Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _3 value "Histamine, glutamate, carbachol, serotonin or gamma-aminobutyric acid (GABA) caused an increase of FGF-1 content" provenance.
- _3 value "BRCA1 is involved in maintaining genomic integrity and, as a regulator of the G2/M checkpoint, contributes to DNA repair and cell survival." provenance.
- _5 value "The IL-3-induced generation of IL-4, IL-13 and histamine was inhibited to a statistically significant (P<0.05) extent, only by compounds that act as inhibitors of PDE4." provenance.
- _5 value "The IL-3-induced generation of IL-4, IL-13 and histamine was inhibited to a statistically significant (P<0.05) extent, only by compounds that act as inhibitors of PDE4." provenance.
- _5 value "The IL-3-induced generation of IL-4, IL-13 and histamine was inhibited to a statistically significant (P<0.05) extent, only by compounds that act as inhibitors of PDE4." provenance.
- _5 value "The effects of the isoform-selective inhibitors, 8-methoxymethyl-IBMX (PDE 1 inhibitor), siguazodan (PDE3 inhibitor), rolipram (PDE4 inhibitor), denbufylline (PDE4 inhibitor), Org 30029 (mixed PDE3 and 4 inhibitor) and zaprinast (PDE5 inhibitor), were studied. Of these selective compounds, only rolipram, denbufylline and Org 30029 inhibited the IgE-dependent generation of IL-4, IL-13 and histamine from basophils" provenance.
- _5 value "The effects of the isoform-selective inhibitors, 8-methoxymethyl-IBMX (PDE 1 inhibitor), siguazodan (PDE3 inhibitor), rolipram (PDE4 inhibitor), denbufylline (PDE4 inhibitor), Org 30029 (mixed PDE3 and 4 inhibitor) and zaprinast (PDE5 inhibitor), were studied. Of these selective compounds, only rolipram, denbufylline and Org 30029 inhibited the IgE-dependent generation of IL-4, IL-13 and histamine from basophils" provenance.
- _5 value "The effects of the isoform-selective inhibitors, 8-methoxymethyl-IBMX (PDE 1 inhibitor), siguazodan (PDE3 inhibitor), rolipram (PDE4 inhibitor), denbufylline (PDE4 inhibitor), Org 30029 (mixed PDE3 and 4 inhibitor) and zaprinast (PDE5 inhibitor), were studied. Of these selective compounds, only rolipram, denbufylline and Org 30029 inhibited the IgE-dependent generation of IL-4, IL-13 and histamine from basophils" provenance.
- _7 value "The effects of the isoform-selective inhibitors, 8-methoxymethyl-IBMX (PDE 1 inhibitor), siguazodan (PDE3 inhibitor), rolipram (PDE4 inhibitor), denbufylline (PDE4 inhibitor), Org 30029 (mixed PDE3 and 4 inhibitor) and zaprinast (PDE5 inhibitor), were studied. Of these selective compounds, only rolipram, denbufylline and Org 30029 inhibited the IgE-dependent generation of IL-4, IL-13 and histamine from basophils" provenance.
- _5 value "The nonselective PDE inhibitors, isobutyl-methylxanthine (IBMX) and theophylline, attenuated the IgE-mediated generation of IL-4 and IL-13 and, also, the release of histamine from basophils." provenance.
- _4 value "OS exists in three distinct isoforms: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). NO derived from the constitutive isoforms of NOS (nNOS and eNOS) and other NO-adduct molecules (nitrosothiols) have been shown to be modulators of bronchomotor tone." provenance.
- _4 value "Diminution of JAB1 with JAB1 antisense abolished alphav integrin up-regulation of MMP1. We conclude alphav integrin signals through JAB1 to prolong MMP1 production and that this signaling pathway in fibroblasts may lead to abnormal scarring" provenance.
- _4 value "Isoproterenol (150 mg kg(-1) intraperitonially twice at an interval of 24 h) caused increase in the levels of serum marker enzymes via creatinekinase (CK), creatinekinase-MB (CK-MB) isoenzyme, lactatedehydrogenase (LDH) and lactatedehydrogenase isoenzyme (LDH1)." provenance.
