expresses MKP-1 from the human metallothionein IIa promoter. Conditional expression of MKP-1 inhibited PMA-induced ERK2, SAPK, and p38 MAPK activity." provenance.
- _6 value "To examine directly the role of MKP-1 in the regulation of these protein kinases in vivo, we established a U937 cell line that conditionally expresses MKP-1 from the human metallothionein IIa promoter. Conditional expression of MKP-1 inhibited PMA-induced ERK2, SAPK, and p38 MAPK activity." provenance.
- _4 value "These observations suggested that the inverse gene expression of PGIS and TXS in macrophages contributes to immune responses by modulating the relative levels of prostacyclin and thromboxane A2." provenance.
- _3 value "# Ariadne: Furthermore, they demonstrated that retinoic acid is also a potent stimulant of IGFBP-5 synthesis by bone cells and results in increased amounts of IGFBP-5 in the ECM ( 20 ). [MolSynthesis]" provenance.
- _4 value "PAI-1 binding partially protects IGFBP-5 from proteolysis, suggesting that it is one of the ECM components that is involved in mediating this effect." provenance.
- _3 value "this effect ws mimicked by dibutyryl cAMP which indicated the involvement of elevated cAMP in the PGE2-mediated enhancement of BTG1." provenance.
- _6 value "ecto-ATPase activity in human neutrophils after stimulation with phorbol myristate acetate or N-formylmethionyl-leucyl-phenylalanine" provenance.
- _5 value "Study on signal transduction through Mp1 revealed that Tpo induces activation of JAK2 and Tyk2, which in turn activate STAT1, STAT3 and STAT5. Further, Tpo stimulates transcription factors GATA-1 and NF-E2, which induce differentiation markers, GPIIb/IIIa and Pm-1." provenance.
- _3 value "thiazolidinediones and fibrates exert their action by activating distinct transcription factors of the peroxisome proliferator activated receptor (PPAR) family, resulting in increased expression of lipoprotein lipase (LPL) and decreased expression of apolipoprotein (apo) C-III" provenance.
- _3 value "C1Q synthesis by tissue mononuclear phagocytes from normal and from damaged rat liver: up-regulation by dexamethasone, down-regulation by interferon gamma, and lipopolysaccharide" provenance.
- _6 value "We have identified a novel signaling protein, termed Daxx, that binds specifically to the Fas death domain. Overexpression of Daxx enhances Fas-mediated apoptosis and activates the Jun N-terminal kinase (JNK) pathway" provenance.
- _5 value "Modified assertion" provenance.
- _4 value "SAPK4 has a TGY dual phosphorylation motif and is activated in response to cellular stresses and proinflammatory cytokines" provenance.
- _5 value "The substrate specificity of SAPK4 in vitro was similar to that of SAPK3. Both enzymes phosphorylated the transcription factors ATF2, Elk-1 and SAP-1 at similar rates" provenance.
- _5 value "HOXB1 and Pbx1 cooperatively activate transcription through the Hoxb-1 gene autoregulatory element" provenance.
- _5 value "coactivators, such as ncoa1 and creb are required for efficient steroid receptor transactivation" provenance.
- _5 value "coactivators, such as ncoa1 and creb are required for efficient steroid receptor transactivation" provenance.
- _5 value "coactivators, such as ncoa1 and creb are required for efficient steroid receptor transactivation" provenance.
- _5 value "coactivators, such as ncoa1 and creb are required for efficient steroid receptor transactivation" provenance.
- _5 value "coactivators, such as ncoa1 and creb are required for efficient steroid receptor transactivation" provenance.
- _5 value "coactivators, such as ncoa1 and creb are required for efficient steroid receptor transactivation" provenance.
- _5 value "coactivators, such as ncoa1 and creb are required for efficient steroid receptor transactivation" provenance.
- _5 value "coactivators, such as ncoa1 and creb are required for efficient steroid receptor transactivation" provenance.
- _2 value "histone deacetylase inhibitor, trichostatin A, strongly potentiated PR-driven transcription" provenance.
- _4 value "histone deacetylase inhibitor, trichostatin A, strongly potentiated PR-driven transcription" provenance.