Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _7 value "IFN-gamma treatment of human hepatoma Hep3B cells attenuates IFN-alpha activation of STAT1 (signal transducers and activators of transcription factor 1), STAT2 and STAT3, but enhances IFN-gamma and interleukin 6 activation of STATs" provenance.
- _5 value "IFN-gamma treatment of human hepatoma Hep3B cells attenuates IFN-alpha activation of STAT1 (signal transducers and activators of transcription factor 1), STAT2 and STAT3, but enhances IFN-gamma and interleukin 6 activation of STATs" provenance.
- _5 value "IFN-gamma treatment of human hepatoma Hep3B cells attenuates IFN-alpha activation of STAT1 (signal transducers and activators of transcription factor 1), STAT2 and STAT3, but enhances IFN-gamma and interleukin 6 activation of STATs" provenance.
- _5 value "IFN-gamma treatment of human hepatoma Hep3B cells attenuates IFN-alpha activation of STAT1 (signal transducers and activators of transcription factor 1), STAT2 and STAT3, but enhances IFN-gamma and interleukin 6 activation of STATs" provenance.
- _8 value "Overexpression of STAT1 via stable transfection enhances IFN-gamma activation of STAT1, but surprisingly attenuates IFN-alpha activation of STAT1, STAT2 and STAT3" provenance.
- _4 value "Analysis of the proliferative effect of GLI2 revealed that GLI2 is able to induce G1-S phase progression in contact-inhibited keratinocytes." provenance.
- _5 value "Modified assertion" provenance.
- _3 value "Ariadne: SAHA also suppresses expression of receptors that have been shown to trigger MM cell proliferation, survival, and/or migration, such as CD138 (syndecan-1), CD71 (transferrin receptor), IL-21R, and CXCR-4 ( 29 ... 32 )." provenance.
- _5 value "From mutations file" provenance.
- _3 value "Furthermore, our data unveil a previously unexpected link between extracellular matrix production and LDL signaling." provenance.
- _3 value "the requirement for Eps8 in IV5 cell proliferation" provenance.
- _5 value "interleukinalpha (IL-1alpha) inhibits glucocorticoid receptor (GR) nuclear translocation and dexamethasone (Dex)-induced gene transcription" provenance.
- _3 value "We show that both ATP and NGF upregulate the expression of the stress-induced heat shock protein HSP70 and HSP90" provenance.
- _3 value "LPS treatment produces a rapid and marked decrease in the mRNA levels of all three RXR isoforms, PPARalpha and PPARdelta, and TRalpha and TRbeta in the heart" provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _5 value "Therefore, study was performed to determine the effect of IR on the expression and phosphorylation of FAK and two of its substrates, p130cas and paxillin, in vitro. IR induced phosphorylation of FAK (tyr397 and tyr925) but did not change FAK expression. Additionally, IR induced phosphorylation of paxillin (tyr31 and tyr181) within 30 min and an up-regulation of paxillin expression 2-6 h after exposure. Furthermore, a higher amount of phosphorylated p130cas was found in irradiated cells. Immunofluorescence staining demonstrated that in A549 cells, all three proteins colocalize at sites of focal adhesions at the cytoplasmic face of the cell membrane and to lamellopodia. " provenance.
- _4 value "IL-6 or IL1beta, induce AP-1 or NF-kB activation, respectively, leading to GR inhibition." provenance.
- _5 value "IL-6 or IL1beta, induce AP-1 or NF-kB activation, respectively, leading to GR inhibition." provenance.
- _5 value "c-Jun N-terminal kinase (JNK), which phosphorylates and inactivates GR" provenance.
- _6 value "c-Jun N-terminal kinase (JNK), which phosphorylates and inactivates GR" provenance.
- _5 value "Caveolin-1 downregulation enhanced beta-catenin-TCF/LEF-1 transcriptional activity in a GSK-3beta-independent manner." provenance.
- _4 value "Chronic EGF treatment resulted in transcriptional downregulation of caveolin-1 and induction of the transcriptional repressor Snail, correlating with downregulation of E-cadherin expression." provenance.
