Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _5 value "91254338" provenance.
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- _5 value "9582017;10533983" provenance.
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- _5 value "96275134" provenance.
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- _6 value "In addition, expression of MMP- 2 can be modulated by several signal transduction pathways . For example, activation of the mitogen-activated protein (MAP) kinase kinase (MEK1) signaling pathway stimulates increased secretion and proteolytic activation of MMP-2 and tumor invasion, whereas a MEK1-specific inhibitor suppresses the activation of MMP-2" provenance.
- _5 value "We demonstrated that silencing of gelsolin expression by small interfering RNA sensitized cells to butyrate-induced apoptosis through amplification of the activation of caspase-9 and caspase-7. These data therefore demonstrate that gelsolin protects cells from butyrate-induced apoptosis and suggest that Ras promotes apoptosis, at least in part, through its ability to down-regulate the expression of gelsolin." provenance.
- _3 value "CD2-associated protein (CD2AP) is an adaptor molecule involved in T cell receptor signaling and podocyte homeostasis. CD2AP-deficient mice develop nephrotic syndrome and renal failure caused by glomerulosclerosis. Here we report that increased transforming growth factor-beta1 (TGF-beta1) expression and apoptosis were present in podocytes at the onset of albuminuria and were followed by depletion of podocytes associated with progressive focal-segmental glomerulosclerosis in CD2AP-/- mice. Conditionally immortalized podocytes derived from CD2AP-/- mice were more susceptible to TGF-beta-induced apoptosis compared with CD2AP+/+ podocytes. Reconstitution of CD2AP rescued CD2AP-/- podocytes from TGF-beta-induced apoptosis. CD2AP was required for early activation of anti-apoptotic phosphatidylinositol 3-kinase (PI3K)/AKT and extracellular signal-regulated kinase 1/2 by TGF-beta. In contrast, activation of pro-apoptotic p38 MAPK by TGF-beta was accelerated and enhanced in the absence of CD2AP. CD2AP was not required for PI3K/AKT activation by insulin and epidermal growth factor, indicating that CD2AP is a selective mediator of anti-apoptotic TGF-beta signaling. In summary, we identified CD2AP as a novel mediator for selective activation of survival pathways and repression of apoptosis signaling by TGF-beta in podocytes. Together, our in vitro and in vivo findings suggest that TGF-beta-induced podocyte apoptosis is an early pathomechanism in mice developing focal-segmental glomerulosclerosis associated with functional impairment of CD2AP." provenance.
- _5 value "CD2AP was required for early activation of anti-apoptotic phosphatidylinositol 3-kinase (PI3K)/AKT and extracellular signal-regulated kinase 1/2 by TGF-beta" provenance.
- _3 value "increased transforming growth factor-beta1 (TGF-beta1) expression and apoptosis were present in podocytes at the onset of albuminuria and were followed by depletion of podocytes associated with progressive focal-segmental glomerulosclerosis in CD2AP-/- mice" provenance.
- _5 value "increased transforming growth factor-beta1 (TGF-beta1) expression and apoptosis were present in podocytes at the onset of albuminuria and were followed by depletion of podocytes associated with progressive focal-segmental glomerulosclerosis in CD2AP-/- mice" provenance.
- _2 value "stretch-induced activation is very rapid and exhibits some features of satellite cell heterogeneity." provenance.
- _5 value "Exposure to TNF-alpha activates transcription factors NF-kappaB, Smad3/4, and PPARalpha/gamma" provenance.
- _3 value "Table 2: Decreased by Thiazolidinedione" provenance.
- _8 value "# GeneRif: IQGAP1 functions as a VEGFR2-associated scaffold protein to organize ROS-dependent VEGF signaling, thus promoting EC migration & proliferation, which may contribute to repair & maintenance of the functional integrity of established blood vessels." provenance.
- _6 value "In cultured ECs, VEGF stimulation rapidly promotes recruitment of Rac1 to IQGAP1, which inducibly binds to VEGFR2 and which, in turn, is associated with tyrosine phosphorylation of IQGAP1." provenance.
- _6 value "In Rh30 cells, ASK1 was found to physically interact with protein phosphatase 5 (PP5), previously identified as a negative regulator of ASK1. Rapamycin did not affect either protein level of PP5 or association of PP5 with ASK1. Instead, rapamycin caused rapid dissociation of the PP2A-B\" regulatory subunit (PR72) from the PP5-ASK1 complex, which was associated with reduced phosphatase activity of PP5. This effect was dependent on expression of eukaryotic initiation factor 4E-binding protein 1 (4E-BP1)" provenance.
