Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _3 value "from full text - Table 1 Gene expression profiles of MMIS myeloma cells after 1 and 7 days of telomestatin treatment (day 7 results)" provenance.
- _3 value "Glycogen-depleting exercise and HIGH-CHO resulted in a 300% increase in muscle glycogen content (P concentrations were twofold higher after LOW- vs. HIGH-CHO (P exercise-diet manipulation exerted a significant effect on transcription of all carbohydrate-related genes, with an increase in GLUT4 and glycogenin mRNA abundance and a reduction in PDK-4 transcription after HIGH-CHO (all P 0.05). FAT/CD36 (P increased following LOW-CHO. genes involved in glucose regulation are increased following a high-carbohydrate diet." provenance.
- _3 value "Table 2. Selected enzymes and regulatory proteins of fatty acid and lipid metabolism" provenance.
- _3 value "Table 2. Selected enzymes and regulatory proteins of fatty acid and lipid metabolism" provenance.
- _3 value "Table 3. Nuclear receptors, fatty acid binding proteins, and ABC transporters" provenance.
- _3 value "Table 5. Regulated enzymes of urea cycle and selected enzymes of amino acid metabolism" provenance.
- _3 value "Table 6. Regulated enzymes of the SAM cycle, subsequent reactions and methyl transferases" provenance.
- _3 value "Table 6. Regulated enzymes of the SAM cycle, subsequent reactions and methyl transferases" provenance.
- _3 value "Table 7. Regulated enzymes of cholesterol and DHEA metabolism" provenance.
- _3 value "Table 7. Regulated enzymes of cholesterol and DHEA metabolism" provenance.
- _3 value "Table 9. DNA repair and apoptosis genes" provenance.
- _3 value "Table 9. DNA repair and apoptosis genes" provenance.
- _3 value "Table 9. DNA repair and apoptosis genes" provenance.
- _3 value "Table 9. DNA repair and apoptosis genes" provenance.
- _3 value "Table 9. DNA repair and apoptosis genes" provenance.
- _3 value "glucose up-regulates OPN mRNA and protein expression in primary cultures of human RPTECs" provenance.
- _3 value "Moreover, SDF-1/CXCL12 stimulation of HIMEC triggers CXCR4-linked G proteins, phosphorylates ERK1/2, and activates proliferative and chemotactic responses. Pharmacological studies indicate SDF-1/CXCL12 evokes HIMEC chemotaxis via activation of ERK1/2 and phosphoinositide 3-kinase signaling pathways." provenance.
- _3 value "Consistently, HoxA9 wild-type overexpression activated the EphB4 promoter as determined by reporter gene expression. HoxA9 binds to the EphB4 promoter and stimulates its expression resulting in an increase of endothelial cell migration and tube forming activity." provenance.
- _5 value "SOCS2 binds to the GH receptor and inhibits GH signaling, including attenuation of STAT5 activation" provenance.
- _2 value "Pathologies (splenomegaly, lymphadenopathy associated with lymphocytic infiltration, autoimmunity) associated with the Fasl KO mice are nearly identical to those of the Casp8 (PMID 16157684) (Casp8 is downstream of Fasl in the extrinisc apoptotic cascade that regulates B- and T-cell turnover) KO mice and due to uncontrolled proliferation of lymphocytes directly, a direct result of decreased lymphocytic apoptosis. Pathologies are due to uncontrolled proliferation of B- and T-cells in the absence of apoptosis." provenance.
- _5 value "Kinase activity of IRAK-1 (Fig. 6A) and IRAK-4 (Fig. 6B) increased in neutrophils stimulated with LPS. Both phosphorylation and activation of IRAK-1 were diminished in neutrophils treated with antioxidants before LPS exposure (Fig. 6A). Similarly, as shown in Fig. 6B, activation of IRAK-4 was diminished in neutrophils exposed to antioxidants before stimulation with LPS." provenance.
