Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _3 value "Using the estrogen receptor-negative, retinoid receptor-positive breast cancer cell line SKRB-3, we found that treatment with ATRA significantly decreased the expression of PKCalpha, as well as reducing ERK MAPK phosphorylation. ATRA treatment leads to dephosphorylation of Rb, and consequently to G(1) arrest" provenance.
- _6 value "ER expression alters the transcriptional regulation of PPARG - targeted gene expression and reduces both basal and stimulated PPARG-mediated reporter activity, suggesting a cross-talk between PPARG andERsignaling in breast cancer cells (89). Activation of PPARG by PGJ2 results in a significant inhibition of ErbB-2 and ErbB-3 tyrosine phosphorylation caused by neuregulin 1 (NRG1) and neuregulin 2 (NRG2) in MCF-7 cells (90)" provenance.
- _4 value "STATs are important regulators of breast development and carcinogenesis. Constitutively elevated STAT DNA-binding activity is seen in primary breast tumor specimens from patients with advanced disease compared to adjacent nontumor tissues Constitutively active STAT3 mediates oncogenic transformation in immortalized fi- broblasts and induces tumor formation in nude mice, suggesting a pivotal role of STAT3 in transformation (48) Berclaz et al. found a very strong correlation between nuclear STAT3 andEGFRexpression in breast cancers cells. ProstaglandinHsynthetases (composed of Cox- 1 and Cox-2 isoenzymes) convert arachidonic acid into prostaglandins that are further modified to produce important signal molecules Induced Cox-2 expression is seen in almost all tumor sites. It was shown over a decade ago that both PGE1 and PGE2 enhance mitogenesis in mammary epithelial cells stimulated with EGF (165,166). In Hs578T breast cancer cells, Cox-2 expression is related to digestion of basement membrane, resulting in cellular invasiveness (167). Cox-2 expression is seen in the majority of HER2-overexpressing breast cancers, and in a small fraction of HER2-negative breast cancers as well (164) Posttranslational farnesylation is required for Ras to function in the inner membrane surface, a process catalyzed by farnesyl transferase. Substrates for this enzyme include all four Ras proteins as well as other non-Ras proteins (e.g., RhoB) that have the amino acid CAAX motif where X represents methionine or serine A direct role of Raf in the development of human cancers is well documented in literature (161). In MCF-7 cells, Raf-1 and A-Raf are upregulated after treatment with (-) estradiol, but not in ER-negative cells. Overexpression of constitutively active Raf-1 causes cell cycle progression and results in an increased proliferative response to (-) estradiol (273). Raf-1 protein is overexpressed in the cytosol fraction of human breast cancer tissues but not in normal mammary gland tissue ( Geldanamycin, herbimycin A, 17-allylaminogeldanamycin (17-AAG), radicicol, KF25706, and KF58333 represent a class of compounds that bind to heat-shock protein-90 (Hsp90) (Table II). They destabilize Hsp90-associating proteins including Raf- 1, ErbB2, Akt, p53, v-Src, Bcr-Abl, HIF-1a, ER, PR, and glucocorticoid receptors (277). Hence, geldanamycin and its analogs are not specific for any one target. Geldanamycin causes destabilization of Raf- 1 and loss of Raf-1-Ras association, the Raf-MEKMAPK signaling pathway (278,279). Geldanamycin increases the recruitment of chaperone-interacting protein (CHIP), which is known to efficiently ubiquitinate and down-regulate ErbB2 in COS7 cells (280). KF58333, an oxime derivative of radicicol, is a potent growth inhibitor of high- and low-Her2 expressing breast cell lines (212). 17-AAG, a geldanamycin analog, has less toxicity than its predecessor and is able to downregulate Akt expression, inhibit PI3K and Akt activity, suppress cyclin D expression, and ultimately inhibit growth of HER2-overexpressing breast cancer It has been shown that Akt has antiapoptosis effect by phosphorylating Bad and other death proteins (285-287). Akt" provenance.
- _3 value "Hypoxia caused a twofold increase in XDH/XO enzymatic and promoter activity." provenance.
- _3 value "Modified assertion" provenance.
- _3 value "Atorvastatin therapy reduced both macrophage oxidative stress and cholesterol content, and upregulated PON2 expression" provenance.
- _2 value "Activin and ACTH but not BMP-6 increased cAMP production" provenance.
- _4 value "Ang II reduced the expression levels of BMP-6 but increased that of activin betaB" provenance.