- _3 value "The gene expression from ML to pellet at day 7 included an increase in cartilage matrix proteins like collagen type XI, tenascin C, dermatopontin, COMP and fibronectin." provenance.
- _3 value "The late phase consisted of a strong downregulation of extracellular signal-regulated protein kinase (ERK-1) and an upregulation of p38 kinase and SOX-9, suggesting that the late phase mimicked parts of the signaling processes involved in the early chondrogenesis in limb bud cells." provenance.
- _3 value "The late phase consisted of a strong downregulation of extracellular signal-regulated protein kinase (ERK-1) and an upregulation of p38 kinase and SOX-9, suggesting that the late phase mimicked parts of the signaling processes involved in the early chondrogenesis in limb bud cells." provenance.
- _5 value "ACAT activity increased in parallel by 1.8-fold." provenance.
- _5 value "Smad7 negatively regulates transforming growth factor (TGF)-beta superfamily signaling by binding to activated type I receptors, thereby preventing the phosphorylation of receptor-regulated Smads (R-Smads), as well as by recruiting HECT-type E3 ubiquitin ligases to degrade type I receptors through a ubiquitin-dependent mechanism." provenance.
- _5 value "We demonstrated that the STAT3-regulated promoter of the pro-apoptotic Fas gene was activated upon STRA13 over-expression and that co-expression of STRA13 with STAT3 beta or STAT3 alpha modulated the transcriptional outcome. Forced expression of STRA13 induced apoptosis, in agreement with the STRA13 activation effect on the Fas promoter." provenance.
- _5 value "In addition, Akt interacts with the coactivator and the activity of Akt is required to maintain the steady-state level of p300." provenance.
- _6 value "GRKs 2, 3, 5 and 6 are able to desensitize the TSHR in vitro" provenance.
- _2 value "the demethylation of the CDKN2A gene promoter in both cell lines induced by 5- aza-dC alone or in combination with TSA, the expression of both CDKN2A and APC genes increased" provenance.
- _2 value "the demethylation of the CDKN2A gene promoter in both cell lines induced by 5- aza-dC alone or in combination with TSA, the expression of both CDKN2A and APC genes increased" provenance.
- _3 value "In addition, we showed that intracellular content of reactive oxygen species (ROS) was 9.66+/-0.52 in GFP-PIG11 transfection, higher than 5.21+/-0.08 in GFP only and 5.99+/-0.45 in vehicle control (P<0.01)." provenance.
- _4 value "These results suggest the dependence of G6PD gene expression on HIF" provenance.
- _3 value "We observed a significant increase in SUMO-1 mRNAs and proteins after hypoxic stimulation in vivo" provenance.
- _5 value "increased levels of SUMO-1 participate in the modulation of HIF-1alpha function" provenance.
- _3 value "Table 1 Gene products with significantly altered RNA expression levels in D3 analog-conditioned compared to control BMDCs" provenance.
- _3 value "Table 1 Gene products with significantly altered RNA expression levels in D3 analog-conditioned compared to control BMDCs" provenance.
- _3 value "Table 1 Gene products with significantly altered RNA expression levels in D3 analog-conditioned compared to control BMDCs" provenance.
- _3 value "Table 1 Gene products with significantly altered RNA expression levels in D3 analog-conditioned compared to control BMDCs" provenance.
- _3 value "Table 1 Gene products with significantly altered RNA expression levels in D3 analog-conditioned compared to control BMDCs" provenance.
- _3 value "Table 1 Gene products with significantly altered RNA expression levels in D3 analog-conditioned compared to control BMDCs" provenance.
- _3 value "Table 1 Gene products with significantly altered RNA expression levels in D3 analog-conditioned compared to control BMDCs" provenance.
- _3 value "Table 1 Gene products with significantly altered RNA expression levels in D3 analog-conditioned compared to control BMDCs" provenance.
- _3 value "Table 1 Gene products with significantly altered RNA expression levels in D3 analog-conditioned compared to control BMDCs" provenance.
- _3 value "Table 1 Gene products with significantly altered RNA expression levels in D3 analog-conditioned compared to control BMDCs" provenance.
- _2 value " 3.3. The p38 MAPK in senescence and tumor suppression The description of a possible p38 MAPK/p21/HBP1 pathway coincides with several reports for possible roles of p38 MAPK in senescence and tumor suppression. Senescence is characterized as an irreversible cell cycle arrest that occurs upon extended passage of cells in culture. The process of senescence can be triggered by telomere shortening, H2O2 exposure, or chronic Ras stimulation in primary cells." provenance.