- _3 value "Table III. Differentially expressed genes in H. pylori-infected gastric mucosa" provenance.
- _3 value "Table III. Differentially expressed genes in H. pylori-infected gastric mucosa" provenance.
- _3 value "Table III. Differentially expressed genes in H. pylori-infected gastric mucosa" provenance.
- _3 value "Table III. Differentially expressed genes in H. pylori-infected gastric mucosa" provenance.
- _3 value "Table III. Differentially expressed genes in H. pylori-infected gastric mucosa" provenance.
- _3 value "Table III. Differentially expressed genes in H. pylori-infected gastric mucosa" provenance.
- _4 value "glucose deprivation activated ATF6 but suppressed the SREBP2-regulated transcription." provenance.
- _3 value "After 14 days of hyperleptinemia, adipocytes had become shrunken, fatless, and encased in a thick basement-membrane-like matrix. They were crowded with mitochondria that were much smaller than those of brown adipocytes. Their gene expression profile revealed striking up-regulation of peroxisome proliferator-activated receptor gamma coactivator 1alpha (an up-regulator of mitochondrial biogenesis not normally expressed in white fat), increased uncoupling proteins-1 and -2" provenance.
- _4 value "FPF production is positively regulated by glucocorticoids and negatively regulated by dihydrotestosterone (DHT) and transforming growth-factor beta (TGF-beta)." provenance.
- _6 value "Human ECs and VSMCs express telomerase activity, which is drastically activated by mitogenic stimuli via a protein kinase C-dependent pathway [64] but the activity declined with in vitro aging due to a decrease in expression of TERT, leading to telomere shortening and cellular senescence [41,65]." provenance.
- _5 value "Here we show that p62, like TRAF6, is upregulated during RANK-L-induced osteoclastogenesis and that the genetic inactivation of p62 in mice leads to impaired osteoclastogenesis in vitro and in vivo, as well as inhibition of IKK activation and NF-kappa B nuclear translocation." provenance.
- _5 value "mFKBP23 binds to mouse immunoglobulin binding protein (mBiP). The same assay with the recombinant proteins of the N- and C-termini of mFKBP23 shows that the binding of the C-terminus is Ca(2+)-dependent" provenance.
- _7 value "All stimuli resulted primarily in activation of MEF2D DNA binding. Exposure of cells to osmotic or oxidative stress increased MEF2 DNA binding via pathways that were completely blocked by MAPK inhibitors and partially blocked by inhibitors of PKC, PI 3-kinase, and AMPK." provenance.
- _4 value "Exposure of cells for 20 min to 120 nM insulin, 0.1 and 1.0 mM hydrogen peroxide, osmotic stress (400 mM mannitol), or 1.0 mM 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR) led to a profound increase in MEF2 DNA binding." provenance.
- _4 value "In epitrochlearis muscle, MAPK inhibitors blocked contraction but not AICAR-mediated MEF2 DNA binding." provenance.
- _3 value "Nucling-deficient cells, in which galectin-3 expression is up-regulated, appeared to be resistant to some forms of pro-apoptotic stress as compared with wild-type cells." provenance.
- _5 value "Nucling-deficient cells, in which galectin-3 expression is up-regulated, appeared to be resistant to some forms of pro-apoptotic stress as compared with wild-type cells." provenance.
- _3 value "we observed a shift in expression from RNA and protein markers of immature germ cells to those indicative of mature germ cells, including expression of VASA, BOL, SCP1, SCP3, GDF9 and TEKT1." provenance.
- _7 value "In vitro kinase assays using the combined STAT1 proteins as substrates from immunoprecipitation and glutathione S-transferase pull down show that active ERK1, JNK1, p38 kinase, MEK1 and MSK1 stimulated phosphorylation of STAT1 (Ser727) indirectly through an unidentified factor or a downstream kinase." provenance.
