Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _3 value "Table 2. Differentially expressed genes identified by SAGE" provenance.
- _3 value "Table 2. Differentially expressed genes identified by SAGE" provenance.
- _3 value "Table 2. Differentially expressed genes identified by SAGE" provenance.
- _3 value "Table 2. Differentially expressed genes identified by SAGE" provenance.
- _3 value "Table 2. Differentially expressed genes identified by SAGE" provenance.
- _3 value "Table 2. Differentially expressed genes identified by SAGE" provenance.
- _3 value "Table 2. Differentially expressed genes identified by SAGE" provenance.
- _3 value "Table 2. Differentially expressed genes identified by SAGE" provenance.
- _3 value "Table 2. Differentially expressed genes identified by SAGE" provenance.
- _3 value "Table 2. Differentially expressed genes identified by SAGE" provenance.
- _3 value "Table 2. Differentially expressed genes identified by SAGE" provenance.
- _3 value "Table 2. Differentially expressed genes identified by SAGE" provenance.
- _3 value "Table 2. Differentially expressed genes identified by SAGE" provenance.
- _3 value "Table 2. Differentially expressed genes identified by SAGE" provenance.
- _3 value "Table 2. Differentially expressed genes identified by SAGE" provenance.
- _3 value "Table 2. Gene Expression Profiling Reveals Decreased Expression of 53 Genes in Pituitary Tumors from LHCTP Mice" provenance.
- _3 value "Table 2. Gene Expression Profiling Reveals Decreased Expression of 53 Genes in Pituitary Tumors from LHCTP Mice" provenance.
- _3 value "Table 2. Gene Expression Profiling Reveals Decreased Expression of 53 Genes in Pituitary Tumors from LHCTP Mice" provenance.
- _3 value "Table 2. Gene Expression Profiling Reveals Decreased Expression of 53 Genes in Pituitary Tumors from LHCTP Mice" provenance.
- _3 value "Table 2. Gene Expression Profiling Reveals Decreased Expression of 53 Genes in Pituitary Tumors from LHCTP Mice" provenance.
- _3 value "Table 2. Gene Expression Profiling Reveals Decreased Expression of 53 Genes in Pituitary Tumors from LHCTP Mice" provenance.
- _3 value "Table 2. Gene Expression Profiling Reveals Decreased Expression of 53 Genes in Pituitary Tumors from LHCTP Mice" provenance.
- _3 value "Table 2. Gene Expression Profiling Reveals Decreased Expression of 53 Genes in Pituitary Tumors from LHCTP Mice" provenance.
- _3 value "Table 2. Gene Expression Profiling Reveals Decreased Expression of 53 Genes in Pituitary Tumors from LHCTP Mice" provenance.
- _3 value "Table 2. Gene Expression Profiling Reveals Decreased Expression of 53 Genes in Pituitary Tumors from LHCTP Mice" provenance.
- _3 value "Table 2. Gene Expression Profiling Reveals Decreased Expression of 53 Genes in Pituitary Tumors from LHCTP Mice" provenance.
- _3 value "Table 2. Gene Expression Profiling Reveals Decreased Expression of 53 Genes in Pituitary Tumors from LHCTP Mice" provenance.
- _3 value "Table 2. Gene Expression Profiling Reveals Decreased Expression of 53 Genes in Pituitary Tumors from LHCTP Mice" provenance.
- _3 value "Table 2. Gene Expression Profiling Reveals Decreased Expression of 53 Genes in Pituitary Tumors from LHCTP Mice" provenance.
- _3 value "Table 2. Gene Expression Profiling Reveals Decreased Expression of 53 Genes in Pituitary Tumors from LHCTP Mice" provenance.
- _3 value "table 1. Gene Expression Profiling Reveals Increased Expression of 54 Genes in Pituitary Tumors from LHCTP Mice" provenance.
- _3 value "table 1. Gene Expression Profiling Reveals Increased Expression of 54 Genes in Pituitary Tumors from LHCTP Mice" provenance.
- _3 value "table 1. Gene Expression Profiling Reveals Increased Expression of 54 Genes in Pituitary Tumors from LHCTP Mice" provenance.
- _3 value "table 1. Gene Expression Profiling Reveals Increased Expression of 54 Genes in Pituitary Tumors from LHCTP Mice" provenance.
- _3 value "table 1. Gene Expression Profiling Reveals Increased Expression of 54 Genes in Pituitary Tumors from LHCTP Mice" provenance.
- _3 value "table 1. Gene Expression Profiling Reveals Increased Expression of 54 Genes in Pituitary Tumors from LHCTP Mice" provenance.
