Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _4 value "The results support the following pathway, whereby TNF-alpha enhances expression of ICAM-1 in NHBE cells: TNF-alpha --> TNF-RI --> PC-PLC --> DAG --> PKC --> (NF-kappaB?) --> ICAM-1 mRNA --> ICAM-1 surface expression." provenance.
- _3 value "Oxidative stress caused by phorbol esters or reactive oxygen up-regulates the class A scavenger receptor (SR-A) in human smooth muscle cells (SMC)" provenance.
- _2 value "Administration of desipramine (20 mg/kg, i.p.) 30 min prior to 6-OHDA injection protected neostriatal and cerebellar noradrenergic neurons NE levels" provenance.
- _2 value "Infusion of 6-OHDA reduced norepinephrine (NE) content in all the brain areas examined (in hypothalamus, striatum, and cerebellum)" provenance.
- _7 value "Heterologous expression of PSD-95 enhanced NRG activation of ErbB4 and MAP kinase." provenance.
- _5 value "Treatment with pharmacological inhibitors of p38 MAPK or with a dominant negative form of MKK3, an upstream regulator of p38 MAPK, significantly reduced or ablated the sorbitol induction of sgk promoter activity" provenance.
- _4 value "Treatment of in vitro stimulated Peripheral blood lymphocytes (PBLs) with TNF alpha (30 ng/ml for 48 hours) showed a 10 fold increase in the chemokines namely MIP-1 alpha, MIP-1 beta, and RANTES. This up regulation was substantially decreased by NF kappa B-inhibitory peptide (KBI). Moreover treatment with KBI significantly weaker response on CCR5 expression, suggesting that NF kappa B signal is important for CCR5 down regulation induced by TNF alpha." provenance.
- _5 value "The stimulatory or inhibitory effects of histamine on cytokine production were all antagonized by H2 receptor antagonists ranitidine and famotidine in a concentration-dependent manner, but not by H1 and H3 receptor antagonists. Selective H2 receptor agonists, 4-methylhistamine and dimaprit, mimicked the effects of histamine on five kinds of cytokine production." provenance.
- _4 value "Sp1 is required for Madh7 promoter activation in TGFbeta response. It interacts with distinct region in the promoter." provenance.
- _4 value "Cyclin D2 and Cyclin D3 protein levels increased slightly in the first 24 hours after Erythropoietin (Epo)+/Stem cell factor (Scf)- stimulation but declined sharply after 48 hours." provenance.
- _4 value "Cyclin D2 and Cyclin D3 protein levels increased slightly in the first 24 hours after Erythropoietin (Epo)+/Stem cell factor (Scf)- stimulation but declined sharply after 48 hours." provenance.
- _4 value "Cyclin D2 and Cyclin D3 protein levels increased slightly in the first 24 hours after Erythropoietin (Epo)+/Stem cell factor (Scf)- stimulation but declined sharply after 48 hours." provenance.
- _4 value "Cyclin D2 and Cyclin D3 protein levels increased slightly in the first 24 hours after Erythropoietin (Epo)+/Stem cell factor (Scf)- stimulation but declined sharply after 48 hours." provenance.
- _4 value "However, TP expression was related to high angiogenesis only in cases with absence of c-erB-2 expression (P < 0.0001). c-erbB-2 expression in poorly vascularised tumours was linked with poor outcome (P = 0.03)." provenance.
- _3 value "Secreted tPA antigen levels decreased approximately 53% (3.3+/-0.14 versus 6.97+/-0.42 microg/mL) and mRNA levels decreased approximately 70% in HTG-VLDL -treated HUVECs compared with NTG-VLDL-treated and culture medium control cells" provenance.
- _6 value "IFN-gamma induced Fas expression of the cells without the activation of caspase8 or caspase3 during 16 hours of incubation, while deprivation of EPO induced expression of Fas and the activation of both caspase8 and caspase3" provenance.
- _5 value "Modified assertion" provenance.
- _6 value "Modified assertion" provenance.
- _5 value "# Ariadne: We have previously shown that BMK1 regulates c- jun gene expression through direct phosphorylation and activation of transcription factor MEF2C. [Regulation]" provenance.
- _5 value "Here, we demonstrate that, in addition to MEF2C, BMK1 phosphorylates and activates MEF2A and MEF2D but not MEF2B. The blocking of BMK1 signaling inhibits the epidermal growth factor-dependent activation of these three MEF2 transcription factors. The sites phosphorylated by activated BMK1 were mapped to Ser-355, Thr-312, and Thr-319 of MEF2A and Ser-179 of MEF2D both in vitro and in vivo." provenance.
