Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _5 value "CrkII overexpression enhanced the autophosphorylation of FAK at Tyr-397 and tyrosine phosphorylation of p130(Cas) (Crk-associated substrate, Cas) upon stimulation of integrin by fibronectin." provenance.
- _3 value "Activation of the inducible form of cyclooxygenase, COX-2, and of the interleukins IL-1, IL-6, and IL-8, as well as of the NF-kappaB pathway, was observed preferentially in cells in contact with bacterial supernatant." provenance.
- _3 value "Activation of the inducible form of cyclooxygenase, COX-2, and of the interleukins IL-1, IL-6, and IL-8, as well as of the NF-kappaB pathway, was observed preferentially in cells in contact with bacterial supernatant." provenance.
- _3 value "Activation of the inducible form of cyclooxygenase, COX-2, and of the interleukins IL-1, IL-6, and IL-8, as well as of the NF-kappaB pathway, was observed preferentially in cells in contact with bacterial supernatant." provenance.
- _3 value "Among others, Fos, Jun, and EGR-1 were upregulated by the bacterial supernatant and by live bacteria" provenance.
- _3 value "Early infection was characterized by an upregulation of anti-apoptotic genes and a downregulation of pro-apoptotic genes. This correlated with a necrotic, rather than apoptotic cell death." provenance.
- _3 value "Early infection was characterized by an upregulation of anti-apoptotic genes and a downregulation of pro-apoptotic genes. This correlated with a necrotic, rather than apoptotic cell death." provenance.
- _3 value "Early infection was characterized by an upregulation of anti-apoptotic genes and a downregulation of pro-apoptotic genes. This correlated with a necrotic, rather than apoptotic cell death." provenance.
- _3 value "Early infection was characterized by an upregulation of anti-apoptotic genes and a downregulation of pro-apoptotic genes. This correlated with a necrotic, rather than apoptotic cell death." provenance.
- _3 value "Increased expression of bhlhb2 and Mig-6, promoter regions which harbor HIF responding elements, was explained by an increased expression of the HIF-1alpha protein." provenance.
- _6 value "Figure 4. After TGF-B treatment, expression of TGF-BRI, Smad2, p-Smad2, p21, and p53 was further upregulated accompanying with downregulated expression of Cdk2 and Cdc2." provenance.
- _6 value "Figure 4. After TGF-B treatment, expression of TGF-BRI, Smad2, p-Smad2, p21, and p53 was further upregulated accompanying with downregulated expression of Cdk2 and Cdc2." provenance.
- _4 value "Figure 4. After TGF-B treatment, expression of TGF-BRI, Smad2, p-Smad2, p21, and p53 was further upregulated accompanying with downregulated expression of Cdk2 and Cdc2." provenance.
- _2 value "Fat accumulation correlated with systemic oxidative stress in humans and mice. Production of ROS increased selectively in adipose tissue of obese mice, accompanied by augmented expression of NADPH oxidase and decreased expression of antioxidative enzymes." provenance.
- _2 value "Fat accumulation correlated with systemic oxidative stress in humans and mice. Production of ROS increased selectively in adipose tissue of obese mice, accompanied by augmented expression of NADPH oxidase and decreased expression of antioxidative enzymes." provenance.
- _5 value "Finally, in obese mice, treatment with NADPH oxidase inhibitor reduced ROS production in adipose tissue, attenuated the dysregulation of adipocytokines, and improved diabetes, hyperlipidemia, and hepatic steatosis." provenance.
- _5 value "Finally, in obese mice, treatment with NADPH oxidase inhibitor reduced ROS production in adipose tissue, attenuated the dysregulation of adipocytokines, and improved diabetes, hyperlipidemia, and hepatic steatosis." provenance.
- _5 value "Finally, in obese mice, treatment with NADPH oxidase inhibitor reduced ROS production in adipose tissue, attenuated the dysregulation of adipocytokines, and improved diabetes, hyperlipidemia, and hepatic steatosis." provenance.
- _3 value "The mRNA expression levels of adiponectin and PPARg were diminished by incubation with H2O2 (Figure 6A) in a dose-dependent manner. In contrast, ROS increased the mRNA expression levels of PAI-1, IL-6, and monocyte chemotactic protein-1 (MCP-1) in 3T3-L1 adipocytes" provenance.
- _3 value "The mRNA expression levels of adiponectin and PPARg were diminished by incubation with H2O2 (Figure 6A) in a dose-dependent manner. In contrast, ROS increased the mRNA expression levels of PAI-1, IL-6, and monocyte chemotactic protein-1 (MCP-1) in 3T3-L1 adipocytes" provenance.