- _4 value "title := \"Connective tissue growth factor is up-regulated in the diabetic retina: amelioration by angiotensin-converting enzyme inhibition.\" Diabetes was associated with a greater than 2-fold increase in CTGF mRNA levels, which was attenuated by perindopril treatment. CTGF immunoreactivity was increased almost 2-fold in diabetes and was ameliorated by the ACE inhibitor perindopril." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _5 value "FGF-2 stimulated Sp1 phosphorylation in an ERK1/2- but not p38-dependent manner, the growth factor enhancing Sp1 interaction with the PDGFR-alpha promoter. Mutation of residues Thr(453) and Thr(739) in Sp1 (amino acids phosphorylated by ERK) blocked FGF-2 repression of PDGFR-alpha transcription." provenance.
- _4 value "PDGFR-alpha transcription, mRNA, and protein expression were repressed in SMCs exposed to fibroblast growth factor-2 (FGF-2)" provenance.
- _6 value "The ability of CXCL12 to stimulate proliferation and survival is mediated by activation of the Erk 1/2 and phosphatidylinositol 3-kinase pathways in many cell types Taken together these data indicate that the ability of AMD 3100 to decrease tumor growth in animal models reflects direct inactivation of CXCR4 in tumor cells and consequent inhibition of Erk 1/2 and phosphatidylinositol 3-kinase pathways, resulting in increased tumor cell apoptosis and decreased proliferation." provenance.
- _5 value "The ability of CXCL12 to stimulate proliferation and survival is mediated by activation of the Erk 1/2 and phosphatidylinositol 3-kinase pathways in many cell types Taken together these data indicate that the ability of AMD 3100 to decrease tumor growth in animal models reflects direct inactivation of CXCR4 in tumor cells and consequent inhibition of Erk 1/2 and phosphatidylinositol 3-kinase pathways, resulting in increased tumor cell apoptosis and decreased proliferation." provenance.
- _4 value "Modified assertion" provenance.
- _5 value "From mutations file" provenance.
- _3 value "Modified assertion" provenance.
- _5 value "Figure 2 - Gene expression changes due to overexpression of HOXA9 in human hematopoietic cell lines ##BW## " provenance.
- _5 value "Figure 2 - Gene expression changes due to overexpression of HOXA9 in human hematopoietic cell lines ##BW## " provenance.
- _5 value "Figure 2 - Gene expression changes due to overexpression of HOXA9 in human hematopoietic cell lines ##BW## " provenance.
- _5 value "Figure 2 - Gene expression changes due to overexpression of HOXA9 in human hematopoietic cell lines ##BW## " provenance.
- _5 value "Figure 2 - Gene expression changes due to overexpression of HOXA9 in human hematopoietic cell lines ##BW## " provenance.
- _5 value "Figure 2 - Gene expression changes due to overexpression of HOXA9 in human hematopoietic cell lines ##BW## " provenance.
- _5 value "Figure 2 - Gene expression changes due to overexpression of HOXA9 in human hematopoietic cell lines ##BW## " provenance.
- _5 value "Figure 2 - Gene expression changes due to overexpression of HOXA9 in human hematopoietic cell lines ##BW## " provenance.
- _5 value "Figure 2 - Gene expression changes due to overexpression of HOXA9 in human hematopoietic cell lines ##BW## " provenance.
- _5 value "Figure 2 - Gene expression changes due to overexpression of HOXA9 in human hematopoietic cell lines ##BW## " provenance.
- _5 value "Figure 2 - Gene expression changes due to overexpression of HOXA9 in human hematopoietic cell lines ##BW## " provenance.
- _5 value "Figure 2 - Gene expression changes due to overexpression of HOXA9 in human hematopoietic cell lines ##BW## " provenance.
- _5 value "Figure 2 - Gene expression changes due to overexpression of HOXA9 in human hematopoietic cell lines ##BW## " provenance.
- _5 value "Figure 2 - Gene expression changes due to overexpression of HOXA9 in human hematopoietic cell lines ##BW## " provenance.
- _6 value "Modified assertion" provenance.
- _3 value "EEIG1 was clearly induced by 17 beta-estradiol" provenance.
- _3 value "EEIG1 was expressed in ER-positive but not in ER-negative breast cancer cell lines. EEIG1 expression was repressed by antiestrogens 4-OH-tamoxifen and ICI 182,780" provenance.
- _2 value "Down-regulation of resistin mRNA and protein by ?-adrenergic activation has been confirmed in one study" provenance.