- _5 value "Here, we demonstrate that, in addition to MEF2C, BMK1 phosphorylates and activates MEF2A and MEF2D but not MEF2B. The blocking of BMK1 signaling inhibits the epidermal growth factor-dependent activation of these three MEF2 transcription factors. The sites phosphorylated by activated BMK1 were mapped to Ser-355, Thr-312, and Thr-319 of MEF2A and Ser-179 of MEF2D both in vitro and in vivo." provenance.
- _6 value "Stat5 proteins activated by IL-2. The phosphorylated tyrosines on IL-2Rbeta can then serve as docking sites for signaling molecules that otherwise cannot associate with IL-2Rbeta, including the adaptor protein Shc, Stat5a, and Stat5b (Figure 2). For example, only phosphorylated (but not non-phosphorylated) peptides spanning either Tyr-392 or Tyr-510 of IL-2Rbeta can efficiently compete with IL-2-induced Stat5 DNA binding to a GAS motif " provenance.
- _6 value "Stat5 proteins activated by IL-2. The phosphorylated tyrosines on IL-2Rbeta can then serve as docking sites for signaling molecules that otherwise cannot associate with IL-2Rbeta, including the adaptor protein Shc, Stat5a, and Stat5b (Figure 2). For example, only phosphorylated (but not non-phosphorylated) peptides spanning either Tyr-392 or Tyr-510 of IL-2Rbeta can efficiently compete with IL-2-induced Stat5 DNA binding to a GAS motif IL-2-mediated hetero-dimerization of its receptor triggers a rapid increase in the recruitment of Jak3 and activation of both Jak1 and Jak3 (Johnston et al., 1994; Witthuhn et al., 1994). These kinases phosphorylate the receptor as well as each other, and activate other signaling molecules associated with the receptor. The phosphorylated tyrosines on IL-2Rbeta can then serve as docking sites for signaling molecules that otherwise cannot associate with IL-2Rbeta, including the adaptor protein Shc, Stat5a, and Stat5b" provenance.
- _4 value "JunB suppresses cell proliferation by transcriptional activation of p16(INK4a) expression." provenance.
- _5 value "In vitro, PKC directly phosphorylated platelet syntaxin 4 and recombinant syntaxin 4. PKC phosphorylation in vitro inhibited (71 +/- 8%) the binding of syntaxin 4 to SNAP-23." provenance.
- _4 value "ATF-2/c-Jun binding to the activator protein-1 sequence at -190 plays a key role for induction of c-Jun gene by Ang II." provenance.
- _6 value "DN mutants of Rac1 (DN-Rac1) and MEK kinase (DN-MEKK1) also abolished it" provenance.
- _4 value "Incubation of RAW 264.7 cells with 8-Br-cAMP resulted in a significant increase in steady-state CD14 mRNA levels. The increase in mRNA levels was also associated with both cell-associated and soluble CD14 protein." provenance.
- _3 value "Indeed, many cells in CHK1-/- embryos had condensed and fragmented nuclei that is characteristic of apoptosis (Fig. 2E)." provenance.
- _6 value "PTPepsilonC expression resulted in lower levels of IL-6-induced tyrosine phosphorylation of Jak1, Tyk2, gp130 (Il6st), and Stat3compared with parent cells." provenance.
- _6 value "PTPepsilonC expression resulted in lower levels of IL-6-induced tyrosine phosphorylation of Jak1, Tyk2, gp130 (Il6st), and Stat3compared with parent cells." provenance.
- _3 value "RTP was partially phosphorylated at seven or more sites. The phosphorylation was reversible, and was enhanced by an increased level of intracellular cAMP and inhibited by both a protein kinase A inhibitor and a calmodulin kinase inhibitor. Protein kinase A directly phosphorylated recombinant RTP in vitro." provenance.
- _4 value "Modified assertion" provenance.
- _4 value "ANP significantly attenuated production of TNF-alpha and IL-1beta without affecting production of IL-10 and IL-1ra." provenance.