- _8 value "Replacement of threonine 84 with glutamate reduced the activation of PAK1 by an active form of the small G protein Cdc42, suggesting that phosphorylation by OSR1 modulates the G protein sensitivity of PAK isoforms." provenance.
- _2 value "endogenous OSR1 is activated only by osmotic stresses, notably sorbitol and to a lesser extent NaCl." provenance.
- _5 value "AMPK directly phosphorylates eEF2 kinase, and we identify the major site of phosphorylation as Ser-398...in eEF2 kinase is enhanced in intact cells under a range of conditions that activate AMPK and increase the phosphorylation of eEF2." provenance.
- _4 value "Confirmation of up-regulated Plag1 targets by Northern blot analysis." provenance.
- _4 value "Table 2. Identification of genes consistently and significantly induced by PLAG1. Genes induced by at least 2.5-fold in each of 2 sets of Plag1 overexpressing clones compared to 2 sets of control cells. " provenance.
- _4 value "Table 2. Identification of genes consistently and significantly induced by PLAG1. Genes induced by at least 2.5-fold in each of 2 sets of Plag1 overexpressing clones compared to 2 sets of control cells. " provenance.
- _4 value "Table 2. Identification of genes consistently and significantly induced by PLAG1. Genes induced by at least 2.5-fold in each of 2 sets of Plag1 overexpressing clones compared to 2 sets of control cells. " provenance.
- _4 value "Table 2. Identification of genes consistently and significantly induced by PLAG1. Genes induced by at least 2.5-fold in each of 2 sets of Plag1 overexpressing clones compared to 2 sets of control cells. " provenance.
- _4 value "Table 2. Identification of genes consistently and significantly induced by PLAG1. Genes induced by at least 2.5-fold in each of 2 sets of Plag1 overexpressing clones compared to 2 sets of control cells. " provenance.
- _4 value "Table 3. Identification of genes consistently and significantly repressed by PLAG1" provenance.
- _4 value "PKCalpha upregulated alpha6beta4 protein expression, leading to increased keratinocyte attachment to laminin-5 and to the underlying matrix." provenance.
- _4 value "PKCdelta and PKCzeta induced downregulation of alpha6beta4 protein expression, leading to reduced keratinocyte attachment to laminin-5 and enhanced gradual detachment from the underlying matrix." provenance.
- _5 value "Further studies reveal that PML can selectively suppress AR transactivation and PML protein expression positively correlates with increased p21 protein level and enhances p53 transcription ability in CWR22R cells" provenance.
- _3 value "4) the use of alternative sugars and other carbon sources like fatty acids, ethanol, glycerol, pyruvate, and lactate;" provenance.
- _3 value "4) the use of alternative sugars and other carbon sources like fatty acids, ethanol, glycerol, pyruvate, and lactate;" provenance.
- _6 value "5. Myosin (de)phosphorylation and muscle contraction The contractile function of actomyosin culminates in muscle tissue. Phosphorylation of the myosin regulatory light chains is sufficient to trigger contraction in smooth muscle (192). This phosphorylation is promoted by raising the concentration of Ca2+, which activates MLCK. The Ca2+-independent net increase in phosphorylation of the regulatory light chains induced by Rho-kinase (139), ILK (264), ZIPK (264), and ZIPK-like kinase (55, 231) sensitizes muscles to Ca2+. Muscle contractility is also influenced by variations in the composition of myosin phosphatase. Thus the sensitivity of vascular smooth muscles to regulation by nitric oxide via the activation of cGMPdependent protein kinase 1-alpha depends on the presence of leucine zippers in the splice variants of the large and small Mypt that are expressed in this tissue (339). In chicken gizzard, a developmental switch between leucine zipperpositive and -negative Mypts correlates with the loss of cGMP-mediated myosin relaxation at hatching (203). Other forms of splice variance of the Mypt1-encoding gene have also been implicated in the developmental regulation of muscle contractility (108). The importance of the enzymes that control the contractility of smooth muscles in arteries (193), airways (182), and corpora carvenosa (381) makes them potential targets in the treatment of cardiac and cerebral vascular spasms, asthma, and erectile dysfunction. In striated muscle, contraction is triggered by membrane depolarization. Even though phosphorylation of the myosin regulatory light chain is not required for contraction, it does positively affect the speed