Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _6 value "SKRP1 specifically enhanced the activation of MKK7 by ASK1" provenance.
- _3 value "The results below were combined from Tables 1 and 3 in the paper (Table 2 contained nothing suitable). These genes were upregulated (fold change >= 4.0)." provenance.
- _3 value "The results below were combined from Tables 1 and 3 in the paper (Table 2 contained nothing suitable). These genes were upregulated (fold change >= 4.0)." provenance.
- _3 value "These genes were downregulated (fold change < 0.33)." provenance.
- _4 value "recently found that exposure of vascular smooth muscle cells to HG augments the Ang II activation of the growth promoting JAK/STAT pathway. We found that Ang II-induced JAK2, STAT1, STAT3, STAT5A/B and SHP-2 phosphorylations were enhanced by HG, whereas that of SHP-1 was reduced." provenance.
- _3 value "Further, PTH (1-38), (1-31), PTHrP (1-34), and forskolin, which elevate cAMP levels, stimulated the promoter, while PTH (3-34) and (7-34), which do not readily stimulate cAMP accumulation, and PMA that directly activates protein kinase C, had no effect on promoter activity" provenance.
- _5 value "PKA also decreased Raf-1 serine 338 phosphorylation of Raf-1, previously shown to be required for Raf-1 activation. " provenance.
- _5 value "acetylation-deficient AR mutants were selectively defective in DHT-induced trans activation of androgen-responsive reporter genes and coactivation by SRC1, Ubc9, TIP60, and p300." provenance.
- _5 value "In human embryonic kidney 293 cells, IL-1beta induces IkappaB kinase beta (IKKbeta) activation, IkappaBalpha degradation, NF-kappaB transactivation, and weak Akt activation." provenance.
- _6 value "in embryonic kidney cells expressing full-length DCC, NTN1 causes increased transient phosphorylation and activity of ERK1 and ERK2 but not of JNK1, JNK2 or MAPK14 this phosphorylation was mediated by MAP2K1 (aka MEK1) and/or MAP2K2 (aka MEK2)" provenance.
- _5 value "The stimulation of cells derived from the kidney proximal tubules with apoA-I or HDL induces a concentration-dependent secretion of AI-BP indicating an important role for AI-BP, in the renal tubular degradation or resorption of apoA-I." provenance.
- _8 value "PP1 treatment blocks EGF-induced activation of the anti-apoptotic protein kinase Akt suggesting that Src may regulate activation of Akt, perhaps by a Src --> c-Cbl --> phosphatidylinositol 3'-kinase --> Akt pathway." provenance.
- _7 value "eNOS-derived NO and its biological effects are determined by the levels of eNOS protein and by eNOS catalytic activity; the latter is regulated partly through the dynamic interaction with an inhibitory protein (caveolin) and a stimulatory protein (calmodulin)." provenance.
- _4 value "Stimulation with rhCD40L resulted in a potent induction of NF-kB binding activity, which was inhibited in cells overexpressing I-kBa (Figure 5A). " provenance.
- _4 value "proteasomal inhibitors do not affect apoB degradation stimulated by either fish oils or insulin a variety of experimental data indicate that these stimuli induce the degradation of apoB after translocation, assembly with lipids, and exit from the ER interestingly, inhibition of phosphatidylinositol 3-kinase reduces the degradation stimulated by either fish oils or insulin" provenance.
- _3 value "Twenty-eight genes were found to be induced or upregulated by heat-shock in IMC-3 cells. These included genes involved in the apoptosis (e.g., CC3, caspase10), tumor invasion (e.g., CC3, TIMP-3), cell cycle checkpoint control (e.g., DP-1, CDC25A), signal transduction (e.g., MEK1) as well as genes associated with heat stress (e.g., Hsp70B', Hsp40)" provenance.
- _3 value "Using cDNA microarrays, we identified StarD4 as a gene whose expression decreased more than 2-fold in the livers of mice fed a high-cholesterol diet." provenance.