- _4 value "Interestingly, co-expression of DSCR1 strongly inhibited the induction of the IL-2 reporter by co-stimulation with PMA and ionophore. Similarly, DSCR1115-197, the truncated version of DSCR1 that retained CaNA binding activity, was able to act as a dose-dependent inhibitor, though not as efficiently as DSCR1 full-length. In contrast, co-expression of DSCR11-156, the mutant incapable of CaNA binding, had no effect on the activation assay, strongly suggesting that the inhibition caused by DSCR1 is mediated through calcineurin binding. ZAKI-4 was also able to inhibit calcineurin function, as measured by its ability to suppress IL-2 reporter activation (Fig. 5A)." provenance.
- _3 value "oxidized LDL significantly reduced IGF-1 and IGF-1R mRNA by 80 and 61%, respectively, and reduced IGF-1 and IGF-1R protein expression by 63 and 46%." provenance.
- _4 value "indicating that local IL-4 inhibits the formation of osteoclast-like cells. Messenger RNA levels of IL-17, IL-12, and cathepsin K in the synovial tissue were suppressed, as were IL-6 and IL-12 protein production." provenance.
- _7 value "all three RAR subtypes, RARalpha, RARbeta, and RARgamma, could effectively inhibit phorbol ester 12-O-tetradecanoylphorbol-13-acetate-induced AP-1 activity and the activity of oncogenes c-Jun and c-Fos on AP-1 containing reporter genes in the presence of retinoic acid (RA)" provenance.
- _5 value "we show that ATM interacts with BRCA1, and this association is enhanced by radiation. We also demonstrate that BRCA1 is a substrate of ATM kinase in vitro and in vivo. Using phospho-specific antibodies against serines 1387, 1423, and 1457 of BRCA1, we demonstrate radiation-induced, ATM-dependent phosphorylation of BRCA1 at these sites ... from full text, A-T lymphoblastoid cells" provenance.
- _5 value "we show that ATM interacts with BRCA1, and this association is enhanced by radiation. We also demonstrate that BRCA1 is a substrate of ATM kinase in vitro and in vivo. Using phospho-specific antibodies against serines 1387, 1423, and 1457 of BRCA1, we demonstrate radiation-induced, ATM-dependent phosphorylation of BRCA1 at these sites ... from full text, A-T lymphoblastoid cells" provenance.
- _3 value "HEF1 belongs to a select group of caspase substrates cleaved in apoptosis to promote the morphological changes characteristic of programmed cell death inducing expression of HEF1 in MCF-7 or HeLa cells causes extensive apoptosis, as assessed by multiple criteria." provenance.
- _4 value "The addition of all-trans retinoic acid (ATRA) in combination with basic fibroblast growth factor (bFGF) to human fibroblasts results in a synergistic induction of tissue inhibitor of metalloproteinases-1 (TIMP-1) protein production...An incubation of 10 min to 12 h with bFGF alone followed by ATRA gave a similar synergistic induction of TIMP-1 protein to that seen with both agents together. Treatment of cells with ATRA first followed by bFGF was ineffective." provenance.
- _5 value "Tst-1 Activates the sst1 Gene Promoter by Binding to the fp2b DNA Region" provenance.
- _4 value "C/EBPdelta is involved in regulating G(0) growth arrest and apoptosis of mouse mammary epithelial cells." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _4 value "Whereas the expression of Prep1 or Pbx forms alone had no effect, coexpression of Pbx1a/1b-Prep1 inhibited the glucagon promoter when activated by cotransfected Pax6 or another transcription factor in non-glucagon-producing cells." provenance.
- _5 value "One site, Ser(364), is conserved with c-Raf but two additional sites, Ser(428) and Thr(439), are unique to B-Raf." provenance.
- _6 value "One site, Ser(364), is conserved with c-Raf but two additional sites, Ser(428) and Thr(439), are unique to B-Raf." provenance.
- _6 value "One site, Ser(364), is conserved with c-Raf but two additional sites, Ser(428) and Thr(439), are unique to B-Raf." provenance.
- _4 value "We recently demonstrated that through up-regulation of TNFalpha, ATF2 increases the resistance of late stage melanoma cells to apoptosis induced by UV-irradiation." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _5 value "Gadd45 family proteins interact with several nuclear hormone receptors including RXR alpha, RAR alpha, ER alpha, PPAR alpha, PPAR beta, and PPAR gamma2 in vitro. Interaction between Gadd45 family proteins and nuclear hormone receptors resulted in modest activation of transactivating function of nuclear hormone receptors in reporter systems." provenance.