- _6 value "In vitro kinase assays using the combined STAT1 proteins as substrates from immunoprecipitation and glutathione S-transferase pull down show that active ERK1, JNK1, p38 kinase, MEK1 and MSK1 stimulated phosphorylation of STAT1 (Ser727) indirectly through an unidentified factor or a downstream kinase." provenance.
- _6 value "In vitro kinase assays using the combined STAT1 proteins as substrates from immunoprecipitation and glutathione S-transferase pull down show that active ERK1, JNK1, p38 kinase, MEK1 and MSK1 stimulated phosphorylation of STAT1 (Ser727) indirectly through an unidentified factor or a downstream kinase." provenance.
- _6 value "In vitro kinase assays using the combined STAT1 proteins as substrates from immunoprecipitation and glutathione S-transferase pull down show that active ERK1, JNK1, p38 kinase, MEK1 and MSK1 stimulated phosphorylation of STAT1 (Ser727) indirectly through an unidentified factor or a downstream kinase." provenance.
- _4 value "IGF1R Disruption of intercellular adhesion; enhancement of intercellular adhesion EGFR Inhibition of ligand-dependent EGFR activation; ligand-independent activation of EGFR SRC Loss of epithelial differentiation; invasiveness" provenance.
- _5 value "The putative transcriptional activators of PDK isozymes, peroxisome proliferator-activated receptor-alpha (PPAR-alpha) protein, and forkhead homolog in rhabdomyosarcoma (FKHR) mRNA were also measured." provenance.
- _7 value "PC4 enhances the DNA binding of p53 to its cognate site in vitro and directly interacts with p53 in vivo." provenance.
- _3 value "ET-1 mRNA expression was increased by I/R. mRNA levels for ETA receptors showed no change, whereas ETB receptor transcripts increased in the I/R group. The increases in ET-1 and ETB mRNA were not prevented by the GdCl3 pretreatment. The mRNA levels for iNOS and eNOS significantly increased within the I/R group" provenance.
- _3 value "TGFbeta1 inhibits and HGF induces proliferation; (3) TGFbeta1 and activin-A equipotently inhibit HGF secretion more than BMP-2" provenance.
- _7 value "TGFbeta1 inhibits and HGF induces proliferation; (3) TGFbeta1 and activin-A equipotently inhibit HGF secretion more than BMP-2" provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _2 value "Here we demonstrate that ceramide controls macroautophagy, a major lysosomal catabolic pathway." provenance.
- _4 value "Using these cells as well as ERalpha-positive MCF-7 and ZR-75-1 cells, we show that tumour necrosis factor alpha (TNFalpha) and the phosphatidylinositol-3-kinase (PI3-kinase) modulate transrepression function of ERalpha by reducing its stability." provenance.
- _3 value "down-regulated" provenance.
- _3 value "down-regulated" provenance.
- _3 value "down-regulated" provenance.
- _3 value "down-regulated" provenance.
- _3 value "Table 6 Genes up-regulated or down-regulated by one or more of the compounds [ICI, Ral or trans-hydroxytamoxifen (TOT)-1 �M] but not by E2 (10 nM)" provenance.
- _3 value "Table 6 Genes up-regulated or down-regulated by one or more of the compounds [ICI, Ral or trans-hydroxytamoxifen (TOT)-1 �M] but not by E2 (10 nM)" provenance.
- _3 value "Table 6 Genes up-regulated or down-regulated by one or more of the compounds [ICI, Ral or trans-hydroxytamoxifen (TOT)-1 �M] but not by E2 (10 nM)" provenance.
- _3 value "Table 6 Genes up-regulated or down-regulated by one or more of the compounds [ICI, Ral or trans-hydroxytamoxifen (TOT)-1 �M] but not by E2 (10 nM)" provenance.
- _3 value "Table 6 Genes up-regulated or down-regulated by one or more of the compounds [ICI, Ral or trans-hydroxytamoxifen (TOT)-1 �M] but not by E2 (10 nM)" provenance.
