Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _4 value "downregulated" provenance.
- _4 value "downregulated" provenance.
- _4 value "downregulated" provenance.
- _4 value "downregulated" provenance.
- _4 value "downregulated" provenance.
- _4 value "downregulated" provenance.
- _4 value "downregulated" provenance.
- _4 value "downregulated" provenance.
- _4 value "downregulated" provenance.
- _4 value "downregulated" provenance.
- _4 value "downregulated" provenance.
- _4 value "downregulated" provenance.
- _4 value "downregulated" provenance.
- _4 value "downregulated" provenance.
- _4 value "downregulated" provenance.
- _3 value "Fig. 3. Representative list of the effects of DF, CR, and DF and CR (DFCR) together on hepatic gene expression. upregulated" provenance.
- _3 value "Fig. 3. Representative list of the effects of DF, CR, and DF and CR (DFCR) together on hepatic gene expression. upregulated" provenance.
- _3 value "downregulated" provenance.
- _6 value "The anti-apoptotic effect of calbindin-D28k involves inhibition of glucocorticoid induced caspase 3 activation as well as ERK activation." provenance.
- _4 value "The anti-apoptotic effect of calbindin-D28k involves inhibition of glucocorticoid induced caspase 3 activation as well as ERK activation." provenance.
- _6 value "In vitro, Tbx2 repressed the activity of regulatory fragments of Cx40, Cx43, and Nppa." provenance.
- _3 value "OPN stimulates T cell proliferation and induces T cells and macrophages to express other Th1 cytokines...it is involved in macrophage recruitment during inflammation" provenance.
- _3 value "estrogen stimulates the expression of ezrin and the LDLR" provenance.
- _3 value "down regulated by Long-term CR" provenance.
- _3 value "down regulated by Long-term CR" provenance.
- _3 value "down regulated by Long-term CR" provenance.
- _3 value "down regulated by Long-term CR" provenance.
- _3 value "upregulated by Long-term CR" provenance.
- _3 value "upregulated by Long-term CR" provenance.
- _3 value "upregulated by Long-term CR" provenance.
- _3 value "upregulated by Long-term CR" provenance.
- _7 value "CEACAM6 cross-linking increased c-Src activation and induced tyrosine phosphorylation of p125(FAK) focal adhesion kinase.Focal adhesion kinase phosphorylation was dependent on c-Src kinase activation, for which caveolin-1 was required.CEACAM6 cross-linking induced a significant increase in cellular resistance to anoikis. These observations represent the first characterization of the mechanism through which this important cell surface oncoprotein influences intracellular signaling events and hence malignant cellular behavior." provenance.
- _5 value "Modified assertion" provenance.
- _2 value "Here, we report that bile acids inhibit the expression of gluconeogenic genes, including glucose-6-phosphatase (G6Pase), phosphoenolpyruvate carboxykinase, and fructose 1,6-bis phosphatase in an SHP-dependent fashion. Cholic acid diet decreased the mRNA levels of these gluconeogenic enzymes, whereas those of SHP were increased." provenance.
- _2 value "Here, we report that bile acids inhibit the expression of gluconeogenic genes, including glucose-6-phosphatase (G6Pase), phosphoenolpyruvate carboxykinase, and fructose 1,6-bis phosphatase in an SHP-dependent fashion. Cholic acid diet decreased the mRNA levels of these gluconeogenic enzymes, whereas those of SHP were increased." provenance.
- _6 value "Mice were sacrificed 12 h after fasting, and the livers were removed for Northern blot analysis. Bile acid homeostasis is tightly controlled by the feedback mechanism in which an atypical orphan nuclear receptor (NR) small heterodimer partner (SHP) inactivates several NRs such as liver receptor homologue-1 and hepatocyte nuclear factor 4." provenance.
- _6 value "Remarkably, Foxo1 interacted with SHP in vivo and in vitro, which led to the repression of Foxo1-mediated G6Pase transcription by competition with a coactivator cAMP response element-binding protein-binding protein. These findings reveal a novel mechanism by which bile acids regulate gluconeogenic gene expression via an SHP-dependent regulatory pathway." provenance.