- _3 value " As depicted in Fig. 1, several observations indicated that HBP1 could be part of proliferation barriers with shared functional similarity to RB in differentiation and in G1 control. HBP1 is consistently up regulated in differentiation and under conditions of cell cycle arrest in muscle, adipocyte, erythroid, and other cell types." provenance.
- _4 value "2.3.2. p47 phox, reactive oxygen species, and growth factor signaling. Using a high-affinity HBP1 binding site, we scanned databases for new possible target genes that might illuminate the role of HBP1 in G1 progression and in tumor suppression. From this initial database search, the p47 phox gene was identified. The p47 phox gene encodes a subunit of the NADPH oxidase, which has emerged as an integral component of mitogenic pathways [Berasi, 2004 #885]. 2.3.2.1. Cell cycle and cancer implications As shown in Fig. 5, the NADPH oxidase catalyzes the one electron reduction of O2 to O2 (superoxide) with NADPH as the electron donor. The NADPH oxidase is the principle source of intracellular reactive oxygen species (ROS) that is generated by mitogenic signaling. The p47phox gene is a regulatory subunit for the NADPH oxidase complex. The general configuration of the NADPH oxidase complex consists of ubiquitous cytoplasmic regulatory subunits (e.g., p47phox) that combine with a membrane complex that includes a tissue-specific gp91phox catalytic subunits (sometimes denoted NOX; reviewed in (Cheng et al., 2001). The assembly of regulatory and catalytic components generates the active NADPH oxidase complex. The importance of a functional NADPH oxidase is underscored by the observation that mutations of the p47phox and gp91phox genes are associated with chronic granulomatosis, in which patients have increased susceptibility to bacterial and fungal infections (reviewed in Cheng et al., 2001). In these patients, the mutations in p47 phox and gp91 phox compromise NADPH oxidase activity. Unlike the tissue-specific catalytic subunits, the regulatory and cytoplasmic components are largely ubiquitous. For example, the expression of the same p47phox/NCF1 gene occurs in most cell types (reviewed in Cheng et al., 2001). For non-immune cells, the regulation of NADPH oxidase activity and of intracellular ROS levels dictate the efficacy of signaling networks involved in cancer (reviewed in Xu et al., 2002 and Finkel, 2003). Mitogenic stimulation with growth factors (e.g., EGF, PDGF, etc.) in non-immune cells requires ROS that is generated from the NADPH oxidase complex (reviewed in Sauer et al., 2001). Recent studies have highlighted a key role for ROS in modulating signaling networks through reversible cysteine oxidation in the control of tyrosine phosphatase activity (Meng et al., 2002 and Nimnual et al., 2003); reviewed in Xu et al., 2002). NADPH oxidase activity and ROS levels also have an integral role in signaling that is regulated by the small G-proteins RAS and RAC (Irani et al., 1997 and Joneson and Bar-Sagi, 1998). Stable transfection of NIH/3T3 fibroblasts with active Ras (H-RasV12) results in transformation and in significant intracellular ROS generation." provenance.
- _3 value "An increase in b-catenin levels increases the pool of nuclear beta-catenin-TCF/LEF complexes, which, in turn, activate a gene expression program to establish the oncogenic phenotype." provenance.
- _4 value "Both dominant-negative and chemical reagents were used to establish the finding that p38 MAPK signaling can trigger cell senescence. One report systematically showed that p38 MAPK activity was responsible for executing senescence in response to all the known stimuli telomere shortening, H2O2 exposure, and chronic RAS oncogene signaling (Haq et al., 2002; Wang et al., 2002 and Iwasa et al., 2003). When considered together, several papers also suggest that p38 MAPK activation is linked to tumor suppression (Bulavin et al., 2002; Pruitt et al., 2002; Brancho et al., 2003 and Liao and Hung, 2003)." provenance.
- _4 value "Cyclin D1 and MYC are examples of direct Wnt target genes in proliferation and whose activation requires the LEF/TCF sites in the respective promoters (He et al., 1998 and Tetsu and McCormick, 1999). Cyclin D1 and MYC have critical roles in G1 progression, but Cyclin D1 expression best correlates with breast proliferation." provenance.
- _3 value "Each of these stimuli triggers a cell cycle arrest and the expression of a battery of senescence associated markers (e.g., SA-associated b-galactosidase). Other markers include the p16 and p21 CDK inhibitors, of which the latter is a new p38 MAPK target." provenance.
- _3 value "Each of these stimuli triggers a cell cycle arrest and the expression of a battery of senescence associated markers (e.g., SA-associated b-galactosidase). Other markers include the p16 and p21 CDK inhibitors, of which the latter is a new p38 MAPK target." provenance.
