Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _7 value "Phosphorylation of both substrates requires the interaction of mTOR with two other proteins, the regulatory associated protein of target of rapamycin (raptor) and GbL (Kim et al. 2003)." provenance.
- _3 value "Recently published data have revealed rapid up-regulation of Akt activity in isolated skeletal muscle subjected to passive stretch, which appears specific to fast-twitch muscle (Sakamoto et al. 2003). The stretch-induced activation of Akt is completely blocked through pretreatment with wortmannin, an inhibitor of PI3K. In other studies phosphorylation of both 4E-BP1 and S6K1 has been shown to be enhanced in response to muscle loading (Baar & Esser, 1999; Bodine et al. 2001; Nader & Esser, 2001; Rommel et al. 2001) and positively contributes to the up-regulation of select gene expression necessary to elicit long-term increases in skeletal muscle accretion." provenance.
- _8 value "TSC2, in a complex with TSC1, normally represses signalling through mTOR, and phosphorylation by Akt/PKB inhibits this function of TSC2 (for review, see Manning & Cantley, 2003)." provenance.
- _4 value "This concept is illustrated by the results of studies utilizing diabetic rats in which animals engaged in resistance exercise (Farrell et al. 1999; Fedele et al. 2000; Kostyak et al. 2001). In such studies rats are operantly conditioned to touch an illuminated bar high on a Plexiglas exercise cage while wearing a weighted vest strapped over the scapulae (Fluckey et al. 1995). The movement performed during the exercise requires the animals to complete concentric and eccentric muscle contractions of the hindlimb musculature (Fluckey et al. 1995). While moderatelydiabetic animals (fed arterial insulin, approximately 180 pM) exhibit an increase in protein synthesis rate as well as augmented eIF2B activity post-exercise, severely-diabetic (fed arterial insulin, approximately 72 pM) animals exhibit depressed protein synthesis rates and eIF2B activity at rest, which fails to change with subsequent exercise (Farrell et al. 1999; Fedele et al. 2000; Kostyak et al. 2001)." provenance.
- _4 value "Here, we report that mice carrying a targeted mutation in the PI3Kgamma gene causing loss of kinase activity (PI3KgammaKD/KD) display reduced inflammatory reactions but no alterations in cardiac contractility." provenance.
- _6 value "Thus, cardiac PI3Kgamma participates in two distinct signaling pathways: a kinase-dependent activity that controls PKB/Akt as well as MAPK phosphorylation and contributes to TAC-induced cardiac remodeling, and a kinase-independent activity that relies on protein interactions to regulate PDE3B activity and negatively modulates cardiac contractility." provenance.
- _5 value "From mutations file" provenance.
- _3 value "After 14-day simultaneous denervation of the soleus (Sol), tibialis anterior (TA), extensor digitorum longus (EDL), and gastrocnemius (Gastr) muscles by sciatic nerve section, DHPR mRNA increased preferentially in the Sol and TA (+1.6-fold), whereas it increased in the EDL (+1.6-fold) and TA (+1.8-fold) after selective denervation of these muscles by peroneal nerve section" provenance.
- _5 value "From mutations file" provenance.
- _3 value "VPF could be a mediator of the high permeability of tumor blood vessels" provenance.
- _5 value "Y1175 and Y1214 are the 2 major VEGFA-dependent autophosphorylation sites in VEGFR2" provenance.
- _3 value "endocrine gland-derived VEGF (EGVEGF), a novel angiogenic factor that is selectively expressed in steroidogenic tissues, plays a cooperative role with VEGF in the regulation of angiogenesis in the human ovary" provenance.
- _3 value "in vitro, VEGF prevents endothelial apoptosis induced by serum starvation" provenance.
- _3 value "inactivation of a single VEGF allele resulted in embryonic lethality between d11 and d12 these findings indicate a critical VEGF gene-dosage dependence during development" provenance.
- _3 value "known endothelial cell mitogens such as aFGF or bFGF" provenance.
- _6 value "nuclear localization for FOXO4, which is inhibited by PI3K activation, normally down-regulates the HIF1 protein" provenance.
- _3 value "similarities between the mechanisms leading to hypoxic regulation of VEGF and EPO hypoxia inducibility is conferred on both genes by homologous sequences" provenance.
