Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _3 value "FIG. 3. Genes upregulated by androgen in the caput epididymis" provenance.
- _3 value "FIG. 3. Genes upregulated by androgen in the caput epididymis" provenance.
- _3 value "FIG. 3. Genes upregulated by androgen in the caput epididymis" provenance.
- _3 value "FIG. 3. Genes upregulated by androgen in the caput epididymis" provenance.
- _3 value "FIG. 3. Genes upregulated by androgen in the caput epididymis" provenance.
- _3 value "FIG. 3. Genes upregulated by androgen in the caput epididymis" provenance.
- _3 value "FIG. 7. Genes upregulated in the epididymis by removal of androgen" provenance.
- _3 value "FIG. 7. Genes upregulated in the epididymis by removal of androgen" provenance.
- _3 value "FIG. 7. Genes upregulated in the epididymis by removal of androgen" provenance.
- _3 value "FIG. 9. Genes upregulated by androgen in the cauda epididymis" provenance.
- _3 value "FIG. 9. Genes upregulated by androgen in the cauda epididymis" provenance.
- _3 value "scotin, a protein identified recently as a p53 target able to induce ER stress" provenance.
- _4 value "PPARgamma agonists ameliorate endothelial cell activation" provenance.
- _3 value "These data suggest that upregulation of Fas expression and downregulation of FLIP is a mechanism through which Hcy induces EC apoptosis" provenance.
- _6 value "Functional analysis revealed that hMI-ER1 represses Sp1-activated transcription from the minimal promoter by a histone deacetylase-independent mechanism." provenance.
- _5 value "These studies argue that Tyr-371 plays a key role in activating the E3 activity of c-Cbl and that the Y371E mutant may partially mimic phosphorylation at that site." provenance.
- _6 value "Modified assertion" provenance.
- _6 value "Rac1 activation by EGF was completely eliminate in cells transfected with pSUPER-beta-Pix (Fig. 2C). This result demonstrates that beta-Pix is an essential GEF for Rac1. # beta-PIX = ARHGEF7" provenance.
- _3 value "The exposure of control Caco-2 or HEK293T cells to EGF (100 ng/ml) resulted in an increased generation of ROS, as revealed by an increase in DCF fluorescence (Fig. 1A and B). " provenance.
- _3 value "The exposure of control Caco-2 or HEK293T cells to EGF (100 ng/ml) resulted in an increased generation of ROS, as revealed by an increase in DCF fluorescence (Fig. 1A and B). " provenance.
- _4 value "Treatment of the cells with LY294002 as a PI3K inhibitor blocked beta-Pix-induced ROS generation as well as ROS generation in control cells upon the addition of EGF (Fig. 3A)." provenance.
- _4 value "Treatment of the cells with LY294002 as a PI3K inhibitor blocked beta-Pix-induced ROS generation as well as ROS generation in control cells upon the addition of EGF (Fig. 3A)." provenance.
- _5 value "Treatment of the cells with LY294002 as a PI3K inhibitor blocked beta-Pix-induced ROS generation as well as ROS generation in control cells upon the addition of EGF (Fig. 3A)." provenance.
- _5 value "GATA, Ets, and Sp1 consensus sequences within this region are each necessary and function combinatorially in ERK-activated transcription." provenance.
- _5 value "In this study, we demonstrate that ectopic expression of Mlf1 prevented J2E erythroleukemic cells from undergoing biological and morphological maturation in response to erythropoietin (Epo). We show that Mlf1 inhibited Epo-induced cell cycle exit and suppressed a rise in the cell cycle inhibitor p27(Kip1)." provenance.
- _3 value "Here we show that the expression of AdipoR1/R2 in insulin target organs, such as skeletal muscle and liver, is significantly increased in fasted mice and decreased in refed mice" provenance.
- _4 value "fld mice exhibited 2 fold reductions in expression of ... PPARG and CEBPA and in ... aP2. The expression of DGAT was reduced 3 fold in fld tissue" provenance.
- _4 value "Because cyclin-dependent kinase (Cdk)5 and p35 cleavage (p25 formation) have been reported to be targets of intracellular Ca(2+), and subsequently correlated to apoptosis," provenance.