- _5 value "Each of these stimuli triggers a cell cycle arrest and the expression of a battery of senescence associated markers (e.g., SA-associated b-galactosidase). Other markers include the p16 and p21 CDK inhibitors, of which the latter is a new p38 MAPK target." provenance.
- _4 value "Several papers have now linked the p38 MAPK signaling pathway to senescence (Haq et al., 2002; Wang et al., 2002 and Iwasa et al., 2003). In these reports, the activation of the upstream kinases MKK 6 and MKK 3 lead to a senescent phenotype that was dependent on p38 MAPK activity." provenance.
- _3 value "The importance of intracellular ROS in RAS-mediated transformation is highlighted by the observation that pharmacological inhibition of the NADPH oxidase reverses transformation (Irani et al., 1997)." provenance.
- _7 value "The interaction of RB and E2F transcription factors represents a functional interaction that has been the predominant focus in the field. RB and the related family members p107 and p130 can each bind E2F to repress genes that are otherwise important for progression from G1 to S phase. The binding of RB, p107, or p130 has two simultaneous consequences: (1) binding prevents E2F from interacting with transcriptional co-activators (e.g., p300); and (2) binding recruits chromatin-modifying enzymes [e.g., histone deacetylases (HDACs)] to silence transcription. E2F itself is a family of transcription factors that include six E2F and three DP proteins, which together form the heterodimeric complex that comprises E2F transcriptional activity (reviewed in Trimarchi and Lees, 2002 and Yee and Wang, 2003). While there is considerable complexity, gene repression in G1 phase utilizes RB and E2Fs 1, 2, 3, and 4, while gene repression in G0 utilizes primarily p130 and E2Fs 4 and 5. binding prevents E2F from interacting with transcriptional co-activators (e.g., p300); and" provenance.
- _5 value "# GeneRif: Data show that pro-collagen type I alpha 2 expression is activated through binding of Nkx2.5 and is repressed by the binding of deltaEF1/ZEB1 Furthermore, we show that the expression is activated through the binding of the homeodomain protein Nkx2.5, which is further potentiated in the presence of GATA6. In contrast, this element was repressed by the binding of the zinc-finger protein deltaEF1/ZEB1." provenance.
- _7 value "pro-collagen type I alpha 2 gene in vascular smooth muscle cells expression is activated through the binding of the homeodomain protein Nkx2.5, which is further potentiated in the presence of GATA6. In contrast, this element was repressed by the binding of the zinc-finger protein deltaEF1/ZEB1" provenance.
- _5 value "As shown in Fig. 6C, the PKA inhibitor decreased the phosphorylation of endogenous Bad in a dose-dependent manner." provenance.
- _3 value "TABLE 1. LPS and IKKg target gene profiling in murine pre-B cells" provenance.
- _3 value "TABLE 1. LPS and IKKg target gene profiling in murine pre-B cells" provenance.
- _3 value "TABLE 1. LPS and IKKg target gene profiling in murine pre-B cells" provenance.
- _3 value "TABLE 1. LPS and IKKg target gene profiling in murine pre-B cells" provenance.
- _3 value "TABLE 1. LPS and IKKg target gene profiling in murine pre-B cells" provenance.
- _3 value "The common upregulated genes in well and poorly differentiated cell types at both irradiation doses included SCYA5, CYP51, SMARCD2, COX6C, MAPK8, FOS, UBE2M, RPL6, PDGFRL, TRAF2, TNFAIP6, ITGB4, GSTM3, and SP3 and common downregulated genes involved NFIL3, SMARCA2, CAPZA1, MetAP2, CITED2, DAP3, MGAT2, ATRX, CIAO1, and STAT6" provenance.
- _3 value "The common upregulated genes in well and poorly differentiated cell types at both irradiation doses included SCYA5, CYP51, SMARCD2, COX6C, MAPK8, FOS, UBE2M, RPL6, PDGFRL, TRAF2, TNFAIP6, ITGB4, GSTM3, and SP3 and common downregulated genes involved NFIL3, SMARCA2, CAPZA1, MetAP2, CITED2, DAP3, MGAT2, ATRX, CIAO1, and STAT6" provenance.
- _3 value "The common upregulated genes in well and poorly differentiated cell types at both irradiation doses included SCYA5, CYP51, SMARCD2, COX6C, MAPK8, FOS, UBE2M, RPL6, PDGFRL, TRAF2, TNFAIP6, ITGB4, GSTM3, and SP3 and common downregulated genes involved NFIL3, SMARCA2, CAPZA1, MetAP2, CITED2, DAP3, MGAT2, ATRX, CIAO1, and STAT6" provenance.