Matches in Nanopublications for { ?s <http://www.w3.org/ns/prov#value> ?o ?g. }
- _3 value "after stress stimuli to some cell types, Egr1 is required for programmed cell death or apoptosis in both normal and tumor cells" provenance.
- _5 value "That hypothesis is consistent with the presence of a functional p53-response element within the promoter region of the mouse SIP gene and confirmed by the induction of SIP mRNA expression in mouse embryo fibroblasts upon activation of a p53-dependent pathway by transfection with rasV12 or rasV12/E1A" provenance.
- _3 value "LIG-1 inversely correlates with proliferative ability of epidermal keratinocytes." provenance.
- _3 value "As demonstrated by cis element double-stranded (decoy) oligodeoxynucleotides, NF-kappaB was involved in IL-6 release by MCP-1, whereas proliferation was dependent on AP-1." provenance.
- _5 value "MCP-1 also induced extracellular signal-regulated kinase, which, along with IL-6 release, was inhibited by pertussis toxin." provenance.
- _4 value "MCP-1 stimulated the binding activity of NF-kappaB and of activator protein-1 (AP-1)" provenance.
- _4 value "MCP-1 stimulated the binding activity of NF-kappaB and of activator protein-1 (AP-1)" provenance.
- _4 value "Modified assertion" provenance.
- _6 value "PD98059 prevented MCP-1-induced extracellular signal-regulated kinase activation and cell proliferation" provenance.
- _5 value "Stimulation of VSMCs with MCP-1 induced proliferation and resulted in a concentration- and time-dependent release of the proinflammatory cytokine interleukin-6 (IL-6). MCP-1 also induced extracellular signal-regulated kinase, which, along with IL-6 release, was inhibited by pertussis toxin." provenance.
- _5 value "Stimulation of VSMCs with MCP-1 induced proliferation and resulted in a concentration- and time-dependent release of the proinflammatory cytokine interleukin-6 (IL-6). MCP-1 also induced extracellular signal-regulated kinase, which, along with IL-6 release, was inhibited by pertussis toxin." provenance.
- _5 value "Modified assertion" provenance.
- _4 value "Modified assertion" provenance.
- _5 value "Modified assertion" provenance.
- _6 value "Modified assertion" provenance.
- _5 value "From mutations file" provenance.
- _5 value "From mutations file" provenance.
- _5 value "From mutations file" provenance.
- _5 value "From mutations file" provenance.
- _5 value "From mutations file" provenance.
- _5 value "From mutations file" provenance.
- _5 value "From mutations file" provenance.
- _3 value "Lipoxygenase (LOX) metabolites from arachidonic acid and linoleic acid have been implicated in atherosclerosis, inflammation, keratinocyte differentiation and tumour progression. We previously showed that peroxisome proliferator-activated receptors (PPARs) play a role in keratinocyte differentiation and that the PPARalpha ligand 8S-hydroxyeicosatetraenoic acid is important in this process. We hypothesized that blocking LOX activity would block PPAR-mediated keratinocyte differentiation. Three LOX inhibitors, nordihydroguaiaretic acid, quercetin and morin, were studied for their effects on primary keratinocyte differentiation and PPAR activity. All three LOX inhibitors blocked calcium-induced expression of the differentiation marker keratin 1. In addition, activity of a PPAR-responsive element was inhibited in the presence of all three inhibitors, and this effect was mediated primarily through PPARalpha and PPARgamma. LOX inhibitors decreased the activity of a chimaeric PPAR-Gal4-ligand-binding domain reporter system and this effect was reversed by addition of PPAR ligands. Ligand-binding studies revealed that the LOX inhibitors bind directly to PPARs and demonstrate a novel mechanism for these inhibitors in altering PPAR-mediated gene expression." provenance.
- _3 value "These results support a key antiapoptotic role for cytosolic HSP60." provenance.
- _3 value "known antiapoptotic effects of HSP27 and HSP72" provenance.
- _7 value "Conditional overexpression of p27 in c-myc(+/+) cells caused inhibition of Cdk4/6 activity and elicited defects in G(0)-to-S phase progression very similar to those seen in c-myc(-/-) cells. Overexpression of cyclin D1 in c-myc(-/-) cells rescued the defect in Cdk4/6 activity, indicating that the limiting factor is the number of cyclin D-Cdk4/6 complexes." provenance.
- _3 value "Conditional overexpression of p27 in c-myc(+/+) cells caused inhibition of Cdk4/6 activity and elicited defects in G(0)-to-S phase progression very similar to those seen in c-myc(-/-) cells. Overexpression of cyclin D1 in c-myc(-/-) cells rescued the defect in Cdk4/6 activity, indicating that the limiting factor is the number of cyclin D-Cdk4/6 complexes." provenance.