- _3 value "Using cDNA microarrays, we identified StarD4 as a gene whose expression decreased more than 2-fold in the livers of mice fed a high-cholesterol diet." provenance.
- _4 value "he CS-dependent induction of ho-1 may be achieved potentially, at least in part, via activation of transcription factors binding to AP-1 and C/EBP recognition elements, which are both integral parts of the murine ho-1 promoter" provenance.
- _3 value "Hypoxic stimulation (5% O(2)) of MDA231 cells increased their steady-state level of ctgf mRNA by approximately 2-fold within 1.5 h, and the levels remained at a plateau up to 6 h, and then decreased by 12 h as compared with the cells cultured under the normoxic condition. Membrane-type 1 MMP (MT1-MMP) mRNA levels was also increased within a few hours of the exposure to hypoxia." provenance.
- _2 value "Finally, leptin activates phospholipase C and voltage-dependent Ca2 + channels, most likely L-type and N-type Ca2 + channels, an effect that might underlie leptin-induced catecholamine secretion [121]." provenance.
- _5 value "E2F1,2,3 indicated in Rb-independent repression of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor 1 (PAI-1)" provenance.
- _3 value "The information below is from table 3 [SH]" provenance.
- _2 value "High-dose aspirin treatment resulted in a approximately 25% reduction in fasting plasma glucose, associated with a approximately 15% reduction in total cholesterol and C-reactive protein, a approximately 50% reduction in triglycerides, and a approximately 30% reduction in insulin clearance, despite no change in body weight." provenance.
- _4 value "Vegf (10ng/ml) treatment induced the Tyrosine phosphorylation of FAK in Raw cells. Tyrosine phosphorylation was observed at Y397 and Y925 in FAK." provenance.
- _4 value "RNA interference-mediated downregulation of endogenous RASSF1A expression in human epithelial cells results in abnormal accumulation of cyclin D1 protein" provenance.
- _4 value "growth inhibitors such as transforming growth factor TGF beta block Mat2a up-regulation while increasing Mat1a mRNA levels" provenance.
- _4 value "These genes come from a Table 1. I have taken only the human genes; there is additional animal data. Omitted from this list are human facts in the table that we already have." provenance.
- _3 value "Below are the contents of a table from the paper" provenance.
- _3 value "Below are the contents of a table from the paper" provenance.
- _5 value "Insulin stimulates malic enzyme (ME)-chloramphenicol acetyltransferase (CAT) and collagenase-1-CAT fusion gene expression in H4IIE cells through identical activator protein-1 (AP-1) motifs." provenance.
- _4 value "In conclusion, we show here that insulin regulates HIF-1 action through a PI3K/TOR-dependent pathway, resulting in increased VEGF expression." provenance.
- _3 value "19-norD(2) was less potent than 1,25(OH)(2)D(3) in stimulating expression of CaT1, Calbindin D9k and PMCA1." provenance.
- _3 value "19-norD(2) was less potent than 1,25(OH)(2)D(3) in stimulating expression of CaT1, Calbindin D9k and PMCA1." provenance.
- _5 value "Modified assertion" provenance.
- _4 value "Oncogene cooperation by Tbx3 correlates with an ability of Tbx3 to suppress the induction of p19ARF and p53 that is typically caused by overexpression Myc and Ras, and to protect against Myc-induced apoptosis." provenance.
- _4 value "NGF can protect the injured nerve tissues through stimulating the expression of bcl-2 protein, inhibiting the expression of bax protein and inhibiting the neuronal apoptosis after SCI." provenance.
- _6 value "Beta Catenin" provenance.
- _5 value "AKT phosphorylates the proapoptotic Bcl-2 family member Bad at Ser-136 phosphorylated Bad is sequestered in the cytoplasm to 14-3-3" provenance.
