Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _6 value "Both L11 and L23 have been shown to activate p53 by inhibiting MDM2-mediated p53 suppression." provenance.
- _6 value "BMP signaling leading to Smad1/5/8 activation via ALK2/3/6" provenance.
- _6 value "Treatment of differentiating cells with Activin A leads to activation of Smad2/3 and expression of nodal, lefty-A and lefty-B, while inhibition of ALK4/5/7 by the kinase inhibitor SB-431542 blocks activation of Smad2/3" provenance.
- _6 value "Treatment of differentiating cells with Activin A leads to activation of Smad2/3 and expression of nodal, lefty-A and lefty-B, while inhibition of ALK4/5/7 by the kinase inhibitor SB-431542 blocks activation of Smad2/3" provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _4 value "LOX-1 activation leads to the expression of CD40/40 L in endothelial cells and upregulation of matrix metalloproteinases." provenance.
- _4 value "This receptor is transcriptionally upregulated by tumour necrosis factor-a, angiotensin II, shear stress and ox-LDL" provenance.
- _4 value "A PERIOD-like domain (amino acids 591-719) of AIP1 binds to the intact RING finger of TRAF2, and specifically enhances TRAF2-induced ASK1 activation. At the same time, the binding of AIP1 to TRAF2 inhibits TNF-induced IKK-NF-kappaB signaling." provenance.
- _4 value "Up-regulation of NPM is hypoxia-inducible factor-1 (HIF-1)-dependent. The NPM promoter encodes a functional HIF-1-responsive element that can be activated by hypoxia or forced expression of HIF-1alpha." provenance.
- _4 value "upregulation of the ETB receptor mediating vasodilation and downregulation of the ETA receptor mediating vasoconstriction" provenance.
- _3 value "% We found that sFRP3 unexpectedly increased osteoblast differentiation, Secreted frizzled-related proteins (sFRPs) are a truncated form of frizzled receptor, missing both the transmembrane and cytosolic domains." provenance.
- _4 value "Wnt3A, but not sFRP3 treatment, increased cellular beta-catenin levels, and sFRP3 failed to block Wnt3A-induced increase in cellular beta-catenin levels. PR" provenance.
- _2 value "Activation of the NO/cGMP pathway results in a strong reduction of platelet aggregation elicited by agonists such as thrombin (Azuma et al., 1986; Radomski et al., 1987; Benjamin et al., 1991; Moro et al., 1996; Rao et al., 1990)." provenance.
- _3 value "NO has been described to inhibit sGC expression and sGC activity in a cGMP-dependent manner (Filippov et al., 1997)." provenance.
- _3 value "TABLE 2. Hypoxia-induced translationally regulated genes" provenance.
- _3 value "TABLE 2. Hypoxia-induced translationally regulated genes" provenance.
- _3 value "TABLE 2. Hypoxia-induced translationally regulated genes" provenance.
- _3 value "TABLE 2. Hypoxia-induced translationally regulated genes" provenance.
- _3 value "TABLE 2. Hypoxia-induced translationally regulated genes" provenance.
- _3 value "TABLE 2. Hypoxia-induced translationally regulated genes" provenance.
- _3 value "TABLE 2. Hypoxia-induced translationally regulated genes" provenance.
- _3 value "TABLE 2. Hypoxia-induced translationally regulated genes" provenance.
- _5 value "Downregulation of Ets2 in prostate cancer cells was associated with reduced levels of the anti-apoptotic protein bcl-x(L) and growth regulatory factors cyclin D1 and c-myc." provenance.
- _3 value "The present study demonstrates for the first time that AM and its receptor component (CRLR/RAMP2) mRNAs were concomitantly expressed in various adipose tissues, whose tissue-specific upregulation was induced during the development of obesity;whereas steady-state AM mRNA levels conversely decreased in other organs, such as kidney and liver" provenance.
- _4 value "Activation of PI 3-kinase but not Akt was necessary for FOXN1-induced differentiation." provenance.
- _6 value "Activation of PI 3-kinase but not Akt was necessary for FOXN1-induced differentiation." provenance.
- _4 value "Activation of PI 3-kinase but not Akt was necessary for FOXN1-induced differentiation." provenance.
- _4 value "FOXN1 promoted early stages of terminal differentiation whereas Akt activation was sufficient to induce late stages" provenance.
- _4 value "FOXN1 promoted early stages of terminal differentiation whereas Akt activation was sufficient to induce late stages" provenance.
- _3 value "From full text supplementary table 1" provenance.
- _3 value "From full text supplementary table 1" provenance.
- _3 value "From full text supplementary table 1" provenance.
- _3 value "Hook1, Tuba1, Tubd1, Dncic2, Kif3b, Rnf19/Dorfin, Pcnt2, Nin and Smc4l1, all decreased with maternal aging" provenance.
- _3 value "Hook1, Tuba1, Tubd1, Dncic2, Kif3b, Rnf19/Dorfin, Pcnt2, Nin and Smc4l1, all decreased with maternal aging" provenance.
