Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _4 value "increased alpha 2/beta-AR balance in adipocytes promotes obesity by stimulating adipocyte hyperplasia" provenance.
- _5 value "SOCS-1 and SOCS-3 inhibit interleukin (IL)-4-dependent signal transducer and activator of transcription 6 (Stat6) activation of and subsequent gene induction. By contrast, SOCS-2 and cytokine-inducible Src homology domain 2 (SH2)-containing protein up-regulate these processes" provenance.
- _7 value "SOCS-1 and SOCS-3 inhibit interleukin (IL)-4-dependent signal transducer and activator of transcription 6 (Stat6) activation of and subsequent gene induction. By contrast, SOCS-2 and cytokine-inducible Src homology domain 2 (SH2)-containing protein up-regulate these processes" provenance.
- _4 value "Modified assertion" provenance.
- _5 value "Taken together, our data indicate that PAR-1 is both necessary and sufficient for mediating the stimulatory effects of thrombin on CTGF/FISP12 mRNA levels. They further show that these stimulatory effects are not restricted to human fibroblasts and confirm the critical role of PAR-1 in mediating the effects of thrombin on mesenchymal cell function." provenance.
- _4 value "The constitutively active Rho GTPases, V12Cdc42 and V12Rac1, both stimulate actin nucleation in permeabilized neutrophils." provenance.
- _4 value ". Insulin also increases the uptake of fatty acids derived from circulating lipoproteins by stimulating lipoprotein lipase activity in adipose tissue." provenance.
- _2 value "Insulin promotes adipocyte triglyceride stores by a number of mechanisms, including fostering the differentiation of preadipocytes to adipocytes and, in mature adipocytes, stimulating glucose transport and triglyceride synthesis (lipogenesis), as well as inhibiting lipolysis" provenance.
- _4 value "rodents or humans are treated with the b3 adrenergic agonist CL316,243 (25, 26). Since b3 adrenergic receptors are expressed almost exclusively in fat, effects of these agents would be expected to be initiated by alterations in fat. Treatment with CL316,243 results in enhanced sensitivity of both whole body glucose uptake and suppression of hepatic glucose production (25). Thus, increasing glucose uptake selectively in fat with b3 adrenergic receptor agonists may improve whole body glucose uptake, with the effects in fat indirectly resulting in increased insulin sensitivity in liver." provenance.
- _4 value "Inhibitors of the enzyme 5-lipoxygenase reduce proliferation and initiate programmed cell death in many different types of malignantly transformed cells" provenance.
- _5 value "we demonstrated that both HBP1 and RB were involved in the activation of H1(0) gene expression." provenance.
- _5 value "To determine if Src family kinases (SFKs) are involved, we demonstrated that CSF-1 activated Fyn and Lyn in cells expressing wild-type (WT) or DeltaKI receptors. Moreover, CSF-1-induced Akt activity in cells expressing DeltaKI is SFK dependent since Akt activation was prevented by pharmacological or genetic inhibition of SFK activity. The docking protein Gab2 may link SFK to PI3-kinase. CSF-1 induced Gab2 tyrosyl phosphorylation and association with PI3-kinase in cells expressing WT or DeltaKI receptors. " provenance.
- _6 value "PKB phosphorylation and activity were reduced to the same extent as they were with PTEN expression. Finally we found that SHIP-2, like PTEN, caused a potent cell cycle arrest in G(1) in glioblastoma cells, which is associated with an increase in the stability of expression of the cell cycle inhibitor p27(KIP1) In these studies PtdIns(3,4,5)P3 and PtdIns(3,4)P2 were equally effective at allowing phosphorylation by PDK-1" provenance.
- _4 value "Reexpression of PTEN or treatment with the PI3K inhibitor LY294002 abolished the levels of both PtdIns(3, 4)P2 and PtdIns(3,4,5)P3, reduced phosphorylation of PKB on Thr308 and Ser473, and inhibited PKB activity." provenance.
- _4 value "Expression of oncogene products reverses hnRNP A1-dependent repression of CD44 v5 exon inclusion without down-regulating hnRNP A1 expression levels." provenance.