- _3 value "similarities between the mechanisms leading to hypoxic regulation of VEGF and EPO hypoxia inducibility is conferred on both genes by homologous sequences" provenance.
- _3 value "the angiogenic effects of various factors, including EGF, TGFalpha, TGFbeta, TNFalpha, angiogenin, etc were reported" provenance.
- _2 value "these molecules all were shown to have activity in angiogenesis bioassays, either directly, by promoting endothelial cell proliferation or indirectly, via recruitment of inflammatory cells that could, in turn, release endothelial mitgoens" provenance.
- _5 value "IL-9 stimulation of human ASM cells resulted in release of eotaxin1/CCL11" provenance.
- _4 value "Lymphatic vessels expressed CLEVER-1 constitutively in skin in vivo, whereas on vascular endothelium it appeared only upon inflammation." provenance.
- _5 value "This induction was mediated at the transcriptional level by a pathway that required activation of the protein kinase Ca/bI isozyme (PKC), mitogen-activated protein kinase kinase 1 and 2 (MEK), and extracellular signal-regulated kinase (ERK)." provenance.
- _5 value "PGE2-dependent activation of C/EBPbeta was blocked by expression of a mutated regulatory subunit of protein kinase A or by mutation of two previously identified cAMP-sensitive cis-acting regulatory elements within the promoter between bp -111 and -61. Nuclear protein binding to these elements was induced by PGE2, required new protein synthesis, and was sensitive to antibody to the transcription factor termed Fos-related antigen 2 (Fra-2)." provenance.
- _3 value "prostaglandin E2 (PGE2) rapidly enhances C/EBPbeta mRNA and protein expression" provenance.
- _4 value "Pharmacological induction of Hsp70 was found to reduce both apoptotic and necrotic astrocyte death induced by glucose deprivation or oxygen glucose deprivation." provenance.
- _7 value "Overexpression of NCOA-1, NCOA-2, and NCOA-3 enhanced E2-mediated gene expression by 3.17 +/- 0.51-, 2.33 +/- 0.8-, and 3.65 +/- 0.65-fold, respectively, and enhanced cell survival by suppressing tumor necrosis factor alpha (TNF-alpha)-induced cell death Overexpression of NCOA-1 and NCOA-3 exerted potent survival effects in breast carcinoma cells." provenance.
- _2 value "elevated SMRT corepressor mRNA expression often associated with reduced sensitivity to 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)2D3). the antiproliferative action of 1alpha,25(OH)2D3 can be 'restored' by cotreatment with low doses of HDAC inhibitors such as trichostatin A" provenance.
- _3 value "elevated SMRT corepressor mRNA expression often associated with reduced sensitivity to 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)2D3). the antiproliferative action of 1alpha,25(OH)2D3 can be 'restored' by cotreatment with low doses of HDAC inhibitors such as trichostatin A" provenance.
- _4 value "of 1alpha,25(OH)2D3 plus TSA cooperatively upregulated eight (out of 1176) genes, including MAPK-APK2 and GADD45alpha." provenance.
- _3 value "Apollon inhibits apoptosis" provenance.
- _5 value "SMAC induced apoptosis in Apollon-deficient cells, but not in Apollon-expressing cells" provenance.
- _3 value "SOCS-2 overexpression in Caco-2 cells inhibited cell proliferation and promoted differentiation" provenance.
- _3 value "Biliverdin significantly improved survival of recipients following SITx after prolonged intestinal ischemia (6 hours). Biliverdin treatment (1) led to a significant decrease in mRNA expression of iNOS, Cox-2, and ICAM-1 as well as the inflammatory cytokines IL-6 and IL-1beta" provenance.
- _4 value "Biliverdin significantly improved survival of recipients following SITx after prolonged intestinal ischemia (6 hours). Biliverdin treatment (1) led to a significant decrease in mRNA expression of iNOS, Cox-2, and ICAM-1 as well as the inflammatory cytokines IL-6 and IL-1beta" provenance.
- _3 value "Supplementary Table 1. Gene Regulation by Caloric Restriction and Compounds Including Nuclear Receptor Agonists downregulated by caloric restriction" provenance.
- _3 value "Supplementary Table 1. Gene Regulation by Caloric Restriction and Compounds Including Nuclear Receptor Agonists downregulated by caloric restriction" provenance.
- _3 value "Supplementary Table 1. Gene Regulation by Caloric Restriction and Compounds Including Nuclear Receptor Agonists downregulated by caloric restriction" provenance.