- _5 value "Gadd45 family proteins interact with several nuclear hormone receptors including RXR alpha, RAR alpha, ER alpha, PPAR alpha, PPAR beta, and PPAR gamma2 in vitro. Interaction between Gadd45 family proteins and nuclear hormone receptors resulted in modest activation of transactivating function of nuclear hormone receptors in reporter systems." provenance.
- _4 value "TNF alpha, IFN gamma and IL1 beta induced the tyrosine and threonine phosphorylation of ERK MAP kinases. Treatment with PD98059, an inhibitor of MEK1 and MEK2 kinase inhibited ERK MAP kinase phosphorylation by IFN gamma, TNF alpha and IL1 beta." provenance.
- _4 value "TNF alpha induced the expression of mRNAs encoding c-fos and c-jun after 30 min of stimulation. Induction of c-fos mRNA reached maximum at 60 min and of c-jun reached a maximum level at 45 min of TNFA stimulation." provenance.
- _4 value "We demonstrate here that Nor1 is expressed in the pituitary gland and adrenal cortex, and that ACTH and angiotensin II (AngII) treatment of adrenal fasciculata cells induces Nor1 expression." provenance.
- _4 value "\"Insulin inhibits the ubiquitin-dependent degrading activity of the 26S proteasome.\"" provenance.
- _4 value "Modified assertion" provenance.
- _3 value "# Ariadne: These facts indicate that the expression of hepatic CYP51 is maintained by serum insulin, and its lowest physiological level is sufficient for supporting the expression of CYP51. [Expression]" provenance.
- _5 value "Transient transfection of Hox/HOXA5 activated the p53 promoter" provenance.
- _5 value "Ser(136) is thought to be phosphorylated by protein kinase B (PKB, also called Akt), which is activated when cells are exposed to agonists that stimulate phosphatidylinositol 3-kinase (PI3K)" provenance.
- _6 value "Treatment of cells with phosphoinositide 3-kinase (PI 3-kinase) inhibitors or expression of a dominant-negative PI 3-kinase prevent phosphorylation of DAPP1 at Tyr(139), and a PH-domain mutant of DAPP1, which does not interact with PtdIns(3,4,5)P(3) or PtdIns(3,4)P(2), is not phosphorylated at Tyr(139) following agonist stimulation of cells." provenance.
- _5 value "in HEK-293 cells, the agonists insulin, insulin-like growth factor-1 and epidermal growth factor induce the phosphorylation of DAPP1 at Tyr(139). " provenance.
- _4 value "Northern blot analysis verified a significant down-regulation of the receptor tyrosine kinase substrate Eps8, cyclin D1, and CD44 mRNAs, and a substantial up-regulation of phosphatidylinositol 3-kinase p85, IGF-I, and serine protease inhibitor-2.2 mRNAs in SFK cells both Eps8 and CD44 mRNA levels were reduced greatly in the brain tissues of the cerebrum isolated from the PrP(-)(/-) mice" provenance.
- _4 value "Northern blot analysis verified a significant down-regulation of the receptor tyrosine kinase substrate Eps8, cyclin D1, and CD44 mRNAs, and a substantial up-regulation of phosphatidylinositol 3-kinase p85, IGF-I, and serine protease inhibitor-2.2 mRNAs in SFK cells both Eps8 and CD44 mRNA levels were reduced greatly in the brain tissues of the cerebrum isolated from the PrP(-)(/-) mice" provenance.
- _5 value "Inhibition of the NF-kappaB pathway downstream of MyD88 potentiates apoptosis, indicating that these two pathways bifurcate at the level of MyD88. TLR2 signals for apoptosis through MyD88 via a pathway involving Fas-associated death domain protein (FADD) and caspase 8." provenance.
- _5 value "Modified assertion" provenance.
- _6 value "MyD88 initiates a signaling pathway which sequentially involves IL-1R-associated kinase 1 (IRAK1), tumor necrosis factor-{alpha} receptor (TNFR)-associated factor 6 (TRAF6) and nuclear factor (NF)-{kappa}B-inducing kinase (NIK) (Medzhitov et al., 1998; Muzio et al., 1998a; O'Neill and Greene, 1998; Kopp and Medzhitov, 1999; Yang et al., 1999; Zhang et al., 1999)." provenance.
- _5 value "These data indicate that TLR2 is a novel 'death receptor' that engages the apoptotic machinery without a conventional cytoplasmic death domain. Through TLR2, BLP induces the synthesis of the precursor of the pro-inflammatory cytokine interleukin-1beta (IL-1beta)." provenance.