- _4 value "p14ARF expression was able to greatly inhibit the MCF-7/Adr cell proliferation. Furthermore, p14ARF expression resulted in decrease of MDR-1 mRNA and P-glycoprotein production, which linked to the reducing resistance of MCF-7/Adr cells to doxorubicin." provenance.
- _6 value "Modified assertion" provenance.
- _4 value "The multinuclear cells formed after IL-7 stimulation was found to increase the expression of calcitonin, an authentic marker for human osteoclasts by 200 fold." provenance.
- _5 value "\"Inhibition of EGFR-mediated phosphoinositide-3-OH kinase (PI3-K) signaling and glioblastoma phenotype by signal-regulatory proteins (SIRPs).\"" provenance.
- _5 value "We report here that c-Cbl, which is a Gab1-like docking protein, also becomes tyrosine-phosphorylated in response to Met activation and serves as a docking molecule for various SH2-containing molecules, including Crk. We further show that Cbl is similarly capable of enhancing Met-induced JNK activation, and several lines of experimentation suggests that it does so by interacting with Crk. " provenance.
- _4 value "The expression of wild type Bmx in 32D myeloid progenitor cells resulted in apoptosis in the presence of G-CSF, while cells expressing a kinase dead mutant of Bmx differentiated into mature granulocytes." provenance.
- _4 value "The expression of wild type Bmx in 32D myeloid progenitor cells resulted in apoptosis in the presence of G-CSF, while cells expressing a kinase dead mutant of Bmx differentiated into mature granulocytes." provenance.
- _3 value "The gC1q domain of EMILIN-1 can form relatively stable and compact homotrimers and this association is then followed by a multimeric assembly of disulfide-bonded protomers. Recombinant EMILIN-1 purified from the supernatant of 293 cells represents a very efficient ligand for cell adhesion of several cell types." provenance.
- _7 value "TGF-beta increased cell adhesion to vitronectin and up-regulated the surface level of alpha(v)beta(5) via increasing beta(5) protein synthesis by a transcriptional mechanism." provenance.
- _5 value "The autophosphorylation rate was dependent on Abl protein concentration consistent with an intermolecular reaction." provenance.
- _8 value "Furthermore, growth factor stimulation of these RTKs promotes increased cell proliferation and migration when cells are attached to the alpha(v)beta(3) ligand, vitronectin." provenance.
- _8 value "The integrin-RTK cooperation may make it possible for cell attachment to induce an RTK response independently of the growth factor ligand. Cells that attach to fibronectin (a ligand of avb3) show autophosphorylation of PDGF-Rb (6) and relocation of the receptor to focal contacts" provenance.
- _3 value "The AIAR messenger RNA (mRNA) content of the ventral prostate was low in normal and castrated rats, transiently increased after androgen administration to castrated rats, attaining a peak 12-24 h after the treatment" provenance.
- _3 value "PAF acetylhydrolase is regulated in vivo by hormonal control (145). Estrogens decrease PAF acetylhydrolase levels in the plasma of adult male and adult female rats, and progestins have the opposite effect" provenance.
- _4 value "The first transcript described is found only in peripheral leukocytes and is the one that increases in response to PAF. It has consensus sequences for NF-kB, SP-1, and INR, and the response to PAF and phorbol esters requires the NF-kB consensus binding sites" provenance.
- _3 value "Chronic elevated glucose reduces the expression levels of the PPAR target genes, uncoupling protein 2 and acyl-CoA oxidase" provenance.
- _4 value "In this study, we identified vascular endothelial growth factor (VEGF) as a gene product induced by heregulin-beta1. The stimulation by heregulin-beta1 of breast cancer epithelial cells induced the expression of the VEGF mRNA and protein and its promoter activity. Heregulin-beta1 also stimulated angiogenesis in a VEGF-dependent manner." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _3 value "Furthermore, expression of CD38 mRNA mediated through RAR alpha is induced synergistically by treatment with ATRA + GM-CSF." provenance.
- _4 value "The increased GFA activity led to 1.4- and 2.1-fold increased pancreatic insulin content in 2- and 10-month-old transgenic mice, respectively (P < 0.005)." provenance.
- _5 value "Modified assertion" provenance.
