Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _3 value "\"Differential gene expression modulated by the cytoplasmic domain of Fc gamma RIa (CD64) alpha-chain.\" Expression of M-CSF, MIC-1, and LSP1 was greater after stimulation of WT-Fc{gamma}RI relative to the TL-Fc{gamma}RI, while expression of MIP-2 and IL-1Ra were lower after stimulation of WT-Fc{gamma}RI relative to the TL-Fc{gamma}RI (Table II)." provenance.
- _5 value "\"Differential gene expression modulated by the cytoplasmic domain of Fc gamma RIa (CD64) alpha-chain.\" Expression of M-CSF, MIC-1, and LSP1 was greater after stimulation of WT-Fc{gamma}RI relative to the TL-Fc{gamma}RI, while expression of MIP-2 and IL-1Ra were lower after stimulation of WT-Fc{gamma}RI relative to the TL-Fc{gamma}RI (Table II)." provenance.
- _5 value "\"Differential gene expression modulated by the cytoplasmic domain of Fc gamma RIa (CD64) alpha-chain.\" Expression of M-CSF, MIC-1, and LSP1 was greater after stimulation of WT-Fc{gamma}RI relative to the TL-Fc{gamma}RI, while expression of MIP-2 and IL-1Ra were lower after stimulation of WT-Fc{gamma}RI relative to the TL-Fc{gamma}RI (Table II)." provenance.
- _3 value "Moreover, because metformin has protective effects on nondiabetic beta-cells exposed to high glucose or free fatty acid levels, we investigated its direct action on T2D islet cells. Diabetic islets were characterized by reduced insulin content, decreased amount of mature insulin granules, impaired glucose-induced insulin secretion, reduced insulin mRNA expression, and increased apoptosis with enhanced caspase-3 and -8 activity. These alterations were associated with increased oxidative stress, as shown by higher nitrotyrosine concentrations, increased expression of protein kinase C-beta2 and nicotinamide adenine dinucleotide phosphate reduced-oxidase," provenance.
- _4 value "Moreover, because metformin has protective effects on nondiabetic beta-cells exposed to high glucose or free fatty acid levels, we investigated its direct action on T2D islet cells. Diabetic islets were characterized by reduced insulin content, decreased amount of mature insulin granules, impaired glucose-induced insulin secretion, reduced insulin mRNA expression, and increased apoptosis with enhanced caspase-3 and -8 activity. These alterations were associated with increased oxidative stress, as shown by higher nitrotyrosine concentrations, increased expression of protein kinase C-beta2 and nicotinamide adenine dinucleotide phosphate reduced-oxidase," provenance.
- _3 value "Twenty-four-hour incubation of T2D islets with metformin was associated with increased insulin content, increased number and density of mature insulin granules, improved glucose-induced insulin release, and increased insulin mRNA expression. Moreover, apoptosis was reduced, with concomitant decrease of caspase-3 and -8 activity. These changes were accompanied by reduction or normalization of several markers of oxidative stress. Thus, T2D islets have several functional and survival defects, which can be ameliorated by metformin; the beneficial effects of the drug are mediated, at least in part, by a reduction of oxidative stress." provenance.
- _6 value "These studies therefore identify Akt2 as a critical kinase that regulates ezrin phosphorylation and activation." provenance.
- _5 value "in intestinal absorptive epithelia Purified Akt directly phosphorylates recombinant ezrin at threonine 567" provenance.
- _4 value "An additional gelatinase with a molecular weight of approximately 82 kD, representing the active form of MMP9, was observed in acrolein- or H2O2-treated samples, which was absent in the control samples (Figure 6A).....Western blots demonstrated protein levels of pro- MMP9 (92 kD) and MMP9 (82 kD) in the conditioned medium increased following acrolein or H2O2 treatment as compared with the PBS-treated (control) samples (Figure 6C)." provenance.
- _4 value "Multiple agents, including cigarette smoke (15), activated eosinophils (16), interleukin-13 (17), neutrophil elastase (18), Pseudomonas aeruginosa (19), and phorbol 12-myristate 13- acetate (PMA) (20) increase MUC5AC in airway epithelial cells (NCI-H292)..." provenance.