and force of contraction (346). Thus a gradient of myosin regulatory light chain phosphorylation correlates with the pattern of cardiac contraction (99). The role of the Mypt2-based myosin phosphatase in the contraction of striated muscle has been poorly studied. C. Scd5-Associated PP1 Fungi lack Mypt or Neurabin homologs, yet in budding yeast PP1 has also been implicated in the organization of cortical actin. Thus, after shifting of the temperature- sensitive PP1 mutant glc7-10 to a restrictive temperature, the actin ring at the bud neck disappeared, actin cables became rare, and actin no longer showed its typical polarized localization (16). This mutant was also de- ficient in vacuolar fusion and in secretory and endocytotic vesicular transport (292). Strikingly similar phenotypes were observed after the functional disruption of Scd5, Rvs167, or Sla2 (32, 59, 167, 259, 277). Scd5 has been identified as a PP1-binding protein in various screens (173, 372, 374), and recently, it was found that disruption of the RVXF motif of Scd5 that mediates the interaction with PP1 severely disturbed endocytosis and actin organization (78). Rvs167 and Sla2 interact physically and genetically with Scd5 (32, 59, 167, 259). Also, mutation of either Rvs167 or Sla2, like that of PP1, compromised the integrity of the cell wall at high temperatures, presumably because of a disruption in the transport of vesicles with cargoes required for the construction of the cell wall (16, 59, 259). Collectively, the available data indicate that PP1, Scd5, Rvs167, and Sla2 function together in a signaling pathway that regulates vesicular transport and the polarized distribution of actin patches. Possibly, Scd5 targets PP1 to actin patches and vesicles. Potential substrates of Scd5-associated PP1 include the phosphoproteins Sla2, Sla1, and Pan1. The latter two proteins have both been found to interact with PP1 in yeast two-hybrid screens (372, 374) and to be components of a complex involved in actin organization, endocytosis, and cell wall morphogenesis (357). Because homologs of various proteins introduced in this section have been identified in animals, where they have also been implicated in actin organization and endocytosis (167), it is tempting to speculate..." provenance.
- _5 value "The sensitivity of the Rb phosphatase in intact cells to various cell-permeable cytotoxins also points to PP1 (396). D. Exit From the Pachytene Stage in Yeast Meiosis In yeast, a premature exit from the pachytene stage after the initiation of meiotic recombination is prevented by the so-called \"pachytene checkpoint\" (reviewed in Ref. 303). An active checkpoint results in the phosphorylation and activation of protein kinase Mek1, which keeps its substrate Red1 phosphorylated (29, 102). When recombination has ended in late pachytene, the checkpoint is inactivated by the dephosphorylation of Red1 by PP1 (30). Overexpression of PP1 bypasses the checkpoint precociously. The nature of the regulatory subunit(s) associated with this meiotic function of PP1 remains unclear. A number of findings originally pointed to Gip1, a PP1- binding protein that is specifically expressed in middle meiosis and that is essential for sporulation (372). Thus it was reported that 1) Gip1 was required for the targetting of PP1 to chromosomes in late pachytene, 2) yeast cells lacking Gip1 displayed a pachytene arrest that was similar to that of cells with constitutively active Mek1 or with a deficient version of PP1, and 3) this arrest was alleviated by overexpression of PP1 (30). However, in a more recent study, deletion of the Gip1-encoding gene was found not to affect meiotic progression, but instead to interfere with the normal localization of sporulation-specific septins and the deposition of spore wall material (347). Strikingly, replacement of PP1 by a mutant version that fails to interact with Gip1 yielded a similar phenotype. IV. CELL CYCLE ARREST AND APOPTOSIS PP1 not only activates the Rb protein at the M/G1 transition (see sect. IIIC), but it is also implicated in the control of Rb at the G1/S transition and in Rb-mediated cell cycle arrest." provenance.
- _5 value "These effects are achieved via direct phosphorylation or transcriptional control of key metabolic enzymes. Two mechanisms are involved in the transcriptional control: phosphorylation-dependent nuclear exclusion of transcriptional repressors (106) and phosphorylation at specific promotors of serine-10 of histone H3, which facilitates acetylation of lysine-14 and transcription (230)." provenance.
