Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _4 value "Adhesion of MDCK cells to immobilized fibronectin also leads to activation of SGK1. " provenance.
- _5 value "Treatment of MDCK cells with HGF leads to a time-dependent activation of SGK1 that is blocked by wortmanin." provenance.
- _6 value "Treatment of MDCK cells with HGF leads to a time-dependent activation of SGK1 that is blocked by wortmanin." provenance.
- _3 value "Thapsigargin-induced mPer1 and mPer2 mRNA expressions took distinct signaling pathways from protein kinase C and cAMP, but were partially inhibited by inhibitors of MEK1 and p38 mitogen-activated protein kinase, respectively" provenance.
- _4 value "Cyclic stretch with an area change of 7% had no such effect. Infection of PVSMCs with recombinant adenoviruses expressing constitutively active forms of upstream molecules that activate JNK and p38 also led to apoptosis." provenance.
- _4 value "Cyclic stretch with an area change of 7% had no such effect. Infection of PVSMCs with recombinant adenoviruses expressing constitutively active forms of upstream molecules that activate JNK and p38 also led to apoptosis." provenance.
- _7 value "PPARgamma agonists inhibited EAE in association with a decrease in IL-12 production and differentiation of neural antigen-specific Th1 cells." provenance.
- _5 value "Furthermore, MDM2, a negative regulator of p53 expression was upregulated 3 days after Adv/p16 infection, and MDM2 was subsequently cleaved by caspase-3; MDM2 cleavage was inhibited by Ac-DEVD-CHO treatment." provenance.
- _3 value "The results below were combined from Tables 1 and 3 in the paper (Table 2 contained nothing suitable). These genes were upregulated (fold change >= 4.0)." provenance.
- _3 value "The results below were combined from Tables 1 and 3 in the paper (Table 2 contained nothing suitable). These genes were upregulated (fold change >= 4.0)." provenance.
- _3 value "The results below were combined from Tables 1 and 3 in the paper (Table 2 contained nothing suitable). These genes were upregulated (fold change >= 4.0)." provenance.
- _3 value "The results below were combined from Tables 1 and 3 in the paper (Table 2 contained nothing suitable). These genes were upregulated (fold change >= 4.0)." provenance.
- _3 value "The results below were combined from Tables 1 and 3 in the paper (Table 2 contained nothing suitable). These genes were upregulated (fold change >= 4.0)." provenance.
- _3 value "The results below were combined from Tables 1 and 3 in the paper (Table 2 contained nothing suitable). These genes were upregulated (fold change >= 4.0)." provenance.
- _3 value "The results below were combined from Tables 1 and 3 in the paper (Table 2 contained nothing suitable). These genes were upregulated (fold change >= 4.0)." provenance.
- _3 value "The results below were combined from Tables 1 and 3 in the paper (Table 2 contained nothing suitable). These genes were upregulated (fold change >= 4.0)." provenance.
- _3 value "The results below were combined from Tables 1 and 3 in the paper (Table 2 contained nothing suitable). These genes were upregulated (fold change >= 4.0)." provenance.
- _3 value "The results below were combined from Tables 1 and 3 in the paper (Table 2 contained nothing suitable). These genes were upregulated (fold change >= 4.0)." provenance.
- _3 value "The results below were combined from Tables 1 and 3 in the paper (Table 2 contained nothing suitable). These genes were upregulated (fold change >= 4.0)." provenance.
- _3 value "The results below were combined from Tables 1 and 3 in the paper (Table 2 contained nothing suitable). These genes were upregulated (fold change >= 4.0)." provenance.
- _3 value "The results below were combined from Tables 1 and 3 in the paper (Table 2 contained nothing suitable). These genes were upregulated (fold change >= 4.0)." provenance.
- _3 value "The results below were combined from Tables 1 and 3 in the paper (Table 2 contained nothing suitable). These genes were upregulated (fold change >= 4.0)." provenance.
- _3 value "These genes were downregulated (fold change < 0.33)." provenance.