- _5 value "Conditional overexpression of p27 in c-myc(+/+) cells caused inhibition of Cdk4/6 activity and elicited defects in G(0)-to-S phase progression very similar to those seen in c-myc(-/-) cells. Overexpression of cyclin D1 in c-myc(-/-) cells rescued the defect in Cdk4/6 activity, indicating that the limiting factor is the number of cyclin D-Cdk4/6 complexes." provenance.
- _3 value "Insulin increases protein levels of liver-enriched transcriptional inhibitory protein (LIP), an inhibitory form of C/EBP beta, in a phosphatidylinositol 3-kinase-dependent manner." provenance.
- _4 value "glucocorticoids promote, whereas insulin disrupts, the association of CREB-binding protein (CBP) and RNA polymerase II with the hepatic PEPCK gene promoter in vivo." provenance.
- _6 value "glucocorticoids promote, whereas insulin disrupts, the association of CREB-binding protein (CBP) and RNA polymerase II with the hepatic PEPCK gene promoter in vivo." provenance.
- _6 value "Modified assertion" provenance.
- _4 value "Primary mammary tumor cells treated with TGF-beta1 and truncated TGF-receptor II fusion protein (Fc:TGF-beta receptor II) together displayed abundant beta-catenin expression that was localized to the cell membranes. However, beta-catenin expression was downregulated in cells treated with TGF-beta1 alone." provenance.
- _3 value "The addition of exogenous N-acetylsphingosine (C2-ceramide) or increasing endogenous ceramide levels inhibited the expression of C/EBPalpha and PPARgamma, and blocked adipocyte development." provenance.
- _3 value "The addition of exogenous N-acetylsphingosine (C2-ceramide) or increasing endogenous ceramide levels inhibited the expression of C/EBPalpha and PPARgamma, and blocked adipocyte development." provenance.
- _3 value "17alpha-Ethinyl estradiol (EE) pretreatment reduced the IL-1beta induction of approximately one third of these genes. Estrogen receptor alpha (ERalpha) was required for this inhibitory activity, because EE inhibition of IL-1beta-stimulated gene expression occurred in ERbeta knockout mice, but not in ERalpha knockout mice. Table 2. EE induction of gene expression in the mouse liver" provenance.
- _3 value "17alpha-Ethinyl estradiol (EE) pretreatment reduced the IL-1beta induction of approximately one third of these genes. Estrogen receptor alpha (ERalpha) was required for this inhibitory activity, because EE inhibition of IL-1beta-stimulated gene expression occurred in ERbeta knockout mice, but not in ERalpha knockout mice. Table 2. EE induction of gene expression in the mouse liver" provenance.
- _3 value "17alpha-Ethinyl estradiol (EE) pretreatment reduced the IL-1beta induction of approximately one third of these genes. Estrogen receptor alpha (ERalpha) was required for this inhibitory activity, because EE inhibition of IL-1beta-stimulated gene expression occurred in ERbeta knockout mice, but not in ERalpha knockout mice. Table 2. EE induction of gene expression in the mouse liver" provenance.
- _3 value "17alpha-Ethinyl estradiol (EE) pretreatment reduced the IL-1beta induction of approximately one third of these genes. Estrogen receptor alpha (ERalpha) was required for this inhibitory activity, because EE inhibition of IL-1beta-stimulated gene expression occurred in ERbeta knockout mice, but not in ERalpha knockout mice. Table 2. EE induction of gene expression in the mouse liver" provenance.
- _3 value "17alpha-Ethinyl estradiol (EE) pretreatment reduced the IL-1beta induction of approximately one third of these genes. Estrogen receptor alpha (ERalpha) was required for this inhibitory activity, because EE inhibition of IL-1beta-stimulated gene expression occurred in ERbeta knockout mice, but not in ERalpha knockout mice. Table 2. EE induction of gene expression in the mouse liver" provenance.
- _5 value "Estrogen receptor alpha (ERalpha) was required for this inhibitory activity, because EE inhibition of IL-1beta-stimulated gene expression occurred in ERbeta knockout mice, but not in ERalpha knockout mice" provenance.
- _5 value "Modified assertion" provenance.
- _3 value "D3 mRNA was markedly induced by treatment for 6 h with epidermal growth factor, acid or basic fibroblast growth factors (10 ng/ml), or a 3-h treatment with a phorbol ester [12-O-tetradecanoylphorbol-13-acetate (TPA), 1 microM] or 10% fetal bovine serum. However, preincubation of cells overnight with 50 nM DEX completely blocked the D3-inducing effects of basic fibroblast growth factor" provenance.