- _7 value "but this interaction is blocked by phosphorylation of the RyRs by PKA (243)." provenance.
- _7 value "but this interaction is blocked by phosphorylation of the RyRs by PKA (243)." provenance.
- _3 value "HGF transcripts and protein levels are increased during the early phase of muscle regeneration, and this increase is proportional to the degree of injury" provenance.
- _2 value "muscle regeneration can also be induced by repeated bouts of intensive exercise, and in fact, eccentric exercise is particularly potent at inducing muscle damage" provenance.
- _2 value "neutrophils are the first inflammatory cells to invade the injured muscle, with a significant increase in their number being observed as early as 1-6 hours after myotoxin or exercise-induced muscle damage" provenance.
- _3 value "Among the strongly induced genes were many involved in protein degradation, including polyubiquitins, Ub fusion proteins, the Ub ligases atrogin-1/MAFbx and MuRF-1, multiple but not all subunits of the 20S proteasome and its 19S regulator, and cathepsin L. Many genes required for ATP production and late steps in glycolysis were down-regulated, as were many transcripts for extracellular matrix proteins. Some genes not previously implicated in muscle atrophy were dramatically up-regulated (lipin, metallothionein, AMP deaminase, RNA helicase-related protein, TG interacting factor) and several growth-related mRNAs were down-regulated (P311, JUN, IGF-1-BP5)" provenance.
- _3 value "In all four conditions, mRNAs for translation initiation factors EIF4A2, EIF4G3, and EIF4EBP1, which act through cap-independent mechanisms, increased (Fig. 4b )." provenance.
- _3 value "GADD34-PP1c recruited by Smad7 inhibits TGFbeta-induced cell cycle arrest and mediates TGFbeta resistance in responding to UV light irradiation." provenance.
- _7 value "GADD34-PP1c recruited by Smad7 inhibits TGFbeta-induced cell cycle arrest and mediates TGFbeta resistance in responding to UV light irradiation." provenance.
- _2 value "U0126, an inhibitor for MEK and LY294002, an inhibitor for phosphatidylinositol 3-kinase (PI3K), sensitized resistant UM-SCC-23 to cisplatin-induced cell death. " provenance.
- _3 value "We examined the expression and function of a gene we previously cloned from its downregulation in a muscle atrophy model. The encoded protein was named myodulin because of sequence homologies with the cartilage-specific chondromodulin-I (ChM-I) protein," provenance.
- _3 value "The lysosomal genes neuraminidase, CLN3, and CLCN5 and the small GTP-binding proteins Rab7L1 and Arl7 were also increased." provenance.
- _5 value "Expi-accelerated apoptosis is mediated via BAFF receptor among three known BAFF receptors: BAFF receptor, tumor necrosis factor (TNF) receptor homologue TACI (transmembrane activator and CAML-interactor), and BCMA (another TNFR homologue, B cell maturation antigen). The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR." provenance.
- _5 value "We find that RanBPM is phosphorylated on serine residues; phosphorylation of RanBPM is increased by stress stimuli and decreased by treatment with the p38 kinase inhibitor SB203580." provenance.
- _3 value "OPN transcription and promoter activity are significantly up-regulated in response to NO" provenance.
- _6 value "SREBP-1 competitively inhibited PGC-1 recruitment, a requirement for HNF-4alpha activation" provenance.
- _4 value "Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibition, carbonylation and translocation from cytoplasm to nucleus and DNA fragmentation were also induced by DETA/NO exposure" provenance.
- _5 value "Modified assertion" provenance.
- _6 value "Inhibition of PI-3K, Akt, and p70(S6k) by overexpression of a dominant-negative mutant of PI-3K (Deltap85) impaired nickel-induced HIF-1 transactivation." provenance.
- _3 value "The present study indicated that exposure of mouse epidermal Cl41 cells to either Ni(3)S(2) or NiCl(2) resulted in activation of phosphatidylinositol 3-kinase (PI-3K), Akt, and p70 S6 kinase (p70(S6k))" provenance.
- _3 value "Ectopic expression of Cables in human endometrial cells dramatically slows cell proliferation" provenance.