- _3 value "Multiple agents, including cigarette smoke (15), activated eosinophils (16), interleukin-13 (17), neutrophil elastase (18), Pseudomonas aeruginosa (19), and phorbol 12-myristate 13- acetate (PMA) (20) increase MUC5AC in airway epithelial cells (NCI-H292)..." provenance.
- _4 value "Phosphorylation on Chk1(Ser-345), Chk2(Thr-68), and p53(Ser-15)following oxidative damage by IR involved both ATM and ATR. phosphorylation on Chk1, Chk2, and p53 was found to be ATM-dependent, whereas ATR also contributed to Chk1 phosphorylation ... from full text, A549 cells" provenance.
- _3 value "frequent promoter region hypermethylation and transcriptional silencing of SLIT2 in lung, breast, colorectal and glioma cell lines and primary tumours." provenance.
- _4 value "IL6 induces phosphorylation of STAT3 on Tyr705 and activates STAT3." provenance.
- _4 value "ROS levels in 3T3-L1 adipocytes can be reduced significantly with pharmacological agents that lower the mitochondrial membrane potential, or by overexpression of uncoupling protein 1 or superoxide dismutase. In parallel with ROS, interleukin-6 secretion from adipocytes is significantly reduced." provenance.
- _8 value "Furthermore, co-transfection experiments showed the ability of Nkx2-5 and GATA4 to transactivate the minimal Cx40 promoter while Tbx5 repressed Nkx2-5/GATA4-mediated activation. " provenance.
- _5 value "The male GH pulse-activated transcription factor STAT5b" provenance.
- _5 value "UTI (50,000 U/kg i.v.) inhibited LPS (5 mg/kg i.v.)-induced increases in lung tissue levels of Egr-1, TNF-alpha mRNA, and TNF-alpha in rats." provenance.
- _3 value "pharmacological doses of testosterone simultaneously down-regulated the level of OAT protein and up-regulated the expression of arginase II and ODC genes" provenance.
- _3 value "Fatty acid synthase, malic enzyme, ATP citrate lyase, insulin-sensitive glucose transporter, and glucose-6-phosphate dehydrogenase mRNA levels were coordinately reduced (by up to 50-fold) during fasting in RP and in SC relative to fed rats." provenance.
- _5 value "the COUP-TFII promoter activity is indeed regulated by Ets-1 Ets-1 to enhance the COUP-TFII promoter activity. Furthermore, other members of the ETS family such as Ets-2 or ETV1 are also potent regulators of the COUP-TFII promoter." provenance.
- _4 value "IL-6 infusion resulted in muscle atrophy characterized by a preferential loss of myofibrillar protein (-17%). IL-6 induced a decrease in the phosphorylation of ribosomal S6 kinase (-60%) and STAT5 (-33%), whereas that of STAT3 was increased approximately twofold." provenance.
- _4 value "IL-6 infusion resulted in muscle atrophy characterized by a preferential loss of myofibrillar protein (-17%). IL-6 induced a decrease in the phosphorylation of ribosomal S6 kinase (-60%) and STAT5 (-33%), whereas that of STAT3 was increased approximately twofold." provenance.
- _7 value "IL-6 infusion resulted in muscle atrophy characterized by a preferential loss of myofibrillar protein (-17%). IL-6 induced a decrease in the phosphorylation of ribosomal S6 kinase (-60%) and STAT5 (-33%), whereas that of STAT3 was increased approximately twofold." provenance.
- _4 value "The total amount of STAT5 protein was significantly increased in the IL6 infused muscles (Contra: 455 49 mg vs. IL-6: 651 54 mg)." provenance.
- _3 value "We have recently demonstrated that increased S6K1 phosphorylation is induced by IGF-I infusion and is associated with the development of skeletal muscle hypertrophy (28)." provenance.
- _5 value "Overexpression of GRK2 promoted H1HR phosphorylation in intact HEK293 cells and completely inhibited inositol phosphate production stimulated by H1HR" provenance.
- _6 value "Overexpression of GRK2 promoted H1HR phosphorylation in intact HEK293 cells and completely inhibited inositol phosphate production stimulated by H1HR" provenance.
- _3 value "Suppression of VRK1 expression by specific small interfering RNA provokes several defects in proliferation, situating the protein in the regulation of this process." provenance.