- _3 value "These genes were downregulated (fold change < 0.33)." provenance.
- _3 value "These genes were downregulated (fold change < 0.33)." provenance.
- _3 value "These genes were downregulated (fold change < 0.33)." provenance.
- _5 value "E(2)-induced Erk activation is predominantly mediated through the secretion of HRG and activation of HER-2" provenance.
- _4 value "Modified assertion" provenance.
- _4 value "ISGF3 is a heterodimer complex of STAT1, STAT2 and interferon regulatory factor, IRF9 and IRF1. The inhibitory effects of IFNbeta were abrogated in BMMs of mice deficient on STAT1 and IRF9, indicating that the inhibitory action is linked to the ISGF3 mediated gene induction pathway." provenance.
- _4 value "RANKL induced the expression of TRAF6. This expression was not altered on treatment with IFNbeta." provenance.
- _2 value "Peroxisomes proliferate in response to external signals triggered by peroxisome-proliferator-activated receptor signalling pathways. Peroxisome-derived oxidative stress as a consequence of this proliferation is increasingly recognized to participate in pathologies ranging from carcinogenesis in rodents to alcoholic and non-alcoholic steatosis hepatitis in humans." provenance.
- _7 value "In the case of the novel PKCepsilon isoform, these are Thr(566) in the activation loop, Thr(710) in the turn motif and Ser(729) in the C-terminal hydrophobic motif. These studies reveal that the mechanism of phosphorylation of a novel PKC is the same as that for conventional PKCs: PDK-1 phosphorylation of the activation loop triggers autophosphorylation of the hydrophobic motif. " provenance.
- _4 value "cloned a complementary DNA, called Human Immune Associated Nucleotide 1 (hIAN1), whose messenger RNA (mRNA) level expression is inversely correlated to the TAL-1 mRNA level in human leukemic T-cell lines." provenance.
- _4 value "an ALL cell line (EU-4) transfected with the MDM2 gene was associated with elevated expression of p65 and in vitro resistance to doxorubicin (Adriamycin)." provenance.
- _5 value "In human monocytes and macrophages, interferon-gamma (IFNgamma) augmented mRNA and surface expression of toll-like receptor 4 (TLR4), a crucial component of the signaling receptor complex for bacterial lipopolysaccharide (LPS)." provenance.
- _5 value "In human monocytes and macrophages, interferon-gamma (IFNgamma) augmented mRNA and surface expression of toll-like receptor 4 (TLR4), a crucial component of the signaling receptor complex for bacterial lipopolysaccharide (LPS)." provenance.
- _6 value "LPS increased TLR4 mRNA levels, but concomitantly decreased its surface expression. IFNgamma counteracted the LPS-induced downregulation of TLR4." provenance.
- _4 value "LPS increased TLR4 mRNA levels, but concomitantly decreased its surface expression. IFNgamma counteracted the LPS-induced downregulation of TLR4." provenance.
- _5 value "Table 1. Identification of FOXO3a target genes by transcriptional profiling." provenance.
- _5 value "Table 1. Identification of FOXO3a target genes by transcriptional profiling." provenance.
- _5 value "Table 1. Identification of FOXO3a target genes by transcriptional profiling." provenance.
- _3 value "\"Monitoring changes in gene expression in renal ischemia-reperfusion in the rat.\" RESULTS: Alterations in expression of 18 genes were identified by microarray analysis. Nine genes were up-regulated (ADAM2, HO-1, UCP-2, and thymosin beta4 in the early phase and clusterin, vanin1, fibronectin, heat-responsive protein 12 and FK506 binding protein in the established phase), whereas another nine were down-regulated (glutamine synthetase, cytochrome p450 IId6, and cyp 2d9 in the early phase and cyp 4a14, Xist gene, PPARgamma, alpha-albumin, uromodulin, and ADH B2 in the established phase)." provenance.