- _5 value "D3 mRNA was markedly induced by treatment for 6 h with epidermal growth factor, acid or basic fibroblast growth factors (10 ng/ml), or a 3-h treatment with a phorbol ester [12-O-tetradecanoylphorbol-13-acetate (TPA), 1 microM] or 10% fetal bovine serum. However, preincubation of cells overnight with 50 nM DEX completely blocked the D3-inducing effects of basic fibroblast growth factor" provenance.
- _4 value "Recently, we reported that the AS3 protein mediates the androgen-induced quiescence in androgen-target human cell lines." provenance.
- _4 value "Ariadne: Furthermore, CST3 and cathepsin L are thought to promote sperm maturation through modification of sperm surface proteins and soluble proteins in the surrounding fluid ( 18 )" provenance.
- _3 value "the early phase of the stimulatory action of aldosterone on sodium reabsorption in tight epithelia involves hormone-regulated genes that remain to be identified from rats treated with aldosterone, found Ndr1 in response, which consists of four isoforms and belongs to a new family of differentiation-related genes" provenance.
- _4 value "TIEG1 promotes TGFbeta/Smad signaling by down-regulating negative feedback through the inhibitory Smad7." provenance.
- _4 value "(1) thrombin, a PAR-1 peptide, and histamine cause rapid concentration- and time-dependent phosphorylation on tyrosines 402 (Src kinase binding site), 881 (Grb2 binding site), and 580 (an autophosphorylation site) thrombin-stimulated phosphorylation is dependent on intracellular calcium and independent of PKC and PI-3 kinase" provenance.
- _4 value "(1) thrombin, a PAR-1 peptide, and histamine cause rapid concentration- and time-dependent phosphorylation on tyrosines 402 (Src kinase binding site), 881 (Grb2 binding site), and 580 (an autophosphorylation site) thrombin-stimulated phosphorylation is dependent on intracellular calcium and independent of PKC and PI-3 kinase" provenance.
- _3 value "(1) thrombin, a PAR-1 peptide, and histamine cause rapid concentration- and time-dependent phosphorylation on tyrosines 402 (Src kinase binding site), 881 (Grb2 binding site), and 580 (an autophosphorylation site) thrombin-stimulated phosphorylation is dependent on intracellular calcium and independent of PKC and PI-3 kinase" provenance.
- _4 value "PP1, an inhibitor of SRC kinase totally inhibited both basal and thrombin stimulated p42/44 MAPK phosphorylation, indicating dependence of MAP kinase activation on Src tyrosine kinase." provenance.
- _5 value "Brain-derived neurotrophic factor (BDNF) binds to and activates the TrkB tyrosine kinase receptor to regulate cell differentiation, survival, and neural plasticity in the nervous system." provenance.
- _3 value "Adenylyl cyclase activation is thought to be responsible for most cellular responses to PTH and PTHrP, although many actions appear to be independent of adenylyl cyclase. PTH treatment of cells that express the NHERF2 PTH1R complex markedly activates phospholipase C beta and inhibits adenylyl cyclase through stimulation of inhibitory G proteins (G(i/o) proteins)." provenance.
- _5 value "Adenylyl cyclase activation is thought to be responsible for most cellular responses to PTH and PTHrP, although many actions appear to be independent of adenylyl cyclase. PTH treatment of cells that express the NHERF2 PTH1R complex markedly activates phospholipase C beta and inhibits adenylyl cyclase through stimulation of inhibitory G proteins (G(i/o) proteins)." provenance.
- _4 value "Adenylyl cyclase activation is thought to be responsible for most cellular responses to PTH and PTHrP, although many actions appear to be independent of adenylyl cyclase. PTH treatment of cells that express the NHERF2 PTH1R complex markedly activates phospholipase C beta and inhibits adenylyl cyclase through stimulation of inhibitory G proteins (G(i/o) proteins)." provenance.
- _5 value "The parathyroid hormone 1 receptor (PTH1R) is a class II G-protein-coupled receptor. PTH1R agonists include both PTH, a hormone that regulates blood calcium and phosphate, and PTH-related protein (PTHrP)" provenance.
- _4 value "Furthermore, Wnt-3A overexpression results in decreases in both N-cadherin and GSK-3beta protein levels, whereas Wnt-3A as well as kinase-dead GSK-3beta overexpression increase total and nuclear levels of both beta-catenin and LEF-1." provenance.