- _4 value "In contrast to Sox7, exogenous expression of Gata-4 or Gata-6 induced the expression of laminin alpha1 and Hnf1b in undifferentiated F9 and F9H1Sox7 cells without RA/Bt2cAMP treatment (Fig. 5 and 6 )." provenance.
- _4 value "we determined whether the oxidative stress that occurs in response to T. cruzi infection contributes to the catalytic impairment of respiratory complexes and to subsequent mitochondrial dysfunction in murine myocardium. Our data show that oxidative injuries, as determined by the levels of lipid peroxides and protein carbonyls, are incurred in cardiac mitochondria as early as 3 days postinfection and persist throughout the infection and disease. We observed substantial carbonylation of the specific subunits of mitochondrial respiratory complexes in infected murine hearts. Of note is the oxidative modification of NDUFS1, NDUFS2, and NDUFV1, which form the catalytic core of the CI complex; UQCRC1, UQCRC2, and UQCRQ, the subunits of the core subcomplex, and UQCRH and CYC1, which form the cyt c(1) subcomplex of CIII; and a gamma chain that is essential for ATP synthesis by CV complex. The extent of oxidative modifications of the subunits correlated with the catalytic defects of the respiratory complexes in the infected myocardium. Taken together, our data demonstrate that respiratory complexes are oxidatively damaged in response to the stress of T. cruzi infection. These data also suggest involvement of the specific susceptibility of the protein subunits, and not generalized mitochondrial oxidative damage in respiratory chain impairment of chagasic hearts." provenance.
- _4 value "Increased expression of the NF-kB target genes GADD45? (De Smaele et al. 2001; Papa et al. 2004) and XIAP (Tang et al. 2001) has been implicated in this process and it appears that NF-kB functions to suppress the TNF-stimulated ROS production that causes sustained JNK activation (Sakon et al. 2003)." provenance.
- _4 value "Wild-type and Jnk1-/- Jnk2-/- (Jnk-/-) fibroblasts....Furthermore, TNF-stimulated NF-kB DNA binding activity was detected in nuclear extracts prepared from wild-type and Jnk-/- fibroblasts, but not from wild-type (N-IkBa) or Jnk-/- (N-IkBa) fibroblasts," provenance.
- _3 value "It (Apoc3) is predominantly produced in liver, and its hepatic expression is inhibited by insulin" provenance.
- _3 value "We performed microarray-based expression profiling on livers 0-40 h post-hepatectomy corresponding to G0, G1, and S phases. # supplemental data table" provenance.
- _3 value "We performed microarray-based expression profiling on livers 0-40 h post-hepatectomy corresponding to G0, G1, and S phases. # supplemental data table" provenance.
- _3 value "We performed microarray-based expression profiling on livers 0-40 h post-hepatectomy corresponding to G0, G1, and S phases. # supplemental data table" provenance.
- _3 value "We performed microarray-based expression profiling on livers 0-40 h post-hepatectomy corresponding to G0, G1, and S phases. # supplemental data table" provenance.
- _3 value "We performed microarray-based expression profiling on livers 0-40 h post-hepatectomy corresponding to G0, G1, and S phases. # supplemental data table" provenance.
- _5 value "Interestingly, ER stress stimulated SMC apoptosis, as demonstrated by annexin V binding, caspase-3 activation, and DNA laddering. The induction of apoptosis by ER stress was potentiated by HO inhibition, whereas it was prevented by addition of HO substrate." provenance.
- _4 value "The induction of HO-1 by ER stress was blocked by actinomycin D or cycloheximide and was independent of any changes in HO-1 mRNA stability." provenance.
- _3 value "endoplasmic reticulum (ER) stress induced by a variety of experimental agents stimulated a time- and concentration-dependent increase in HO-1 mRNA and protein in vascular smooth muscle cells (SMC)." provenance.
- _4 value "In cells, ARAP3 was tyrosine phosphorylated when co-expressed with Src-family kinases (SFKs), upon stimulation with growth factors and during adhesion to the extracellular matrix (ECM) substrate fibronectin." provenance.
- _5 value "These SNPs overlap a TTF-1 binding site and TTF-1-activated RET transcription is also decreased by the HSCR-associated SNPs." provenance.