- _6 value "The small G protein RhoA and its GDP/GTP exchange factors (GEFs) Net and Dbl can transform NIH 3T3 fibroblasts, dependent on the activity of the RhoA effector kinase ROCK." provenance.
- _7 value "WAVE proteins are members of the Wiskott-Aldrich syndrome protein (WASP) family of scaffolding proteins that coordinate actin reorganization by coupling Rho-related small molecular weight GTPases to the mobilization of the Arp2/3 complex." provenance.
- _5 value "Modified assertion" provenance.
- _6 value "# Ariadne: Thus, our findings provide support for a signaling pathway in which Mekk3 activity leads to the activation of p38 MAPK, which in turn regulates MEF2C. [Regulation]" provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _4 value "Here, we demonstrate that in astrocyte cultures IGF-I regulates NFkappaB, a transcription factor known to play a key role in the inflammatory reaction. IGF-I induces a site-specific dephosphorylation of IkappaBalpha (phospho-Ser(32)) in astrocytes." provenance.
- _4 value "Here, we demonstrate that in astrocyte cultures IGF-I regulates NFkappaB, a transcription factor known to play a key role in the inflammatory reaction. IGF-I induces a site-specific dephosphorylation of IkappaBalpha (phospho-Ser(32)) in astrocytes." provenance.
- _3 value "Differentiation of human THP-1 cells into foam cells on treatment with 12-O-tetradecanoylphorbol 13-acetate (PMA) observed in atherosclerotic lesions. When these THP-1 differentiated cells were subsequently treated with oxidized low density lipoprotein (Ox-LDL), it was observed that CA2 (carbonic anhydrase II) expressed low. At the end of fourth day of treatment with Ox-LDL the expression of CA2 was decreased by 7.58-folds when compared with control. This indicates that Ox-LDL down-regulates CA2 in differentiated THP-1cells." provenance.
- _3 value "Differentiation of human THP-1 cells into foam cells on treatment with 12-O-tetradecanoylphorbol 13-acetate (PMA) observed in atherosclerotic lesions. When these THP-1 differentiated cells were subsequently treated with oxidized low density lipoprotein (Ox-LDL), it was observed that CYBB (cytochrome b-245, beta polypeptide) expressed low. At the end of fourth day of treatment with Ox-LDL the expression of CYBB was decreased by 6.32-folds when compared with control. This indicates that Ox-LDL down-regulates CYBB in differentiated THP-1cells." provenance.
- _3 value "Differentiation of human THP-1 cells into foam cells on treatment with 12-O-tetradecanoylphorbol 13-acetate (PMA) was observed in atherosclerotic lesions. When these THP-1 differentiated cells were subsequently treated with oxidized low density lipoprotein (Ox-LDL), it was observed that CTSG (cathepsin G) expressed low. At the end of fourth day of treatment with Ox-LDL the expression of CTSG was decreased by 4.98-folds when compared with control. This indicates that Ox-LDL down-regulates CTSG in differentiated THP-1cells." provenance.
- _3 value "Differentiation of human THP-1 cells into foam cells on treatment with 12-O-tetradecanoylphorbol 13-acetate (PMA) was observed in atherosclerotic lesions. When these THP-1 differentiated cells were subsequently treated with oxidized low density lipoprotein (Ox-LDL), it was observed that MNDA (myeloid cell nuclear differentiation antigen) expressed low. At the end of fourth day of treatment with Ox-LDL the expression of MNDA was decreased by 5.58-folds when compared with control. This indicates that Ox-LDL down-regulates MNDA in differentiated THP-1cells." provenance.
- _3 value "Differentiation of human THP-1 cells into foam cells on treatment with 12-O-tetradecanoylphorbol 13-acetate (PMA) was observed in atherosclerotic lesions. When these THP-1 differentiated cells were subsequently treated with oxidized low density lipoprotein (Ox-LDL), it was observed that UPP1 (uridine phosphorylase) was highly regulated. At the end of fourth day of treatment with Ox-LDL the expression of UPP1 was increased by 5.37-folds when compared with control. This indicates that Ox-LDL up-regulates UPP1 in differentiated THP-1cells." provenance.