- _3 value "Reporter assays demonstrated that the promoter activity of phosphoenolpyruvate carboxykinase and fructose 1,6-bis phosphatase via hepatocyte nuclear factor 4, or that of G6Pase via the forkhead transcription factor Foxo1, was down-regulated by treatment with chenodeoxicholic acid and with transfected SHP." provenance.
- _3 value "However, when the cells enter quiescence, the URH49 mRNA level decreases 3-6-fold while the UAP56 mRNA level remains relatively constant. The amount of URH49 mRNA increases to the level found in proliferating cells within 5 h when quiescent cells are growth-stimulated or when protein synthesis is inhibited." provenance.
- _5 value "Akt/phosphoinositide 3-kinase (PI3-kinase) pathway with LY294002 and wortmannin prevents the ability of ET-1 to induce alpha-SMA, ezrin, paxillin, and moesin and to promote matrix contraction." provenance.
- _4 value "Figure 8. Endothelin induces {alpha}-SMA, paxillin, moesin, and ezrin expression; SSc fibroblasts overexpress {alpha}-SMA, paxillin, moesin, and ezrin in a manner that is dependent on endogenous ET-1 signaling. Normal and SSc fibroblasts were treated with and without 100 nM ET-1 (24 h) as indicated in the presence or absence of bosentan or wortmannin. Cell layers were harvested, and equal amounts of protein were subjected to SDS-PAGE and Western blot analysis with anti-{alpha}-SMA, anti-paxillin, anti-moesin, and anti-ezrin antibodies, as indicated. As a loading control, Western analysis with an anti-GAPDH antibody also was performed." provenance.
- _4 value "Modified assertion" provenance.
- _4 value "Down-regulation of the transcriptional repressor E2F6 by TGFbeta1" provenance.
- _3 value "Expression of connective tissue growth factor (CTGF), a member of the CCN gene family, is known to be significantly induced by mechanical stress." provenance.
- _3 value "Fibroblasts growing under stressed conditions within a three-dimensional collagen gel showed at least a 15 times higher level of Cyr61 mRNA than cells growing under relaxed conditions. Upon relaxation, the decline of the Cyr61 mRNA to a lower level occurred within 2 h, and was thus quicker than the response of CTGF. The regulation was fully reversible when stress was reapplied. Thus, Cyr61 represents another typical example of a stress-responsive gene. The level of the Nov mRNA was low in the stressed state, but increased in the relaxed state." provenance.
- _6 value "The mechanism by which CCL19 activates ERK1/2 was determined to be beta-arrestin-dependent, because it is reduced both by depletion of beta-arrestin-2 with small interfering RNA and by elimination of the phosphorylation sites in the tail of the receptor" provenance.
- _6 value "Modified assertion" provenance.
- _5 value "27(Kip1) (p27), a CDK inhibitor, migrates into the nucleus, where it controls cyclin-CDK complex activity for proper cell cycle progression" provenance.
- _4 value "Fibroblast like synoviocytes were stimulated with 10ng/ml of TGF-beta for 24 hours. TGF-beta induced the production of IL6." provenance.
- _3 value "p70S6K inhibitor rapamycin (RAPA) targets mesenchymal cells to shut down the sustained expression of vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF), via silencing of the PDGFRalpha-p70S6K pathway" provenance.
- _4 value "Loss of TIS7 caused the down-regulation of muscle-specific genes, such as those for MyoD, myogenin, and laminin-alpha2." provenance.
- _4 value "Loss of TIS7 caused the down-regulation of muscle-specific genes, such as those for MyoD, myogenin, and laminin-alpha2." provenance.
- _6 value "Functional analyses revealed that Alien, DAX-1 and thyroid hormone receptor mediated transcriptional silencing is strongly enhanced in the presence of active MLK2." provenance.
- _4 value "Nur77 is essential for POMC stimulation by IL-1 in corticotrophs" provenance.
- _5 value "MRN stimulates the kinase activity of ATM in vitro toward its substrates p53, Chk2, and histone H2AX. MRN makes multiple contacts with ATM and appears to stimulate ATM activity by facilitating the stable binding of substrates .. phospho-sites from Figs 1-2" provenance.
- _3 value "Additionally, KLF6 inhibits cellular transformation induced by several oncogenes (c-sis/PDGF-B, v-src, H-Ras, and EGFR) that are components of signaling cascades implicated in GBM." provenance.