- _4 value "Adhesion of human skin fibroblasts cells to fibronectin or anti-beta1-integrin for 30 minutes resulted in tyrosine phosphorylation of ERK-1, indicating that phosphorylation induced by fibronectin was at least partially dependent on beta1-integrins. Phosphorylation occurred as early as 5 minutes after plating cells and maximal response (4 to 5-fold enhanced activation) was obtained after 20 minutes of adhesion to fibronectin." provenance.
- _7 value "Upon attachment to fibronectin, ECV 304 cells transfected with dn Cdc42 or dn Rac1 mutants exhibited the phosphorylated form of FAK. FAK phosphorylated at Tyr397 appeared within 60 minutes and was detected even in the presence of dn Cdc42 or dn Rac1, indicating that these integrin-induced signaling components are still activated by attachment when Cdc42 and Rac1 are blocked." provenance.
- _6 value "An increase in c-Jun phosphorylation by ERK was also found to accompany the increased AP-1 activity as detected by Western blot." provenance.
- _3 value "Dietary cholesterol stimulates CYP7A1 transcription via activation of oxysterol receptor, LXR alpha, whereas bile acids repress transcription through FXR-mediated induction of SHP protein. " provenance.
- _3 value "Angiotensin II is a potent stimulant for the contraction of vascular smooth muscle. It also stimulates the synthesis and release of aldosterone from the adrenal cortex." provenance.
- _5 value "myogenin as an important transcriptional target under the control of three intracellular signaling pathways, namely, the p38 mitogen-activated protein kinase- (MAPK), calcium-calmodulin-dependent protein kinase- (CaMK), and calcineurin-mediated pathways,... Our data support a model in which all three signaling pathways act in parallel but nonredundantly to control myogenin expression. Inhibition of any one pathway will result in abolished or reduced myogenin expression" provenance.
- _2 value "Overexpression of Se-W markedly reduced the sensitivity of both cell lines to H2O2 cytotoxicity. The intracellular peroxide concentration of the transfected cells was lower than that of the parental cells in the absence or presence of extracellular H2O2." provenance.
- _3 value "Overexpression of Se-W markedly reduced the sensitivity of both cell lines to H2O2 cytotoxicity. The intracellular peroxide concentration of the transfected cells was lower than that of the parental cells in the absence or presence of extracellular H2O2." provenance.
- _5 value "The PI3K inhibitor, LY294002, and a tumor suppressor, PTEN, negatively regulate the PI3K/Akt pathway and repress AR activity." provenance.
- _3 value "Herein we show that inhibition of the aldehyde-metabolizing enzyme aldose reductase (AR) inhibits NF-kappa B activation during restenosis of balloon-injured rat carotid arteries as well as VSMC proliferation due to tumor necrosis factor alpha (TNF-alpha) stimulation" provenance.
- _2 value "NADPH oxidase inhibitor PH2I, xanthine oxidase inhibitor allopurinol, and free-radical scavenger catalase also prevented TCDC-induced contraction TCDC caused H2O2 production, lipid peroxidation, and increased PGE2 synthesis and activities of catalase and SOD." provenance.
- _5 value "That hypothesis is consistent with the presence of a functional p53-response element within the promoter region of the mouse SIP gene and confirmed by the induction of SIP mRNA expression in mouse embryo fibroblasts upon activation of a p53-dependent pathway by transfection with rasV12 or rasV12/E1A" provenance.
- _6 value "MCP-1 also induced extracellular signal-regulated kinase, which, along with IL-6 release, was inhibited by pertussis toxin." provenance.
- _5 value "Modified assertion" provenance.
- _5 value "From mutations file" provenance.
- _3 value "17alpha-Ethinyl estradiol (EE) pretreatment reduced the IL-1beta induction of approximately one third of these genes. Estrogen receptor alpha (ERalpha) was required for this inhibitory activity, because EE inhibition of IL-1beta-stimulated gene expression occurred in ERbeta knockout mice, but not in ERalpha knockout mice. Table 2. EE induction of gene expression in the mouse liver" provenance.
