Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _6 value "identified four sites (Ser-124, Thr-308, Thr-450, and Ser-473) on Akt1 that are phosphorylated in vivo. Thr-308 and Ser-473 are inducibly phosphorylated after treatment of cells with extracellular stimuli, whereas Ser-124 and Thr-450 appear to be basally phosphorylated The third mechanism by which 3'-phosphorylated phosphoinositides regulate Akt activity is by controlling the accessibility of Akt as a substrate for PDKs. In in vitro reconstitution assays, the binding of PI3,4,5P to the Akt PH domain is required for PDK-1 to phosphorylate Akt In addition, PDK-1 complexed with either a fragment of PRK2, PRK2, or a PRK2-related peptide may be regulated by increased phospholipid concentrations" provenance.
- _8 value "Dlk can induce apoptosis. In search for interaction partners that might serve as regulators or targets of this kinase we identified apoptosis antagonizing transcription factor (AATF) Interestingly, AATF interfered with Dlk-induced apoptosis." provenance.
- _3 value "On treatment of LNCaP cells with R1881 (a synthetic androgen) it was observed that IGFBP-3 was markedly suppressed both by high and low concentrations of R1881. Levels of IGFBP-3 tended to be lower in biopsies from cancer patients as compared to patients with benign prostatic hyperplasia. It was further found that the marked increase in IGFBP-3 induced by ATRA was largely neutralized by androgen." provenance.
- _3 value "Treatment with Synthetic Androgen (R1881) resulted in a consistent downregulation of mRNA expression of Peg3 mRNA in LNCaP cells. Combined addition of androgen and actinomycin D revealed no change in the stability of Peg3 mRNA suggesting that androgens decrease Peg3 expression by inhibiting the rate of transcription" provenance.
- _5 value "\"IGF-II enhances trichostatin A-induced TGFbeta1 and p21(Waf1,Cip1, sdi1) expression in Hep3B cells.\"" provenance.
- _5 value "The c-Jun activation caused by Sgn2 overexpression is independent of JNK and mitogen-activated protein kinase kinase 4." provenance.
- _3 value "We here demonstrated that there was a dramatic rise of Id2 and Id3 mRNA levels when 3T3-L1 adipocytes or isolated rat fat cells were exposed to lipolytic and anti-lipogenic agents, forskolin and isoproterenol." provenance.
- _3 value "We here demonstrated that there was a dramatic rise of Id2 and Id3 mRNA levels when 3T3-L1 adipocytes or isolated rat fat cells were exposed to lipolytic and anti-lipogenic agents, forskolin and isoproterenol." provenance.
- _3 value "We here demonstrated that there was a dramatic rise of Id2 and Id3 mRNA levels when 3T3-L1 adipocytes or isolated rat fat cells were exposed to lipolytic and anti-lipogenic agents, forskolin and isoproterenol." provenance.
- _3 value "We here demonstrated that there was a dramatic rise of Id2 and Id3 mRNA levels when 3T3-L1 adipocytes or isolated rat fat cells were exposed to lipolytic and anti-lipogenic agents, forskolin and isoproterenol." provenance.
- _5 value "We here demonstrated that there was a dramatic rise of Id2 and Id3 mRNA levels when 3T3-L1 adipocytes or isolated rat fat cells were exposed to lipolytic and anti-lipogenic agents, forskolin and isoproterenol." provenance.
- _6 value "We conclude that Syk activation following Fcgamma receptor engagement initiates downstream signaling events leading to mitogen-activated protein kinase activation independent of PI 3-kinase activation." provenance.
- _3 value "1alpha,25-dihydroxyvitamin D(3) (D(3)) promotes the maturation of myeloid cells and surface expressions of CD14 and CD11b, markers of cell differentiation in response to D(3)." provenance.
- _3 value "1alpha,25-dihydroxyvitamin D(3) (D(3)) promotes the maturation of myeloid cells and surface expressions of CD14 and CD11b, markers of cell differentiation in response to D(3)." provenance.
- _5 value "Modified assertion" provenance.
- _3 value "PMA at 100 nmol/L strongly potentiated adhesion and tyrosine phosphorylation of p125(FAK) and p72(syk)" provenance.