- _3 value "Table 6 Genes up-regulated or down-regulated by one or more of the compounds [ICI, Ral or trans-hydroxytamoxifen (TOT)-1 �M] but not by E2 (10 nM)" provenance.
- _3 value "Table 6 Genes up-regulated or down-regulated by one or more of the compounds [ICI, Ral or trans-hydroxytamoxifen (TOT)-1 �M] but not by E2 (10 nM)" provenance.
- _3 value "Table 6 Genes up-regulated or down-regulated by one or more of the compounds [ICI, Ral or trans-hydroxytamoxifen (TOT)-1 �M] but not by E2 (10 nM)" provenance.
- _3 value "Table 6 Genes up-regulated or down-regulated by one or more of the compounds [ICI, Ral or trans-hydroxytamoxifen (TOT)-1 �M] but not by E2 (10 nM)" provenance.
- _3 value "Table 6 Genes up-regulated or down-regulated by one or more of the compounds [ICI, Ral or trans-hydroxytamoxifen (TOT)-1 �M] but not by E2 (10 nM)" provenance.
- _3 value "Tables 1 and 2 which are the highest fold change increase and decrease, respectively, in response to 5mM aspirin" provenance.
- _3 value "Tables 1 and 2 which are the highest fold change increase and decrease, respectively, in response to 5mM aspirin" provenance.
- _3 value "Tables 1 and 2 which are the highest fold change increase and decrease, respectively, in response to 5mM aspirin" provenance.
- _5 value "Here, we investigate the role of PML nuclear body in MEF transactivation. We show that PML, but not Sp100, induced the accumulation of MEF in PML nuclear bodies and that MEF and PML physically interacted. This interaction stimulated MEF transcriptional activity, resulting in the up-regulation of endogenous lysozyme expression." provenance.
- _3 value "Teratogen-induced alterations in gene expression play an important role in the genesis of malformations in animals. The recent development of DNA microarrays now offers the opportunity to monitor global changes in gene expression and therefore the potential to obtain significant new information concerning both normal and abnormal development. RNA was isolated from day-9 mouse embryos at 1 and 5 h after exposure to hyperthermia (HS) or 4-hydroperoxycyclophosphamide (4CP) and compared to RNA isolated from concurrent controls using mouse cDNA microarrays. Cy5/Cy3 intensity data were extracted using Spot-on Image software and then normalized using the statistical software program R/maanova. Differentially expressed genes were identified using a linear mixed-effects model and p values derived from t-test statistics. Approximately 9000 genes show statistically significant alterations in expression in day-9 mouse embryos exposed to HS or 4CP. HS and 4CP also induce alterations in the expression of distinct sets of genes, e.g., DNA replication/repair, cell cycle, signal transduction, and transcription-related genes. As expected, a variety of heat shock genes are upregulated by HS but not 4CP. Among genes whose expression is altered by both HS and 4CP, cluster analysis identified three p53 target genes (Cyclin G1, Gtse1, and Mdm2), and follow up studies confirmed that p53 is activated in embryos exposed to these two teratogens. In addition, cluster analyses also revealed that HS but not 4CP induces the downregulation of genes encoding key enzymes in the cholesterol biosynthesis pathway. Thus, our microarray data have identified one potentially important pathway (p53) common to both HS- and 4CP-induced teratogenesis and another pathway (cholesterol biosynthesis) potentially important, but specific to HS-induced teratogenesis." provenance.