- _4 value "Bmp2 induced Smad1 and Smad5 phosphorylation within 15 minutes of its addition, with the highest level being reached by 30-60 minutes." provenance.
- _6 value "Akt then phosphorylates tuberin on three residues (S939, S1130 and T1462 of full length human tuberin), and this inhibits the tuberin-hamartin complex through an as-yet-undefined mechanism (reviewed in [8])." provenance.
- _6 value "Rheb-GTP then activates mammalian (m)TOR, either directly or indirectly, through an unknown effector (question mark)." provenance.
- _6 value "In addition, we have shown that the EP(4) receptor, but not the EP(2), can activate the extracellular signal-regulated kinases (ERKs) 1 and 2 by way of PI3K leading to the induction of early growth response factor-1 (EGR-1), a transcription factor traditionally associated with wound healing" provenance.
- _3 value "preliminary experiments have shown that in mdx and the dydy dystrophic mice that MGF is not upregulated as it is in normal mice when the muscle is stretched" provenance.
- _4 value "In lean mice and db/db mice, injection of insulin produced rapid tyrosine phosphorylation of insulin receptor substrate 1 (IRS-1), recruitment of p85, the regulatory subunit of phosphatidylinositol 3-kinase and phosphorylation of the downstream signaling molecule Akt. CNTF (0.1 mg/kg per day or 0.3 mg/kg per day) treatment increased hepatic insulin sensitivity as evidenced by the robust phosphorylation of IRS-1. However, food restriction alone failed to improve hepatic insulin sensitivity." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _4 value "a p38 MAP kinase phosphorylation site (serine 401) were identified in the HBP1 protein. Furthermore, the docking and phosphorylation sites on HBP1 were specific for p38 MAP kinase" provenance.
- _6 value "IL-1beta also increased tyrosine phosphorylation of PLC-gamma in Src kinase-dependent manner. Pharmacological inhibition of the PLC-PKC cascade by using specific inhibitor for PLC-gamma (U73122) and PKC (GFX) strongly inhibited IL-1beta-induced Erk and Akt activation." provenance.
- _8 value "IL-1beta also increased tyrosine phosphorylation of PLC-gamma in Src kinase-dependent manner. Pharmacological inhibition of the PLC-PKC cascade by using specific inhibitor for PLC-gamma (U73122) and PKC (GFX) strongly inhibited IL-1beta-induced Erk and Akt activation." provenance.
- _3 value "Additionally, up-regulation of Myf-5 and MyoD occurs at the injury site in proliferating satellite cells indicating cell commitment [13-17]." provenance.
- _5 value "Basic fibroblast growth factor (bFGF) stimulates satellite cell proliferation while inhibiting differentiation [2]. bFGF also promotes muscle regeneration in mdx mice [26], which undergo repeated cycles of degeneration and regeneration resulting from a mutation in the dystrophin gene; in humans, deficiency of dystrophin causes Duchenne muscular dystrophy [27,28]." provenance.
- _4 value "Coinciding with the down-regulation of Pax gene expression, muscle precursor cells committed to the skeletal muscle lineage (myoblasts) translocate to the subjacent myotome, where the muscle regulatory factors Myogenin and MRF4 direct differentiation and fusion into multi-nucleated myofibers." provenance.
- _4 value "These results indicate that amylin is positively regulated by cAMP and PKA through the transcription factors HNF-1 and NFY." provenance.
- _3 value "PPARalpha-knockout mice also had greatly augmented liver neutrophil accumulation" provenance.
- _4 value "The EPAC-specific cAMP analog 8CPT-2Me-cAMP (8-(4-chloro-phenylthio)-2'-O-methyladenosine-3',5'-cAMP) activates Rap1 in B-CLL cells, but, unlike rolipram/forskolin or 8-Bromo-cAMP, it does not induce PKA activation, as judged by phosphorylation of the transcription factor cAMP-response element binding protein (CREB)." provenance.
- _6 value "Ang II secretion was regulated by insulin in a concentration dependent manner, with maximal stimulation occurring at 1000 nmol/L (Figure 7); however, in the presence of RSG, the insulin-mediated rise in Ang II secretion was reduced significantly at all insulin concentrations" provenance.
- _2 value "In this study, protein analysis suggests that hyperinsulinaemia may be an important factor in obesity-related hypertension." provenance.
- _2 value "In this study, protein analysis suggests that hyperinsulinaemia may be an important factor in obesity-related hypertension." provenance.