- _3 value "Recently, we reported that the AS3 protein mediates the androgen-induced quiescence in androgen-target human cell lines." provenance.
- _5 value "Importantly, co-expression of SIAH1 completely reverses repression of Smad7 promoter activity by TIEG1." provenance.
- _4 value "Furthermore, Wnt-3A overexpression results in decreases in both N-cadherin and GSK-3beta protein levels, whereas Wnt-3A as well as kinase-dead GSK-3beta overexpression increase total and nuclear levels of both beta-catenin and LEF-1." provenance.
- _3 value "Increased extracellular tonicity effected a time-dependent reduction in eNOS and iNOS protein levels, eNOS mRNA levels, and eNOS gene promoter activity over the first 8 h of the incubation." provenance.
- _2 value "BC concentrate dose-dependently relaxed the norepinephrine (0.1 microM)-precontracted aorta" provenance.
- _4 value "Cell death induced by ceramide was significantly reduced by insulin-like growth factor-binding protein-3 in the MCF-10A cells and depleting insulin-like growth factor-binding protein-3 with transforming growth factor-beta in these cells consequently increased their susceptibility to ceramide." provenance.
- _5 value "the phosphorylation of Raf-1 on Ser-259 induced by paclitaxel he region surrounding Ser-259 in Raf-1 conforms to a consensus sequence for phosphorylation by Akt" provenance.
- _5 value "TR2 orphan receptor (TR2), a member of the nuclear receptor superfamily without identified ligands, is found to be expressed in the breast cancer cell lines and to function as a repressor to suppress ER-mediated transcriptional activity. Utilizing an interaction blocker, ER-6 (amino acids 312-340), responsible for TR2 interaction, the suppression of ER by TR2 could be reversed, suggesting that this suppression is conferred by the direct protein-protein interaction." provenance.
- _4 value "In contrast, the PI3K inhibitor LY492002 has no effect on insulin-stimulated phosphorylation of ETS-2, despite the fact that it diminishes insulin-stimulated phosphorylation of Akt." provenance.
- _6 value "Modified assertion" provenance.
- _5 value "Finally, IL-18-induced cell surface VCAM-1 expression was inhibited by treatment with AS ODNs to c-Src, IRAK, PI3-kinase, and ERK1/2 by 57, 43, 41, and 32% compared with control sense ODN treatment, respectively." provenance.
- _5 value "In an alternate pathway, inhibition of IL-1 receptor-associated kinase-1 (IRAK) with AS ODN to IRAK reduced IL-18-induced expression of nuclear factor kappaB (NFkappaB). Finally, IL-18-induced cell surface VCAM-1 expression was inhibited by treatment with AS ODNs to c-Src, IRAK, PI3-kinase, and ERK1/2" provenance.
- _5 value "Furthermore, ATP-citrate lyase was phosphorylated in vitro by recombinant protein kinase B on the same site. Taken together, these results demonstrate that serine 454 of ATP-citrate lyase is a novel and major in vivo substrate for protein kinase B." provenance.
- _3 value "We show that peroxiredoxins I and II are present in the cytoplasm of pancreatic islet cells as well as in insulinoma cell lines beta TC6-F7 and INS-1. Peroxiredoxins I and II were up-regulated by all stress agents used." provenance.
- _3 value "We show that peroxiredoxins I and II are present in the cytoplasm of pancreatic islet cells as well as in insulinoma cell lines beta TC6-F7 and INS-1. Peroxiredoxins I and II were up-regulated by all stress agents used." provenance.
- _5 value "nonreceptor tyrosine kinases, such as Btk, Tec, Fes, and Hck are activated through the Il6R receptor" provenance.