- _3 value "Teratogen-induced alterations in gene expression play an important role in the genesis of malformations in animals. The recent development of DNA microarrays now offers the opportunity to monitor global changes in gene expression and therefore the potential to obtain significant new information concerning both normal and abnormal development. RNA was isolated from day-9 mouse embryos at 1 and 5 h after exposure to hyperthermia (HS) or 4-hydroperoxycyclophosphamide (4CP) and compared to RNA isolated from concurrent controls using mouse cDNA microarrays. Cy5/Cy3 intensity data were extracted using Spot-on Image software and then normalized using the statistical software program R/maanova. Differentially expressed genes were identified using a linear mixed-effects model and p values derived from t-test statistics. Approximately 9000 genes show statistically significant alterations in expression in day-9 mouse embryos exposed to HS or 4CP. HS and 4CP also induce alterations in the expression of distinct sets of genes, e.g., DNA replication/repair, cell cycle, signal transduction, and transcription-related genes. As expected, a variety of heat shock genes are upregulated by HS but not 4CP. Among genes whose expression is altered by both HS and 4CP, cluster analysis identified three p53 target genes (Cyclin G1, Gtse1, and Mdm2), and follow up studies confirmed that p53 is activated in embryos exposed to these two teratogens. In addition, cluster analyses also revealed that HS but not 4CP induces the downregulation of genes encoding key enzymes in the cholesterol biosynthesis pathway. Thus, our microarray data have identified one potentially important pathway (p53) common to both HS- and 4CP-induced teratogenesis and another pathway (cholesterol biosynthesis) potentially important, but specific to HS-induced teratogenesis." provenance.
- _3 value "Teratogen-induced alterations in gene expression play an important role in the genesis of malformations in animals. The recent development of DNA microarrays now offers the opportunity to monitor global changes in gene expression and therefore the potential to obtain significant new information concerning both normal and abnormal development. RNA was isolated from day-9 mouse embryos at 1 and 5 h after exposure to hyperthermia (HS) or 4-hydroperoxycyclophosphamide (4CP) and compared to RNA isolated from concurrent controls using mouse cDNA microarrays. Cy5/Cy3 intensity data were extracted using Spot-on Image software and then normalized using the statistical software program R/maanova. Differentially expressed genes were identified using a linear mixed-effects model and p values derived from t-test statistics. Approximately 9000 genes show statistically significant alterations in expression in day-9 mouse embryos exposed to HS or 4CP. HS and 4CP also induce alterations in the expression of distinct sets of genes, e.g., DNA replication/repair, cell cycle, signal transduction, and transcription-related genes. As expected, a variety of heat shock genes are upregulated by HS but not 4CP. Among genes whose expression is altered by both HS and 4CP, cluster analysis identified three p53 target genes (Cyclin G1, Gtse1, and Mdm2), and follow up studies confirmed that p53 is activated in embryos exposed to these two teratogens. In addition, cluster analyses also revealed that HS but not 4CP induces the downregulation of genes encoding key enzymes in the cholesterol biosynthesis pathway. Thus, our microarray data have identified one potentially important pathway (p53) common to both HS- and 4CP-induced teratogenesis and another pathway (cholesterol biosynthesis) potentially important, but specific to HS-induced teratogenesis." provenance.
- _3 value "Teratogen-induced alterations in gene expression play an important role in the genesis of malformations in animals. The recent development of DNA microarrays now offers the opportunity to monitor global changes in gene expression and therefore the potential to obtain significant new information concerning both normal and abnormal development. RNA was isolated from day-9 mouse embryos at 1 and 5 h after exposure to hyperthermia (HS) or 4-hydroperoxycyclophosphamide (4CP) and compared to RNA isolated from concurrent controls using mouse cDNA microarrays. Cy5/Cy3 intensity data were extracted using Spot-on Image software and then normalized using the statistical software program R/maanova. Differentially expressed genes were identified using a linear mixed-effects model and p values derived from t-test statistics. Approximately 9000 genes show statistically significant alterations in expression in day-9 mouse embryos exposed to HS or 4CP. HS and 4CP also induce alterations in the expression of distinct sets of genes, e.g., DNA replication/repair, cell cycle, signal transduction, and transcription-related genes. As expected, a variety of heat shock genes are upregulated by HS but not 4CP. Among genes whose expression is altered by both HS and 4CP, cluster analysis identified three p53 target genes (Cyclin G1, Gtse1, and Mdm2), and follow up studies confirmed that p53 is activated in embryos exposed to these two teratogens. In addition, cluster analyses also revealed that HS but not 4CP induces the downregulation of genes encoding key enzymes in the cholesterol biosynthesis pathway. Thus, our microarray data have identified one potentially important pathway (p53) common to both HS- and 4CP-induced teratogenesis and another pathway (cholesterol biosynthesis) potentially important, but specific to HS-induced teratogenesis." provenance.
