Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _5 value "Within the cardiac isoform's amino-terminal extension, serines are present at residues 23 and 24 (Ser23/Ser24), which serve as substrates for protein kinase A (PKA), which is activated in response to ?-adrenergic stimulation of the heart (3). Several investigations report that PKA-mediated phosphorylation of cTnI results in a reduction in myofilament Ca2+ sensitivity (4), an increase in cross-bridge cycling (5), and increased binding of cTnI to the thin filament. Cardiac TnI is also a substrate for protein kinase C (PKC) phosphorylation at Ser43/Ser45 and Thr144 (position 143 in the human protein) (6). However, the substrate specificity of these sites is not absolute, since PKC can phosphorylate the PKA sites (7-9). " provenance.
- _3 value "protein kinase C phosphorylation of cTnI plays a dominant role in depressing contractility and exerts an antithetic role on the ability of protein kinase A to increase relaxation" provenance.
- _3 value "protein kinase C phosphorylation of cTnI plays a dominant role in depressing contractility and exerts an antithetic role on the ability of protein kinase A to increase relaxation" provenance.
- _5 value "results indicate that BCL-6 negatively regulates proliferation of the monocytic/macrophage lineage by suppressing an autocrine IL-6/STAT3-mediated gene expression program." provenance.
- _4 value "results indicate that BCL-6 negatively regulates proliferation of the monocytic/macrophage lineage by suppressing an autocrine IL-6/STAT3-mediated gene expression program." provenance.
- _2 value "DNA mutations as a result of lipid peroxidation" provenance.
- _5 value "In addition, in the Foxd1 deficient ventral diencephalon, Foxg1 invades the Foxd1 domain, Zic2 and Islet1 expression are minimized, and Slit2 prematurely expands" provenance.
- _4 value "From table 1 in full text: proteasome inhibition by PS-341 induced endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) in HNSCC cells" provenance.
- _4 value "From table 1 in full text: proteasome inhibition by PS-341 induced endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) in HNSCC cells" provenance.
- _4 value "From table 1 in full text: proteasome inhibition by PS-341 induced endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) in HNSCC cells" provenance.
- _5 value "Finally, it (AMPK) phosphorylates the ubiquitous co-activator p300 at a specific site (Ser89), reducing its ability to bind to nuclear hormone receptors and thus activate their target genes" provenance.
- _3 value "classes of drug inhibit complex I of the respiratory chain and this might be how they activate AMPK" provenance.
- _5 value "the mechanism for AMPK activation by stresses involves an upstream kinase... The upstream kinase purified from rat liver is a complex between LKB1, STRAD and MO25 and all three subunits are required for full activity" provenance.
- _5 value "the mechanism for AMPK activation by stresses involves an upstream kinase... The upstream kinase purified from rat liver is a complex between LKB1, STRAD and MO25 and all three subunits are required for full activity" provenance.
- _4 value "GPR30 down-regulated the expression of cofactor transcription intermediary factor 2 (TIF2) analyzed using quantitative RT-PCR analysis, and also diminished the expression of TIF2 at protein level analyzed by Western blotting using nuclear extracts from mammary epithelial cells." provenance.
- _4 value "We found compression and tension significantly increased the secretions of both CAB and CAL in PDL cells, which were exhibited in a time- and force magnitude-dependent manner." provenance.
- _3 value "When analyzed using a semiquantitative polymerase chain reaction assay, CAB and CAL mRNA were increased in response to both compression and tension forces." provenance.
- _5 value "Previously, we demonstrated a novel interaction between the intracellular domain of the nerve growth factor-regulated TrkA receptor tyrosine kinase and an N-terminal fragment of RasGrf1. We now show that RasGrf1 is phosphorylated and interacts with TrkA, -B, and -C in co-transfection studies." provenance.
- _3 value "Table 1. Estrogen-Induced/AP-1-Independent Genes" provenance.
- _4 value "Table 2. Estrogen-Induced/AP-1-Dependent Genes" provenance.
- _4 value "Table 2. Estrogen-Induced/AP-1-Dependent Genes" provenance.
- _4 value "Table 2. Estrogen-Induced/AP-1-Dependent Genes" provenance.
- _4 value "Table 2. Estrogen-Induced/AP-1-Dependent Genes" provenance.
- _4 value "Table 2. Estrogen-Induced/AP-1-Dependent Genes" provenance.
- _4 value "Table 2. Estrogen-Induced/AP-1-Dependent Genes" provenance.