- _4 value "Additionally, KLF6 inhibits cellular transformation induced by several oncogenes (c-sis/PDGF-B, v-src, H-Ras, and EGFR) that are components of signaling cascades implicated in GBM." provenance.
- _6 value "In the absence of RIP1, TLR3-mediated signals activating NF-kappa B, but not the kinase JNK or interferon-beta, were abolished, suggesting that RIP1 mediates Trif-induced NF-kappa B activation." provenance.
- _5 value "IFN-gamma induces the serine/threonine phosphorylation of PU.1 in cultured monocytes ... This phosphorylation, as well as the IFN-gamma-induced PU.1 binding and gp91(phox) protein synthesis, is slightly affected by the casein kinase II inhibitor, daidzein, but is abrogated by the protein kinase C (PKC) -alpha and -beta inhibitor, Go6976" provenance.
- _4 value "Gene transcripts for oncogenes and tumor markers such as pleiomorphic adenoma gene-like 1 (Plagl1) tumor antigen (L6) and claudin 3 were markedly elevated following LH and FSH stimulation." provenance.
- _4 value "Gene transcripts for oncogenes and tumor markers such as pleiomorphic adenoma gene-like 1 (Plagl1) tumor antigen (L6) and claudin 3 were markedly elevated following LH and FSH stimulation." provenance.
- _4 value "In contrast, increase in tumor rejection antigen (gp96) 1 and decrease in connective tissue growth factor (CTGF), transforming growth factor-beta 1 induced transcript 1 (TGFB1Il), pim-1 oncogene (PIM1), v-maf musculoaponeurotic fibrosarcoma oncogene homologue (MAF) and CD24 antigen" provenance.
- _4 value "stimulation of cells with saturating doses of gonadotropins gives rise to the expression of genes coding for presenilin 1 and 2, along with the up-regulation of genes involved in steroidogenesis such as StAR, cytochrome P450scc enzyme system and aromatase." provenance.
- _4 value "stimulation of cells with saturating doses of gonadotropins gives rise to the expression of genes coding for presenilin 1 and 2, along with the up-regulation of genes involved in steroidogenesis such as StAR, cytochrome P450scc enzyme system and aromatase." provenance.
- _4 value "stimulation of cells with saturating doses of gonadotropins gives rise to the expression of genes coding for presenilin 1 and 2, along with the up-regulation of genes involved in steroidogenesis such as StAR, cytochrome P450scc enzyme system and aromatase." provenance.
- _5 value "Notch signaling, which promotes keratinocyte differentiation, is upregulated in embryonic keratinocyte and epidermis, and elevated caspase 3 expression, which we identify as a transcriptional Notch1 target, accounts in part for the high commitment of embryonic keratinocytes to terminal differentiation. Table 1. Genes Concomitantly Upregulated in Embryonic Keratinocytes and in Response to Increased Notch1 Activity Figure 3. Elevated caspase 3 Expression in Embryonic Keratinocytes and Skin and in Response to Notch1 Activation." provenance.
- _5 value "From Full Text: We have recently demonstrated that 11 other poorly studied protein kinases that belong to the AMPK subfamily (NUAK1, NUAK2, BRSK1, BRSK2, QSK, SIK, QIK, MARK1, MARK2, MARK3, MARK4), are activated in vitro following phosphorylation of their T-loop threonine residues by LKB1 (16). We have also developed assays to measure the activities of the endogenous AMPK-related kinases and found that the activities of these enzymes are markedly reduced in LKB1-deficient fibroblasts or HeLa cells (16). These results imply that LKB1 functions as a master \"upstream\" protein kinase, regulating the activities of AMPK and the AMPK-related kinases. LKB1 and AMPK-related kinase activities have thus far been studied only in cultured cell lines and not in tissues of relevance to diabetes. Because the beneficial effects of exercise and metformin for type 2 diabetes are thought to be at least partly mediated through activation of AMPK, we sought to determine whether LKB1 and AMPK-related kinases are also regulated by muscle contraction and/or phenformin in rat skeletal muscles." provenance.