- _3 value "\"Monitoring changes in gene expression in renal ischemia-reperfusion in the rat.\" RESULTS: Alterations in expression of 18 genes were identified by microarray analysis. Nine genes were up-regulated (ADAM2, HO-1, UCP-2, and thymosin beta4 in the early phase and clusterin, vanin1, fibronectin, heat-responsive protein 12 and FK506 binding protein in the established phase), whereas another nine were down-regulated (glutamine synthetase, cytochrome p450 IId6, and cyp 2d9 in the early phase and cyp 4a14, Xist gene, PPARgamma, alpha-albumin, uromodulin, and ADH B2 in the established phase)." provenance.
- _5 value "Hypoxia-induced expression of NERF2 and Tie2 was blocked by angiopoietin-2, a competitive inhibitor of angiopoietin-1, and by recombinant soluble extracellular domain of Tie2 but not by VEGF-neutralizing antibodies." provenance.
- _5 value "Hypoxia-induced expression of NERF2 and Tie2 was blocked by angiopoietin-2, a competitive inhibitor of angiopoietin-1, and by recombinant soluble extracellular domain of Tie2 but not by VEGF-neutralizing antibodies." provenance.
- _3 value "Further, PTH (1-38), (1-31), PTHrP (1-34), and forskolin, which elevate cAMP levels, stimulated the promoter, while PTH (3-34) and (7-34), which do not readily stimulate cAMP accumulation, and PMA that directly activates protein kinase C, had no effect on promoter activity" provenance.
- _4 value "Transient transfection experiments revealed that Cux-1 is an inhibitor of p27 promoter activity." provenance.
- _5 value "Ser301 of CBP was identified as a major target of CaMKIV phosphorylation in vitro and in vivo." provenance.
- _5 value "Dexamethasone treatment of AM decreased MMP-9 activity in cell culture supernatants from AM stimulated with IL-1beta and LPS (Figures 8A and 8B) for all subject groups to baseline (P < 0.01). However, dexamethasone did not decrease the MMP-9 activity in the AM supernatant treated with CSM (Figures 8C and 9)." provenance.
- _5 value "MMP release from alveolar macrophages can be stimulated by lipopolysaccharide (LPS), phorbol esters, interleukin (IL)-1beta , platelet derived growth factor (PDGF), and tumor necrosis factor (TNF)-alpha (17)," provenance.
- _5 value "Therefore, IL-16 activation of eosinophils is CD4-mediated to elicit the extracellular release of preformed RANTES and eotaxin, which then in an autocrine fashion act on plasma membrane CCR3 receptors to stimulate both enhanced LTC(4) production and the preferential release of IL-4, but not IL-12, from within eosinophils." provenance.
- _7 value "These results suggested that NPR located at the plasma membrane regulates EPO expression in hypoxia, including HIF-1 activation and translocation." provenance.
- _5 value "PKA also decreased Raf-1 serine 338 phosphorylation of Raf-1, previously shown to be required for Raf-1 activation. " provenance.
- _5 value "PKA also decreased Raf-1 serine 338 phosphorylation of Raf-1, previously shown to be required for Raf-1 activation. " provenance.
- _5 value "The cyclic AMP (cAMP)-dependent protein kinase (PKA) can inhibit Raf-1 by direct phosphorylation. We have mapped all cAMP-induced phosphorylation sites in Raf-1, showing that serines 43, 259, and 621 are phosphorylated by PKA in vitro and induced by cAMP in vivo. " provenance.
- _6 value "The cyclic AMP (cAMP)-dependent protein kinase (PKA) can inhibit Raf-1 by direct phosphorylation. We have mapped all cAMP-induced phosphorylation sites in Raf-1, showing that serines 43, 259, and 621 are phosphorylated by PKA in vitro and induced by cAMP in vivo. " provenance.