- _4 value "Isoproterenol (150 mg kg(-1) intraperitonially twice at an interval of 24 h) caused increase in the levels of serum marker enzymes via creatinekinase (CK), creatinekinase-MB (CK-MB) isoenzyme, lactatedehydrogenase (LDH) and lactatedehydrogenase isoenzyme (LDH1)." provenance.
- _3 value "Follow-up analyses with MCP-1 enzyme-linked immunosorbent assay (for quantitation of MCP-1 protein) and real-time polymerase chain reaction (PCR) (for MCP-1 mRNA) demonstrated that LTB4 strongly induced expression of MCP-1 protein and mRNA in a time-dependent and dose-dependent fashion." provenance.
- _5 value "Supplemental information 1 Increased gene expression in the skeletal muscle of FOXO1 mice." provenance.
- _5 value "TABLE II - Gene with decreased expression in the skeletal muscle of FOXO1 mice" provenance.
- _5 value "TABLE II - Gene with decreased expression in the skeletal muscle of FOXO1 mice" provenance.
- _5 value "TABLE II - Gene with decreased expression in the skeletal muscle of FOXO1 mice" provenance.
- _5 value "TABLE II - Gene with decreased expression in the skeletal muscle of FOXO1 mice" provenance.
- _3 value "we created transgenic mice specifically overexpressing FOXO1 in skeletal muscle. These mice weighed less than the wild-type control mice, had a reduced skeletal muscle mass, and the muscle was paler in color. Microarray analysis revealed that the expression of many genes related to the structural proteins of type I muscles (slow twitch, red muscle) was decreased. Histological analyses showed a marked decrease in size of both type I and type II fibers and a significant decrease in the number of type I fibers in the skeletal muscle of FOXO1 mice. " provenance.
- _3 value "Hp plays a provocative antioxidant role" provenance.
- _4 value "The CAGA sequence is specific for Smad3/4 binding, implying that CD105 is involved in inhibition of TGF-beta1/Smad3 signalling. Furthermore, CD105 overexpression reduced serine phosphorylation of Smad3 and inhibited subsequent nuclear translocation of Smad3. CD105 resulted in high phosphorylation of JNK1, which is able to activate c-Jun. c-Jun is known to inhibit Smad3 transcriptional activity on CAGA sites, suggesting that CD105 may also inhibit Smad3 signalling through JNK1" provenance.
- _4 value "Overexpression of the wild type or mutant AR into myoblasts and treatment with testosterone induced both greater proliferation and faster differentiation of the cells compared to those expressing endogenous AR. Additionally, when treated with estrogen, these cells were able to proliferate and differentiate to similar levels as cells treated with testosterone." provenance.
- _5 value "Mast cell-derived chymase seems to be important in the regulation of local angiotensin (A) II formation in cardiovascular tissues. In human heart, chymase accounts for 80% of A II formation." provenance.
- _3 value "At day 4 after cisplatin injection mRNA, protein levels and enzyme activity of proapoptotic renal endonuclease G (Endo G) were increased compared with saline-treated mice. % In situ hybridization and immunohistochemical studies localized the increased expression of Endo G mRNA to the cytosolic compartment and Endo G protein to the nuclear compartment of proximal tubules in cisplatin-treated mice" provenance.
- _6 value "Dominant-negative forms of Ras and/or Rac-1 significantly suppressed HIF-1 activation by muscarinic signaling. Signaling via M1- and M3- but not M2- or M4-AchRs promote accumulation and transcriptional activation of HIF-1alpha." provenance.
- _6 value "Dominant-negative forms of Ras and/or Rac-1 significantly suppressed HIF-1 activation by muscarinic signaling. Signaling via M1- and M3- but not M2- or M4-AchRs promote accumulation and transcriptional activation of HIF-1alpha." provenance.