- _4 value "We demonstrated that VIP (1-100 nm), like PACAP38, stimulates lipolysis in isolated adipocytes, as determined by glycerol release." provenance.
- _5 value "Collagen synthesis is activated via the angiotensin II type 1 (AT1) receptor. We demonstrate that transforming growth factor-beta1, a major product of stimulated AT1 receptor, does not activate solely collagen synthesis but synergistically the synthesis of hnRNP A1, E1, and K as well." provenance.
- _4 value "Reporter gene cell transfection experiments and RNA stability assays show that hnRNPs A1, E1, and K stimulate collagen expression by stabilizing mRNAs We report identification of three mRNA-binding proteins, heterogeneous nuclear ribonucleoprote (hnRNP) A1, E1, and K, as positive effectors of collagen synthesis acting at the post-transcriptional level by interaction with the 3'-untranslated regions (3'-UTRs) of COL1A1, 1A2, and 3A1 mRNAs" provenance.
- _4 value "Reporter gene cell transfection experiments and RNA stability assays show that hnRNPs A1, E1, and K stimulate collagen expression by stabilizing mRNAs We report identification of three mRNA-binding proteins, heterogeneous nuclear ribonucleoprote (hnRNP) A1, E1, and K, as positive effectors of collagen synthesis acting at the post-transcriptional level by interaction with the 3'-untranslated regions (3'-UTRs) of COL1A1, 1A2, and 3A1 mRNAs" provenance.
- _4 value "Reporter gene cell transfection experiments and RNA stability assays show that hnRNPs A1, E1, and K stimulate collagen expression by stabilizing mRNAs We report identification of three mRNA-binding proteins, heterogeneous nuclear ribonucleoprote (hnRNP) A1, E1, and K, as positive effectors of collagen synthesis acting at the post-transcriptional level by interaction with the 3'-untranslated regions (3'-UTRs) of COL1A1, 1A2, and 3A1 mRNAs" provenance.
- _4 value "Reporter gene cell transfection experiments and RNA stability assays show that hnRNPs A1, E1, and K stimulate collagen expression by stabilizing mRNAs We report identification of three mRNA-binding proteins, heterogeneous nuclear ribonucleoprote (hnRNP) A1, E1, and K, as positive effectors of collagen synthesis acting at the post-transcriptional level by interaction with the 3'-untranslated regions (3'-UTRs) of COL1A1, 1A2, and 3A1 mRNAs" provenance.
- _3 value "Table 4. Gene ontology biological process groupings for differentially expressed genes in FR (food restriction) mice" provenance.
- _3 value "Table 4. Gene ontology biological process groupings for differentially expressed genes in FR (food restriction) mice" provenance.
- _3 value "Table 4. Gene ontology biological process groupings for differentially expressed genes in FR (food restriction) mice" provenance.
- _4 value "Furthermore, p38(MAPK), ERK1/2, JNK, and Smad1 were phosphorylated by BMP4. Using specific MAPK inhibitors, a dominant negative Smad1 construct, and Smad1 siRNA, we found that the antiproliferative and prodifferentiation effects of BMP4 were Smad1 dependent with JNK also contributing to differentiation." provenance.
- _5 value "cell invasion and Rac activity were induced by H-RasV12 and inhibited by the CD44 blocking antibody" provenance.
- _3 value "Ectopic expression of Dkk-3/REIC in HeLa, Hep3B and Huh 7 cells led to suppression of cell growth, which was primarily attributable to induction of cell apoptosis." provenance.
- _4 value "LA might preserve the redox balance, thereby blocking the activation of inhibitory inflammatory serine kinases including IKKb" provenance.
- _3 value "There are several adipocyte-derived molecules that negatively influence insulin sensitivity in vivo, including IL6 and plasminogen activator inhibitor 1" provenance.
- _3 value "These serine kinases are mediators of inflammation, resulting in the inhibition of insulin-stimulated glucose transport" provenance.
- _4 value "activation of PPARd is associated with an anti-obesity and more insulin sensitive phenotype" provenance.
- _2 value "adiponectin and leptin contribute to an insulin-sensitive phenotype via their ability to activate AMP-activated kinase and increase fatty acid oxidation" provenance.
- _3 value "contractile activity results in the activation of AMP-activated kinase AMPK activation leads to an increase in glucose transport, possibly through several mechanisms. AMPK can phosphorylate and activate endothelial nitric oxide synthase and nitric oxide production might contribute to excercise stimulated glucose transport" provenance.