- _6 value "Immediate (1 min) PAF-induced STAT-3 phosphorylation required the activation of G alpha(q) protein, adenylate cyclase, and PKA, and was independent of these intermediates at delayed (30 min) and prolonged (60 min) PAF exposure." provenance.
- _2 value "To investigate whether mRNA expression of key enzymes in the long-chain fatty acid (FA), glucose, and lactic acid metabolic pathways differs between these two types of cardiac hypertrophy, we used the hearts of spontaneously hypertensive rats (SHR; 19 weeks old) as a model of the hypertensive heart, swim-trained rats (Trained; 19 weeks old, swimming training for 15 weeks) as a model of the athletic heart, and sedentary Wistar-Kyoto rats (Control; 19 weeks old). SHR developed hypertensive cardiac hypertrophy, of which cardiac function was deteriorated, whereas Trained rats developed an athletic heart, of which cardiac function was enhanced. " provenance.
- _5 value "Ectodin inhibited the activity of BMP2, BMP4, BMP6, and BMP7 for mouse preosteoblastic MC3T3-E1 cells, and bound to these BMPs with high affinity" provenance.
- _5 value "In nuclei, S100C/A11 liberated Sp1/3 from nucleolin. The resulting free Sp1/3 transcriptionally activated p21CIP1/WAF1, a representative negative regulator of cell growth" provenance.
- _6 value "These data demonstrate that Gi, but not Gq or G12/13, signaling pathways are required for activation of Akt in platelets, and Gi signaling pathways, stimulated by secreted ADP, play an essential role in the activation of Akt in platelets. his phosphorylation and activation of Akt were dramatically inhibited in the presence of AR-C69931MX, a P2Y12 receptor-selective antagonist," provenance.
- _5 value "Modified assertion" provenance.
- _2 value "In addition, there was a 68% decrease (5.7 plusminus 2 versus 1.8 plusminus 0.7 mumol/g; P = 0.035) in intramuscular triglyceride content in controlfl/fl animals, but no TZD-induced reduction in intramyocellular triglyceride content in MKO mice (Fig. 5d)." provenance.
- _5 value "Modified assertion" provenance.
- _4 value "The mechanism of tumor suppressor action of JDP2 can be partially explained by the generation of inhibitory AP-1 complexes via the increase of JunB, JunD, and Fra2 expression and decrease of c-Jun expression." provenance.
- _4 value "The mechanism of tumor suppressor action of JDP2 can be partially explained by the generation of inhibitory AP-1 complexes via the increase of JunB, JunD, and Fra2 expression and decrease of c-Jun expression." provenance.
- _3 value "Endothelial cells transfected with sense PAX2 acquired spindle shape morphology, showed enhanced motility and Matrigel invasion, and displayed an enhanced expression of alphavbeta3 integrin." provenance.
- _5 value "Moreover, IL-18 could significantly increase MMP-9 but not MMP-2 production at both mRNA and/or protein level, slightly up-regulate TIMP-1 mRNA, and clearly induce TIMP-2 mRNA secretion." provenance.
- _6 value "overexpression of APE/Ref-1 enhanced NIS promoter activity 2-fold. When the expression plasmid of APE/Ref-1 was transfected together with an expression plasmid for PAX8, a strong cooperative effect was detected with an increase of NIS promoter activity 9-fold over control." provenance.
- _3 value "Progesterone, dexamethasone, and estradiol also inhibited StAR mRNA expression" provenance.
- _3 value "Flavopiridol also inhibited the expression of the TNF-induced NF-kappaB-regulated gene products cyclin D1, cyclooxygenase-2, and matrix metalloproteinase-9." provenance.
- _3 value "Flavopiridol also inhibited the expression of the TNF-induced NF-kappaB-regulated gene products cyclin D1, cyclooxygenase-2, and matrix metalloproteinase-9." provenance.
- _5 value "Cyclic AMP and interleukin-1 (IL-1) induction of surfactant protein-A (SP-A) expression in fetal lung type II cells is mediated by increased binding of thyroid transcription factor-1 (TTF-1) and NF-kappaB proteins p50 and p65 to the TBE (TTF-1-binding element" provenance.
- _5 value "Dex increased expression of the NF-kappaB inhibitory partner, IkappaBalpha, suggests that the decrease in TBE binding activity may be caused, in part, by GR inhibition of NF-kappaB interaction with this site." provenance.