- _6 value "From Full Text: We have recently demonstrated that 11 other poorly studied protein kinases that belong to the AMPK subfamily (NUAK1, NUAK2, BRSK1, BRSK2, QSK, SIK, QIK, MARK1, MARK2, MARK3, MARK4), are activated in vitro following phosphorylation of their T-loop threonine residues by LKB1 (16). We have also developed assays to measure the activities of the endogenous AMPK-related kinases and found that the activities of these enzymes are markedly reduced in LKB1-deficient fibroblasts or HeLa cells (16). These results imply that LKB1 functions as a master \"upstream\" protein kinase, regulating the activities of AMPK and the AMPK-related kinases. LKB1 and AMPK-related kinase activities have thus far been studied only in cultured cell lines and not in tissues of relevance to diabetes. Because the beneficial effects of exercise and metformin for type 2 diabetes are thought to be at least partly mediated through activation of AMPK, we sought to determine whether LKB1 and AMPK-related kinases are also regulated by muscle contraction and/or phenformin in rat skeletal muscles." provenance.
- _6 value "From Full Text: We have recently demonstrated that 11 other poorly studied protein kinases that belong to the AMPK subfamily (NUAK1, NUAK2, BRSK1, BRSK2, QSK, SIK, QIK, MARK1, MARK2, MARK3, MARK4), are activated in vitro following phosphorylation of their T-loop threonine residues by LKB1 (16). We have also developed assays to measure the activities of the endogenous AMPK-related kinases and found that the activities of these enzymes are markedly reduced in LKB1-deficient fibroblasts or HeLa cells (16). These results imply that LKB1 functions as a master \"upstream\" protein kinase, regulating the activities of AMPK and the AMPK-related kinases. LKB1 and AMPK-related kinase activities have thus far been studied only in cultured cell lines and not in tissues of relevance to diabetes. Because the beneficial effects of exercise and metformin for type 2 diabetes are thought to be at least partly mediated through activation of AMPK, we sought to determine whether LKB1 and AMPK-related kinases are also regulated by muscle contraction and/or phenformin in rat skeletal muscles." provenance.
- _4 value "Insulin action on Na+, K+-ATPase was dependent on ERK1/2 in HSMCs. Insulin also increased phosphorylation and plasma membrane content of the Na+,K+-ATPase alpha1- and alpha2-subunits. The insulin induced phosphorylation at threonine and proline motif of alpha subunits inhibited by ERK1/2 inhibitors and its upstream kinase inhibitors. Results of in-vitro assay showed that ERK1/2 phosphorylated alpha subunits of Na+, K+-ATPase." provenance.
- _4 value "Insulin action on Na+, K+-ATPase was dependent on ERK1/2 in HSMCs. Insulin also increased phosphorylation and plasma membrane content of the Na+,K+-ATPase alpha1- and alpha2-subunits. The insulin induced phosphorylation at threonine and proline motif of alpha subunits inhibited by ERK1/2 inhibitors and its upstream kinase inhibitors. Results of in-vitro assay showed that ERK1/2 phosphorylated alpha subunits of Na+, K+-ATPase." provenance.
- _5 value "Insulin stimulates Na(+),K(+)-ATPase activity and induces translocation of Na(+),K(+)-ATPase molecules to the plasma membrane in skeletal muscle." provenance.
- _5 value "Insulin-stimulated Na(+),K(+)-ATPase activation, phosphorylation, and translocation of alpha-subunits to the plasma membrane were abolished by 20 microm PD98059, which is an inhibitor of MEK1/2, an upstream kinase of ERK1/2. Furthermore, inhibitors of phosphatidylinositol 3-kinase (100 nm wortmannin) and protein kinase C (10 microm GF109203X) had similar effects." provenance.
- _6 value "Insulin-stimulated Na(+),K(+)-ATPase activation, phosphorylation, and translocation of alpha-subunits to the plasma membrane were abolished by 20 microm PD98059, which is an inhibitor of MEK1/2, an upstream kinase of ERK1/2. Furthermore, inhibitors of phosphatidylinositol 3-kinase (100 nm wortmannin) and protein kinase C (10 microm GF109203X) had similar effects." provenance.