- _6 value "acetylation-deficient AR mutants were selectively defective in DHT-induced trans activation of androgen-responsive reporter genes and coactivation by SRC1, Ubc9, TIP60, and p300." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _5 value "In human embryonic kidney 293 cells, IL-1beta induces IkappaB kinase beta (IKKbeta) activation, IkappaBalpha degradation, NF-kappaB transactivation, and weak Akt activation." provenance.
- _6 value "Modified assertion" provenance.
- _4 value "We have also identified a novel interaction between CaMKK-stimulated Akt and interleukin-1 receptor-associated kinase 1 (IRAK1), which plays a key role in IL-1beta-induced NF-kappaB activation. CaMKKc and Akt overexpression decreases IRAK1-mediated NF-kappaB activity and its association with MyD88 in response to IL-1beta stimulation." provenance.
- _3 value "The activities of both kinase and phosphatase components are tightly regulated [1]. PDK activity increases in the presence of elevated concentrations of NADH and acetyl-CoA, whereas elevated concentrations of NAD+, CoA [7] and pyruvate inhibit kinase activity [8]." provenance.
- _4 value "The activities of both kinase and phosphatase components are tightly regulated [1]. PDK activity increases in the presence of elevated concentrations of NADH and acetyl-CoA, whereas elevated concentrations of NAD+, CoA [7] and pyruvate inhibit kinase activity [8]." provenance.
- _4 value "Further, NF-kappaB is an obligatory mediator of most of these TNF-alpha responses....Absence of NF-kappaB activation (through overexpression on the inhibitor in the same cell) abolished suppression of >98% of the genes normally suppressed by TNF-alpha and induction of 60-70% of the genes normally induced by TNF-alpha" provenance.
- _4 value "Further, NF-kappaB is an obligatory mediator of most of these TNF-alpha responses....Absence of NF-kappaB activation (through overexpression on the inhibitor in the same cell) abolished suppression of >98% of the genes normally suppressed by TNF-alpha and induction of 60-70% of the genes normally induced by TNF-alpha" provenance.
- _4 value "Further, NF-kappaB is an obligatory mediator of most of these TNF-alpha responses....Absence of NF-kappaB activation (through overexpression on the inhibitor in the same cell) abolished suppression of >98% of the genes normally suppressed by TNF-alpha and induction of 60-70% of the genes normally induced by TNF-alpha" provenance.
- _4 value "Further, NF-kappaB is an obligatory mediator of most of these TNF-alpha responses....Absence of NF-kappaB activation (through overexpression on the inhibitor in the same cell) abolished suppression of >98% of the genes normally suppressed by TNF-alpha and induction of 60-70% of the genes normally induced by TNF-alpha" provenance.
- _4 value "Further, NF-kappaB is an obligatory mediator of most of these TNF-alpha responses....Absence of NF-kappaB activation (through overexpression on the inhibitor in the same cell) abolished suppression of >98% of the genes normally suppressed by TNF-alpha and induction of 60-70% of the genes normally induced by TNF-alpha" provenance.
- _4 value "Nuclear factor-kappaB (NF-kappaB) was activated within 15 min of TNF-alpha addition." provenance.
- _5 value "Table 1. List of genes upregulated by VP16 Six5wt overexpression in P19 cells" provenance.
- _5 value "Table 1. List of genes upregulated by VP16 Six5wt overexpression in P19 cells" provenance.
- _3 value "OVCA2 mRNA and protein are ubiquitously expressed and that they are downregulated in the lung cancer cell line Calu-6 after treatment with RA and 4HPR." provenance.
- _5 value "FKHR is phosphorylated by protein kinase B (PKB) at Thr24, Ser256 and Ser319 in response to growth factors, stimulating the nuclear exit and inactivation of this transcription factor." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _5 value "A stable cell line of HEp-2 overexpressing RNase L inhibitor, RLI-14, which exhibits an IFN-gamma-induced gene expression pattern similar to that of the parent cell line, shows a significant reduction in RNase L activity and IFN-gamma-mediated antiviral effect, compared with HEp-2 cells. " provenance.