- _2 value "Pg was able to counterbalance the stimulatory effect of estrogen or serum on proliferation and on expression level of Id-1, which generally stimulates cell proliferation and inhibits differentiation." provenance.
- _3 value "Pg was able to counterbalance the stimulatory effect of estrogen or serum on proliferation and on expression level of Id-1, which generally stimulates cell proliferation and inhibits differentiation." provenance.
- _5 value "PP1� expression is upregulated (3.1�0.6-fold versus control) in heart of RTEF-1 mice by Western blot analysis. " provenance.
- _3 value "Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts Galectin-3, a macrophage-derived mediator" provenance.
- _3 value "Table 1 Rosiglitazone-induced mitochondrial gene expression in ob/ob mouse adipocytes" provenance.
- _3 value "Table 1 Rosiglitazone-induced mitochondrial gene expression in ob/ob mouse adipocytes" provenance.
- _3 value "Table 1 Rosiglitazone-induced mitochondrial gene expression in ob/ob mouse adipocytes" provenance.
- _4 value "BACKGROUND AND AIMS: The farnesoid X receptor (FXR) is an endogenous sensor for bile acids and inhibits bile acid synthesis by inducing small heterodimer partner (SHP) gene expression. The aim of this study was to investigate whether FXR is expressed by and modulates function of hepatic stellate cells (HSCs). METHODS: The antifibrotic activity of FXR ligand was tested in 2 rodent models: the porcine serum and bile duct ligation (BDL). RESULTS: Twelve-week administration of 1-10 mg/kg 6-ethyl chenodeoxycholic acid (6-ECDCA), a synthetic FXR ligand, to porcine serum-treated rats prevented liver fibrosis development and reduced liver expression of alpha1(I) collagen, TGF-beta1 and alpha-SMA mRNA by approximately 90%. Therapeutic administration of 6-ECDCA, 3 mg/kg, to BDL rats reduced liver fibrosis and alpha1(I) collagen, transforming growth factor (TGF)-beta1, alpha-SMA, and tissue metalloproteinase inhibitor (TIMP)-1 and 2 messenger RNA (mRNA) by 70%-80%. No protection was observed in BDL rats treated with CDCA, 3 mg/kg, and ursodeoxycholic acid, 15 mg/kg. FXR expression was detected in HSCs. Exposure of HSCs to FXR ligands caused a 3-fold increase of SHP, reduced alpha1(I)collagen and TGF-beta1 by approximately 60%-70% and abrogates alpha1(I) collagen mRNA up-regulation induced by thrombin and TGF-beta1. By retrovirus infection and small interference RNA, we generated SHP overexpressing and SHP-deficient HSC-T6. Using these cell lines, we demonstrated that SHP binds JunD and inhibits DNA binding of adaptor protein (AP)-1 induced by thrombin. CONCLUSIONS: By demonstrating that an FXR-SHP regulatory cascade promotes resolution of liver fibrosis, this study establish that FXR ligands might represent a novel therapeutic option to treat liver fibrosis." provenance.
- _2 value "Hydrophobic bile acids induce CD95 (Fas, APO-1)-dependent hepatocyte apoptosis, which involves epidermal growth factor receptor (EGFR)-catalyzed CD95 tyrosine phosphorylation. The mechanisms underlying bile salt-induced EGFR activation remain unclear. METHODS: Bile acid-induced EGFR activation was studied in 24-hour cultured rat hepatocytes and perfused rat liver. " provenance.
- _6 value "Here we show that CD43 engagement led to the membrane translocation and enzymatic activity of specific PKC isoenzymes: cPKC (alpha/beta), nPKC (epsilon and theta;), aPKC (zeta) and PKCmu." provenance.
- _6 value "Here we show that CD43 engagement led to the membrane translocation and enzymatic activity of specific PKC isoenzymes: cPKC (alpha/beta), nPKC (epsilon and theta;), aPKC (zeta) and PKCmu." provenance.
- _4 value "Constitutive HOXB6 expression blocks myeloid differentiation" provenance.
- _6 value "Furthermore, acute and long-term pretreatment of ECs with thrombin or PAR1 peptide agonist suppressed the TGF-beta-induced serine phosphorylation of Smad2, a critical mediator of TGF-beta signaling. Moreover, activation of PAR1 led to a profound and spread cytosolic clustering formation of Smad2/3 and markedly prevented Smad2/3 nuclear translocation evoked by TGF-beta1." provenance.