- _3 value "PMA at 100 nmol/L strongly potentiated adhesion and tyrosine phosphorylation of p125(FAK) and p72(syk)" provenance.
- _6 value "PMA at 100 nmol/L strongly potentiated adhesion and tyrosine phosphorylation of p125(FAK) and p72(syk)" provenance.
- _5 value "The levels of cyclin D1 were elevated in tumors resulting from high levels of ornithine decarboxylase activity and the expression of v-Ha-ras. There appeared to be a cooperative effect of ornithine decarboxylase and v-Ha-ras in causing the accumulation of G1-related cyclin D1. Histone or Rb-associated kinase activities of cyclin complexes was elevated." provenance.
- _5 value "Modified assertion" provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _5 value "AKT2 triggers BAD phosphorylation at Ser-136, creating a binding site for 14-3-3 protein (22, 24). When BAD forms a complex with 14-3-3, it is unable to heterodimerize with and inhibit the survival activity of Bcl-XL or Bcl-2." provenance.
- _3 value "nerve growth factor overexpressing keratinocytes were partially resistant to apoptosis induced by increasing doses of ultraviolet B" provenance.
- _4 value "nerve growth factor overexpressing keratinocytes were partially resistant to apoptosis induced by increasing doses of ultraviolet B" provenance.
- _3 value "ultraviolet B radiation downregulated nerve growth factor mRNA and protein" provenance.
- _3 value "ultraviolet B radiation downregulated nerve growth factor mRNA and protein" provenance.
- _6 value "Treatment of androgen responsive prostate cancer cells with dihydrotestosterone leads to a rapid and reversible activation of mitogen-activated protein kinases MAPKs (also called extracellular signal-regulated kinases or Erks)." provenance.
- _5 value "The present work provides evidence that cAMP, through PKA-mediated CREB phosphorylation, and phenobarbital induce ALA-S expression at the transcriptional level, while heme represses it." provenance.
- _5 value "To delineate possible signaling pathways accounting for these gene expression, a subset of specific kinase inhibitors, SB203580, PD98059, rapamycin, LY294002, and Ro-32-0432, which inhibit p38 (HOG), MEK (MAPKK), S6 kinase, PI3 kinase, and protein kinase C (PKC), respectively, were employed. The IEGs were classified into three categories according to their susceptibility to the inhibitors. Expression of the first group (c-fos, jun-B, egr-1, tis11, tis21, thrombospondin-1, erp, thyroid hormone receptor [N-10], cyr61, and zf9) was mainly dependent on PKC and MEK pathways, while that of the second class (gene33 and tis10) exhibited an additional dependence on PI3 kinase pathways." provenance.
- _4 value "To delineate possible signaling pathways accounting for these gene expression, a subset of specific kinase inhibitors, SB203580, PD98059, rapamycin, LY294002, and Ro-32-0432, which inhibit p38 (HOG), MEK (MAPKK), S6 kinase, PI3 kinase, and protein kinase C (PKC), respectively, were employed. The IEGs were classified into three categories according to their susceptibility to the inhibitors. Expression of the first group (c-fos, jun-B, egr-1, tis11, tis21, thrombospondin-1, erp, thyroid hormone receptor [N-10], cyr61, and zf9) was mainly dependent on PKC and MEK pathways, while that of the second class (gene33 and tis10) exhibited an additional dependence on PI3 kinase pathways." provenance.
- _4 value "To delineate possible signaling pathways accounting for these gene expression, a subset of specific kinase inhibitors, SB203580, PD98059, rapamycin, LY294002, and Ro-32-0432, which inhibit p38 (HOG), MEK (MAPKK), S6 kinase, PI3 kinase, and protein kinase C (PKC), respectively, were employed. The IEGs were classified into three categories according to their susceptibility to the inhibitors. Expression of the first group (c-fos, jun-B, egr-1, tis11, tis21, thrombospondin-1, erp, thyroid hormone receptor [N-10], cyr61, and zf9) was mainly dependent on PKC and MEK pathways, while that of the second class (gene33 and tis10) exhibited an additional dependence on PI3 kinase pathways." provenance.