- _3 value "Teratogen-induced alterations in gene expression play an important role in the genesis of malformations in animals. The recent development of DNA microarrays now offers the opportunity to monitor global changes in gene expression and therefore the potential to obtain significant new information concerning both normal and abnormal development. RNA was isolated from day-9 mouse embryos at 1 and 5 h after exposure to hyperthermia (HS) or 4-hydroperoxycyclophosphamide (4CP) and compared to RNA isolated from concurrent controls using mouse cDNA microarrays. Cy5/Cy3 intensity data were extracted using Spot-on Image software and then normalized using the statistical software program R/maanova. Differentially expressed genes were identified using a linear mixed-effects model and p values derived from t-test statistics. Approximately 9000 genes show statistically significant alterations in expression in day-9 mouse embryos exposed to HS or 4CP. HS and 4CP also induce alterations in the expression of distinct sets of genes, e.g., DNA replication/repair, cell cycle, signal transduction, and transcription-related genes. As expected, a variety of heat shock genes are upregulated by HS but not 4CP. Among genes whose expression is altered by both HS and 4CP, cluster analysis identified three p53 target genes (Cyclin G1, Gtse1, and Mdm2), and follow up studies confirmed that p53 is activated in embryos exposed to these two teratogens. In addition, cluster analyses also revealed that HS but not 4CP induces the downregulation of genes encoding key enzymes in the cholesterol biosynthesis pathway. Thus, our microarray data have identified one potentially important pathway (p53) common to both HS- and 4CP-induced teratogenesis and another pathway (cholesterol biosynthesis) potentially important, but specific to HS-induced teratogenesis." provenance.
- _3 value "Teratogen-induced alterations in gene expression play an important role in the genesis of malformations in animals. The recent development of DNA microarrays now offers the opportunity to monitor global changes in gene expression and therefore the potential to obtain significant new information concerning both normal and abnormal development. RNA was isolated from day-9 mouse embryos at 1 and 5 h after exposure to hyperthermia (HS) or 4-hydroperoxycyclophosphamide (4CP) and compared to RNA isolated from concurrent controls using mouse cDNA microarrays. Cy5/Cy3 intensity data were extracted using Spot-on Image software and then normalized using the statistical software program R/maanova. Differentially expressed genes were identified using a linear mixed-effects model and p values derived from t-test statistics. Approximately 9000 genes show statistically significant alterations in expression in day-9 mouse embryos exposed to HS or 4CP. HS and 4CP also induce alterations in the expression of distinct sets of genes, e.g., DNA replication/repair, cell cycle, signal transduction, and transcription-related genes. As expected, a variety of heat shock genes are upregulated by HS but not 4CP. Among genes whose expression is altered by both HS and 4CP, cluster analysis identified three p53 target genes (Cyclin G1, Gtse1, and Mdm2), and follow up studies confirmed that p53 is activated in embryos exposed to these two teratogens. In addition, cluster analyses also revealed that HS but not 4CP induces the downregulation of genes encoding key enzymes in the cholesterol biosynthesis pathway. Thus, our microarray data have identified one potentially important pathway (p53) common to both HS- and 4CP-induced teratogenesis and another pathway (cholesterol biosynthesis) potentially important, but specific to HS-induced teratogenesis." provenance.