- _5 value "PIASxbeta and Ubc9 enhance the transcriptional activity of PPARgamma independent of PPARgamma sumoylation." provenance.
- _3 value "inhibitors of histone deacetylase (HDAC) activity, butyrate, trichostatin A, and suberoylanilide hydroxamic acid, prevented IFNgamma-induced JAK1 activation, STAT1 phosphorylation, its nuclear translocation, and STAT1-dependent gene activation." provenance.
- _4 value "inhibitors of histone deacetylase (HDAC) activity, butyrate, trichostatin A, and suberoylanilide hydroxamic acid, prevented IFNgamma-induced JAK1 activation, STAT1 phosphorylation, its nuclear translocation, and STAT1-dependent gene activation." provenance.
- _3 value "inhibitors of histone deacetylase (HDAC) activity, butyrate, trichostatin A, and suberoylanilide hydroxamic acid, prevented IFNgamma-induced JAK1 activation, STAT1 phosphorylation, its nuclear translocation, and STAT1-dependent gene activation." provenance.
- _4 value "inhibitors of histone deacetylase (HDAC) activity, butyrate, trichostatin A, and suberoylanilide hydroxamic acid, prevented IFNgamma-induced JAK1 activation, STAT1 phosphorylation, its nuclear translocation, and STAT1-dependent gene activation." provenance.
- _4 value "inhibitors of histone deacetylase (HDAC) activity, butyrate, trichostatin A, and suberoylanilide hydroxamic acid, prevented IFNgamma-induced JAK1 activation, STAT1 phosphorylation, its nuclear translocation, and STAT1-dependent gene activation." provenance.
- _5 value "silencing of HDAC1, HDAC2, and HDAC3 through RNA interference markedly decreased IFNgamma-driven gene activation and that overexpression of HDAC1, HDAC2, and HDAC3 enhanced STAT1-dependent transcriptional activity." provenance.
- _7 value "Mutant analysis of the GM-CSF promoter shows that the Ets1 binding site of the promoter is essential for the synergy between AML1 and CN in Jurkat T cells." provenance.
- _4 value "Both IL13 and IL4 induces the phosphorylation of STAT6." provenance.
- _4 value "IL-7 stimulation resulted in the inactivation of Bad by phosphorylation at Ser-112, -136, and -155" provenance.
- _4 value "expression of ATIP1 in eukaryotic cells leads to inhibition of insulin, basic fibroblast growth factor, and epidermal growth factor-induced ERK2 activation and DNA synthesis, and attenuates insulin receptor autophosphorylation" provenance.
- _4 value "In addition, p300-deficient (p300(-)) cells fail to undergo G(1)/S arrest after UV irradiation. These abnormalities are associated with prolongation of p53 stability, reduced p53-acetylation, blunting of MDM2 activation, failure to transactivate p21, and a disproportionate increase in PUMA levels." provenance.
- _3 value "Silibinin down-regulated PSA mRNA expression and PSA secretion in conditioned medium under basal and DHT (10(-8)M) stimulated conditions, which was paralleled by PDEF down-regulation." provenance.
- _3 value "We analyzed the profiles of newly synthesized proteins by GA with 2-dimensional gel electrophoresis and MALDI-TOF MS and found that two families of proteins were expressed by GA. One was similar to the protein family synthesized by heat shock (Hsp70, Hsp73, Hsp65, Hsp90, vimentin, tubulin, Ras homolog); and the other was a family of protein specific to GA (calreticulin, annexin III, thioredoxin peroxidase)." provenance.
- _3 value "We analyzed the profiles of newly synthesized proteins by GA with 2-dimensional gel electrophoresis and MALDI-TOF MS and found that two families of proteins were expressed by GA. One was similar to the protein family synthesized by heat shock (Hsp70, Hsp73, Hsp65, Hsp90, vimentin, tubulin, Ras homolog); and the other was a family of protein specific to GA (calreticulin, annexin III, thioredoxin peroxidase)." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _4 value "In E , reverse transcription-PCR analysis demonstrated that HOXB13 down-regulates the expression of cyclin D1 RNA in HOXB13-PC3 cells." provenance.