- _5 value "To delineate possible signaling pathways accounting for these gene expression, a subset of specific kinase inhibitors, SB203580, PD98059, rapamycin, LY294002, and Ro-32-0432, which inhibit p38 (HOG), MEK (MAPKK), S6 kinase, PI3 kinase, and protein kinase C (PKC), respectively, were employed. The IEGs were classified into three categories according to their susceptibility to the inhibitors. Expression of the first group (c-fos, jun-B, egr-1, tis11, tis21, thrombospondin-1, erp, thyroid hormone receptor [N-10], cyr61, and zf9) was mainly dependent on PKC and MEK pathways, while that of the second class (gene33 and tis10) exhibited an additional dependence on PI3 kinase pathways." provenance.
- _5 value "To delineate possible signaling pathways accounting for these gene expression, a subset of specific kinase inhibitors, SB203580, PD98059, rapamycin, LY294002, and Ro-32-0432, which inhibit p38 (HOG), MEK (MAPKK), S6 kinase, PI3 kinase, and protein kinase C (PKC), respectively, were employed. The IEGs were classified into three categories according to their susceptibility to the inhibitors. Expression of the first group (c-fos, jun-B, egr-1, tis11, tis21, thrombospondin-1, erp, thyroid hormone receptor [N-10], cyr61, and zf9) was mainly dependent on PKC and MEK pathways, while that of the second class (gene33 and tis10) exhibited an additional dependence on PI3 kinase pathways." provenance.
- _5 value "To delineate possible signaling pathways accounting for these gene expression, a subset of specific kinase inhibitors, SB203580, PD98059, rapamycin, LY294002, and Ro-32-0432, which inhibit p38 (HOG), MEK (MAPKK), S6 kinase, PI3 kinase, and protein kinase C (PKC), respectively, were employed. The IEGs were classified into three categories according to their susceptibility to the inhibitors. Expression of the first group (c-fos, jun-B, egr-1, tis11, tis21, thrombospondin-1, erp, thyroid hormone receptor [N-10], cyr61, and zf9) was mainly dependent on PKC and MEK pathways, while that of the second class (gene33 and tis10) exhibited an additional dependence on PI3 kinase pathways." provenance.
- _5 value "To delineate possible signaling pathways accounting for these gene expression, a subset of specific kinase inhibitors, SB203580, PD98059, rapamycin, LY294002, and Ro-32-0432, which inhibit p38 (HOG), MEK (MAPKK), S6 kinase, PI3 kinase, and protein kinase C (PKC), respectively, were employed. The IEGs were classified into three categories according to their susceptibility to the inhibitors. Expression of the first group (c-fos, jun-B, egr-1, tis11, tis21, thrombospondin-1, erp, thyroid hormone receptor [N-10], cyr61, and zf9) was mainly dependent on PKC and MEK pathways, while that of the second class (gene33 and tis10) exhibited an additional dependence on PI3 kinase pathways." provenance.
- _2 value "Morphological analysis and biochemical characterizations demonstrated that both compounds have similar abilities to induce apoptosis in cells expressing wild-type p53 (MCF-7) or mutant p53 (MDA-MB435 and MDA-MB453)." provenance.
- _3 value "Ca(2+)-store depletion caused an increased expression of p21 and p27 proteins (cyclin-dependent kinase inhibitors), with unchanged mutant p53 protein of C6 cells but reduced amounts of the cell cycle regulators: cyclin-dependent kinase 2 (CDK2), cdc2, cyclin C, cyclin D1, cyclin D3 and proliferating cell nuclear antigen (PCNA) in a time-dependent manner" provenance.
- _3 value "NADPH oxidase inhibitor, diphenyleneiodium chloride (DPI), could block cytokine-induced group IIA PLA(2) up-regulation by attenuating NF-kappaB binding. Reactive oxygen species such as H(2)O(2), which are elevated in mesangial cells after cytokine activation, can mimic cytokine-induced NF-kappaB activation." provenance.
- _2 value "Freshly isolated islets from IRS-1 knockout mice and SV40-transformed IRS-1-deficient beta-cell lines exhibit marked insulin secretory defects in response to glucose and arginine" provenance.
- _3 value "Interleukin 4 production by concanavalin A (Con A)-stimulated mesenteric lymph node cells (MLNC) was induced preferentially in infected +/+ mice." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _4 value "Inhibition of ecNOS activity in MCF-7 cells increased tumor cell apoptosis" provenance.