- _3 value "table 1. Gene Expression Profiling Reveals Increased Expression of 54 Genes in Pituitary Tumors from LHCTP Mice" provenance.
- _3 value "table 1. Gene Expression Profiling Reveals Increased Expression of 54 Genes in Pituitary Tumors from LHCTP Mice" provenance.
- _3 value "table 1. Gene Expression Profiling Reveals Increased Expression of 54 Genes in Pituitary Tumors from LHCTP Mice" provenance.
- _3 value "table 1. Gene Expression Profiling Reveals Increased Expression of 54 Genes in Pituitary Tumors from LHCTP Mice" provenance.
- _3 value "table 1. Gene Expression Profiling Reveals Increased Expression of 54 Genes in Pituitary Tumors from LHCTP Mice" provenance.
- _2 value "KO mice showed a significantly greater infarction volume and DNA fragmentation in the cortex than WT mice at 24 hours after ischemia. At 8 hours, cytochrome c release into the cytoplasm was markedly higher in KO mice than in WT mice. Caspase-3 activation was also significantly enhanced in KO mice versus WT mice the deletion of the hsp70.1 gene increases cytochrome c release into the cytoplasm and subsequent caspase-3 activation, thereby exacerbating apoptosis after focal cerebral ischemia." provenance.
- _4 value "KO mice showed a significantly greater infarction volume and DNA fragmentation in the cortex than WT mice at 24 hours after ischemia. At 8 hours, cytochrome c release into the cytoplasm was markedly higher in KO mice than in WT mice. Caspase-3 activation was also significantly enhanced in KO mice versus WT mice the deletion of the hsp70.1 gene increases cytochrome c release into the cytoplasm and subsequent caspase-3 activation, thereby exacerbating apoptosis after focal cerebral ischemia." provenance.
- _3 value "We found that intrinsic ageing of skin in vivo is accompanied by significant increases of RAR alpha mRNA and protein" provenance.
- _4 value "Our data demonstrate that increased intracellular cAMP concentration in endothelial cells prevents thrombin-induced ICAM-1 expression by inhibiting p38 MAPK activation, which in turn prevents phosphorylation of RelA/p65 and transcriptional activity of the bound NF-kappaB." provenance.
- _7 value "In this context, the inhibition of RhoA kinase (ROCK) with Y27632 or by expression of dominant negative forms of RhoA or ROCK impaired the VEGF-induced phosphorylation of Tyr(407) within FAK." provenance.
- _7 value "We also found that the recruitment of paxillin to FAK was inhibited by geldanamycin but not by PP2, whereas both geldanamycin and PP2 inhibited the recruitment of vinculin to FAK." provenance.
- _3 value "Thus in different cell types, isoform-specific patterns of PHD induction by hypoxia and estrogen alter both the relative abundance of the PHDs and their relative contribution to the regulation of HIF." provenance.
- _3 value "Thus in different cell types, isoform-specific patterns of PHD induction by hypoxia and estrogen alter both the relative abundance of the PHDs and their relative contribution to the regulation of HIF." provenance.
- _3 value "Insulin stimulates glucose transport in muscle and adipose tissues by recruiting intracellular membrane vesicles containing the glucose transporter GLUT4 to the plasma membrane." provenance.
- _6 value "The B cell adaptor molecule of 32 kDa (Bam32) is an adaptor that links the B cell antigen receptor (BCR) to ERK and JNK activation and ultimately to mitogenesis. After BCR cross-linking, Bam32 is recruited to the plasma membrane and accumulates within F-actin-rich membrane ruffles." provenance.
- _6 value "The B cell adaptor molecule of 32 kDa (Bam32) is an adaptor that links the B cell antigen receptor (BCR) to ERK and JNK activation and ultimately to mitogenesis. After BCR cross-linking, Bam32 is recruited to the plasma membrane and accumulates within F-actin-rich membrane ruffles." provenance.
- _5 value "results confirmed expression of all three annexins at the mRNA level after SCI. Immunohistochemistry and immunofluorescence double-labeling analyses revealed that increased annexins I, II, and V were localized in neurons and glial cells. Annexins, a family of structurally related calcium- and phospholipid-binding proteins, have potent anti-inflammatory effects by inhibiting the activity of phospholipase A(2) (PLA2))," provenance.
- _6 value "rapamycin blocked aldosterone-induced Src activation. We conclude that Src activation by aldosterone is mediated through the mineralocorticoid receptor and HSP84." provenance.
- _6 value "Inhibition of AR by sorbinil or tolrestat prevented TNF-alpha-induced increase in Bax and Bak and the downregulation of Bcl-2. Inhibition of AR abrogated AP-1 DNA binding activity and prevented the activation of caspase-3, JNK, and p38 MAPK in cells stimulated by TNF-alpha. Exposure to TNF-alpha also induced apoptotic cell death, which was attenuated by AR inhibition or antisense ablation" provenance.