- _5 value "Modified assertion" provenance.
- _3 value "We find that expression of activating transcription factor 3 (ATF3), a member of the ATF/CREB subfamily of basic-region leucine zipper (bZIP) proteins, is induced in response to endoplasmic reticulum (ER) stress or amino acid starvation by a mechanism requiring eIF2 kinases PEK (Perk or EIF2AK3) and GCN2 (EIF2AK4), respectively" provenance.
- _2 value "Camptothecin-induced S- or G2/M arrest was intensified by transfection of GSTP1 antisense vector, and subsequent apoptosis was attenuated by transfection of GSTP1 sense vector. These results suggest that GSTP1 has protective effects against camptothecin-induced cytotoxicity." provenance.
- _4 value "Camptothecin-induced S- or G2/M arrest was intensified by transfection of GSTP1 antisense vector, and subsequent apoptosis was attenuated by transfection of GSTP1 sense vector. These results suggest that GSTP1 has protective effects against camptothecin-induced cytotoxicity." provenance.
- _5 value "Co-immunoprecipitation studies in COS-7 cells showed that RGS6L and RGS6S, but not RGS6LDelta258-293 deletion mutant lacking a DMAP1-binding module, co-immunoprecipitate DMAP1 as well as Dnmt1 in a DMAP1-dependent manner." provenance.
- _5 value "The partial WTIP clone, which interacted with WTIP in the two-hybrid assay, co-localized with WT1 in nuclei, co-precipitated with WT1, and inhibited WT1-dependent transcriptional activation of the amphiregulin promoter." provenance.
- _4 value "it has recently been demonstrated that increased cAMP-levels and in particular the cAMP-dependent protein kinase A (PKA) can modulate erythroid signal transduction pathways.... In other cases, such as the STAT5 pathway, PKA enhances Epo signaling by inducing recruitment of additional co-regulators of transcription. In addition to STAT5, PKA also activates other transcription factors that are required for erythroid gene expression. " provenance.
- _6 value "Insulin enhanced citrate synthase and hexokinase activities and diminished those of glutaminase and glucose-6-phosphate dehydrogenase. Dexamethasone had a similar effect except on glucose-6-phosphate dehydrogenase." provenance.
- _6 value "Insulin enhanced citrate synthase and hexokinase activities and diminished those of glutaminase and glucose-6-phosphate dehydrogenase. Dexamethasone had a similar effect except on glucose-6-phosphate dehydrogenase." provenance.
- _5 value "ACTR and related p160 family members (steroid receptor coactivator-1 and glucocorticoid receptor interacting protein 1 (GRIP-1)) augment ER81 mediated transcription." provenance.
- _6 value "However, electrophoretic mobility shift assays indicated that HFz6 repressed the binding of TCF/lymphoid enhancer factor transcription factors to target DNA" provenance.
- _4 value "Four consequences of hyperglycemia of particular pathological relevance (1) are the formation, auto-oxidation, and interaction with cell receptors of advanced glycation end products (AGEs); activation of various isoforms of protein kinase C; induction of the polyol pathway; and increased hexosamine pathway flux." provenance.
- _3 value "The expression of these UCP's increases in response to elevated mitochondrial oxidative stress (34) and one possible function of these proteins is to lower the mitochondrial membrane potential when superoxide is generated." provenance.
- _3 value "The expression of these UCP's increases in response to elevated mitochondrial oxidative stress (34) and one possible function of these proteins is to lower the mitochondrial membrane potential when superoxide is generated." provenance.
- _4 value "Soluble guanylyl cyclase (sGC) is activated by nitric oxide (NO) and carbon monoxide, resulting in cGMP production." provenance.
- _5 value "Interestingly, supply of AOP2 and/or the AR inhibitor fidarestat protected the cells against hyperglycemia-induced death" provenance.
- _5 value "HDGF also activated specific ERK1/2 signaling" provenance.