- _5 value "RIZ1 is an estrogen receptor (ER) coactivator but is also a histone lysine methyltransferase that methylates lysine 9 of histone H3, an activity known to repress transcription" provenance.
- _5 value "Confocal microscopy, as well as biochemical fractionation, indicated that the EGFR translocates to the mitochondria after EGF stimulation, where it colocalizes with CoxII. " provenance.
- _5 value "Here we show that upon Fas, tumor necrosis factor alpha receptor, or tumor necrosis factor alpha-related apoptosis-inducing ligand receptor stimulation, an inhibition of extracellular signal-regulated kinase 1 and 2 (ERK1/2) activation sensitizes wild-type but not K8-null mouse hepatocytes to apoptosis and that a much weaker ERK1/2 activation occurs in K8-null hepatocytes." provenance.
- _5 value "Here we show that upon Fas, tumor necrosis factor alpha receptor, or tumor necrosis factor alpha-related apoptosis-inducing ligand receptor stimulation, an inhibition of extracellular signal-regulated kinase 1 and 2 (ERK1/2) activation sensitizes wild-type but not K8-null mouse hepatocytes to apoptosis and that a much weaker ERK1/2 activation occurs in K8-null hepatocytes." provenance.
- _4 value "Here we show that upon Fas, tumor necrosis factor alpha receptor, or tumor necrosis factor alpha-related apoptosis-inducing ligand receptor stimulation, an inhibition of extracellular signal-regulated kinase 1 and 2 (ERK1/2) activation sensitizes wild-type but not K8-null mouse hepatocytes to apoptosis and that a much weaker ERK1/2 activation occurs in K8-null hepatocytes." provenance.
- _4 value "As expected, by using western blotting, we observed upregulation of the respective protein (LRIG1) 2 h following EGF treatment, concurrent with gradual disappearance of the respective receptor, ErbB-1 (Figure 1C)." provenance.
- _7 value "In addition, antibodies to the doubly phosphorylated form of the mitogen-activated protein kinase (MAPK/Erk) revealed that downstream signaling to MAPK/ Erk was inhibited upon LRIG1 induction." provenance.
- _3 value "When HEK-293 cells expressing LRIG1 from an ecdysone-inducible promoter (Ecr-293 cells) were stimulated with EGF, they underwent enhanced proliferation, which was suppressed upon induction of LRIG1 expression (Figure 7A)." provenance.
- _5 value "T212 and S214, two sites previously shown to be phosphorylated by glycogen synthase kinase 3beta (GSK3beta) and protein kinase A (PKA)" provenance.
- _3 value "Constitutively active mutant K-ras(V12) in E10 cells led to a highly significant (P < 0.001) increased level of peroxides, and a corresponding increase in the amount of DNA strand-break damage, compared with the parental line E10 and the vector control" provenance.
- _4 value "In conclusion, the results suggest that ROS generation, through COX-2 up-regulation, may contribute to the active oncogenicity of mutant K-ras in the lung as a result of DNA damage" provenance.
- _4 value "To confirm that COX-2 was the source of peroxides in the K-rasV12 transfected cells, we treated the cells with COX-2- specific inhibitor, SC58125." provenance.
- _5 value "Fasting produced a 5.8-fold increase in atrogin-1/MAFbx (P < 0.001). This was attenuated to a 2.5-fold increase by injections of IGF-I (P < 0.05 vs. fasting" provenance.
- _3 value "Fasting produced a 5.8-fold increase in atrogin-1/MAFbx (P < 0.001). This was attenuated to a 2.5-fold increase by injections of IGF-I (P < 0.05 vs. fasting" provenance.
- _3 value "We examined the cAMP-mediated regulation of the epidermal growth factor-like growth factor amphiregulin (AR) in T cells and observed a strong cAMP-induced up-regulation of AR mRNA in a time- and concentration-dependent manner independent of T cell activation." provenance.
- _4 value "Furthermore, ATP content was higher in WT mice compared with ARTg mice during ischemia and reperfusion." provenance.
- _4 value "Recently, we demonstrated that aldose reductase is a component of myocardial ischemic injury CK release was significantly greater in ARTg mice" provenance.