- _5 value "LPS-induced NF-kappaB signaling is similar in IL-10(-/-) and WT BMDCs as measured by IkappaBalpha phosphorylation and degradation, RelA phosphorylation and nuclear translocation, and NF-kappaB transcriptional activity," provenance.
- _5 value "Table 1. Increased transcripts in the trigeminal ganglion of Brn3a mutant mouse embryos" provenance.
- _5 value "Table 1. Increased transcripts in the trigeminal ganglion of Brn3a mutant mouse embryos" provenance.
- _5 value "Table 1. Increased transcripts in the trigeminal ganglion of Brn3a mutant mouse embryos" provenance.
- _5 value "Table 1. Increased transcripts in the trigeminal ganglion of Brn3a mutant mouse embryos" provenance.
- _5 value "Table 2. Decreased transcripts in the trigeminal ganglion of Brn3a mutant mouse embryos" provenance.
- _5 value "Table 2. Decreased transcripts in the trigeminal ganglion of Brn3a mutant mouse embryos" provenance.
- _5 value "Table 2. Decreased transcripts in the trigeminal ganglion of Brn3a mutant mouse embryos" provenance.
- _5 value "Table 2. Decreased transcripts in the trigeminal ganglion of Brn3a mutant mouse embryos" provenance.
- _5 value "Table 2. Decreased transcripts in the trigeminal ganglion of Brn3a mutant mouse embryos" provenance.
- _5 value "Table 2. Decreased transcripts in the trigeminal ganglion of Brn3a mutant mouse embryos" provenance.
- _5 value "Table 2. Decreased transcripts in the trigeminal ganglion of Brn3a mutant mouse embryos" provenance.
- _5 value "Table 2. Decreased transcripts in the trigeminal ganglion of Brn3a mutant mouse embryos" provenance.
- _6 value "Pea3 and Erm are defined by the presence of an evolutionarily conserved Ets domain that mediates DNA binding (Sharrocks et al., 1997). FGF signaling is both necessary and sufficient for their expression (Firnberg and Neubuser, 2002; Kawakami et al., 2003; Raible and Brand, 2001; Roehl and Nusslein- Volhard, 2001), and as both have been shown to be present at regions of FGF signaling in several developmental contexts, they are thought to be general transcriptional targets of FGF signaling (Raible and Brand, 2001; Roehl and Nusslein- Volhard, 2001). Moreover, it has been demonstrated in vitro that DNA binding of Pea3 and Erm to their targets is activated following phosphorylation by MAPK/ERKs (Janknecht et al., 1996; Munchberg and Steinbeisser, 1999; O'Hagan et al., 1996). Thus, in addition to being potential transcriptional targets of FGF signaling, Pea3 and Erm function as transcriptional effectors within cells to transduce FGF signals." provenance.
- _5 value "We show here that transcriptional activation by Pea3 and Erm in response to FGF signaling is both necessary and sufficient for Scx expression in the somite," provenance.
- _5 value "FROM FULL TEXT: Epo, but not SCF induces Stat5 activation, which is mainly required for erythroid differentiation." provenance.
- _5 value "FROM FULL TEXT: In addition, EpoR signalling was suppressed by 30-45 mM LY294002, an inhibitor of PI3K." provenance.
- _6 value "FROM FULL TEXT: Multiple PKC inhibitors suppressed Epo-induced signaling. Most likely, the PKC isoform responsible for control of EpoR signalling is PKCalpha. Go6976, an inhibitor fo rthis PKC class, was particularly effective in attenuating EpoR signalling." provenance.
- _4 value "Resistin causes defective AMPK activation in response to insulin. Since AMPK signaling affects insulin-sensitive glucose metabolism (19 22) and since AMPK can act upstream of Akt signaling (23, 24), we assessed whether resistin overexpression alters AMPK activity. As demonstrated in Figure 7, AMPK phosphorylation (Thr172) was reduced by 60%, 35%, and 64% (P 0.01) in the skeletal muscle, adipose tissue, and liver of rats injected with Adv-resistin, respectively, while AMPK protein content remained unchanged." provenance.
- _4 value "Resistin causes defective AMPK activation in response to insulin. Since AMPK signaling affects insulin-sensitive glucose metabolism (19 22) and since AMPK can act upstream of Akt signaling (23, 24), we assessed whether resistin overexpression alters AMPK activity. As demonstrated in Figure 7, AMPK phosphorylation (Thr172) was reduced by 60%, 35%, and 64% (P 0.01) in the skeletal muscle, adipose tissue, and liver of rats injected with Adv-resistin, respectively, while AMPK protein content remained unchanged." provenance.