- _5 value "Insulin-stimulated Na(+),K(+)-ATPase activation, phosphorylation, and translocation of alpha-subunits to the plasma membrane were abolished by 20 microm PD98059, which is an inhibitor of MEK1/2, an upstream kinase of ERK1/2. Furthermore, inhibitors of phosphatidylinositol 3-kinase (100 nm wortmannin) and protein kinase C (10 microm GF109203X) had similar effects." provenance.
- _4 value " We show here that neither BAFF nor APRIL was able to induce STAT3 phosphorylation but did activate ERK1/2 and PI3K/Akt pathways." provenance.
- _5 value "The protein encoded by this gene (TNFRSF13B) is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17." provenance.
- _5 value "The protein encoded by this gene (TNFRSF17)is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation." provenance.
- _3 value "expression of BAFF and APRIL receptors (B-cell maturation antigen [BCMA], transmembrane activator and calcium modulator and cyclophilin ligand interactor [TACI], and BAFF-R) in a majority of 13 myeloma cell lines and in the purified primary myeloma cells of 11 patients. APRIL and BAFF were potent survival factors for exogenous cytokine-dependent myeloma cell lines and were autocrine growth factors for the RPMI8226 and L363 autonomously growing cell lines. These factors activated nuclear factor (NF)-kappaB, phosphatidylinositol-3 (PI-3) kinase/AKT, and mitogen-activated protein kinase (MAPK) kinase pathways and induced a strong up-regulation of the Mcl-1 and Bcl-2 antiapoptotic proteins in myeloma cells." provenance.
- _4 value "expression of BAFF and APRIL receptors (B-cell maturation antigen [BCMA], transmembrane activator and calcium modulator and cyclophilin ligand interactor [TACI], and BAFF-R) in a majority of 13 myeloma cell lines and in the purified primary myeloma cells of 11 patients. APRIL and BAFF were potent survival factors for exogenous cytokine-dependent myeloma cell lines and were autocrine growth factors for the RPMI8226 and L363 autonomously growing cell lines. These factors activated nuclear factor (NF)-kappaB, phosphatidylinositol-3 (PI-3) kinase/AKT, and mitogen-activated protein kinase (MAPK) kinase pathways and induced a strong up-regulation of the Mcl-1 and Bcl-2 antiapoptotic proteins in myeloma cells." provenance.
- _5 value "expression of BAFF and APRIL receptors (B-cell maturation antigen [BCMA], transmembrane activator and calcium modulator and cyclophilin ligand interactor [TACI], and BAFF-R) in a majority of 13 myeloma cell lines and in the purified primary myeloma cells of 11 patients. APRIL and BAFF were potent survival factors for exogenous cytokine-dependent myeloma cell lines and were autocrine growth factors for the RPMI8226 and L363 autonomously growing cell lines. These factors activated nuclear factor (NF)-kappaB, phosphatidylinositol-3 (PI-3) kinase/AKT, and mitogen-activated protein kinase (MAPK) kinase pathways and induced a strong up-regulation of the Mcl-1 and Bcl-2 antiapoptotic proteins in myeloma cells." provenance.
- _5 value "IL-1beta increased HK activity in both a time- and concentration-dependent manner: activity increased maximally by approximately 50% between 12 and 24 h with an apparent EC(50) of 3 pM. IL-1alpha mimicked, but did not augment, the effects of IL-1beta. Changes in HK activity were associated with both increased Glc metabolism and selective increases in HKII isoform abundance # Pubmed:gene: Proinflammatory interleukin-1 cytokines increase mesangial cell hexokinase activity and hexokinase II isoform abundance." provenance.
- _4 value "Over-weight and moderately obese patients maintained on very low calorie diet, were given either sub cutaneous injections of 80mg pegylated leptin or matching placebo (8 ml). Blood CRP(C-reactive protein) levels were estimated before and after weight loss. Weight loss has led to a significant increase in level of CRP (from 1.30[0.83-11.66] to 2.66[0.79-14.45] mg/liter) in Peg-ob treated group." provenance.
- _3 value "Estrogen and phorbol esters regulate amphiregulin expression by two separate mechanisms in human breast cancer cell lines" provenance.
- _5 value "Importantly, mACTN2 not only served as a primary coactivator for androgen receptor, estrogen receptor and thyroid receptor activities, but also acted synergistically with GRIP1 to enhance these nuclear receptor (NR) functions." provenance.