- _6 value "Additional studies demonstrate that the SH2 (Src homology 2)-domain-containing tyrosine phosphatase SHP2 co-immunoprecipitates with MEKK4 in an IFNgamma-dependent manner and co-localizes with MEKK4 after IFNgamma stimulation in the perinuclear region in HaCaT cells." provenance.
- _6 value "Furthermore, the calcium-binding protein, annexin II, and the calcium-regulated kinase, Pyk2, co-immunoprecipitate with MEKK4 after treatment with IFNgamma. " provenance.
- _6 value "Furthermore, the calcium-binding protein, annexin II, and the calcium-regulated kinase, Pyk2, co-immunoprecipitate with MEKK4 after treatment with IFNgamma. " provenance.
- _3 value "IL-1beta-induced PG depletion" provenance.
- _4 value "Cathepsin S (CTSS) is induced by IFNG in several cell types including smooth muscle cells. Overexpression of IFNG in mice induces emphysema with increased expression of cathepsins B, D, H, L and S." provenance.
- _4 value "Cathepsin S (CTSS) is induced by IFNG in several cell types including smooth muscle cells. Overexpression of IFNG in mice induces emphysema with increased expression of cathepsins B, D, H, L and S." provenance.
- _4 value "Figure 6. Macrophages in COPD. Activated macrophages secrete TGFA, TGFB1, MMP9, MMP12, Cathepsins K, L and S (CTSK, CTSL1, CTSS); IP-10 (Cxcl10), Mig (Cxcl9), ITAC (Cxcl11), MCP1 (Ccl2), GRO-alpha (Cxcl1), LTB4 (Leukotriene B4), IL8, NO and ROS" provenance.
- _4 value "Figure 6. Macrophages in COPD. Activated macrophages secrete TGFA, TGFB1, MMP9, MMP12, Cathepsins K, L and S (CTSK, CTSL1, CTSS); IP-10 (Cxcl10), Mig (Cxcl9), ITAC (Cxcl11), MCP1 (Ccl2), GRO-alpha (Cxcl1), LTB4 (Leukotriene B4), IL8, NO and ROS" provenance.
- _3 value "Figure 6. Macrophages in COPD. Activated macrophages secrete TGFA, TGFB1, MMP9, MMP12, Cathepsins K, L and S (CTSK, CTSL1, CTSS); IP-10 (Cxcl10), Mig (Cxcl9), ITAC (Cxcl11), MCP1 (Ccl2), GRO-alpha (Cxcl1), LTB4 (Leukotriene B4), IL8, NO and ROS" provenance.
- _2 value "Macrophages in COPD. Macrophages may play a pivotal role in COPD as they are activated by cigarette smoke extract and secrete many inflammatory proteins that may orchestrate the inflammatory process in COPD. Neutrophils may be attracted by IL-8, GRO-{alpha}, LTB4, MCP-1, and CD8+ lymphocytes by IP-10, Mig, and I-TAC. Release of elastolytic enzymes including MMPs and cathepsins causes elastolysis and release of TGF-{beta}1 and CTGF. Release of TGF-{alpha} activates EGFR, which stimulates mucus hypersecretion. Macrophages also generate ROS and NO, which together form peroxynitrite and may contribute to steroid resistance." provenance.
- _2 value "Macrophages in COPD. Macrophages may play a pivotal role in COPD as they are activated by cigarette smoke extract and secrete many inflammatory proteins that may orchestrate the inflammatory process in COPD. Neutrophils may be attracted by IL-8, GRO-{alpha}, LTB4, MCP-1, and CD8+ lymphocytes by IP-10, Mig, and I-TAC. Release of elastolytic enzymes including MMPs and cathepsins causes elastolysis and release of TGF-{beta}1 and CTGF. Release of TGF-{alpha} activates EGFR, which stimulates mucus hypersecretion. Macrophages also generate ROS and NO, which together form peroxynitrite and may contribute to steroid resistance." provenance.
- _3 value "ROS activate NF-{kappa}B in an epithelial cell line (Adcock et al., 1994Go) and increase the release of proinflammatory cytokines from cultured human airway epithelial cells (Rusznak et al., 1996Go). Oxidative stress results in activation of histone acetyltransferase activity, which opens up the chromatin structure and is associated with increased transcription of multiple inflammatory genes (Rahman, 2003Go; Tomita et al., 2003Go)" provenance.