- _3 value "Teratogen-induced alterations in gene expression play an important role in the genesis of malformations in animals. The recent development of DNA microarrays now offers the opportunity to monitor global changes in gene expression and therefore the potential to obtain significant new information concerning both normal and abnormal development. RNA was isolated from day-9 mouse embryos at 1 and 5 h after exposure to hyperthermia (HS) or 4-hydroperoxycyclophosphamide (4CP) and compared to RNA isolated from concurrent controls using mouse cDNA microarrays. Cy5/Cy3 intensity data were extracted using Spot-on Image software and then normalized using the statistical software program R/maanova. Differentially expressed genes were identified using a linear mixed-effects model and p values derived from t-test statistics. Approximately 9000 genes show statistically significant alterations in expression in day-9 mouse embryos exposed to HS or 4CP. HS and 4CP also induce alterations in the expression of distinct sets of genes, e.g., DNA replication/repair, cell cycle, signal transduction, and transcription-related genes. As expected, a variety of heat shock genes are upregulated by HS but not 4CP. Among genes whose expression is altered by both HS and 4CP, cluster analysis identified three p53 target genes (Cyclin G1, Gtse1, and Mdm2), and follow up studies confirmed that p53 is activated in embryos exposed to these two teratogens. In addition, cluster analyses also revealed that HS but not 4CP induces the downregulation of genes encoding key enzymes in the cholesterol biosynthesis pathway. Thus, our microarray data have identified one potentially important pathway (p53) common to both HS- and 4CP-induced teratogenesis and another pathway (cholesterol biosynthesis) potentially important, but specific to HS-induced teratogenesis." provenance.
- _9 value "implicating recruitment of HDAC by PML-RAR as the mechanism underlying p53 inhibition" provenance.
- _5 value "A total of 12 human kinases (NUAK1, NUAK2, BRSK1, BRSK2, QIK, QSK, SIK, MARK1, MARK2, MARK3, MARK4 and MELK) are related to AMPK. Here we demonstrate that LKB1 can phosphorylate the T-loop of all the members of this subfamily, apart from MELK, increasing their activity >50-fold." provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _5 value "We recently demonstrated that the LKB1 tumour suppressor kinase, in complex with the pseudokinase STRAD and the scaffolding protein MO25, phosphorylates and activates AMP-activated protein kinase (AMPK)." provenance.
- _5 value "Modified assertion" provenance.
- _6 value "Here we show that the mammalian SIR2 ortholog SIRT1 deacetylates and represses the activity of the forkhead transcription factor Foxo3a and other mammalian forkhead factors." provenance.
- _5 value "In this study we show that merlin is also a target for PKA-induced phosphorylation. In vitro [gamma-(33)P]ATP labeling revealed that both the merlin N and C termini are phosphorylated by PKA. Furthermore, both in vitro and in vivo phosphorylation studies of the wild-type and mutated C termini demonstrated that PKA can phosphorylate merlin at serine 518, a site that is phosphorylated also by p21-activated kinases (PAKs)." provenance.
- _5 value "The silencing mediator of retinoic and thyroid hormone receptors (SMRT) corepressor mediates % transcriptional repression by interacting with transcription factors such as the promyelocytic leukemia zinc finger (PLZF) protein" provenance.
- _9 value "The silencing mediator of retinoic and thyroid hormone receptors (SMRT) corepressor mediates % transcriptional repression by interacting with transcription factors such as the promyelocytic leukemia zinc finger (PLZF) protein" provenance.
- _5 value "Modified assertion" provenance.
- _5 value "FSH-stimulated HIF-1 activity is inhibited by the PI 3-kinase inhibitor LY294002, the Rheb inhibitor FTI-277 (farnesyltransferase inhibitor-277), and the mTOR inhibitor rapamycin. These results show that FSH enhances HIF-1 activity downstream of the PI 3-kinase/AKT/Rheb/mTOR pathway in GCs and that HIF-1 activity is necessary for FSH to induce multiple follicular differentiation markers." provenance.
- _2 value "2. Tumor progression depends on tumor angiogenesis" provenance.