- _5 value "This effect of cAMP is mediated, in part, by protein kinase A phosphorylation of NFAT. The mechanism of regulation involves the creation of a phosphorylation-dependent binding site for 14-3-3." provenance.
- _3 value "We found that the expression of gp130 was dramatically induced at both the mRNA and protein levels by the two megakaryocytic inducers sodium butyrate (NaBut) and PMA." provenance.
- _5 value "cells were first subjected to retroviral-mediated gene transfer with a dominant-negative mutant of Ras (N17Ras). This resulted in a marked inhibition of PDGF-induced FAK tyrosine phosphorylation together with the expected reduction of PDGF-induced extracellular signal-regulated kinase activity (ERK)." provenance.
- _4 value "AP-1-dependent genes, such as collagenase (MMP-13) and stromelysin (MMP-3)" provenance.
- _4 value "we demonstrated that NF-{kappa}B is required for cytokine-induction of the rat MnSOD gene expression in insulin-producing cells." provenance.
- _4 value "It regulates proliferation, differentiation, and maturation of erythroid cells." provenance.
- _4 value "We report that TNF induces DNA replication in growth-arrested LE6 cells and that its effect involves the activation of NFkappaB and STAT3 and an increase in c-myc and IL-6 mRNAs. We conclude that NFkappaB is an essential component of the TNF proliferative pathway and that TNF-induced changes in IL-6 mRNA, STAT3, and c-myc mRNA are dependent on NFkappaB activation." provenance.
- _5 value "We report that TNF induces DNA replication in growth-arrested LE6 cells and that its effect involves the activation of NFkappaB and STAT3 and an increase in c-myc and IL-6 mRNAs. We conclude that NFkappaB is an essential component of the TNF proliferative pathway and that TNF-induced changes in IL-6 mRNA, STAT3, and c-myc mRNA are dependent on NFkappaB activation." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _4 value "TTF-1 protein synergistically stimulated the hSP-B promoter with RARalpha, CBP, and nuclear receptor coactivators in H441 cells." provenance.
- _3 value "Akt kinase activity and Rac1 peptide phosphorylation were down-regulated by the treatment of SK-MEL28 cells with wortmannin or LY294002 (a phosphoinositide 3-kinase inhibitor), but JNK/SAPK kinase activity was up-regulated." provenance.
- _3 value "Akt kinase activity and Rac1 peptide phosphorylation were down-regulated by the treatment of SK-MEL28 cells with wortmannin or LY294002 (a phosphoinositide 3-kinase inhibitor), but JNK/SAPK kinase activity was up-regulated." provenance.
- _4 value "Akt kinase activity and Rac1 peptide phosphorylation were down-regulated by the treatment of SK-MEL28 cells with wortmannin or LY294002 (a phosphoinositide 3-kinase inhibitor), but JNK/SAPK kinase activity was up-regulated." provenance.
- _4 value "Akt kinase activity and Rac1 peptide phosphorylation were down-regulated by the treatment of SK-MEL28 cells with wortmannin or LY294002 (a phosphoinositide 3-kinase inhibitor), but JNK/SAPK kinase activity was up-regulated." provenance.
- _5 value "Akt kinase activity and Rac1 peptide phosphorylation were down-regulated by the treatment of SK-MEL28 cells with wortmannin or LY294002 (a phosphoinositide 3-kinase inhibitor), but JNK/SAPK kinase activity was up-regulated." provenance.
- _4 value "Akt kinase activity and Rac1 peptide phosphorylation were down-regulated by the treatment of SK-MEL28 cells with wortmannin or LY294002 (a phosphoinositide 3-kinase inhibitor), but JNK/SAPK kinase activity was up-regulated." provenance.
- _6 value "Rac1 also activates MEKK3, which in turn phosphorylates MKK3" provenance.
- _6 value "Overexpression of N17Ras completely eliminated ERK phosphorylation at 5 minutes and 24 hours following NGF treatment indicating that Ras plays a critical role in the apoptotic pathways that are induced by NGF-mediated activation of TrkA receptors in the cells." provenance.