- _5 value "Importantly, mACTN2 not only served as a primary coactivator for androgen receptor, estrogen receptor and thyroid receptor activities, but also acted synergistically with GRIP1 to enhance these nuclear receptor (NR) functions." provenance.
- _3 value "Insulin-induced gene 1 (INSIG-1)" provenance.
- _5 value "Expression of tight junction proteins, including claudin-1, occludin and ZO-1, was downregulated in MDCK cells exogenously expressing Snail protein." provenance.
- _5 value "# sentences for pubmedID=15075319: # GeneRif: activity of ESE-1 is positively and negatively modulated by other interacting proteins including Ku70, Ku86, p300, and CBP. # Pubmed:gene: Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86. Interestingly, Ku70 and Ku 86 negatively regulate the transcriptional activity of ESE-1." provenance.
- _6 value "In contrast, co-transfection of p300 and CBP with ESE-1 enhances the transcriptional activity of ESE-1" provenance.
- _5 value "Interestingly, Ku70 and Ku 86 negatively regulate the transcriptional activity of ESE-1." provenance.
- _3 value "STAT3 inhibition markedly decreased survivin expression, and forced expression of survivin rescued AGS cells from apoptosis induced by STAT3 inhibition." provenance.
- _5 value "Figure 5. Regulation of the core cell-death machinery by E2F-1 and the p53 family. E2F-1 can regulate apoptosis in many ways. It can induce cell death by stabilizing the levels of p53 through activating the ARF tumor suppressor, which suppresses Mdm2, a negative regulator of p53. The p53 protein regulates the transcription of several celldeath genes including BH3-only proteins, proapoptotic Bcl-2 protein Bax and the caspase-9 adaptor Apaf-1. In cells lacking p53, E2F-1 can act through p73, a member of p53 family that activates some of the same target genes as p53. E2F-1 can also directly regulate the transcription of several different caspases and suppress cell survival pathways by suppressing Mcl-1 expression or by inhibiting NFkB-mediated antiapoptotic signaling." provenance.
- _5 value "Figure 5. Regulation of the core cell-death machinery by E2F-1 and the p53 family. E2F-1 can regulate apoptosis in many ways. It can induce cell death by stabilizing the levels of p53 through activating the ARF tumor suppressor, which suppresses Mdm2, a negative regulator of p53. The p53 protein regulates the transcription of several celldeath genes including BH3-only proteins, proapoptotic Bcl-2 protein Bax and the caspase-9 adaptor Apaf-1. In cells lacking p53, E2F-1 can act through p73, a member of p53 family that activates some of the same target genes as p53. E2F-1 can also directly regulate the transcription of several different caspases and suppress cell survival pathways by suppressing Mcl-1 expression or by inhibiting NFkB-mediated antiapoptotic signaling." provenance.
- _6 value "Expression of dominant negative PKCepsilon inhibited IFN-gamma-induced STAT1alpha-dependent transcription." provenance.
- _5 value "cross-talk and activation between the PI 3-kinase/Akt and p38 MAPK pathways that is essential for efficient myoblast differentiation. During myoblast differentiation, Akt kinase activity correlated with S473 but not T308 phosphorylation and occurred 24 h after p38 activation Akt2 promoter activity and protein levels were regulated by p38 activation, thus providing a mechanism for communication." provenance.
- _6 value "cross-talk and activation between the PI 3-kinase/Akt and p38 MAPK pathways that is essential for efficient myoblast differentiation. During myoblast differentiation, Akt kinase activity correlated with S473 but not T308 phosphorylation and occurred 24 h after p38 activation Akt2 promoter activity and protein levels were regulated by p38 activation, thus providing a mechanism for communication." provenance.
- _4 value "Stimulation of MCF-7 cells with 10 nM of EGF and progestin resulted in activation of extracellular signal-regulated protein kinase (ERK)1/2 within 5 min." provenance.
- _6 value "Nuclear exclusion of the forkhead transcription factor FOXO3a by protein kinase Akt contributes to cell survival." provenance.
- _5 value "expression of GSK3a, which has previously been shown to be deactivated by Akt (16) and in rat skeletal muscle is inhibited by both IGF1 and insulin and increased by stretch and contraction" provenance.