- _2 value "We reported that the endoplasmic reticulum (ER) stress pathway involving CHOP, a member of the C/EBP transcription factor family, plays a key role in nitric oxide (NO)-mediated apoptosis of macrophages and pancreatic beta cells. We also showed that the cytosolic chaperone pair of hsp70 and dj1 (hsp40/hdj-1) or dj2 (HSDJ/hdj-2) prevents NO-mediated apoptosis upstream of cytochrome c release from mitochondria. To analyze roles of the chaperone pair in preventing apoptosis, RAW 264.7 macrophages stably expressing hsp70 and dj1 or dj2 were established. The chaperone pair prevented LPS/IFN-gamma-induced and NO-mediated apoptosis downstream of CHOP induction." provenance.
- _3 value "Over-expression of L36a led to enhanced colony formation and cell proliferation." provenance.
- _4 value "dbp drives the timing expression of cyp7a, implicated in bile acid production and cyp2alpha4, which catalyzes the steroids metabolism" provenance.
- _5 value "ZNF216 also inhibited tumor necrosis factor (TNF)-, interleukin-1-, and Toll-like receptor 4-induced NFkappaB activation in a dose-dependent manner." provenance.
- _4 value "ZNF216 also inhibited tumor necrosis factor (TNF)-, interleukin-1-, and Toll-like receptor 4-induced NFkappaB activation in a dose-dependent manner. overexpression of ZNF216 sensitized cells to TNF-induced apoptosis." provenance.
- _6 value "ZNF216 also inhibited tumor necrosis factor (TNF)-, interleukin-1-, and Toll-like receptor 4-induced NFkappaB activation in a dose-dependent manner. overexpression of ZNF216 sensitized cells to TNF-induced apoptosis." provenance.
- _6 value "ZBRK1 is a KRAB domain containing Zinc-finger protein and is known to repress target gene transcription in a BRCA1-dependent manner" provenance.
- _5 value "We recently revealed that p38 MAPK-mediated serine phosphorylation of both Stat1 and Stat3 is required for the induction of 15-lipoxygenase (15-LO) expression by IL-13" provenance.
- _3 value "from full text - Table 1 Gene expression profiles of MMIS myeloma cells after 1 and 7 days of telomestatin treatment (day 7 results)" provenance.
- _3 value "from full text - Table 1 Gene expression profiles of MMIS myeloma cells after 1 and 7 days of telomestatin treatment (day 7 results)" provenance.
- _3 value "from full text - Table 1 Gene expression profiles of MMIS myeloma cells after 1 and 7 days of telomestatin treatment (day 7 results)" provenance.
- _3 value "from full text - Table 1 Gene expression profiles of MMIS myeloma cells after 1 and 7 days of telomestatin treatment (day 7 results)" provenance.
- _3 value "from full text - Table 1 Gene expression profiles of MMIS myeloma cells after 1 and 7 days of telomestatin treatment (day 7 results)" provenance.
- _3 value "from full text - Table 1 Gene expression profiles of MMIS myeloma cells after 1 and 7 days of telomestatin treatment (day 7 results)" provenance.
- _3 value "from full text - Table 1 Gene expression profiles of MMIS myeloma cells after 1 and 7 days of telomestatin treatment (day 7 results)" provenance.
- _3 value "from full text - Table 1 Gene expression profiles of MMIS myeloma cells after 1 and 7 days of telomestatin treatment (day 7 results)" provenance.
- _3 value "from full text - Table 1 Gene expression profiles of MMIS myeloma cells after 1 and 7 days of telomestatin treatment (day 7 results)" provenance.
- _3 value "from full text - Table 1 Gene expression profiles of MMIS myeloma cells after 1 and 7 days of telomestatin treatment (day 7 results)" provenance.
- _3 value "from full text - Table 1 Gene expression profiles of MMIS myeloma cells after 1 and 7 days of telomestatin treatment (day 7 results)" provenance.
- _3 value "from full text - Table 1 Gene expression profiles of MMIS myeloma cells after 1 and 7 days of telomestatin treatment (day 7 results)" provenance.
- _3 value "from full text - Table 1 Gene expression profiles of MMIS myeloma cells after 1 and 7 days of telomestatin treatment (day 7 results)" provenance.
- _3 value "from full text - Table 1 Gene expression profiles of MMIS myeloma cells after 1 and 7 days of telomestatin treatment (day 7 results)" provenance.