- _6 value "Expression of either dominant-negative Rac3N17 or PBD F107 almost completely blocked Pak and JNK activities, demonstrating that Rac3 is upstream of these proteins (Fig. 4B). " provenance.
- _6 value "A similar effect of Sp1 and Sp3 on transcription was seen in mRNA concentrations and enzyme activities of endogenous FAS and ACL." provenance.
- _6 value "A similar effect of Sp1 and Sp3 on transcription was seen in mRNA concentrations and enzyme activities of endogenous FAS and ACL." provenance.
- _6 value "mRNA concentrations and enzyme activities of endogenous acetyl-CoA carboxylase were suppressed by Sp1 and greatly increased by Sp3." provenance.
- _3 value "Upregulation of DDA3 could be detected within 2 h after down-shifting the temperature to 32.5 degrees C; upon shifting back to 38.5 degrees C, DDA3 mRNA rapidly degraded with a half-life of less than 2 h." provenance.
- _7 value "complex formation between PKC-zeta and Raf-1 is mediated strongly by the 14-3-3beta and -theta" provenance.
- _9 value "protein kinase C-zeta (PKC-zeta) can phosphorylate and activate Raf-1 in a signalling complex" provenance.
- _3 value "Treatment of synovial fibroblast obtained from Osteoarthritis (OA) patients with 5ng/ml TNFalpha markedly increased NF-kappaB nuclear binding accumulation. IL-11 at 25ng/ml decreased the TNFalpha stimulated NF-kappaB level." provenance.
- _5 value "Angiogenic basic fibroblast growth factor (bFGF) or vascular endothelial growth factor (VEGF) increased TXA(2) synthesis in endothelial cells three- to fivefold." provenance.
- _3 value "Angiogenic basic fibroblast growth factor (bFGF) or vascular endothelial growth factor (VEGF) increased TXA(2) synthesis in endothelial cells three- to fivefold." provenance.
- _5 value "Modified assertion" provenance.
- _4 value "These studies demonstrate that GATA6 is a direct target gene for Nkx2.5 in the developing heart and reveal a mutually reinforcing regulatory network of Nkx2.5 and GATA transcription factors during cardiogenesis." provenance.
- _4 value "Mutagenesis of the GBS inhibited TTF-1-dependent activation of the SP-A promoter, and the activity of the GBS was influenced by mutations in any of three distinct TTF-1 regulatory elements located within the 5'-flanking region of the SP-A gene." provenance.
- _4 value "Transfection of a construct expressing GATA-6- engrailed fusion protein inhibited basal expression of the SP-A/chloramphenicol acetyltransferase construct in MLE-15 cells." provenance.
- _5 value "In transient cotransfection assays using CV1 cells with full-length human AR and a mouse mammary tumor virus luciferase reporter vector, there was an androgen-dependent 3- to 5-fold greater increase in luciferase activity with PIAS1 over that obtained with an equal amount of control antisense cDNA or mutant PIAS1" provenance.
- _4 value "Effect of NGF on the Expression of PSA Continuous exposure of LNCaP cells to NGF markedly enhanced the expression of PSA, a typical marker of cellular differentiation in prostatic epithelial cells." provenance.
- _4 value "binding of L-glutamate to the class II metabotropic glutamate receptor, norepinephrine (NE)-dependent formation of cAMP was inhibited, resulting in decreased serotonin-N-acetyltransferase (NAT) activity and melatonin output." provenance.
- _4 value "Macrophages of diabetic patients expressed higher Ppara and Pparb mRNA levels than did macrophages of control subject. Macrophages of diabetic patients also expressed significantly lower Pparg mRNA levels compared with levels in macrophages of control subjects." provenance.
- _4 value "The normal actions of HNF-1 include enhancing the transcription of apo B 23 24 25 and suppressing the transcription of apo AI. 27 Thus, in subjects with type 2 diabetes, the lower plasma total and LDL cholesterol and apo B levels would also be consistent with transactivational loss of function of the HNF1A S319 product." provenance.
- _5 value "The mechanism for the cell cycle downregulation appeared to be a transcriptional downregulation of E2F-1, a transcription factor that regulates genes required for cell cycle progression beyond the G1/S interphase." provenance.