- _3 value "LPS exposure leads to an increase of MMP-2 and MMP-9 in bronchoalveolar lavage (BAL) from various animals (19,24,25). Similar results were obtained in rats after subacute hyperoxia (26) or after exposure to ozone (27)." provenance.
- _5 value "Characterization of purified recombinant IKKalpha and IKKbeta revealed that both kinases directly phosphorylate S32 and S36 in IkBalpha ( [22 and 49]). " provenance.
- _5 value "Phosphorylation of full-length IkBalpha by IKK epsilon was also examined using the recombinant kinase. The wild-type IkBalpha was efficiently phosphorylated by IKK epsilon, while substitution of serines 32 and 36 with alanine decreased the level of phosphorylation 5-fold (Figure 2C). " provenance.
- _6 value "GEF activity of Ras-GRF1 toward Ha-Ras, as defined by in vitro GDP binding and release assays, was augmented after tyrosine phosphorylation by ACK1." provenance.
- _4 value "As expected, mRNA levels for LPL were reduced in fld white adipose tissue, as were those of adipsin. We also found that uncoupling protein 1 mRNA in brown adipose tissue from fld mice was reduced." provenance.
- _4 value "As previously described, white adipose tissue from fld mice expresses substantially reduced levels of lipoprotein lipase (LPL) activity ( 2 ), which may contribute to the reduced lipid accumulation in these cells." provenance.
- _3 value "However, in fld mice, a greater proportion of the cholesterol was present in the HDL fraction and less cholesterol was present in the LDL/VLDL fraction" provenance.
- _4 value "The lack of lipid accumulation in fld/fld adipose tissue could be attributed, in part, to a failure to induce expression of lipoprotein lipase and enzymes involved in fatty acid synthesis, such as fatty acid synthase and acetyl-CoA carboxylase." provenance.
- _5 value "Modified assertion" provenance.
- _6 value " FIG. 7. Lyn induces SAPK activation by an MKK7- and MEKK1-dependent, SEK1-independent mechanism." provenance.
- _3 value "These changes were accompanied by rapid and profound mitochondrial dysfunction characterized by opening of the mitochondrial PT pore, proton electrochemical gradient (Deltapsim) suppression, and increased reactive oxygen species production." provenance.
- _6 value "The serine/threonine kinase Akt (also known as protein kinase B) (Akt/PKB) is activated upon T-cell antigen receptor (TCR) engagement or upon expression of an active form of phosphatidylinositide (PI) 3-kinase in T lymphocytes." provenance.
- _3 value "Expression of goosecoid resulted in reduced cell proliferation and enhanced neurite outgrowth in response to NGF." provenance.
- _3 value "We have previously shown marked induction of the stress-inducible gene heme oxygenase-1 (HO-1) in vivo and in vitro after hyperoxia." provenance.
- _5 value "the most proximal NFI site is essential for B-FABP promoter activity in transiently transfected malignant glioma cells." provenance.
- _5 value "Previous studies indicated that transcription of myogenin was dependent on MyoD and MEF2 proteins. We find that expression of a dominant negative form of PI3-K or growth in the presence of LY294002 inhibits cellular activity of MEF2 but not of MyoD. Evidence reveals that whereas MEF2 transcriptional activity is inhibited, its DNA binding activity remains unaffected." provenance.
- _5 value "AND-34 displays GEF activity on RalA, Rap1A, and R-Ras but not Ha-Ras GTPases in cells" provenance.
- _7 value "FGF-2 (/=10(-12) m) also increased cathepsin K and MMP-9 mRNA levels in mouse and rabbit osteoclasts. FGF-2 acts directly on mature osteoclasts through activation of FGFR1 and p42/p44 MAP kinase, causing the stimulation of bone resorption at physiological or pathological concentrations." provenance.
- _6 value "FGF-2 (/=10(-12) m) also increased cathepsin K and MMP-9 mRNA levels in mouse and rabbit osteoclasts. FGF-2 acts directly on mature osteoclasts through activation of FGFR1 and p42/p44 MAP kinase, causing the stimulation of bone resorption at physiological or pathological concentrations." provenance.
- _5 value "Ariadne: Both IL-1 and IL-18 activate IRAK (Robinson et al. 1997 ), NF-kappaB in Th1 cells (Matsumoto et al. 1997 ; Robinson et al. 1997 ), and TRAF6 (Kojima et al. 1998 ). [Regulation]" provenance.