- _4 value "Amphiregulin (AR) and epidermal growth factor effects on expression and activity of the extracellular matrix metalloproteinase inducer (EMMPRIN) were examined in NS2T2A1 breast tumor cells. Both growth factors induced mRNA and protein expression of EMMPRIN, and matrix metalloproteinase (MMP) -2 and -9 enzymatic activity." provenance.
- _3 value "1 alpha, 25(OH)(2)D(3) changed the expression levels of numerous previously unreported genes, including many involved in transcription, cell adhesion, DNA synthesis, apoptosis, redox status, and intracellular signaling. Upregulated genes from table 1 and table 2 Upregulated genes from table 3." provenance.
- _3 value "1 alpha, 25(OH)(2)D(3) changed the expression levels of numerous previously unreported genes, including many involved in transcription, cell adhesion, DNA synthesis, apoptosis, redox status, and intracellular signaling. Upregulated genes from table 1 and table 2 Upregulated genes from table 3." provenance.
- _3 value "1 alpha, 25(OH)(2)D(3) changed the expression levels of numerous previously unreported genes, including many involved in transcription, cell adhesion, DNA synthesis, apoptosis, redox status, and intracellular signaling. Upregulated genes from table 1 and table 2 Upregulated genes from table 3." provenance.
- _3 value "1 alpha, 25(OH)(2)D(3) changed the expression levels of numerous previously unreported genes, including many involved in transcription, cell adhesion, DNA synthesis, apoptosis, redox status, and intracellular signaling. Upregulated genes from table 1 and table 2 Upregulated genes from table 3." provenance.
- _3 value "1 alpha, 25(OH)(2)D(3) changed the expression levels of numerous previously unreported genes, including many involved in transcription, cell adhesion, DNA synthesis, apoptosis, redox status, and intracellular signaling. Upregulated genes from table 1 and table 2 Upregulated genes from table 3." provenance.
- _2 value "1alpha, 25(OH) (2)D(3) induces proliferation arrest and epithelial differentiation of human SW480-ADH colon cancer cells." provenance.
- _3 value "Downregulated genes from table 3." provenance.
- _3 value "Downregulated genes from table 3." provenance.
- _6 value "In addition, soluble trimeric CD40L (sCD40L), released from activated platelets, may engage platelet CD40 in an autocrine or paracrine manner (indicated by +), resulting in shape change and {alpha}-granule release." provenance.
- _3 value "Neutrophils provide an essential defense against bacterial and fungal infection and play a major role in tissue damage during inflammation. Using oligonucleotide microarrays, we have examined the time course of changes in gene expression induced by stimulation with live, opsonized Escherichia coli, soluble lipopolysaccharide, and the chemoattractant formyl-methionyl-leucyl-phenylalanine. The results indicate that activated neutrophils generate a broad and vigorous set of alterations in gene expression. The responses included changes in the levels of transcripts encoding 148 transcription factors and chromatin-remodeling genes and 95 regulators of protein synthesis or stability. Clustering analysis showed distinct temporal patterns with many rapid changes in gene expression within the first hour of exposure. In addition to the temporal clustering of genes, we also observed rather different profiles associated with each stimulus, suggesting that even a nonvirulent organism such as E. coli is able to play a dynamic role in shaping the inflammatory response. Principal component analysis of transcription factor genes demonstrated clear separation of the neutrophil-response clusters from those of resting and stimulated human monocytes. The present study indicates that combinatorial transcriptional regulation including alterations of chromatin structure may play a role in the rapid changes in gene expression that occur in these terminally differentiated cells." provenance.
- _3 value "Neutrophils provide an essential defense against bacterial and fungal infection and play a major role in tissue damage during inflammation. Using oligonucleotide microarrays, we have examined the time course of changes in gene expression induced by stimulation with live, opsonized Escherichia coli, soluble lipopolysaccharide, and the chemoattractant formyl-methionyl-leucyl-phenylalanine. The results indicate that activated neutrophils generate a broad and vigorous set of alterations in gene expression. The responses included changes in the levels of transcripts encoding 148 transcription factors and chromatin-remodeling genes and 95 regulators of protein synthesis or stability. Clustering analysis showed distinct temporal patterns with many rapid changes in gene expression within the first hour of exposure. In addition to the temporal clustering of genes, we also observed rather different profiles associated with each stimulus, suggesting that even a nonvirulent organism such as E. coli is able to play a dynamic role in shaping the inflammatory response. Principal component analysis of transcription factor genes demonstrated clear separation of the neutrophil-response clusters from those of resting and stimulated human monocytes. The present study indicates that combinatorial transcriptional regulation including alterations of chromatin structure may play a role in the rapid changes in gene expression that occur in these terminally differentiated cells." provenance.