- _4 value "Modified assertion" provenance.
- _5 value "In vitro studies using two human TEC lines demonstrated that p63 was capable of up-regulating intercellular adhesion molecule-1 (ICAM-1) and enhancing the production of IL-6 and IL-8." provenance.
- _3 value "Treatment with 1 microM ( micromol/liter(-1)) progesterone resulted in 2.91 +/- 0.75-fold elevation in PK1 expression" provenance.
- _3 value "from free full text Table" provenance.
- _3 value "from free full text Table" provenance.
- _3 value "A later peak of follistatin expression (2- to 3-fold increase) was noted starting from day 10 and persisted until day 30. To deter- mine whether follistatin activation coincides with the appearance of activated satellite cells, we analyzed the expression of several markers of satellite cells activation. Msx1 is transcribed in quiescent satellite cells and its expression is extinguished upon cell activation (Cor- nelison et al., 2000). On the other hand, only activated satellite cells express MyoD (Cornelison and Wold, 1997), Numb (Conboy and Rando, 2002), and, at later stages, myogenin (Cornelison and Wold, 1997). Twelve hours after muscle injury, we noted that expression of Msx1 was reduced while MyoD and Numb expression increased." provenance.
- _3 value "Finally, we reduced follistatin in skeletal myoblasts by infecting them with a retrovirus expressing a short hairpin (sh) RNA-targeting follistatin. Cells transduced with sh RNA follistatin and exposed to TSA had decreased levels of follistatin upon TSA stimulation (Figure 7D) and were less responsive to TSA compared to control cells (Figures 7E - 7G). Taken together, the results reported in this paragraph strongly suggest that myoblasts with reduced levels of follistatin become refractory to TSA treatment. FOLLISTATIN EXPRESSION IS INDUCED UPON MUSCLE INJURY AND COINCIDES WITH EXPRESSION OF MARKERS OF SATELLITE CELL ACTIVATION HDAC inhibitors induce follistatin gene expression in mouse primary myoblasts (Figure 3). To evaluate whether satellite cell activation is associated with increased follistatin gene expression, we analyzed temporal expression profiling data generated in a mouse model of muscle injury and regeneration (Zhao et al., 2002). Twelve hours after injury, the levels of follistatin were increased 7-fold and remained elevated (approximately 2-fold) for 5 days (Supplemental Figure S1)." provenance.
- _3 value "Myogenin expression increased 4 days following injury. M-cadherin, a late marker of satellite cells activation (Cornelison and Wold, 1997), was also highly expressed at 72 hr after injury (Supplemental Figure S1)." provenance.
- _3 value "In addition, dopamine inhibited the rotenone sensitive NADH-cytochrome c reductase (complexes I?III) activity in the presence of cytochrome c as the electron acceptor, in a dose-dependent manner (Table 1). " provenance.
- _5 value "Gene reporter experiments with proximal promoters revealed that HNF-3 gamma transactivated CYP2C8, CYP2C9, and CYP2C19 (25-, 4-, and 4-fold, respectively)" provenance.
- _5 value "Gene reporter experiments with proximal promoters revealed that HNF-3 gamma transactivated CYP2C8, CYP2C9, and CYP2C19 (25-, 4-, and 4-fold, respectively)" provenance.
- _6 value "Here, we show that a novel pro-apoptotic pathway that is induced by RXR agonist is negatively regulated by casein kinase 1alpha (CK1alpha). CK1alpha associates with RXR in an agonist-dependent manner and phosphorylates RXR. The ability of an RXR agonist to recruit CK1alpha to a complex with RXR in cells correlates inversely with its ability to inhibit growth" provenance.
- _7 value "Here, we show that a novel pro-apoptotic pathway that is induced by RXR agonist is negatively regulated by casein kinase 1alpha (CK1alpha). CK1alpha associates with RXR in an agonist-dependent manner and phosphorylates RXR. The ability of an RXR agonist to recruit CK1alpha to a complex with RXR in cells correlates inversely with its ability to inhibit growth" provenance.