- _9 value "We showed that thrombin via PAR1 induced the internalization of endoglin and type-II TGF-beta receptor (TbetaRII) but not type-I receptors in human ECs." provenance.
- _6 value "We showed that thrombin via PAR1 induced the internalization of endoglin and type-II TGF-beta receptor (TbetaRII) but not type-I receptors in human ECs." provenance.
- _3 value "Tables 2-8 - effects of dihydrotestosterone on gene expression in adipose tissue" provenance.
- _3 value "Tables 2-8 - effects of dihydrotestosterone on gene expression in adipose tissue" provenance.
- _3 value "Tables 2-8 - effects of dihydrotestosterone on gene expression in adipose tissue" provenance.
- _3 value "Tables 2-8 - effects of dihydrotestosterone on gene expression in adipose tissue" provenance.
- _3 value "Tables 2-8 - effects of dihydrotestosterone on gene expression in adipose tissue" provenance.
- _3 value "Tables 2-8 - effects of dihydrotestosterone on gene expression in adipose tissue" provenance.
- _3 value "Tables 2-8 - effects of dihydrotestosterone on gene expression in adipose tissue" provenance.
- _3 value "Tables 2-8 - effects of dihydrotestosterone on gene expression in adipose tissue" provenance.
- _3 value "Tables 2-8 - effects of dihydrotestosterone on gene expression in adipose tissue" provenance.
- _3 value "Tables 2-8 - effects of dihydrotestosterone on gene expression in adipose tissue" provenance.
- _3 value "Tables 2-8 - effects of dihydrotestosterone on gene expression in adipose tissue" provenance.
- _3 value "Tables 2-8 - effects of dihydrotestosterone on gene expression in adipose tissue" provenance.
- _3 value "Tables 2-8 - effects of dihydrotestosterone on gene expression in adipose tissue" provenance.
- _3 value "Tables 2-8 - effects of dihydrotestosterone on gene expression in adipose tissue" provenance.
- _3 value "Tables 2-8 - effects of dihydrotestosterone on gene expression in adipose tissue" provenance.
- _3 value "Tables 2-8 - effects of dihydrotestosterone on gene expression in adipose tissue" provenance.
- _3 value "Tables 2-8 - effects of dihydrotestosterone on gene expression in adipose tissue" provenance.
- _3 value "Tables 2-8 - effects of dihydrotestosterone on gene expression in adipose tissue" provenance.
- _3 value "Tables 2-8 - effects of dihydrotestosterone on gene expression in adipose tissue" provenance.
- _3 value "Tables 2-8 - effects of dihydrotestosterone on gene expression in adipose tissue" provenance.
- _3 value "Tables 2-8 - effects of dihydrotestosterone on gene expression in adipose tissue" provenance.
- _3 value "Tables 2-8 - effects of dihydrotestosterone on gene expression in adipose tissue" provenance.
- _3 value "Tables 2-8 - effects of dihydrotestosterone on gene expression in adipose tissue" provenance.
- _3 value "Tables 2-8 - effects of dihydrotestosterone on gene expression in adipose tissue" provenance.
- _3 value "Tables 2-8 - effects of dihydrotestosterone on gene expression in adipose tissue" provenance.
- _3 value "Tables 2-8 - effects of dihydrotestosterone on gene expression in adipose tissue" provenance.
- _3 value "Tables 2-8 - effects of dihydrotestosterone on gene expression in adipose tissue" provenance.
- _3 value "Tables 2-8 - effects of dihydrotestosterone on gene expression in adipose tissue" provenance.
- _3 value "Tables 2-8 - effects of dihydrotestosterone on gene expression in adipose tissue" provenance.
- _3 value "Tables 2-8 - effects of dihydrotestosterone on gene expression in adipose tissue" provenance.
- _3 value "Tables 2-8 - effects of dihydrotestosterone on gene expression in adipose tissue" provenance.
- _2 value "The present results provide global genomic evidence for a stimulation of glycolysis, fatty acids and triacylglycerol production, lipolysis and cell shape reorganization, as well as cell proliferation and differentiation, by DHT." provenance.
- _3 value "transcripts involved in adipogenesis, and cell cycle and cell shape organization, such as DDX5, C/EBPalpha, cyclin I, procollagen types I, III, IV, V and VI, SPARC and matrix metalloproteinase 2, were upregulated by DHT." provenance.