- _4 value "antisense ablation of AR prevented both TNF-alpha-induced PKC and NF-kappaB activation" provenance.
- _4 value "inhibition of the polyol pathway enzyme aldose reductase (AR) prevents the increase in ICAM-1 and VCAM-1 in human umbilical vein endothelial cells (HUVECs) and decreases monocyte adhesion to these cells." provenance.
- _3 value "Non-small-cell lung carcinomas (NSCLCs) are resistant to the induction of apoptosis by conventional anticancer treatment. However, NSCLC cell lines are sensitive to the action of the broad protein kinase inhibitor, staurosporine (STS). In the NSCLC cell line U1810, STS induced the mitochondrial release of apoptosis-inducing factor (AIF) and cytochrome c (Cyt c) followed by activation of caspases, nuclear condensation, DNA fragmentation and finally cell death." provenance.
- _2 value "Non-small-cell lung carcinomas (NSCLCs) are resistant to the induction of apoptosis by conventional anticancer treatment. However, NSCLC cell lines are sensitive to the action of the broad protein kinase inhibitor, staurosporine (STS). In the NSCLC cell line U1810, STS induced the mitochondrial release of apoptosis-inducing factor (AIF) and cytochrome c (Cyt c) followed by activation of caspases, nuclear condensation, DNA fragmentation and finally cell death." provenance.
- _3 value "AKT promotes the nuclear translocation of MDM2, thereby negatively regulating p53-mediated apoptosis" provenance.
- _4 value "activation of the G2 checkpoint begins with the detection of DNA damage by the sensory molecules ATM and ATR" provenance.
- _3 value "gene transcription that is induced by NFkappaB prevents apoptosis" provenance.
- _5 value "histone H2AX, 53BP1, BRCA1 and NBS1 are all targets of ATM and ATR" provenance.
- _4 value "in the absence of VHL function, continuous activation of HIF1alpha promotes angiogenesis" provenance.
- _6 value "phosphorylated CDC25C associates with 14-3-3theta and is exported from the nucleus, resulting in CDK1 inactivation and the establishment of G2 arrest" provenance.
- _4 value "The addition of ascorbic acid to the SNP treatment resulted in a decrease in mACON enzymatic activity and gene expression." provenance.
- _4 value "An interaction between EGFR and AR has been demonstrated by immunoconfocal and co-immunoprecipitation analysis in PC3-AR cells, suggesting a possible interference of AR on EGFR signalling by interaction of the two proteins." provenance.
- _4 value "Immunoprecipitation studies demonstrated a reduction of EGF-induced tyrosine phosphorylation of EGFR in PC3-AR cells." provenance.
- _5 value "In addition, EGF-stimulated PI3K activity, a key signalling pathway for invasion of these cells, was decreased in PC3-AR cells and further reduced by treatment with R1881, indicating decreased functionality of EGFR." provenance.
- _3 value "Whereas c-Met, with which plexin-B1 can interact, is known to be a potent promoter of angiogenesis, the effects of semaphorin-mediated plexin activation in endothelial cells are still poorly understood." provenance.
- _3 value "calcineurin levels are increased in the diaphragm of the mutant mice but not in the soleus or EDL." provenance.
- _6 value "inhibition of Gi/o protein activation by pertussis toxin, or EGFR by tyrphostin AG1478 obliterated the ability of IGF-I to promote ERK activation." provenance.
- _3 value "MO25 but not LKB1 or STRAD mRNA increased with training (p < 0.05)." provenance.
- _6 value "Moreover, the gp130-dependent EGFR activation was independent of EGF ligands," provenance.
- _5 value "Stat3 controls cell death and tissue remodeling in the mouse mammary gland during involution, which is partially induced by IL6 and LIF." provenance.
- _6 value "The decline of phosphorylated Stat5 was delayed in gp130-null tissue as compared with wild-type tissue" provenance.