- _4 value "Here, we show that a novel pro-apoptotic pathway that is induced by RXR agonist is negatively regulated by casein kinase 1alpha (CK1alpha). CK1alpha associates with RXR in an agonist-dependent manner and phosphorylates RXR. The ability of an RXR agonist to recruit CK1alpha to a complex with RXR in cells correlates inversely with its ability to inhibit growth" provenance.
- _5 value "T-bet transfection also induced IL-12Rbeta2 and CXCR3 expression on human T(H)2 cells, whereas the IL-18 receptor was only induced as a consequence of T-bet-mediated increased responsiveness to IL-12." provenance.
- _5 value "We report here that inhibition of the p38alpha isoform suppressed the ability of Smad3 to mediate TGF-beta-induced transcriptional responses. The inhibition of p38 activity blocked TGF-beta-mediated phosphorylation of the MSK1 kinase, a substrate of p38 that plays an important role in the remodeling of chromatin." provenance.
- _6 value "We report here that inhibition of the p38alpha isoform suppressed the ability of Smad3 to mediate TGF-beta-induced transcriptional responses. The inhibition of p38 activity blocked TGF-beta-mediated phosphorylation of the MSK1 kinase, a substrate of p38 that plays an important role in the remodeling of chromatin." provenance.
- _6 value "IL-7 inhibits TGF-beta-induced PKC-delta phosphorylation at Ser-645 and Thr-505. TGF-beta stimulates, while IL-7 inhibits, PKC-delta activity." provenance.
- _4 value "IL-7 inhibits TGF-beta-induced PKC-delta phosphorylation at Ser-645 and Thr-505. TGF-beta stimulates, while IL-7 inhibits, PKC-delta activity." provenance.
- _4 value "androgens increase the expression of SCAP and favor translocation of the SCAP/SREBP complex to the Golgi apparatus by disturbing the balance between SCAP and its retention proteins. Here we show that the SCAP gene contains an androgen responsive region This region interacts directly with the androgen receptor (AR) and confers androgen responsiveness to promoter-reporter constructs transfected in LNCaP cells" provenance.
- _5 value "are synthesised as inactive precursor proteins in the endoplasmic reticulum, where they are retained by SREBP cleavage activating protein (SCAP) a sterol sensing protein which in turn is linked to a retention protein complex." provenance.
- _4 value "Binding sites for Ap-1 and Sp-1 were among the cis-regulatory elements recognizing consensus transcription factors responsible for basal promoter activity of sequence -268 to +42 bp." provenance.
- _3 value "Forced expression of SIK1 inhibited the ACTH-dependent expression of CYP11A- and StAR protein-genes." provenance.
- _4 value "Adding nicotine or NNK to BEAS-2B or BEAS-2B/NNK cells increased Akt activation in a time-dependent and dosedependent manner, and increased cellular proliferation." provenance.
- _4 value "Antisense ODN to C3 increased expression of SM22alpha mRNA and decreased expression of osteopontin and matrix Gla mRNAs." provenance.
- _4 value "Orlistat reduced phosphorylation of the Rb protein, up-regulated p27Kip1, and down-regulated Skp2. These effects were evident at levels of the drug consistent with the cellular IC50 of Orlistat for inhibition of the FAS thioesterase (1-3 M). To independently verify that the effects of Orlistat could be attributed to its ability to block FAS, similar experiments were conducted with siRNA-targeting FAS (Fig. 4B). Like Orlistat, the siRNA-targeting FAS decreased the phosphorylation of Rb, increased the level of p27Kip1, and reduced the level of Skp2. An siRNA-targeting Skp2 had identical effects upon its downstream target, p27Kip1, and upon the phosphorylation status of the Rb protein. Together, these findings provide strong support for the idea that a FAS blockade acts upon the Rb pathway via regulation of Skp2 and also indicate that a FAS blockade is likely to have effects similar to an Skp2 blockade." provenance.