- _3 value "TABLE I - Ten most highly up- and down-regulated genes. These criteria assured that the signal level was sufficiently high above background to be reliably read and that the reading was not the result of non-uniform noise on the spotted DNA. Identity of spotted DNA was verified by PCR. A failure in PCR testing resulted in exclusion of the spot measurement. A total of 6805 genes passed these quality control criteria. Of these, 268 showed 2-fold differential expression for at least 1 time point." provenance.
- _3 value "TABLE I - Ten most highly up- and down-regulated genes. These criteria assured that the signal level was sufficiently high above background to be reliably read and that the reading was not the result of non-uniform noise on the spotted DNA. Identity of spotted DNA was verified by PCR. A failure in PCR testing resulted in exclusion of the spot measurement. A total of 6805 genes passed these quality control criteria. Of these, 268 showed 2-fold differential expression for at least 1 time point." provenance.
- _3 value "TABLE I - Ten most highly up- and down-regulated genes. These criteria assured that the signal level was sufficiently high above background to be reliably read and that the reading was not the result of non-uniform noise on the spotted DNA. Identity of spotted DNA was verified by PCR. A failure in PCR testing resulted in exclusion of the spot measurement. A total of 6805 genes passed these quality control criteria. Of these, 268 showed 2-fold differential expression for at least 1 time point." provenance.
- _5 value "Phosphorylation of Akt is regulated positively by Btk and Syk and negatively by Lyn. Akt in turn can regulate positively the transcriptional activity of interleukin (IL)-2 and tumor necrosis factor (TNF)-alpha promoters." provenance.
- _6 value "Phosphorylation of Akt is regulated positively by Btk and Syk and negatively by Lyn. Akt in turn can regulate positively the transcriptional activity of interleukin (IL)-2 and tumor necrosis factor (TNF)-alpha promoters." provenance.
- _4 value "Aldehyde oxidase (AOX) is a member of the molybdenum iron-sulfur flavoproteins and is of interest for its role in clinical drug metabolism and as a source of reactive oxygen species (ROS) potentially involved in human pathology." provenance.
- _5 value "These data show that transcription factor SAF-1 is involved in the regulation of IL-6-mediated induction of the human gamma-fibrinogen gene in liver cells." provenance.
- _4 value "IL-10 at a concentration of 10ng/ml produced a modest 2 fold increase in CXCR4 expression on CD4 T cells after 48hours of incubation." provenance.
- _6 value "In addition, introduction of B-Raf enhances and sustains integrin-mediated activation of ERK in wild-type primary fibroblasts" provenance.
- _4 value "Modified assertion" provenance.
- _5 value "Our results demonstrate that hGab-1 was phosphorylated by IR at eight tyrosine residues (Y242, Y285, Y373, Y447, Y472, Y619, Y657, and Y689). Seventy-five percent of the identified radioactivity was incorporated into tyrosine residues Y447, Y472, and Y619 exhibiting features (NYVPM motif) of potential binding sites for the regulatory subunit (p85) of phosphatidylinositol (PI)-3 kinase." provenance.
- _4 value "CD40L induced TNF-alpha production decreased on treating the cells with Src-kinase inhibitors PPI or damnacanthal for 24 hours." provenance.
- _4 value "CD40L-induced increased phosphorylation and activity of p44 and p42 are specific to the CD40-CD40L interaction." provenance.
- _4 value "MEK1/2 inhibitor PD 98059 decreased CD40-ligand induced TNF-alpha production by CD45 deficient microglial cells." provenance.
- _5 value "Modified assertion" provenance.
- _5 value "Modified assertion" provenance.
- _4 value "PP1, a general pharmacologic inhibitor of Src kinases (Fyn and Lyn), completely abrogated p44/42 mapk activation by fibrillar Amyloid beta. The accumulation of phospho p44/42 was greatly reduced in both fibrillar Amyloid beta treated Fyn-/- and Lyn-/- macrophages as compared with wild type cells." provenance.
- _4 value "We have previously reported that in thrombin-stimulated human platelets, cytosolic phospholipase A(2) (cPLA2) is phosphorylated on Ser-505 by p38 protein kinase and on Ser-727 by an unknown kinase." provenance.