- _3 value "Hook1, Tuba1, Tubd1, Dncic2, Kif3b, Rnf19/Dorfin, Pcnt2, Nin and Smc4l1, all decreased with maternal aging" provenance.
- _4 value "A consistent and concomitant reduction in messenger RNA levels of FXR targets, such as BSEP and small heterodimer partner" provenance.
- _4 value "The expression of two main FXR isoforms was specifically decreased in the liver of the FIC1 disease patient." provenance.
- _3 value " In contrast to age-matched (11-15 months) wild-type controls, hearts from Tg26-hDMPK developed cardiomyopathic remodeling with myocardial hypertrophy, myocyte disarray and interstitial fibrosis. " provenance.
- _4 value "Transforming growth factor beta (TGF-beta)-mediated induction of actin stress fibers in normal and metastatic epithelial cells. The stress fiber formation requires de novo protein synthesis, p38Mapk and Smad signaling. Treatment of Tgfb1 significantly affects phosphorylation of Smad2 and treatment of p38mapk inhibitor did not affect the Smad luciferase reporter activity." provenance.
- _5 value "We report here the identification of 14 genes that are % rapidly induced by atRA (retinoic acid induced in neuroblastoma or RAINB), % eight of which were previously not known to be atRA responsive (BTBD11, % calmin, cyclin M2, ephrin B2, HOXD10, NEDD9, RAINB6 and tenascin R)." provenance.
- _5 value "We report here the identification of 14 genes that are % rapidly induced by atRA (retinoic acid induced in neuroblastoma or RAINB), % eight of which were previously not known to be atRA responsive (BTBD11, % calmin, cyclin M2, ephrin B2, HOXD10, NEDD9, RAINB6 and tenascin R)." provenance.
- _7 value "In contrast, chelation of intracellular Ca2+ with BAPTA/AM (20 uM) almost fully blunted ERK1/2 phosphorylation (n = 4; p < 0.002) as well as H-Ras activation (n = 5; p < 0.001) induced by the beta2-AR." provenance.
- _9 value "Whereas overexpression of wild-type Epac1 enhanced the phosphorylation of ERK1/2 induced by the beta2-AR, the receptor response was almost fully blunted (n = 4; p < 0.003) by expression of R279K Epac1 (Fig. 5A)." provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "TABLE 4 Genes Dysregulated in Duodenum on Days 1?5 (30 �mol/kg b.i.d. BZ) " provenance.
- _4 value "4. CBP/p300 family H3, H4, H2A, H2B; Nonhistone proteins Worm to human Global coactivator" provenance.
- _5 value "4. CBP/p300 family H3, H4, H2A, H2B; Nonhistone proteins Worm to human Global coactivator" provenance.
- _4 value "7. ATF2 H4/H2B Yeast to human Sequence-specific DNA-binding activator" provenance.
- _4 value "A multitude of synthetic tyrosine kinase inhibitors have been developed and screened for potential preclinical activity, most of which reversibly compete with ATP for binding to the enzyme's intracellular catalytic domain. The quinazoline derivatives ZD1839 (gefitinib, Iressa) and OSI- 774 (erlotinib, Tarceva) appear to be the most promising to date. ZD1839 is a synthetic anilinoquinazoline [4-(3-chloro-4- fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy) quinazoline] that inhibits the EGFR tyrosine kinase, resulting in G1 cell cycle arrest and upregulation of the p27KIP1 cyclin dependent kinase inhibitor [88-91]" provenance.
- _7 value "Depsipeptide Depsipeptide was originally isolated from a strain of Chromobacterium violaceum. Initial studies with this bicyclic peptide demonstrated a selective decrease in c-myc expression. However, growth inhibition of the Ha-rastransformed NIH-3T3 clonal cell line Ras-1 was also observed in the absence of altered Ha-ras mRNA expression [67]. Depsipeptide appears to regulate the cell cycle at several points, including cell cycle arrest at G0/G1 and inhibition of signal transduction through mitogen-activated protein kinase (MAPK) with resultant p53-independent G1 arrest. EPIDERMAL GROWTH FACTOR RECEPTOR TYROSINE KINASE INHIBITORS Epidermal Growth Factor Receptor Binding by any member of the EGF family of ligands results in receptor dimerization and activation of the intracytoplasmic tyrosine kinase domain. In addition to homodimers, members of this receptor family can also form heterodimers through a series of complex interactions that result in transphosphorylation and the concerted regulation of the involved receptors. Six EGF-like ligands are known to bind and activate EGFR: EGF, TGF?, amphiregulin (cripto-1; CR-1), heparin-binding EGF (HB-EGF), betacellulin (BTC), and epiregulin (EPR) [78, 79]. Ligand binding to EGFR at the cell membrane triggers a signal transduction cascade that leads to the activation of nuclear transcription factors that promote cell division." provenance.