- _3 value "Here we describe the expression and functional characterization of Bv8 in peripheral blood cells, notably monocytes, neutrophils, and dendritic cells, and in the bone marrow. In response to LPS for 3 hours, human monocytes upregulate Prokr1 and prokr2. Mgration is also increased with prok in a ptx sensitive manner" provenance.
- _3 value "In the rat corneal micropocket assay, BRAK was a potent inhibitor of in vivo angiogenesis stimulated by multiple angiogenic factors, including interleukin 8, basic fibroblast growth factor, and vascular endothelial growth factor. In vitro, rBRAK blocked endothelial cell chemotaxis at concentrations as low as 1 nmol/L, suggesting this was a major mechanism for angiogenesis inhibition" provenance.
- _5 value "From mutations file" provenance.
- _4 value "Varying the concentration of ATP (0.1-1 mM) also enhanced this interaction, suggesting that autophosphorylation of CKBB is taking place." provenance.
- _5 value "Mutation of a consensus p38 MAP kinase target site at serine 165 decreased PAK6 kinase activity. Moreover, PAK6 was directly activated by MKK6, and mutation of tyrosine 566 in a consensus MKK6 site (threonine-proline-tyrosine, TPY) in the activation loop of the PAK6 kinase domain prevented activation by MKK6." provenance.
- _6 value "PAK4 and PAK5 were similarly activated by MKK6, consistent with a conserved TPY motif in their activation domains." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _4 value "\"Critical regulation of genes for tumor cell migration by AP-1.\" Strikingly, at low levels GFP-aFos, but not GFP-TAM67, caused a change in colony morphology, impairment of directional motility in a monolayer wound healing assay, as well as inhibition of chemotaxis and haptotaxis. Microarray analysis identified a novel set of AP-1 target genes, including the tumor suppressor TSCL-1 and regulators of actin cytoskeletal dynamics, including the gelsolin-like actin capping protein CapG." provenance.
- _4 value "Gene 33 inhibits EGFR autophosphorylation and specifically blunts epidermal growth factor (EGF)-induced activation and/or phosphorylation of Ras, ERK, JNK, Akt/PKB, and retinoblastoma protein." provenance.
- _5 value "Gene 33 inhibits EGFR autophosphorylation and specifically blunts epidermal growth factor (EGF)-induced activation and/or phosphorylation of Ras, ERK, JNK, Akt/PKB, and retinoblastoma protein." provenance.
- _7 value "Gene 33 inhibits EGFR autophosphorylation and specifically blunts epidermal growth factor (EGF)-induced activation and/or phosphorylation of Ras, ERK, JNK, Akt/PKB, and retinoblastoma protein." provenance.
- _5 value "The endogenous Gene 33 polypeptide is induced by EGF, platelet-derived growth factor, serum, and dexamethasone (Dex) in Rat 2 rat fibroblasts" provenance.
- _2 value "Intracellular ROS production was increased 1.5-fold by high glucose incubation when compared with normal glucose (Fig. 4, A andB), which was reduced to a basal level with coincubation with NAC (Fig. 4A)." provenance.
- _3 value "The in vivo experiments demonstrated that peritoneal macrophages from streptozotocin-induced diabetic mice increased SR-A expression when compared with those from nondiabetic mice" provenance.
- _3 value "These in vitro and in vivo results probably suggest that reactive oxygen species generated from a protein kinase C-dependent NAD(P)H oxidase pathway plays a role in the high glucose-induced up-regulation of SR-A, leading to the increased endocytic degradation of modified LDL for foam cell formation." provenance.
- _4 value "Our results demonstrated that levels of Fli-1 protein, but not RNA, were higher in extracts from cells treated with G-CSF." provenance.
- _5 value "Furthermore, we found that melanoma cell integrin alphav was required for MAPK kinase (MEK) 1 and extracellular signal-regulated kinase (ERK)1/2 activity in 3D-collagen" provenance.
- _5 value "We found that integrin alphav inactivated p53" provenance.
- _3 value "AP-1 is involved in glucose- (25) and UTP-mediated (15) OPN induction" provenance.
- _4 value "NFkappaB and USF-1-USF-2 are involved in the UTP-mediated expression of OPN" provenance.