- _3 value "Supplementary Table 1. Gene Regulation by Caloric Restriction and Compounds Including Nuclear Receptor Agonists downregulated by caloric restriction" provenance.
- _3 value "Supplementary Table 1. Gene Regulation by Caloric Restriction and Compounds Including Nuclear Receptor Agonists downregulated by caloric restriction" provenance.
- _3 value "Supplementary Table 1. Gene Regulation by Caloric Restriction and Compounds Including Nuclear Receptor Agonists downregulated by caloric restriction" provenance.
- _3 value "Supplementary Table 1. Gene Regulation by Caloric Restriction and Compounds Including Nuclear Receptor Agonists downregulated by caloric restriction" provenance.
- _3 value "Supplementary Table 1. Gene Regulation by Caloric Restriction and Compounds Including Nuclear Receptor Agonists downregulated by caloric restriction" provenance.
- _3 value "Supplementary Table 1. Gene Regulation by Caloric Restriction and Compounds Including Nuclear Receptor Agonists downregulated by caloric restriction" provenance.
- _3 value "upregulated by caloric restriction" provenance.
- _3 value "upregulated by caloric restriction" provenance.
- _4 value "MEF2C and GATA-4 each have an activating effect on the alphaT-catenin promoter" provenance.
- _7 value "Yeast two-hybrid analysis using the ligand-binding domain (LBD) of TAK1 as bait identified a novel TAK1-interacting protein, referred to as TIP27, which functions as a repressor of TAK1-mediated transactivation." provenance.
- _4 value "Pharmacological inhibition of PARP suppressed both nitrotyrosine formation, adhesion molecule expression and IL-6 to the levels seen in the normal glucose conditions." provenance.
- _5 value "Pharmacological inhibition of PARP suppressed both nitrotyrosine formation, adhesion molecule expression and IL-6 to the levels seen in the normal glucose conditions." provenance.
- _3 value "Analysis of the expression of differentiation marker genes in early differentiating confluent cultures reveals that cholesterol depletion induces downregulation of keratin 14 (K14) and keratin 10 (K10) and upregulation of involucrin." provenance.
- _2 value "selective hypersensitivity to apoptosis induced by ER stress agents (thapsigargin, tunicamycin, brefeldin A), but not to stimulators of mitochondrial or TNF/Fas-death receptor apoptosis pathways." provenance.
- _4 value "Mst3, a human Ste20-like protein kinase, has been recently demonstrated to undergo a caspase-mediated cleavage during apoptosis. The proteolytic cleavage of the C-terminus of Mst3 caused nuclear translocation of its kinase domain." provenance.
- _2 value "In KD clones, but not in RD-clones, formation of etoposide-induced gamma-H2AX was increased, indicating that PrxV inhibits conversion of topoisomerase II cleavage complexes into double-strand DNA breaks but this inhibition is not caused by its antioxidant activity." provenance.
- _3 value "In KD clones, but not in RD-clones, formation of etoposide-induced gamma-H2AX was increased, indicating that PrxV inhibits conversion of topoisomerase II cleavage complexes into double-strand DNA breaks but this inhibition is not caused by its antioxidant activity." provenance.
- _5 value "In KD clones, but not in RD-clones, formation of etoposide-induced gamma-H2AX was increased, indicating that PrxV inhibits conversion of topoisomerase II cleavage complexes into double-strand DNA breaks but this inhibition is not caused by its antioxidant activity." provenance.
- _2 value "When human primary CD3(+) cells were stimulated with anti-CD3 or calcium ionophore, the KIAA0603 transcript level was upregulated." provenance.
- _7 value "estrogen receptor (ER) alpha- and beta-catenin precipitated within the same immunocomplexes, reciprocally enhanced the transactivation of cognate reporter genes, and were reciprocally recruited to cognate response elements in the promoters of endogenous target genes." provenance.
- _5 value "Inhibition of PI3K resulted in a dose-dependent inhibition of RUNX2 activity with 30, 50, and 90% inhibition at LY294002 concentrations of 5, 10, and 20 �?µM, respectively. RUNX2 protein levels were also reduced, as was pAkt." provenance.
- _3 value "WFDC1/ps20 protein has been previously established as a growth suppressor of the prostate cancer cell line PC3." provenance.