- _5 value "TGF-{beta} is activated by MMP-9...TGF-{beta} causes small airway fibrosis and also activates MMP-9." provenance.
- _4 value "TGFbeta potently downregulates beta-2 adrenergic receptors by inhibiting gene transcription." provenance.
- _6 value "Inhibition of mTOR/S6K1 by rapamycin blunted insulin-induced Ser636/Ser639 phosphorylation of IRS-1, leading to a rapid (approximately 5 min) and persistent increase in IRS-1-associated phosphatidylinositol 3-kinase activity and Akt phosphorylation" provenance.
- _4 value "Time-course studies also revealed that mTOR and S6K1 activation by insulin was accelerated in tissues of obese rats" provenance.
- _7 value "visfatin binds to and activates the insulin receptor." provenance.
- _5 value "Knockdown of Foxo3a expression inhibited the starvation-induced increase in SIRT1 expression. Stimulation of SIRT1 transcription by Foxo3a was mediated through two p53 binding sites present in the SIRT1 promoter, and a nutrient-sensitive physical interaction was observed between Foxo3a and p53. SIRT1 expression was not induced in starved p53-deficient mice." provenance.
- _4 value "aldosterone induces CTGF expression via both p38 MAPK cascade and mineralocorticoid receptor and that cross-talk exists between the two pathways" provenance.
- _6 value "RhoA signaling regulates the activity of the transcription factor SRF (serum response factor) during muscle differentiation." provenance.
- _3 value "Exposure of lymphocytes to 10 nM insulin resulted in a 2-fold increase in rENT2 mRNA and a 50% decrease in the rCNT2 mRNA level." provenance.
- _5 value "Insulin-induced changes in expression level of rENT2 were blocked by wortmannin, an inhibitor of phosphatidylinositide 3-kinase, whereas the effect of insulin on rCNT2 was inhibited by PD98059 and to a lesser extend by wortmannin. PD98059, a MAPK kinase inhibitor." provenance.
- _5 value "TSC1 inhibits Rac1, and TSC2 blocks this activity of TSC1." provenance.
- _5 value "Activation of FGF receptors can activate multiple signal transduction pathways including the phospholipase Cgamma, phosphatidyl inositol 3-kinase, mitogen-activated protein kinase and signal transducers and activators of transcription (STAT) pathways" provenance.
- _6 value "These results indicate that continuous stretch-induced IL-6 secretion in HUVECs depends on outside-in signaling via integrins followed by a PI3-K-PLC-gamma-PKC-IKK-NF-kappaB signaling cascade." provenance.
- _5 value "Pharmacological intervention to inhibit phosphorylation of Foxa2 may be an effective treatment for type 2 diabetes." provenance.
- _5 value "Pharmacological intervention to inhibit phosphorylation of Foxa2 may be an effective treatment for type 2 diabetes." provenance.
- _5 value "Pharmacological intervention to inhibit phosphorylation of Foxa2 may be an effective treatment for type 2 diabetes." provenance.
- _5 value "Pharmacological intervention to inhibit phosphorylation of Foxa2 may be an effective treatment for type 2 diabetes." provenance.
- _5 value "Pharmacological intervention to inhibit phosphorylation of Foxa2 may be an effective treatment for type 2 diabetes." provenance.
- _5 value "Pharmacological intervention to inhibit phosphorylation of Foxa2 may be an effective treatment for type 2 diabetes." provenance.
- _5 value "Rb promotes differentiation of macrophages by opposing the inhibitory functions of Id2 on the transcription factor PU.1, a master regulator of macrophage differentiation." provenance.
- _6 value "5LO stabilizes p53 through phosphorylation at Ser15 and increases expression of the p53-transcriptional target p21. This is achieved by regulating ROS production. Indeed, ROS are increased in 5LO-arrested cells" provenance.
- _6 value "We then examined the levels of DNMT1 and methylated DNA-binding protein 2 (MBD2) expressions in these cells to determine whether this reduction in uPA expression is associated with changes in the DNA methylation machinery. Our results showed that ectopic expression of RAS induced DNMT1 expression and activity and inhibited MBD2 expression." provenance.
- _3 value "Table II. Changes in expression in liver determined by QRT-PCR after treatment for 2 weeks with different known carcinogens and non-carcinogens" provenance.
- _3 value "Table II. Changes in expression in liver determined by QRT-PCR after treatment for 2 weeks with different known carcinogens and non-carcinogens" provenance.
- _5 value "Ptc inhibits association of beta-arrestin 2 with Smo, and this inhibition is relieved in cells treated with Shh." provenance.