- _4 value "The p53 tumor suppressor is inhibited and destabilized by Mdm2. c-Abl is important for p53 activation under stress conditions. In response to DNA damage, c-Abl protects p53 by neutralizing the inhibitory effects of Mdm2. Hdm2 (human Mdm2) phosphorylation at Tyr394. Substitution of Tyr394 by Phe394 enhances the ability of Mdm2 to promote p53 degradation and to inhibit its transcriptional and apoptotic activities. Our results suggest that phosphorylation of Mdm2 by c-Abl impairs the inhibition of p53 by Mdm2, hence defining a novel mechanism by which c-Abl activates p53. Mutation studies revealed that N-terminal and C-terminal of mdm2 are both important for binding c-Abl." provenance.
- _5 value "Dexamethasone induced the phosphorylation of p38 mitogen-activated protein (MAP) kinase." provenance.
- _5 value "Modified assertion" provenance.
- _6 value "OSM caused ligand-independent activation of the AR in DU-145 cells. In the presence of OSM, hydroxyflutamide behaved as an AR agonist. Bicalutamide down-regulated AR activation caused by OSM only at a concentration of 1 microM." provenance.
- _4 value "Among the MMPs, MMP-1, -3, -7, and -13 processed CTGF of the complex into the major NH(2)- and COOH-terminal fragments, whereas VEGF(165) was completely resistant to the MMPs." provenance.
- _7 value "# Ariadne: In addition, GRIP-1/TIF-2 has been shown to interact with RORalpha and to stimulate its transcriptional activity ( 42 ). [Binding]" provenance.
- _3 value "This protein has a potential role in protecting the NADPH oxidase by inactivating H(2)O(2) or altering signaling pathways affected by H(2)O(2)." provenance.
- _5 value "Hyaluronan-CD44 binding stimulated Ras-Mek1-Mapk pathway, which inturn stimulated MMP-2 secretion in a time and dose dependent manner." provenance.
- _3 value "We observed that ox-LDL (40 microg/ml) treatment up-regulated the expression of E- and P-selectins, VCAM-1 and ICAM-1 in HCAECs." provenance.
- _3 value "Table 1." provenance.
- _6 value "cells expressing myrAkt maintained higher levels of transferrin receptor on the cell surface in the absence of IL3 than control cells these results indicate that transferrin receptor surface expression is regulated by IL3 and that myrAkt can support growth factor-independent transferrin receptor expression." provenance.
- _4 value "title := \"ATP regulates the differentiation of mammalian skeletal muscle by activation of a P2X5 receptor on satellite cells.\" Using immunocytochemistry, RT-PCR, and electrophysiology, we demonstrate that the ionotropic P2X5 receptor is present on satellite cells and that activation of a P2X receptor inhibits proliferation, stimulates expression of markers of muscle cell differentiation, including myogenin, p21, and myosin heavy chain, and increases the rate of myotube formation." provenance.
- _6 value "TGF-, which also binds to EGFR, also increased glucose transport to the same extent as insulin and with a similar affinity" provenance.
- _3 value "The activation of PI 3-kinase lipid kinase and the downstream serine/threonine kinase, PKB/Akt, by insulin is critical for the translocation of GLUT4 to the plasma membrane and the increased glucose transport" provenance.
- _6 value "Finally, Ark-mediated repression was significantly attenuated by a dominant negative MEF2C, whereas repression induced by constitutively active Rac was unaffected, indicating that MEF2 proteins are not targets of the Ark -- Rac -- MEK -- ERK cascade." provenance.
- _3 value "In addition to HSP70, other heat shock proteins have been examined for their induction by hypertonicity. A small heat shock protein (B-crystallin [4]), a HSP40 called HLJ1 (34), and a couple of the HSP110 members (Osp94 [16] and HSP105B [42]) are induced by hypertonicity" provenance.
- _6 value "Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek" provenance.