- _3 value "Most robustly expressed were gene sequences NFI-B, ATP1B1, RHOGAP, PLA2G4A, BAX, CASP3, P53, MAO-A, FRA1, HSP70.2, and NR4A1 (NUR77) These data indicate that ischemia elicits expression of an array of functional gene clusters" provenance.
- _3 value "Most robustly expressed were gene sequences NFI-B, ATP1B1, RHOGAP, PLA2G4A, BAX, CASP3, P53, MAO-A, FRA1, HSP70.2, and NR4A1 (NUR77) These data indicate that ischemia elicits expression of an array of functional gene clusters" provenance.
- _5 value "Our data show that the antisense oligodeoxynucleotides (of PSD-95)could inhibit phosphorylation of MLK3 and JNK3" provenance.
- _11 value "By using monoclonal antibodies and recombinant intercellular adhesion molecule 1 (ICAM-1) to engage lymphocyte function-associated antigen 1 (LFA-1) on monocytic cells, we found that the cellular adhesion to vascular cell adhesion molecule 1 (VCAM-1) mediated by very late antigen 4 (VLA-4) was suppressed after this treatment and the suppression depended on the presence of reactive oxygen species (ROSs)." provenance.
- _5 value "TABLE IV Selected genes up-regulated by IRF-7" provenance.
- _5 value "TABLE IV Selected genes up-regulated by IRF-7" provenance.
- _5 value "TABLE IV Selected genes up-regulated by IRF-7" provenance.
- _5 value "TABLE IV Selected genes up-regulated by IRF-7" provenance.
- _5 value "TABLE IV Selected genes up-regulated by IRF-7" provenance.
- _5 value "TABLE IV Selected genes up-regulated by IRF-7" provenance.
- _5 value "TABLE IV Selected genes up-regulated by IRF-7" provenance.
- _5 value "TABLE IV Selected genes up-regulated by IRF-7" provenance.
- _5 value "TABLE IV Selected genes up-regulated by IRF-7" provenance.
- _5 value "TABLE IV Selected genes up-regulated by IRF-7" provenance.
- _5 value "TABLE IV Selected genes up-regulated by IRF-7" provenance.
- _5 value "TABLE IV Selected genes up-regulated by IRF-7" provenance.
- _5 value "TABLE IV Selected genes up-regulated by IRF-7" provenance.
- _5 value "TABLE IV Selected genes up-regulated by IRF-7" provenance.
- _5 value "TABLE IV Selected genes up-regulated by IRF-7" provenance.
- _5 value "TABLE V Selected genes up-regulated by IRF-5" provenance.
- _5 value "TABLE V Selected genes up-regulated by IRF-5" provenance.
- _5 value "TABLE V Selected genes up-regulated by IRF-5" provenance.
- _5 value "TABLE V Selected genes up-regulated by IRF-5" provenance.
- _5 value "TABLE V Selected genes up-regulated by IRF-5" provenance.
- _5 value "TABLE V Selected genes up-regulated by IRF-5" provenance.
- _5 value "TABLE V Selected genes up-regulated by IRF-5" provenance.
- _5 value "TABLE V Selected genes up-regulated by IRF-5" provenance.
- _5 value "TABLE V Selected genes up-regulated by IRF-5" provenance.
- _5 value "TABLE V Selected genes up-regulated by IRF-5" provenance.
- _5 value "TABLE V Selected genes up-regulated by IRF-5" provenance.
- _5 value "TABLE V Selected genes up-regulated by IRF-5" provenance.
- _5 value "TABLE V Selected genes up-regulated by IRF-5" provenance.
- _5 value "TABLE V Selected genes up-regulated by IRF-5" provenance.
- _5 value "TABLE V Selected genes up-regulated by IRF-5" provenance.
- _5 value "TABLE V Selected genes up-regulated by IRF-5" provenance.
- _5 value "TABLE V Selected genes up-regulated by IRF-5" provenance.
- _5 value "TABLE V Selected genes up-regulated by IRF-5" provenance.
- _5 value "TABLE V Selected genes up-regulated by IRF-5" provenance.
- _6 value "Both L11 and L23 have been shown to activate p53 by inhibiting MDM2-mediated p53 suppression." provenance.
- _6 value "Both L11 and L23 have been shown to activate p53 by inhibiting MDM2-mediated p53 suppression." provenance.