- _4 value "INTERPRETED FROM TEXT: Genes downregulated by stable sphingosine 1-phosphate knockdown in an angiosarcoma cell line using Affymetrix Human Genome U133A GeneChips." provenance.
- _4 value "INTERPRETED FROM TEXT: Genes downregulated by stable sphingosine 1-phosphate knockdown in an angiosarcoma cell line using Affymetrix Human Genome U133A GeneChips." provenance.
- _5 value "Similar to freshly isolated HUVECs that respond to proinflammatory stimuli by the transcriptional upregulation of cell adhesion molecules, both AS-M.5 (not shown) and AS-M.5-Silco cells responded to stimulation by tumor necrosis factor-{alpha} (TNF-{alpha}) (100 ng/mL, 6 hours) and lipopolysaccharide (LPS; 1 �g/mL, 6 hours) by a transient induction of transcription of E-selectin and intercellular adhesion molecule-1 (ICAM-1) on the cell surface (Figure 4c). " provenance.
- _4 value "Table II online. Stable knock-down of S1P1 leads to reduced expression of endothelial specific transcripts. The table lists transcripts characteristic for endothelial cells that were downregulated at least two-fold in S1P1-knock-down AS-M.5 cells, as detected by microarray analyses using 22,238 human gene probes. The values indicate signal intensities of two independent analyses for AS-M.5 and AS-M.5, T2, Sil#1, cl.3 and one analysis for AS-M.5, Silco and AS-M.5, T2, Sil#1, cl.2. Where appropriate (genes detected by several probes) values are given as mean (SEM). " provenance.
- _7 value "As expected from the findings in nonmalignant T cells, wt SOCS-3 was able to block IL-2-induced Stat5 phosphorylation (Figure 4b). " provenance.
- _3 value "Here we report that intraperitoneal injections of lipopolysaccharide in rats lead to a strong increase of LTC4S messenger RNA (mRNA) levels after approximately 1 h, particularly in the heart, brain, adrenal glands and liver," provenance.
- _3 value "RT-PCR at d 0 and 28. At d 28, SLC19A3 expression had decreased to 33% of d 0 (P < 0.02 by two-tailed, paired t test). Expression of MCCA, PCCA, PC, ACCA, ACCB, HCS, biotinidase, and SMVT decreased to approximately 80% of d 0 (P < 0.05)." provenance.
- _3 value "RT-PCR at d 0 and 28. At d 28, SLC19A3 expression had decreased to 33% of d 0 (P < 0.02 by two-tailed, paired t test). Expression of MCCA, PCCA, PC, ACCA, ACCB, HCS, biotinidase, and SMVT decreased to approximately 80% of d 0 (P < 0.05)." provenance.
- _3 value "RT-PCR at d 0 and 28. At d 28, SLC19A3 expression had decreased to 33% of d 0 (P < 0.02 by two-tailed, paired t test). Expression of MCCA, PCCA, PC, ACCA, ACCB, HCS, biotinidase, and SMVT decreased to approximately 80% of d 0 (P < 0.05)." provenance.
- _2 value "The extracellular matrix glycosaminoglycan hyaluronan (HA)1 is a large polymer of N-acetyl-D-glucosamine and D-glucuronic acid (molecular mass 105-107 Da) which plays an important role in maintaining tissue integrity as well as facilitating the migration of cells during inflammation, wound repair, and embryonic development (1, 2)." provenance.
- _3 value "It has been evident that either up-regulation of HSP-70i or down-regulation of iNOS can limit tissue injury caused by ischemia/reperfusion or hemorrhage/resuscitation. In our laboratory," provenance.
- _6 value "Modified assertion" provenance.
- _8 value "beta1 integrins play an important role in cell proliferation and in some cancers and we report here that CD98hc enhances beta1 activation of signaling pathways such as FAK, Rac and Akt" provenance.
- _6 value "beta1 integrins play an important role in cell proliferation and in some cancers and we report here that CD98hc enhances beta1 activation of signaling pathways such as FAK, Rac and Akt" provenance.
- _3 value "Fasting decreased, and refeeding restored, FAS and HKII mRNA and protein levels" provenance.
- _3 value "The TAUT activity, expression of TAUT and CDO mRNA were up-regulated by hypertonicity. In contrast, the TAUT activity, expression of TAUT and CDO mRNA were down-regulated by taurine-rich conditions" provenance.
- _4 value "The TAUT activity, expression of TAUT and CDO mRNA were up-regulated by hypertonicity. In contrast, the TAUT activity, expression of TAUT and CDO mRNA were down-regulated by taurine-rich conditions" provenance.