- _4 value "The ability of TGF-beta1 to induce BGN mRNA was critically dependent on Smad signaling, since 1) the up-regulation of BGN mRNA was preceded by a marked increase in Smad2 phosphorylation in TGF-beta1-treated PANC-1 cells, 2) TGF-beta1 was unable to induce BGN mRNA in pancreatic carcinoma cell lines that carry homozygous deletions of the Smad4/DPC4 gene, 3) inhibition of the Smad pathway in PANC-1 cells by transfection with a dominant negative Smad4/DPC4 mutant significantly reduced TGF-beta1-induced BGN mRNA expression, 4) stable reintroduction of wild type Smad4/DPC4 into Smad4-null CFPAC-1 cells restored the TGF-beta1 effect," provenance.
- _5 value "Fetuin knockout (KO) mice demonstrate increased basal and insulin-stimulated phosphorylation of IR and the downstream signaling molecules mitogen-activated protein kinase (MAPK) and Akt in liver and skeletal muscle." provenance.
- _4 value "Whereas c-Jun is up-regulated by an autoregulatory process, JunB is under control of NF-kappa B." provenance.
- _3 value "Consistent with the previous reports, p73 was accumulated after the treatment with cisplatin. Intriguingly, we found a putative p53/p73-binding site in the 5'-upstream region of the human DAN gene. A luciferase reporter assay and an in vitro DNA-binding experiment revealed that this canonical p53/p73-binding site was a functional responsive element and was specific for p73. " provenance.
- _5 value "bFGF downregulates p27(kip1) and upregulates cyclin D2 expression. This contrasts with NT3, which upregulates p27(kip1) and downregulates cyclin D2 expression" provenance.
- _5 value "In the presence of C/ EBPalpha, Nkx2.1 stimulated the CCSP promoter already at 50 ng of Nkx2.1 expression plasmid (Fig. 2 B )." provenance.
- _3 value "in the absence of Mat1a major changes include a relative switch in Mat expression, decreased hepatic AdoMet, GSH, and DNA methylation levels, decreased homocysteine metabolism, and hyperhomocysteinemia consequences of hepatic DNA hypomethylation include increased expression of c-myc and DNA strand break accumulation one possible consequence of hyperhomocystenemia is increased fibrogenesis" provenance.
- _4 value "The expression of the GATA5 antisense cDNA had no effect on the morphology or proliferation of undifferentiated cells (Fig. 5D and data not shown). However, in the absence of GATA5 protein, treatment with RA did not lead to the appearance of endothelial-like morphological and biochemical changes nor to a decrease in cell proliferation as in control cells, even with increasing concentration (10?4 M) and time (5 days) of RA treatment (Fig. 5D). Furthermore, unlike control cells, endothelial markers like ET-1, Flt1, and EPAS1 were not induced in cell lines lacking GATA5 indicating that GATA5 expression is required for endocardial differentiation (Fig. 5E). In order to molecularly define the stage at which differentiation was arrested, RT-PCR analyses were carried out. As shown in Fig. 5E, early endothelial markers like Msx1 and Cx37 were induced, albeit at a relatively lower level than in control cells." provenance.
- _5 value "We found that the zinc-finger region of BCL-6 interacts with c-Jun, JunB, and JunD proteins" provenance.
- _3 value "In rats, the CYP4F family consists of four related genes, CYP4F1, CYP4F4, CYP4F5, and CYP4F6. Here we report development of fluorescent real-time quantitative polymerase chain reaction assays (TaqMan), which allow us to carry out specific quantitation of mRNA expression of all four members of this subfamily. Since no inducers for the CYP4F family are known to date, we validated these assays using clofibrate, a known suppressor of rat CYP4Fs. Additionally, Northern blot hybridization was carried out to validate these assays." provenance.
- _4 value "The activity of both of them is regulated by phosphorylation and subsequent interaction with the coactivator protein CBP (CREB-binding protein)" provenance.
- _5 value "the growth factor-stimulated signaling network controlled by MAPK1,2/PKC can operate with 1 or 2 stable states at low concentrations of MAPK phosphatase, DUSP1, the system exhibits bistable behavior, such that brief stimulus results in sustained MAPK activation" provenance.