- _3 value "Colon carcinoma cell lines stably overexpressing Mirk proliferated in serum-free medium, but the mechanism of Mirk action is unknown." provenance.
- _7 value "Mirk co-immunoprecipitated with the MAPK kinase MKK3, an upstream activator of p38. MKK3 enhanced Mirk kinase activity and the transcriptional activation of HNF-1alpha by Mirk" provenance.
- _3 value "Oxidized VLDL and H(2)O(2) reduced stathmin phosphorylation while HNE increased it," provenance.
- _5 value "Activating FcgammaRIII triggered mRNA synthesis for monocyte chemoattractant protein-1 (MCP-1), MCP-5, cytokine-induced neutrophil chemoattractant, and RANTES" provenance.
- _3 value "multiple drug resistance P-glycoproteins are plasma membrane proteins implicated in the movement of drugs and lipids across membranes their functions are inhibited by progesterone, which has been shown to alter cellular cholesterol homeostasis and has implicated P-glycoproteins in the movement of cholesterol to the endoplasmic reticulum" provenance.
- _5 value "The glycoprotein CD47 (integrin-associated protein, IAP) is present on the surface of virtually all cells, including red blood cells (RBCs). CD47 acts like a marker of self by ligating the macrophage inhibitory receptor signal regulatory protein alpha (SIRPalpha). In this manner mild reactivity of wild-type RBCs with macrophage phagocytic receptors is tolerated, whereas otherwise identical CD47-deficient RBCs are rapidly eliminated." provenance.
- _5 value "It is known that Gp96 is released from cells at necrosis induced, for example, by virus infection. Although this event supports the efficient induction of immune responses, it might also interfere with processes that are susceptible to chronic inflammation, such as wound healing after tissue damage. Therefore, Gp96-mediated stimulation of the immune system requires tight regulation. Here we show that human thrombocytes specifically interact with Gp96 and that binding of Gp96 to platelets is enhanced more than 10-fold on activation by thrombin. Gp96 interferes with neither thrombin-induced platelet activation nor platelet aggregation. However, the presence of platelets during Gp96-mediated DC activation reduces the secretion of proinflammatory cytokines and the activation of DCs." provenance.
- _7 value "It is known that Gp96 is released from cells at necrosis induced, for example, by virus infection. Although this event supports the efficient induction of immune responses, it might also interfere with processes that are susceptible to chronic inflammation, such as wound healing after tissue damage. Therefore, Gp96-mediated stimulation of the immune system requires tight regulation. Here we show that human thrombocytes specifically interact with Gp96 and that binding of Gp96 to platelets is enhanced more than 10-fold on activation by thrombin. Gp96 interferes with neither thrombin-induced platelet activation nor platelet aggregation. However, the presence of platelets during Gp96-mediated DC activation reduces the secretion of proinflammatory cytokines and the activation of DCs." provenance.
- _6 value "It is known that Gp96 is released from cells at necrosis induced, for example, by virus infection. Although this event supports the efficient induction of immune responses, it might also interfere with processes that are susceptible to chronic inflammation, such as wound healing after tissue damage. Therefore, Gp96-mediated stimulation of the immune system requires tight regulation. Here we show that human thrombocytes specifically interact with Gp96 and that binding of Gp96 to platelets is enhanced more than 10-fold on activation by thrombin. Gp96 interferes with neither thrombin-induced platelet activation nor platelet aggregation. However, the presence of platelets during Gp96-mediated DC activation reduces the secretion of proinflammatory cytokines and the activation of DCs." provenance.
- _5 value "Transient transfection of REH pre-B cells with an activated form of Notch2 induced endogenous CD23a, confirming that CD23a is a target gene of Notch2 signaling." provenance.
- _2 value "Ankylosing spondylitis is a chronic inflammatory disease characterized by axial skeletal ankylosis, inflammation at the insertions of tendons (enthesitis), and occasionally, peripheral arthritis. " provenance.
- _3 value "Treatment with etanercept for four months resulted in rapid, significant, and sustained improvement in patients with ankylosing spondylitis." provenance.