- _5 value "Further analysis showed that the signal transducer and activator of transcription 3 (STAT3) was inactivated immediately after BMP-2 treatment." provenance.
- _3 value "We have identified a close relative of ribonucleotide reductase, recently named p53R2, as a p53-inducible gene, and show that this gene is activated by several stress signals that activate a p53 response, including DNA damaging agents and p14(ARF)." provenance.
- _5 value "Consistent with the physical interaction between ER81 and the coactivators CBP and p300, ER81 transcriptional activity was potentiated by CBP/p300 overexpression." provenance.
- _6 value "The mutational inactivation of a tumor suppressor gene, adenomatous polyposis coli (APC), results in the accumulation of cytoplasmic beta-catenin protein and the activation of T-cell factor (TCF)/lymphoid enhancer factor transcriptional factors." provenance.
- _5 value "Modified assertion" provenance.
- _4 value "# Ariadne: On the other hand, the ATP-induced inhibition of Kir6.2/SUR2A channels was reduced by G ..gamma 2 in a concentration-dependent manner (Figure 2 B). [Regulation]" provenance.
- _6 value "# Ariadne: On the other hand, the ATP-induced inhibition of Kir6.2/SUR2A channels was reduced by G ..gamma 2 in a concentration-dependent manner (Figure 2 B). [Regulation]" provenance.
- _6 value "# Ariadne: An in vitro phosphorylation assay demonstrates that Erk2-dependent phosphorylation of GAIP stimulates its GTPase-activating protein activity toward the Galpha i3 protein ( k = 0.187 .. 0.001 s -1 , EC 50 = 1.12 .. 0.10 .. M ) when compared with unphosphorylated recombinant GAIP ( k = 0.145 .. 0.003 s -1 , EC 50 = 3.16 .. 0.12 .. M ) or to GAIP phosphorylated by other Ser/Thr protein kinases (protein kinase C, casein kinase II). [Regulation] # Ariadne: Using a panel of Ser/Thr protein kinases in an in vitro assay, we demonstrate that the phosphorylation of GAIP by a recombinant Erk2 stimulated its GAP activity toward the Galpha i3 protein when compared with the activity of unphosphorylated GAIP . [Regulation]" provenance.
- _6 value "# Pubmed:gene: Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _4 value "Tyrosine phosphorylation of STAM2 is induced by growth factors such as epidermal growth factor and platelet-derived growth factor as well as by cytokines like IL-3." provenance.
- _6 value "Using cotransfection experiments, we find that SPBP enhances the transcriptional activity of various transcription factors such as c-Jun, Ets1, Sp1, and Pax6. Hence, SPBP seems to act as a transcriptional coactivator." provenance.
- _8 value "In transient transfection assays in CHO cells with SoxLZ/Sox6 containing the transactivational region of herpes simplex virus VP16, expression of a reporter gene that carries a cis binding region for Sox proteins was significantly enhanced by the co-expression of Solt and Ca(2+)/calmodulin-dependent protein kinase IV." provenance.
- _2 value "DBP as a Chemotaxin for Phagocytic Cells DBP is reported to augment the chemotactic effect of C5a for macrophages and neutrophils64-66. This chemotactic activity requires binding of DBP to a cell surface site on leukocytes67,68 as part of the inflammatory response." provenance.
- _3 value "DBP has been directly implicated in the activation of macrophages. Activated macrophages develop the capacity for specialized tasks such as chemotaxis, phagocytosis and the lysis of intracellular parasites, as well as destruction of tumor cells. Lysophosphatidylcholine (lyso-Pc) or dodecylglycerol (DDG) injected into the mouse peritoneum normally activate macrophages to generate reactive oxygen intermediates (ROIs) and to ingest cellular debris during the inflammatory response." provenance.
- _5 value "Studies of the DBP gene proximal promoter have identified three functional hepatocyte nuclear factor 1 (HNF1)-binding sites within 2 kb of the transcriptional start site. The activities of the two more distal HNF1-binding sites were found to be dependent upon the relative levels of the two isoforms of this transcription factor, HNF1a and HNF1b. This was because HNF1b acted as a trans-dominant inhibitor of HNF1amediated enhancer activity14. The relative levels of these HNF1 isoforms in liver and kidney may contribute to the differences in the observed levels of DBP mRNA in these two tissues (Fig. 2). In contrast to their opposing effects on the DBP promoter, HNF1a and HNF1b both display only strong enhancing activities on the AFP and ALB promoters." provenance.