- _7 value "Depsipeptide Depsipeptide was originally isolated from a strain of Chromobacterium violaceum. Initial studies with this bicyclic peptide demonstrated a selective decrease in c-myc expression. However, growth inhibition of the Ha-rastransformed NIH-3T3 clonal cell line Ras-1 was also observed in the absence of altered Ha-ras mRNA expression [67]. Depsipeptide appears to regulate the cell cycle at several points, including cell cycle arrest at G0/G1 and inhibition of signal transduction through mitogen-activated protein kinase (MAPK) with resultant p53-independent G1 arrest. EPIDERMAL GROWTH FACTOR RECEPTOR TYROSINE KINASE INHIBITORS Epidermal Growth Factor Receptor Binding by any member of the EGF family of ligands results in receptor dimerization and activation of the intracytoplasmic tyrosine kinase domain. In addition to homodimers, members of this receptor family can also form heterodimers through a series of complex interactions that result in transphosphorylation and the concerted regulation of the involved receptors. Six EGF-like ligands are known to bind and activate EGFR: EGF, TGF?, amphiregulin (cripto-1; CR-1), heparin-binding EGF (HB-EGF), betacellulin (BTC), and epiregulin (EPR) [78, 79]. Ligand binding to EGFR at the cell membrane triggers a signal transduction cascade that leads to the activation of nuclear transcription factors that promote cell division." provenance.
- _5 value "PSF p100 polypyrimidine t ract-binding protein- associated splicing factor; Represses TR and RXR." provenance.
- _5 value "Previous studies have demonstrated a role for cyclin D1 in the repression of several distinct transcription factors (Fig. 4). In addition to binding CDK4, CDK6, and pRB, cyclin D1 forms physical associations with P/CAF (p300/CB P associated factor), Myb, MyoD, and the cyclin D1 myb-like binding protein (DMP1) [8-11]. Cyclin D1 and D2 are capable of inhibiting MyoD [12]. v-Myb is preferentially repressed by cyclin D1 [9], although cyclin D2 and D3 are also capable of repressing v-Myb; the helix-loop-helix-like protein DMP1 is repressed by each of the D-type cyclins [8]. In contrast, the repression of BETA2/NeuroD by cyclin D1 is not reconstituted by either cyclin D2 or D3." provenance.
- _5 value "Previous studies have demonstrated a role for cyclin D1 in the repression of several distinct transcription factors (Fig. 4). In addition to binding CDK4, CDK6, and pRB, cyclin D1 forms physical associations with P/CAF (p300/CB P associated factor), Myb, MyoD, and the cyclin D1 myb-like binding protein (DMP1) [8-11]. Cyclin D1 and D2 are capable of inhibiting MyoD [12]. v-Myb is preferentially repressed by cyclin D1 [9], although cyclin D2 and D3 are also capable of repressing v-Myb; the helix-loop-helix-like protein DMP1 is repressed by each of the D-type cyclins [8]. In contrast, the repression of BETA2/NeuroD by cyclin D1 is not reconstituted by either cyclin D2 or D3." provenance.
- _6 value "RIP140 Represses TR2 , RAR, RXR" provenance.
- _5 value "mSin3A Represses TR, RAR and others" provenance.
- _6 value "PHBP activates scuPA to tcuPA, tcuPA activates matrix metalloproteases (MMPs) and activated MMPs degrade ECM for the tissue remodeling after hepatic injury." provenance.
- _3 value "However, until now, decreased TF expression, induced by statins, has been demonstrated solely on cultured human macrophages or monocytes [105]." provenance.
- _3 value "reductions in plasma thrombin generation markers, such as prothrombin fragment 1+2 (F1+2), fibrinopeptide A (FPA) and thrombin-anti-thrombin III complexes (TAT), has been reported in hypercholesterolemic subjects treated with pravastatin or simvastatin [92, 93]." provenance.
- _3 value "reductions in plasma thrombin generation markers, such as prothrombin fragment 1+2 (F1+2), fibrinopeptide A (FPA) and thrombin-anti-thrombin III complexes (TAT), has been reported in hypercholesterolemic subjects treated with pravastatin or simvastatin [92, 93]." provenance.
- _4 value "We found that the Tyr701 phosphorylation kinetics of Stat1 mediated by IFN stimulation was higher when cells were incubated with IFN-alpha5 than when using IFN-alpha2. Similarly, Tyr(1054/1055) phosphorylation kinetics of Tyk2 were more intense after exposure to IFN-alpha5 than when using IFN-alpha2. Concomitantly, Tyr705 phosphorylation of Stat3 was higher after stimulation with IFN-alpha5 than with IFN-alpha2." provenance.
- _5 value "RhoA activates purified phospholipase C epsilon by a guanine nucleotide dependent mechanism" provenance.
- _7 value "The coactivator PGC-1 enhanced transcriptional activity of HNF-4, and this enhancement was suppressed by rifampicin-activated PXR. " provenance.
- _6 value "In neuroblastoma cells, GEFT promotes the active GTP-bound state of Rac1, Cdc42, and RhoA and increases neurite outgrowth primarily via Rac1. " provenance.
- _4 value "induction of Id1 not only blocks transcriptional activity but also induces myogenin degradation by blocking formation of myogenin-E47 protein complexes" provenance.