- _5 value "However, a mutant at site 371 completely lost the ability to enhance receptor ubiquitination and degradation in living cells ( Figure 6D)." provenance.
- _4 value "p90RSK activation by H(2)O(2) was significantly reduced in fibroblasts derived from transgenic mice deficient in Fyn, but not c-Src. " provenance.
- _4 value "Activation of the Adss1 gene involves the calcineurin-mediated dephosphorylation of NFAT3, allowing its translocation to the nucleus, where it can directly participate in Adss1 gene activation." provenance.
- _4 value "Modified assertion" provenance.
- _3 value "As AR expression can be reduced by an increase in intracellular calcium levels" provenance.
- _2 value "An increase in cAMP and/or cGMP induces vasodilation" provenance.
- _4 value "An up-regulation of Mash1 (Ascl1) expression was observed throughout the dorsomedial cortical ventral zone of Ngn2 mutant embryos at E12.5 and E13.5. This up-regulation was less apparent in the lateral ventral zone in which Ngn1 expression was maintained in Ngn2 mutants. Mash1 up-regulation was strikingly enhanced in the dorsal telencephalon and dorsal thalamus of Ngn1 and Ngn2 double mutant embryos. These results suggest that the Ngns function in a partially redundant manner to restrict Mash1 expression to limited domains of the forebrain neuroepithelium." provenance.
- _4 value "Reduction in the expression levels of Math2 (dorsal -specific neuronal marker) was observed in the dorsal and medial telencephalic preplate of Ngn2 mutant at E12.5 as compared to wild-type. These results demonstrate that Ngn2 plays an important role in the upregulation of dorsal postmitotic markers leading to dorsal neuron specification." provenance.
- _4 value "Reduction in the expression levels of Nscl2 (dorsal -specific neuronal marker) was observed in the dorsal and medial telencephalic preplate of Ngn2 mutant at E12.5 as compared to wild-type. These results demonstrate that Ngn2 plays an important role in the upregulation of dorsal postmitotic markers leading to dorsal neuron specification." provenance.
- _4 value "Stimulation of p46 and p54 JNKs by IL-1b (100 ng/ml, 10 min) were 84�3% and 55�7% of the response to sorbitol, respectively (means�S.E.M. for three independent observations)." provenance.
- _4 value "The cytokine TGF-beta inhibits basal expression of Fas as well as cytokine-mediated Fas expression by microglia" provenance.
- _6 value "FAK is also a phosphorylation target of Rho in cultured fibroblasts (27). 27. Flinn, H. M., and A. J. Ridley. Rho stimulates tyrosine phosphorylation of focal adhesion kinase, p130, and paxillin. J. Cell. Sci. 109: 1133-1141, 1996." provenance.
- _4 value "The degree of FAK activation during myogenesis by b1A-integrin signaling can regulate myoblast progression through proliferation and differentiation (52)." provenance.
- _5 value "p160ROCK is a mediator of endothelin-1 (ET-1) induction of the brain natriuretic peptide promoter by RhoA in hypertrophying cardiac myocytes (40)" provenance.
- _3 value "It is important to investigate the action of hypertonicity on cystic fibrosis gene expression because cystic fibrosis transmembrane conductance regulator (CFTR), the cAMP-regulated Cl(-) channel, regulates ion transport across the secretory epithelia, which are often in a hypertonic environment. The CFTR gene activity is regulated at the transcriptional level" provenance.
- _6 value "# Ariadne: It has been demonstrated that osteoadherin can mediate cell attachment via binding by alpha v eta 3 integrin in vitro ( 45 ). [Regulation]" provenance.
- _5 value "in contrast to the direct recruitment of Stat4 by the IL-12 receptor, Stat4 activation by the human IFN-alpha receptor occurs through indirect recruitment by intermediates involving Stat2" provenance.
- _3 value "In endothelial cells, the PPARgamma agonists troglitazone at 100 micromol/L and 15-deoxy-(Delta12,14)-prostaglandin J(2) (15d-PGJ2) at 20 micromol/L markedly attenuated the tumor necrosis factor-induced expression of VCAM-1 and ICAM-1." provenance.
- _4 value "PACAP gene transcription was also induced by NGF." provenance.