- _5 value "Studies of the DBP gene proximal promoter have identified three functional hepatocyte nuclear factor 1 (HNF1)-binding sites within 2 kb of the transcriptional start site. The activities of the two more distal HNF1-binding sites were found to be dependent upon the relative levels of the two isoforms of this transcription factor, HNF1a and HNF1b. This was because HNF1b acted as a trans-dominant inhibitor of HNF1amediated enhancer activity14. The relative levels of these HNF1 isoforms in liver and kidney may contribute to the differences in the observed levels of DBP mRNA in these two tissues (Fig. 2). In contrast to their opposing effects on the DBP promoter, HNF1a and HNF1b both display only strong enhancing activities on the AFP and ALB promoters." provenance.
- _3 value "In cultured mesangial cells, high glucose levels induce TGF-beta1 production" provenance.
- _2 value "In this paper, we show that ROS may activate aldose reductase, induce diacylglycerol, activate PKC, induce advanced glycation end product formation, and activate the pleiotropic transcription factor nuclear factor-kappa B (NF-kappaB)" provenance.
- _3 value "Ariadne: Furthermore, in the same cell system, leptin has been reported to upregulate the expression of acyl-CoA oxidase (ACO), carnitine palmitoyl transferase-1 (CPT1), and peroxisome proliferator- activated receptor-alpha (PPAR-alpha) [ 15 ], and to increase glucose decarboxylation [ 14 ] and lipolysis [ 13 , 15 , 17 , 18 ]." provenance.
- _3 value "Ariadne: Furthermore, in the same cell system, leptin has been reported to upregulate the expression of acyl-CoA oxidase (ACO), carnitine palmitoyl transferase-1 (CPT1), and peroxisome proliferator- activated receptor-alpha (PPAR-alpha) [ 15 ], and to increase glucose decarboxylation [ 14 ] and lipolysis [ 13 , 15 , 17 , 18 ]." provenance.
- _3 value "For ADAM-9 mRNA, a significant upregulation was found at 1.0 and 10 nM (1.5-1.7-fold increase)." provenance.
- _3 value "In contrast, ADAM-17 mRNA, was significantly inhibited at 0.1 and 1.0 nM (1.7-fold decrease)." provenance.
- _4 value "NGF also induced the expression of the p75 NGF receptor." provenance.
- _3 value "Modified assertion" provenance.
- _3 value "Upon Northern blot analysis, only three of these bands were confirmed as cAMP inducible mRNAs, named cI-1, cI-2, and cI-3 (for cAMP inducible genes 1-3)." provenance.
- _5 value "However, under hypoxia AK1-deficient hearts, compared with the wild type, had a blunted AK-catalyzed phosphotransfer response, lowered intracellular ATP levels, increased P(i)/ATP ratio, and suppressed generation of adenosine" provenance.
- _4 value "However, under hypoxia AK1-deficient hearts, compared with the wild type, had a blunted AK-catalyzed phosphotransfer response, lowered intracellular ATP levels, increased P(i)/ATP ratio, and suppressed generation of adenosine" provenance.
- _4 value "Cells treated with TNF alpha along with IL-1 beta increased G-CSF levels by 6-fold in comparison with when treated with TNF alpha alone." provenance.
- _4 value "Cells treated with TNF alpha along with IL-1 beta increased G-CSF levels by 6-fold in comparison with when treated with TNF alpha alone." provenance.
- _5 value "TNF-alpha or IL-1beta induced both G-CSF and PTHrP production in the conditioned medium." provenance.
- _4 value "TNF-alpha stimulation resulted in an increase in the production of PTHrP from 3.5 to 4 fold." provenance.
- _4 value "mRNA expression of fibrillin-1, emilin, and elastin was strong in quiescent mesangial cells; their gene expression was further up-regulated by transforming growth factor-beta1, while it was transiently reduced when cells were exposed to mitogenic 10% fetal calf serum and platelet-derived growth factor" provenance.