- _3 value "Neutrophils provide an essential defense against bacterial and fungal infection and play a major role in tissue damage during inflammation. Using oligonucleotide microarrays, we have examined the time course of changes in gene expression induced by stimulation with live, opsonized Escherichia coli, soluble lipopolysaccharide, and the chemoattractant formyl-methionyl-leucyl-phenylalanine. The results indicate that activated neutrophils generate a broad and vigorous set of alterations in gene expression. The responses included changes in the levels of transcripts encoding 148 transcription factors and chromatin-remodeling genes and 95 regulators of protein synthesis or stability. Clustering analysis showed distinct temporal patterns with many rapid changes in gene expression within the first hour of exposure. In addition to the temporal clustering of genes, we also observed rather different profiles associated with each stimulus, suggesting that even a nonvirulent organism such as E. coli is able to play a dynamic role in shaping the inflammatory response. Principal component analysis of transcription factor genes demonstrated clear separation of the neutrophil-response clusters from those of resting and stimulated human monocytes. The present study indicates that combinatorial transcriptional regulation including alterations of chromatin structure may play a role in the rapid changes in gene expression that occur in these terminally differentiated cells." provenance.
- _4 value "RNA interference (RNAi) demonstrates that MEKK3 and the scaffold protein are required for p38 activation in response to sorbitol-induced hyperosmolarity." provenance.
- _2 value "RNA interference (RNAi) demonstrates that MEKK3 and the scaffold protein are required for p38 activation in response to sorbitol-induced hyperosmolarity." provenance.
- _4 value "RNA interference (RNAi) demonstrates that MEKK3 and the scaffold protein are required for p38 activation in response to sorbitol-induced hyperosmolarity." provenance.
- _6 value "through its ability to bind actin, relocalize to Rac-containing membrane ruffles and its obligate requirement for p38 activation in response to sorbitol, we have termed this protein osmosensing scaffold for MEKK3 (OSM)." provenance.
- _6 value "through its ability to bind actin, relocalize to Rac-containing membrane ruffles and its obligate requirement for p38 activation in response to sorbitol, we have termed this protein osmosensing scaffold for MEKK3 (OSM)." provenance.
- _3 value "By employing RNA arbitrarily primed-PCR to search for novel phosphatidylinositol 3-kinase-regulated genes in response to insulin in isolated rat adipocytes, we identified fatty aldehyde dehydrogenase (FALDH), a key component of the detoxification pathway of aldehydes arising from lipid peroxidation events Upon insulin injection, FALDH mRNA expression increased in rat liver and white adipose tissue" provenance.
- _4 value "Ectopic expression of FALDH significantly decreased reactive oxygen species production in cells treated by 4-hydroxynonenal, the major lipid peroxidation product, suggesting that FALDH protects against oxidative stress associated with lipid peroxidation" provenance.
- _3 value "We found that nm23-H1 strongly inhibited the liver metastasis of HT-29 cells in nude mice and inhibited the epidermal growth factor (EGF)-induced cell migration in vitro." provenance.
- _5 value "ERK phosphorylates PDE4s" provenance.
- _5 value "catalytic unit of pde4b,c and d families contains a single consensus site for phosphorylation by ERK, which in the PDE4D3 isoform is Ser579 ERK cannot phosphorylate PDE4A" provenance.
- _4 value "elevated cAMP levels lead to the activation of B-Raf and hence to ERK activation" provenance.
- _5 value "on ERK there is a serine residue which can be phosphorylated by PKA, whereupon docking to ERK is ablated" provenance.
- _5 value "the effect of phosphorylation by ERK of PDE4 long isoforms is to cause their inhibition" provenance.
- _6 value "Using histidine decarboxylase gene targeted (HDC(-/-)) BALB/c mice, we studied the effect of the absence of histamine on four cytochrome p450 enzyme activities. Their selective substrates were measured: ethoxyresorufin O-dealkylase activity of CYP1A, pentoxyresorufin O-dealkylase activity of CYP2B, chlorzoxazone 6-hydroxylase activity of CYP2E1 and ethylmorphine N-demethylase activity of CYP3A.The results indicate a significant elevation of CYP2E1 and CYP3A activities" provenance.