- _5 value "Orlistat reduced phosphorylation of the Rb protein, up-regulated p27Kip1, and down-regulated Skp2. These effects were evident at levels of the drug consistent with the cellular IC50 of Orlistat for inhibition of the FAS thioesterase (1-3 M). To independently verify that the effects of Orlistat could be attributed to its ability to block FAS, similar experiments were conducted with siRNA-targeting FAS (Fig. 4B). Like Orlistat, the siRNA-targeting FAS decreased the phosphorylation of Rb, increased the level of p27Kip1, and reduced the level of Skp2. An siRNA-targeting Skp2 had identical effects upon its downstream target, p27Kip1, and upon the phosphorylation status of the Rb protein. Together, these findings provide strong support for the idea that a FAS blockade acts upon the Rb pathway via regulation of Skp2 and also indicate that a FAS blockade is likely to have effects similar to an Skp2 blockade." provenance.
- _5 value "the ablation of FAS activity causes a dramatic down-regulation of Skp2, a component of the E3 ubiquitin ligase that controls the turnover of Kip1 protein. These effects ultimately tie into the retinoblastoma protein pathway and lead to a cell-cycle arrest at the G1/S boundary." provenance.
- _5 value "c-Abl activation by apoptotic agents specifically promotes phosphorylation of Lasp-1 at tyrosine 171, which is associated with the loss of Lasp-1 localization to focal adhesions and induction of cell death." provenance.
- _5 value "Modified assertion" provenance.
- _9 value "A recent work has shown that NFkB-dependent transcription requires the function of transcriptional coactivator proteins (10 12). The CBP and its homologue, p300, are coactivators that interact with the p65 subunit of NFkB to enhance its ability to activate transcription." provenance.
- _5 value "EGF induces tyrosine phosphorylation of tensin3 in MDA-MB-468 cells in a time- and dose-dependent manner, but it is independent of an intact actin cytoskeleton or phosphatidylinositol 3-kinase." provenance.
- _3 value "These findings suggested that induction of TauT by hypertonicity is mediated by the activation of the TonE/TonEBP pathway and confers resistance to hypertonic stress. " provenance.
- _4 value "IL-1beta, TNF-alpha and IL17 combination of cytokines had a particularly strong synergistic effect on the nuclear translocation of C-jun." provenance.
- _4 value "Immunohistochemical analysis of cytokine expression on paraffin sections of mouse paws show that the expression of TNF-alpha was decreased by 55% in mice treated with 2.5Microgram IFN-beta for 7 days in comparison with saline treated mice." provenance.
- _3 value "cTnI breakdown during ischemia is further increased in the presence of antioxidants, suggesting ROS generated during ischemia may play a cTnI protective role" provenance.
- _5 value "Ox-PAPC and its component phospholipids induced a rapid and transient phosphorylation of c-src Tyr418, a hallmark of c-src activation, in human aortic endothelial cells (HAEC)." provenance.
- _6 value "# Ariadne: EGF induced tyrosine phosphorylation of RasGRP3, but not RasGRP1, apparently caused by c-Src; inhibition of c-Src interfered with EGF-induced Rap2B activation and PLC stimulation. [Regulation] PLC and Ca(2+) signaling by the EGF receptor, which activated both PLC-gamma1 and PLC-epsilon, was specifically suppressed by inactivation of Ras-related GTPases with clostridial toxins and expression of dominant-negative Rap2B." provenance.
- _5 value "EGF induced tyrosine phosphorylation of RasGRP3, but not RasGRP1, apparently caused by c-Src; inhibition of c-Src interfered with EGF-induced Rap2B activation and PLC stimulation." provenance.
- _6 value "We have now found that Cdx1 and LEF1, a nuclear effector of Wnt signaling, synergize to induce expression from the Cdx1 promoter through previously documented LEF/T-cell factor response elements. We also found a direct physical interaction between the homeodomain of Cdx1 and the B box of LEF1, suggesting a basis for this synergy. " provenance.