- _7 value "CBP and p300 are highly related proteins that act as cofactors for many transcription factors, including the nuclear hormone receptors, Myb and CREB" provenance.
- _4 value "Kit and other RTKs will activate the MAP kinase signaling pathway and has been reported both to increase the transcriptional activity of Mitf as well as down-regulate Mitf protein levels." provenance.
- _5 value "Kit and other RTKs will activate the MAP kinase signaling pathway and has been reported both to increase the transcriptional activity of Mitf as well as down-regulate Mitf protein levels." provenance.
- _6 value "Kit and other RTKs will activate the MAP kinase signaling pathway and has been reported both to increase the transcriptional activity of Mitf as well as down-regulate Mitf protein levels." provenance.
- _6 value "Kit and other RTKs will activate the MAP kinase signaling pathway and has been reported both to increase the transcriptional activity of Mitf as well as down-regulate Mitf protein levels." provenance.
- _6 value "Kit and other RTKs will activate the MAP kinase signaling pathway and has been reported both to increase the transcriptional activity of Mitf as well as down-regulate Mitf protein levels." provenance.
- _7 value "Wnt signaling is bypassed in many melanoma cell lines owing to mutations in beta catenin which result in its stabilization. Although deregulation of Wnt- and RTK-mediated signaling will affect a range of target genes, both pathways impact on Mitf expression or Mitf levels. Note also that while GSK3beta is regulated by both RTK signaling and the Wnt signaling pathway, it is likely that each pathway regulates a different pool of GSK3beta The presence of a Wnt ligand activates the receptor for Wnt, the seven transmembrane domain protein Frizzled, which in turn leads to activation of Dishevelled, and subsequently to the inhibition of GSK-3. Current models suggest that the action of GSK-3 results in phosphorylation of beta catenin leading to its destabilization and degradation (Cadigan and Nusse 1997) and as a consequence, the presence of a Wnt signal increases the level of beta catenin in the cell. Control of beta catenin degradation is also influenced by components of a complex containing the product of the adenomatous polyposis coli gene APC, which is a good substrate for GSK3beta in vitro and which can form a complex with GSK3beta and beta catenin, together with the axin homolog conductin (Rubinfeld et al. 1993, 1996; Behrens et al. 1998). Indeed, phosphorylation of APC by GSK3beta stimulates its ability to bind beta catenin and overexpression of APC following transfection substantially reduces beta catenin levels (Munemitsu et al. 1995). Similarly, overexpression of conductin also results in degradation of beta catenin and it has been suggested that conductin acts downstream from APC in directing the destabilization of beta catenin containing the product of the adenomatous polyposis coli gene APC, which is a good substrate for GSK3beta in vitro and which can form a complex with GSK3beta and beta catenin, together with the axin homolog conductin (Rubinfeld et al. 1993, 1996; Behrens et al. 1998). Indeed, phosphorylation of APC by GSK3beta stimulates its ability to bind beta catenin and overexpression of APC following transfection substantially reduces beta catenin levels (Munemitsu et al. 1995). Similarly, overexpression of conductin also results in degradation of beta catenin and it has been suggested that conductin acts downstream from APC in directing the destabilization of beta catenin Lef1 in the absence of a Wnt signal can repress transcription in association with Groucho-like factors. Similarly, under some circumstances Pax3 can repress transcription, perhaps through its interaction with HIRA (Magnaghi et al. 1998), amammalian homolog of a yeast transcriptional corepressor, and with the transcriptional repressor hDaxx which can suppress the ability of Pax3 to activate transcription" provenance.
- _3 value "isolation of the Mitf promoter (Fuse et al. 1996) revealed a potential cyclic AMP response element (CRE) at position ?147 relative to the transcription startsite the increase in Mitf protein in B16 melanoma cells that results from the activation of the Mitf promoter through the CRE (Bertolotto et al. 1998a) is transient." provenance.
- _5 value "Modified assertion" provenance.
- _3 value "Human tip49a and tip49b genes were mapped on 3q21 and 19q13.2, respectively. Consistent with the notion that tip49 family genes are essential for cell growth, Northern blot analysis demonstrated that both genes are expressed ubiquitously in human tissues. It is worthy of notice that the testes contained large amounts of the both transcripts." provenance.
- _4 value "As demonstrated in Fig. 6b, steady-state GM-CSF mRNA induced in response to PMA was decreased in the presence of PD98059 (25.5 6 4.4% PMA response; n 5 3; p , 0.001)." provenance.