- _5 value "Foxa2 is an important regulator of the genes encoding Sur1, Kir6.2 and Schad" provenance.
- _4 value "We provide evidence for a role for RIP140 in mediating anti-estrogenic effects of RA. RIP140 small interfering RNA blocks RA-mediated repression of estrogen receptor activity" provenance.
- _6 value "We further demonstrate that active G alpha(q) or G alpha11, but not G alpha12 or G alpha13, strongly enhances p63RhoGEF-induced RhoA activation by direct protein-protein interaction with p63RhoGEF at its C-terminal half. Moreover, the activation of p63RhoGEF by G alpha(q/11) occurs independently of and in competition to the activation of the canonical G alpha(q/11) effector phospholipase C beta." provenance.
- _6 value "Herein, SIRT1 physically interacted with and repressed p300 transactivation, requiring the NAD-dependent deacetylase activity of SIRT1. SIRT1 repression involved the CRD1 transcriptional repression domain of p300. Two residues within the CRD1 domain (Lys-1020 and Lys-1024) were required for SIRT1 repression and served as substrates for SIRT1 deacetylation." provenance.
- _4 value "translocation of Bad from rafts to mitochondria, which correlates with apoptosis" provenance.
- _3 value "A single dose of antisense CK2alpha oligodeoxynucleotide given directly into the PC3-LN4 xenograft tumor in nude mouse induced a dose- and time-dependent tumor cell death in vivo." provenance.
- _5 value "(see introduction) STAT3 and STAT5 are strongly activated by type I IFNs" provenance.
- _5 value "(see introduction) STAT3 and STAT5 are strongly activated by type I IFNs" provenance.
- _3 value "IL-4 and IL-13 are prototypic Th2 cytokines that generate an \"alternatively activated\" phenotype in macrophages. " provenance.
- _4 value "IHA hypoxia improved postischemic contractile recovery, reduced the maximum extent of ischemic contracture, and attenuated I/R-induced depression in Ca(2+)-pump ATPase activity." provenance.
- _3 value "Ser(16) phosphorylation increased at I30 and 1 min of reperfusion (R1) but decreased at R30 in normoxic hearts." provenance.
- _3 value "Examples of genes whose expression was increased or decreased by E2 are provided in Tables 3 and 4, respectively. TABLE 3. Examples of genes up-regulated by E2" provenance.
- _3 value "Examples of genes whose expression was increased or decreased by E2 are provided in Tables 3 and 4, respectively. TABLE 3. Examples of genes up-regulated by E2" provenance.
- _3 value "Examples of genes whose expression was increased or decreased by E2 are provided in Tables 3 and 4, respectively. TABLE 3. Examples of genes up-regulated by E2" provenance.
- _3 value "Examples of genes whose expression was increased or decreased by E2 are provided in Tables 3 and 4, respectively. TABLE 3. Examples of genes up-regulated by E2" provenance.
- _3 value "Examples of genes whose expression was increased or decreased by E2 are provided in Tables 3 and 4, respectively. TABLE 3. Examples of genes up-regulated by E2" provenance.
- _3 value "Examples of genes whose expression was increased or decreased by E2 are provided in Tables 3 and 4, respectively. TABLE 3. Examples of genes up-regulated by E2" provenance.
- _3 value "Examples of genes whose expression was increased or decreased by E2 are provided in Tables 3 and 4, respectively. TABLE 3. Examples of genes up-regulated by E2" provenance.
- _3 value "Examples of genes whose expression was increased or decreased by E2 are provided in Tables 3 and 4, respectively. TABLE 3. Examples of genes up-regulated by E2" provenance.
- _3 value "Examples of genes whose expression was increased or decreased by E2 are provided in Tables 3 and 4, respectively. TABLE 3. Examples of genes up-regulated by E2" provenance.
- _3 value "Table 5. genes upregulated by estrogen in MCF-7 cells" provenance.
- _3 value "Table 6. genes downregulated by estrogen in MCF-7 cells" provenance.
- _3 value "Table 6. genes downregulated by estrogen in MCF-7 cells" provenance.
- _3 value "Table 6. genes downregulated by estrogen in MCF-7 cells" provenance.
- _2 value "SNP, GSNO and SNAP at � 100 mM inhibited the proliferation of human umbilical vein and coronary artery endothelial cells [83]." provenance.
- _2 value "SNP, GSNO and SNAP at � 100 mM inhibited the proliferation of human umbilical vein and coronary artery endothelial cells [83]." provenance.