- _3 value "transcripts involved in adipogenesis, and cell cycle and cell shape organization, such as DDX5, C/EBPalpha, cyclin I, procollagen types I, III, IV, V and VI, SPARC and matrix metalloproteinase 2, were upregulated by DHT." provenance.
- _3 value "transcripts involved in adipogenesis, and cell cycle and cell shape organization, such as DDX5, C/EBPalpha, cyclin I, procollagen types I, III, IV, V and VI, SPARC and matrix metalloproteinase 2, were upregulated by DHT." provenance.
- _3 value "transcripts involved in adipogenesis, and cell cycle and cell shape organization, such as DDX5, C/EBPalpha, cyclin I, procollagen types I, III, IV, V and VI, SPARC and matrix metalloproteinase 2, were upregulated by DHT." provenance.
- _5 value "from full text - IEC-18 cells were stimulated with Ang II or EGF. These stimuli promoted a marked increase in ERK phosphorylation but with different kinetics (Fig. 5A)." provenance.
- _6 value "Furthermore, mutation of S741 and S746, the two serine sites involved in negative regulation by PKC, led to increased mitogenic response and increased activation of PI3-kinase, as well as enhanced Akt activation, Bad phosphorylation and survival" provenance.
- _7 value "The adapter protein Grb2 can directly associate with phosphorylated Y703 and Y936 in c-Kit" provenance.
- _9 value "Other functions associated with Fc receptor-mediated phagocytosis, such as the activation of NADPH-oxidase, were not affected in Gsn-/- mice [55]. An impairment of complement- opsonized phagocytosis was observed in capG/Gsn double-null mice, providing evidence for distinctive and non-overlapping functions of capG and gelsolin in phagocytic processes [50]. Finally, binding and internalization of collagen beads, a process dependent on a2 b1 integrin [53], was also shown to be affected in Gsn-/- fibroblasts [56]." provenance.
- _4 value "Surprisingly, despite the lack of severing activity, capG overexpression also increased fibroblast motility [42]. Gelsolin has also been shown to regulate hematopoietic stem cell motility. Lin-Sca+Kit+ and Lin-Sca+Kit-, are two hematopoietic stem cell populations which show different basal and induced motility capacity. Indeed, they exhibit differential cell motility in response to stromal derived factor 1 (SDF-1), a chemokine influencing cell motility through phosphatidylinositol signaling. Lin-Sca+Kit+ cells, which are more primitive than Lin-Sca+Kit- cells, exhibit a lower response in terms of cell motility, although the activation of the phosphatidylinositol pathway was activated at the same level in the two populations. Proteomics analysis documented a lower expression of gelsolin and adseverin in Lin-Sca+Kit+ than in Lin-Sca+Kit-, providing an explanation for this differential response to SDF-1 [43]. CapG, which lacks severing activity, has also been shown to be involved in regulation of cellular motility in fibroblastic cells [42]. More recently, we were able to demonstrate that capG is also an important regulator of motility function in endothelial cells [29]. Endothelial cells are able to discriminate between different combinations of mechanical forces. In vivo, this capability results in a focalization of vascular areas subjected to atherosclerotic plaque development [44-46]. Indeed, plaques develop at bifurcations and curvatures which are exposed to a particular pattern of blood flow, with a low mean shear stress value and cyclic reversal of flow direction, which is in contrast with the unidirectional pattern of flow characterizing vascular areas protected against plaque development. In response to a plaque-free hemodynamic environment, capG expression and consequently endothelial motility are increased [29], resulting in a faster wound healing process [47], as compared to endothelial cells exposed to plaque-prone conditions. In vivo evidence for gelsolin involvement in cell motility was provided by gelsolin null mice (Gsn-/-), in which motility of osteoclasts was decreased [48]. In these mice, osteoclasts were unable to form cell adhesion structures (podosomes), and therefore their basal as well as their osteopontin- induced motility was affected. Analysis of these mice identified an additional role of gelsolin in the regulation of neuronal growth, cone formation and retraction [49]. Neuronal growth cones are highly motile structures from which lamellipodia and filopodia form and retract. Formation of these structures is a Ca2+-controlled process dependent on actin cytoskeleton remodeling. In Gsn-/- mice, only retraction processes appeared to be delayed, as compared to wild-type mice, suggesting that retraction is solely dependent on the presence of gelsolin," provenance.
- _5 value "Phosphorylation of MDM2 by the protein kinase AKT is thought to regulate MDM2 function in response to survival signals PMID: 11715018" provenance.