- _8 value "Transcriptional activation by signal transducer and activator of transcription 6 (STAT6) has been shown to require the direct interaction not only with co-activators such as p300 and cAMP-responsive element-binding protein-binding protein (CBP) but also with nuclear co-activator 1, a member of the p160/steroid receptor co-activator family. Among the p160/steroid receptor co-activators, only p/CIP (nuclear co-activator 3) has been shown to be up-regulated by interleukin (IL)-4 in B cells through a STAT-6-dependent mechanism using Gene-Chip analysis. In this study, we have investigated the function of p/CIP in the transcriptional activation by STAT6. We found that p/CIP indirectly interacted with STAT6 via p300, and overexpression of the CBP-interacting domain of p/CIP (p/CIP(947-1084)) prevented the interaction of p/CIP with STAT6 by blocking the binding of p/CIP to p300. Whereas expression of p/CIP(947-1084) resulted in a marked reduction of STAT6-mediated transactivation, overexpression of wild type p/CIP resulted in significant enhancement of it. In addition, p/CIP(947-1084) markedly reduced CD23 expression on B cells stimulated with IL-4, whereas overexpression of wild type p/CIP enhanced it. Chromatin immunoprecipitations demonstrate that IL-4 increases the interaction of p/CIP with the murine immunoglobulin heavy chain germ line epsilon promoter in B cells. These results suggest that p/CIP positively regulates STAT6 transcriptional activation through formation of a STAT6, p300/CBP, and p/CIP complex." provenance.
- _5 value "Pretreatment of these cells with candesartan markedly suppressed the activation of ERKs (Fig. 2f). These results indicate that mechanical stress may activate ERKs in cardiomyocytes through the AT1 receptor even in the absence of AII. " provenance.
- _5 value "Here we demonstrate, for the first time, that bone marrow progenitors and thymocytes from Jak 3(-/-) mice have decreased chemotactic responses to CXCL12 and CCL25" provenance.
- _5 value "Table 1. Genes markedly perturbed by HNF-1b RNAi" provenance.
- _5 value "Table 1. Genes markedly perturbed by HNF-1b RNAi" provenance.
- _5 value "Table 1. Genes markedly perturbed by HNF-1b RNAi" provenance.
- _3 value "See Table 6: Microarray and reverse transcription PCR (RT-PCR) comparison. All genes have increased expression in response to Zebularine greater than or equal to 1.5 compared to control." provenance.
- _3 value "See Table 6: Microarray and reverse transcription PCR (RT-PCR) comparison. All genes have increased expression in response to Zebularine greater than or equal to 1.5 compared to control." provenance.
- _6 value "We found that tuberin expression increases p42/44 MAPK phosphorylation and B-Raf kinase activity. Short interfering RNA down-regulation of tuberin decreased the p42/44 MAPK phosphorylation and B-Raf activity. Expression of Rheb, the target of the GTPase-activating domain of tuberin, inhibited wild-type B-Raf kinase but not activated forms of B-Raf." provenance.
- _3 value "agonist of Sirtuin activity, potentiates chromatin-associated SIRT1 protein on the cIAP-2 promoter region,..." provenance.
- _3 value "24 h of starvation also increased heart AMPK activity and Thr172 phosphorylation of AMPK alpha-subunits. Perfusion with insulin decreased both alpha-1 and alpha-2 AMPK activities and increased malonyl-CoA content." provenance.
- _3 value "Perfusion with epinephrine decreased malonyl-CoA content without an effect on AMPK activity but prevented the activation of AMPK by palmitate." provenance.
- _4 value "OVA inhalation in sensitized mice induced substantial cytokine release into Bronchoalveolar lavage fluid (BALF) as compared with untreated mice. MEK1/2 inhibitor, U0126 significantly reduced IL4 levels in BAL fluid in a dose-dependent manner. These results suggest that OVA induced up-regulation of IL4 production was mediated through MEK/ERK pathway." provenance.
- _4 value "Ovalbumin (OVA) inhalation in sensitized mice induced substantial cytokine release into Bronchoalveolar lavage fluid (BALF) as compared with untreated mice. MEK1/2 inhibitor, U0126 significantly ( p < 0.05) reduced IL4 levels in BAL fluid in a dose-dependent manner. U0126 (30 mg/kg) also effectively blocked the OVA-induced ERK1 phosphorylation. These results suggest that OVA-induced upregulation of IL4 is mediated via MEK/ERK pathway." provenance.
- _5 value "Modified assertion" provenance.