- _6 value "in embryonic kidney cells expressing full-length DCC, NTN1 causes increased transient phosphorylation and activity of ERK1 and ERK2 but not of JNK1, JNK2 or MAPK14 this phosphorylation was mediated by MAP2K1 (aka MEK1) and/or MAP2K2 (aka MEK2)" provenance.
- _6 value "in embryonic kidney cells expressing full-length DCC, NTN1 causes increased transient phosphorylation and activity of ERK1 and ERK2 but not of JNK1, JNK2 or MAPK14 this phosphorylation was mediated by MAP2K1 (aka MEK1) and/or MAP2K2 (aka MEK2)" provenance.
- _5 value "Emi1 promotes mitotic entry in Xenopus laevis embryos by inhibiting the APC(Cdc20) ubiquitination complex to allow accumulation of cyclin B. We show here that human Emi1 (hEmi1) functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC(Cdh1) complex. At the G1-S transition, hEmi1 is transcriptionally induced by the E2F transcription factor, much like cyclin A. hEmi1 overexpression accelerates S phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of hEmi1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry. These data suggest that E2F can activate both transcription of cyclin A and the hEmi1-dependent stabilization of APC(Cdh1) targets, such as cyclin A, to promote S phase entry." provenance.
- _4 value "Recently we reported a correlation between the ability of IL-4 to regulate TNFalpha production by monocytes and the expression of the IL-4 receptor gamma chain or gamma common (gamma c chain). interferon alpha (IFNalpha)-treated monocytes expressed less IL-4 receptor gamma c chain, reduced levels of IL-4-activated STAT6 and IL-4 could not suppress LPS-induced TNFalpha production." provenance.
- _3 value "While IL-4 can suppress LPS-induced interleukin beta (IL-beta) and tumour necrosis factor alpha (TNF-alpha) production by monocytes, IL-4 can suppress LPS-induced IL-1 beta, but not TNFalpha production by the more differentiated cells." provenance.
- _5 value "The stimulation of cells derived from the kidney proximal tubules with apoA-I or HDL induces a concentration-dependent secretion of AI-BP indicating an important role for AI-BP, in the renal tubular degradation or resorption of apoA-I." provenance.
- _3 value "The fully active dihydroxylated metabolite of vitamin D(3) induces the expression of CYP3A4 and, to a lesser extent, CYP2B6 and CYP2C9 genes in normal differentiated primary human hepatocytes" provenance.
- _7 value "the vitamin D receptor (VDR) binds and transactivates those xenobiotic-responsive elements (ER6, DR3, and DR4) previously identified in CYP3A4, CYP2B6, and CYP2C9 promoters" provenance.
- _5 value "Furthermore, endogenous Fli-1 was found to be bound to its own gene promoter and to be able to promote the transactivation of its gene." provenance.
- _5 value "The -270/-41 fragment contains two known Spi-1-responding Ets binding sites (EBS), which are also necessary for the activation by Ets-1." provenance.
- _5 value "PP1 treatment blocks EGF-induced activation of the anti-apoptotic protein kinase Akt suggesting that Src may regulate activation of Akt, perhaps by a Src --> c-Cbl --> phosphatidylinositol 3'-kinase --> Akt pathway." provenance.
- _4 value "Stimulation of T47D cells with epidermal growth factor (EGF) results in the activation of the intrinsic tyrosine kinases of the receptor and the phosphorylation of multiple cellular proteins including the receptor, scaffold molecules such as c-Cbl, adapter molecules such as Shc, and the serine/threonine protein kinase Akt. " provenance.
- _4 value "Stimulation of T47D cells with epidermal growth factor (EGF) results in the activation of the intrinsic tyrosine kinases of the receptor and the phosphorylation of multiple cellular proteins including the receptor, scaffold molecules such as c-Cbl, adapter molecules such as Shc, and the serine/threonine protein kinase Akt. " provenance.