- _6 value "A similar inhibition of activation of the MMTV promoter-driven luciferase construct was seen in HeLa cells transfected with MKK7(D), a constitutively functional activator of JNK." provenance.
- _6 value "The mitogen-activated protein (MAP) kinases, p38 and c-Jun N-terminal kinase (JNK), are important mediators of target gene activation by TNF, and JNK activation was earlier shown to inhibit GR-mediated transcriptional activation by direct phosphorylation of GR at Ser-246." provenance.
- _6 value "The mitogen-activated protein (MAP) kinases, p38 and c-Jun N-terminal kinase (JNK), are important mediators of target gene activation by TNF, and JNK activation was earlier shown to inhibit GR-mediated transcriptional activation by direct phosphorylation of GR at Ser-246." provenance.
- _4 value "HGF is secreted by damaged tissue during the early phase of musle regeneration in amounts proportional to the extent of muscle injury" provenance.
- _5 value "binding of IGF1 to certain IGFBPs results in opposing biological effects for instance, binding of IGF1 to IGFBP4 appears to inhibit cell proliferation and differentiation, whereas binding to IGFBP5 has a dual effect (that is, either inhibition or stimulation of IGF1 effects)" provenance.
- _2 value "compensatory hypertrophy can be largely prevented by muscle irradiation, providing compelling evidence that the presence of activated and proliferating satellite cells is indeed necessary for this process" provenance.
- _6 value "follistatin can block the binding of myostatin to the activin IIB receptor by interacting with the C-terminal region of a myostatin dimer" provenance.
- _4 value "follistatin interacts with myostatin and reverses the inhibition exerted by the latter on muscle differentiation of primary chick cells mice overexpressing follistatin under the control of muscle-specific regulatory elements display a muscle phenotype that recapitulates that observed in the absence of myostatin" provenance.
- _3 value "once satellite cells are activated, they express the genes encoding the 2 myogenic regulatory factors Myf5 and MyoD, which are not detectable in quiescent cells" provenance.
- _5 value "phosphorylated IRS1 also stimulates the Ras-Raf-MEK-ERK pathway, a MAPK pathway" provenance.
- _5 value "phosphorylation of mTOR represses, through an adaptor protein known as Raptor, 4EBP1, an inhibitor of EIF4E" provenance.
- _2 value "satellite cells satellite cells are lineage-committed adult stem cells that contribute to postnatal muscle growth and muscle regeneration after injury upon myotrauma, quiescent satellite cells become activated, proliferate, and ultimately fuse to existing damaged muscle fibers or among themselves to form new myofibers" provenance.
- _3 value "the ubiquitin protein ligases MuRF1 and MAFbx... using differential display and cDNA microarray approaches, mRNAs obtained from muscles of rats or mice in which atrophy was induced, the expression of 2 genes was consistently found to be increased, MuRF1 and MAFbx, 2 ubiquitin protein ligases expressed solely in skeletal and cardiac muscles" provenance.
- _6 value "Activated p90rsk phosphorylates several transcription factors including Elk and the cAMP-response element-binding protein (CREB) and the activating protein 1 family of c-Jun, c-fos and activating transcription factor (Pearson et al. 2001)." provenance.
- _3 value "Examples of genes having MEF2-binding sites include GLUT4, creatine kinase, AMP deaminase, myoglobin, myosin (heavy light chains), dystrophin, MyoD and cJun (Black Olson, 1998)." provenance.
- _3 value "Examples of genes having MEF2-binding sites include GLUT4, creatine kinase, AMP deaminase, myoglobin, myosin (heavy light chains), dystrophin, MyoD and cJun (Black Olson, 1998)." provenance.
- _3 value "Examples of genes having MEF2-binding sites include GLUT4, creatine kinase, AMP deaminase, myoglobin, myosin (heavy light chains), dystrophin, MyoD and cJun (Black Olson, 1998)." provenance.
- _3 value "Examples of genes having MEF2-binding sites include GLUT4, creatine kinase, AMP deaminase, myoglobin, myosin (heavy light chains), dystrophin, MyoD and cJun (Black Olson, 1998)." provenance.