- _5 value "Here we demonstrate that cyclin-dependent kinase 2 (CDK2) in association with cyclin A or cyclin E directly binds to beta-catenin. In vivo and in vitro kinase assays with cyclin-CDK2 demonstrate beta-catenin phosphorylation on residues Ser(33), Ser(37), Thr(41), and Ser(45). This phosphorylation promotes rapid degradation of cytosolic beta-catenin via the beta-TrCP-mediated proteasome pathway." provenance.
- _5 value "Here we demonstrate that cyclin-dependent kinase 2 (CDK2) in association with cyclin A or cyclin E directly binds to beta-catenin. In vivo and in vitro kinase assays with cyclin-CDK2 demonstrate beta-catenin phosphorylation on residues Ser(33), Ser(37), Thr(41), and Ser(45). This phosphorylation promotes rapid degradation of cytosolic beta-catenin via the beta-TrCP-mediated proteasome pathway." provenance.
- _5 value "cyclin-CDK2 demonstrate beta-catenin phosphorylation on residues Ser(33), Ser(37), Thr(41), and Ser(45). This phosphorylation promotes rapid degradation of cytosolic beta-catenin" provenance.
- _4 value "AMPK-mediated iNOS inhibition was observed in several cell types (myocytes, adipocytes, macrophages)...AMPK-mediated iNOS inhibition was observed in several cell types (myocytes, adipocytes, macrophages) and primarily resulted from post-transcriptional regulation of the iNOS protein" provenance.
- _5 value "PhosphoElm data from PMID 15212693" provenance.
- _5 value "In vitro translated hBVR and nuclear extract containing hBVR in gel mobility-shift assay bound to AP-1 sites in the ATF-2 promoter region and to an oligonucleotide containing the CRE site. Both bindings could be competed out by excess unlabeled probe; in the presence of hBVR antibody, they displayed shifted bands. Co-transfection of hBVR with ATF-2 or c-jun promoters caused a severalfold increase in luciferase activity. hBVR modulation of ATF-2 and HO-1 expression suggests it has a potential role in regulation of AP-1 and cAMP-regulated genes and a role in cell signaling." provenance.
- _5 value "In vitro translated hBVR and nuclear extract containing hBVR in gel mobility-shift assay bound to AP-1 sites in the ATF-2 promoter region and to an oligonucleotide containing the CRE site. Both bindings could be competed out by excess unlabeled probe; in the presence of hBVR antibody, they displayed shifted bands. Co-transfection of hBVR with ATF-2 or c-jun promoters caused a severalfold increase in luciferase activity. hBVR modulation of ATF-2 and HO-1 expression suggests it has a potential role in regulation of AP-1 and cAMP-regulated genes and a role in cell signaling." provenance.
- _5 value "In vitro translated hBVR and nuclear extract containing hBVR in gel mobility-shift assay bound to AP-1 sites in the ATF-2 promoter region and to an oligonucleotide containing the CRE site. Both bindings could be competed out by excess unlabeled probe; in the presence of hBVR antibody, they displayed shifted bands. Co-transfection of hBVR with ATF-2 or c-jun promoters caused a severalfold increase in luciferase activity. hBVR modulation of ATF-2 and HO-1 expression suggests it has a potential role in regulation of AP-1 and cAMP-regulated genes and a role in cell signaling." provenance.
- _5 value "In vitro translated hBVR and nuclear extract containing hBVR in gel mobility-shift assay bound to AP-1 sites in the ATF-2 promoter region and to an oligonucleotide containing the CRE site. Both bindings could be competed out by excess unlabeled probe; in the presence of hBVR antibody, they displayed shifted bands. Co-transfection of hBVR with ATF-2 or c-jun promoters caused a severalfold increase in luciferase activity. hBVR modulation of ATF-2 and HO-1 expression suggests it has a potential role in regulation of AP-1 and cAMP-regulated genes and a role in cell signaling." provenance.