- _6 value "(b) the activation of protein kinase C-alpha, -beta, -delta, -epsilon, and -zeta but not of PKC-iota and -eta;" provenance.
- _6 value "(c) the phosphorylation of the extracellular signal-regulated protein kinases 1 and 2 (ERK1/2);" provenance.
- _4 value "We found that P2Y6 activation controlled cell proliferation but not the activity of the Na+/K+ATPase." provenance.
- _6 value "The alpha6beta1 integrin has been implicated in breast carcinoma progression, but the mechanisms involved remain elusive." provenance.
- _8 value "The results obtained indicate that alpha6beta1 is necessary for VEGF expression because the ability of hypoxia to activate HIF-1 and to stimulate VEGF transcription in MDA-MB-435 cells is dependent on alpha6beta1 expression by a mechanism that involves protein kinase C-alpha." provenance.
- _3 value "Here we extend these results by showing that ceramide, a second messenger in both TNFalpha and IL-1beta receptor signaling pathways, is a key downstream sphingosine-based lipid that leads to IGF-I resistance." provenance.
- _7 value "Additionally, over-expression of CREG dampened the stretched cardiomyocyte hypertrophy through ERK1/2." provenance.
- _5 value "To understand how cells control E2F6 expression, we analysed the activity of the previously cloned promoter region of the human E2F6 gene. DNase I footprinting, gel electrophoreticmobility shift, transient transfection and site-directed mutagenesis experiments allowed the identification of two functional NRF-1/alpha-PAL (nuclear respiratory factor-1/alpha-palindrome-binding protein)-binding sites within the human E2F6 core promoter region, which are conserved in the mouse and rat E2F6 promoter region. Moreover, ChIP (chromatin immunoprecipitation) analysis demonstrated that overexpressed NRF-1/alpha-PAL is associated in vivo with the E2F6 promoter. Furthermore, overexpression of full-length NRF-1/alpha-PAL enhanced E2F6 promoter activity, whereas expression of its dominant-negative form reduced the promoter activity. Our results indicate that NRF-1/alpha-PAL is implicated in the regulation of basal E2F6 gene expression." provenance.
- _6 value "LKB1-deficient tumors are shown here to exhibit elevated levels of S6K1 activity and phospho-4EBP1, indicative of hyperactivation of mTOR signaling" provenance.
- _4 value "B. Cellular fatty acid metabolism" provenance.
- _4 value "B. Cellular fatty acid metabolism" provenance.
- _4 value "B. Cellular fatty acid metabolism" provenance.
- _6 value "Calcineurin Directly Induces Transcription of the PPARA Target Gene, M-CPT I. muscle-type carnitine palmitoyltransferase I or M-CPT I, which catalyzes the rate-limiting step of fatty acid oxidation, was activated by both Cn and CaMK." provenance.
- _3 value "TABLE I Genes expressed �2 S.D. from array mean at both <0.02 and 2% oxygen" provenance.
- _3 value "TABLE I Genes expressed �2 S.D. from array mean at both <0.02 and 2% oxygen" provenance.
- _3 value "TABLE I Genes expressed �2 S.D. from array mean at both <0.02 and 2% oxygen" provenance.
- _3 value "TABLE I Genes expressed �2 S.D. from array mean at both <0.02 and 2% oxygen" provenance.
- _3 value "TABLE I Genes expressed �2 S.D. from array mean at both <0.02 and 2% oxygen" provenance.
- _3 value "TABLE I Genes expressed �2 S.D. from array mean at both <0.02 and 2% oxygen" provenance.
- _3 value "TABLE I Genes expressed �2 S.D. from array mean at both <0.02 and 2% oxygen" provenance.
- _3 value "TABLE I Genes expressed �2 S.D. from array mean at both <0.02 and 2% oxygen" provenance.
- _3 value "TABLE I Genes expressed �2 S.D. from array mean at both <0.02 and 2% oxygen" provenance.
- _4 value "AR is required for testosterone-meditated induction of CREB phosphorylation." provenance.
- _4 value "VEGF-stimulated induction of DSCR1 was blocked by anti-VEGF receptor-2 monoclonal antibody (mAb), or the specific calcineurin inhibitors cyclosporin A and FK506." provenance.
- _4 value "Ca(2+) influx was thought to trigger FGF-1 synthesis. Such Ca(2+)-mediated enhancement of FGF-1 synthesis, however, did not occur in the presence of norepinephrine (NE), but was restored by KT-5720, an inhibitor of protein kinase A (PKA)" provenance.