- _5 value "Examples of genes having MEF2-binding sites include GLUT4, creatine kinase, AMP deaminase, myoglobin, myosin (heavy light chains), dystrophin, MyoD and cJun (Black Olson, 1998)." provenance.
- _5 value "Examples of genes having MEF2-binding sites include GLUT4, creatine kinase, AMP deaminase, myoglobin, myosin (heavy light chains), dystrophin, MyoD and cJun (Black Olson, 1998)." provenance.
- _5 value "Examples of genes having MEF2-binding sites include GLUT4, creatine kinase, AMP deaminase, myoglobin, myosin (heavy light chains), dystrophin, MyoD and cJun (Black Olson, 1998)." provenance.
- _5 value "MSK1 induction requires simultaneous activation of both ERK and p38 MAPK. Other downstream targets of p38 MAPK include transcription factors such as Elk1 and myocyte-enhancing factor (MEF) 2, whereby p38 MAPK directly phosphorylates nuclear substrates and augments their activity (Chen et al. 2001)." provenance.
- _4 value "PD98059 (MAPK/ERK1 inhibitor) and SB203580 (p38 MAPK inhibitor) respectively. In isolated rat skeletal muscle specific inhibition of ERK1/2 by PD98059 completely abolishes contraction-mediated p90rsk activity (Ryder et al. 2000)." provenance.
- _2 value "exercise leads to the activation of at least three MAPK signalling pathways, i.e. ERK1/2, p38 MAPK and JNK, in skeletal muscle (Zierath, 2002)." provenance.
- _4 value "exercise leads to the activation of at least three MAPK signalling pathways, i.e. ERK1/2, p38 MAPK and JNK, in skeletal muscle (Zierath, 2002)." provenance.
- _6 value "exercise leads to the activation of at least three MAPK signalling pathways, i.e. ERK1/2, p38 MAPK and JNK, in skeletal muscle (Zierath, 2002)." provenance.
- _5 value "exercise leads to the activation of at least three MAPK signalling pathways, i.e. ERK1/2, p38 MAPK and JNK, in skeletal muscle (Zierath, 2002)." provenance.
- _6 value "several downstream substrates of ERK1/2 kinase have been identified (Brunet & Pouyssegur, 1997), including p90 ribosomal S6 kinase (p90rsk, also known as MAPK-activated protein kinase (MAPKAP-K) 1; Zhao et al. 1996) and mitogen- and stress-activated kinases (MSK) 1 and 2 (Deak et al. 1998)." provenance.
- _2 value "A subsequent study using L6 myotubes has shown that chronic treatment with AICAR for 5 d results in increases in GLUT4 and insulin stimulated glucose transport of approximately 60%." provenance.
- _6 value "Activation of NRF-1 by PGC-1 increases the expression of genes that encode mitochondrial respiratory chain proteins (Scarpulla, 2002) and 5-aminolevulinate synthase (Briadotti et al. 1993), as well as mitochondrial transcription factor A, a regulator of mitochondrial DNA transcription and replication" provenance.
- _6 value "PGC-1, NRF-1, NRF-2 and PPARa are involved in the stimulation of mitochondrial biogenesis by exercise and that activation of NRF-1, NRF-2 and PPARa by PGC-1 results in a well-coordinated expression of mitochondrial proteins." provenance.
- _2 value "Regular physical exercise induces increases in the capacity of skeletal muscle to oxidize pyruvate and fatty acids(Holloszy & Booth, 1976) and take up glucose They also prevent and even reverse type 2 diabetes." provenance.
- _2 value "the increase in cytosolic Ca triggered by each wave of sarcolemmal depolarization during muscle contraction also triggers the events that lead to mitochondrial biogenesis and increased GLUT4 expression" provenance.
- _5 value "Activation of mTOR results in phosphorylation of a variety of substrates, including the eIF4E-binding protein (4E-BP1), and the ribosomal protein S6 protein kinase (S6K1; for review, see Gingras et al. 2001)." provenance.