- _6 value "USF proteins are regulated by the extracellular signal-regulated kinase (ERK)1/2 pathway, just as the earlier discovered AP-1 complex, whereas NFkappaB is up-regulated through PKCdelta signals." provenance.
- _5 value "USF proteins are regulated by the extracellular signal-regulated kinase (ERK)1/2 pathway, just as the earlier discovered AP-1 complex, whereas NFkappaB is up-regulated through PKCdelta signals." provenance.
- _3 value "TABLE 3. Gene Expression Prediction Profile [changed in ischemic cardiomyopathy vs. non-ischemic] upregulated" provenance.
- _3 value "TABLE 3. Gene Expression Prediction Profile [changed in ischemic cardiomyopathy vs. non-ischemic] upregulated" provenance.
- _3 value "TABLE 3. Gene Expression Prediction Profile [changed in ischemic cardiomyopathy vs. non-ischemic] upregulated" provenance.
- _3 value "TABLE 3. Gene Expression Prediction Profile [changed in ischemic cardiomyopathy vs. non-ischemic] upregulated" provenance.
- _3 value "TABLE 3. Gene Expression Prediction Profile [changed in ischemic cardiomyopathy vs. non-ischemic] upregulated" provenance.
- _3 value "TABLE 3. Gene Expression Prediction Profile [changed in ischemic cardiomyopathy vs. non-ischemic] upregulated" provenance.
- _3 value "TABLE 3. Gene Expression Prediction Profile [changed in ischemic cardiomyopathy vs. non-ischemic] upregulated" provenance.
- _3 value "TABLE 3. Gene Expression Prediction Profile [changed in ischemic cardiomyopathy vs. non-ischemic] upregulated" provenance.
- _3 value "down" provenance.
- _3 value "down" provenance.
- _3 value "down" provenance.
- _3 value "down" provenance.
- _3 value "down" provenance.
- _3 value "From full text Table 1. by Simon Dao " provenance.
- _5 value "ARA55 interacts with the MH2 domain of Smad3 and suppresses CA-Smad3-induced transcriptional responses" provenance.
- _4 value "Lack of SCD1 function significantly increases insulin sensitivity in skeletal muscles and corrects the hypometabolic phenotype of leptin-deficient ob/ob mice," provenance.
- _2 value "E2 can indirectly affect - by inducing the lipolytic enzyme hormone-sensitive lipase (31) or by increasing the lipolytic effects of epinephrine (32)." provenance.
- _2 value "Fatty acid-b oxidation might also be increased, which might contribute to the decrease in adipose tissue deposition induced by E2 (33)." provenance.
- _4 value "Fatty acid-b oxidation might also be increased, which might contribute to the decrease in adipose tissue deposition induced by E2 (33)." provenance.
- _4 value "In response to strain, Erk is activated and mediates extracellular matrix accumulation and mesangial cell proliferation." provenance.
- _7 value "Either mouse p19(ARF) or human p14(ARF) binds to BCL6 and downregulates BCL6-induced transcriptional repression.ARF-mediated downregulation of the BCL6 activity may account in part for ARF-mediated tumor suppression." provenance.
- _6 value "Fig.1" provenance.
- _6 value "Fig.1" provenance.
- _6 value "Fig.1" provenance.
- _6 value "Fig.1" provenance.
- _5 value "Fig.1" provenance.
- _6 value "Fig.1" provenance.
- _5 value "In the present study, we show that, in addition to being phosphorylated on Thr-581 and Ser-360 by ERK1/2 or p38," provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _6 value "These observations suggest that IH induces HIF-1 transcriptional activity via a novel signaling pathway involving CaM kinase" provenance.
- _3 value "Insulin stimulated phosphorylation of p42 MAP kinase was severely impaired in muscle from obese mice. Thus, insulin stimulated a 4-fold increase in lean muscle p42 MAP kinase phosphorylation versus no significant stimulation in muscle from obese mice." provenance.
- _4 value "GEP is an important factor for HCC growth, invasion, and metastasis. GEP has the potential to serve as a tumor marker and therapeutic target." provenance.
- _3 value "Further, we show that axin2 can repress Wnt signalling leading to reduced cell growth and increased cell death." provenance.