- _4 value "Furthermore, Wnt-3A overexpression results in decreases in both N-cadherin and GSK-3beta protein levels, whereas Wnt-3A as well as kinase-dead GSK-3beta overexpression increase total and nuclear levels of both beta-catenin and LEF-1." provenance.
- _4 value "Furthermore, Wnt-3A overexpression results in decreases in both N-cadherin and GSK-3beta protein levels, whereas Wnt-3A as well as kinase-dead GSK-3beta overexpression increase total and nuclear levels of both beta-catenin and LEF-1." provenance.
- _6 value "up-regulated interaction between beta-catenin and SMAD-4 in response to BMP-2" provenance.
- _6 value "Ask1 constitutes the converging point of the heat shock and oxidative stress-sensing pathways that lead to p38 activation" provenance.
- _4 value "The activation of Ask1 by oxidative stress involves the oxidation of thioredoxin, an endogenous inhibitor of Ask1." provenance.
- _4 value "HGF induced the secretion of VEGF and MIP-2 from LLC/IL-1B cells." provenance.
- _4 value "Inhibition of TGF-beta activity for seven days with solRII decreased proteoglycan (PTG) staining in five of six cartilage compartments compared with treatment with solvent." provenance.
- _5 value "However, apoptosis suppression by C-Raf also occurs in cells lacking expression of Bad or Bcl-2. RESULTS: Here we show that even in the absence of Bcl-2/Bcl-XL, mitochondria-targeted C-Raf inhibits cytochrome c release and caspase activation induced by growth factor withdrawal." provenance.
- _3 value "Furthermore, they reveal that Physiological hyperinsulinemia is sufficient to increase IRS-1 tyrosine phosphorylation and PI3Kinase activity in vivo in skeletal muscle from healthy subjects" provenance.
- _3 value "Furthermore, they reveal that Physiological hyperinsulinemia is sufficient to increase IRS-1 tyrosine phosphorylation and PI3Kinase activity in vivo in skeletal muscle from healthy subjects" provenance.
- _3 value "Physiological hyperinsulinemia increased PI3K activity by 2-fold in control subjects. In contrast insulin failed to increase PI3K activity in skeletal muscle from type-II daibetic subjects" provenance.
- _2 value "These findings couple reduced insulin-stimulated IRS-1 tyrosine phosphorylation and PI3 Kinase activity to impaired insulin stimulated glucose transport in skeletal muscle from lean to moderately obese type II diabetic subjects." provenance.
- _3 value "These findings couple reduced insulin-stimulated IRS-1 tyrosine phosphorylation and PI3 Kinase activity to impaired insulin stimulated glucose transport in skeletal muscle from lean to moderately obese type II diabetic subjects." provenance.
- _3 value "hyperglycemia may induce insulin resistance via increased serine phosphorylation on IRS1." provenance.
- _4 value "insulin mediated glucose transport and cell-surface GLUT4 content are profoundly reduced in skeletal muscle from type II diabetic patients" provenance.
- _5 value "To identify the modified residue, the relevant tryptic peptides from each sample were further analyzed by tandem mass spectrometry. Comparison of the fragment patterns revealed that Asn 851 contained the additional oxygen atom (Fig. 4B). Together these data show that FIH-1 is an asparaginyl hydroxylase that inhibits HIF transcriptional activity by preventing CAD association with the coactivator p300. " provenance.
- _3 value "Among the up-regulated genes common to the PB and EE promotion, and not responding to the non-genotoxic carcinogens in uninitiated liver, the following six genes showed overexpression in PB-promoted hepatocellular carcinomas at week 64, with the levels three times or more than untreated rat liver: ubiquitously expressed mammalian ABC half transporter, apolipoprotein A4, nuclear receptor binding factor-2, CD81, hypothetical protein (HSPC014) and one unidentified gene" provenance.
- _3 value "Among the up-regulated genes common to the PB and EE promotion, and not responding to the non-genotoxic carcinogens in uninitiated liver, the following six genes showed overexpression in PB-promoted hepatocellular carcinomas at week 64, with the levels three times or more than untreated rat liver: ubiquitously expressed mammalian ABC half transporter, apolipoprotein A4, nuclear receptor binding factor-2, CD81, hypothetical protein (HSPC014) and one unidentified gene" provenance.
- _3 value "Among the up-regulated genes common to the PB and EE promotion, and not responding to the non-genotoxic carcinogens in uninitiated liver, the following six genes showed overexpression in PB-promoted hepatocellular carcinomas at week 64, with the levels three times or more than untreated rat liver: ubiquitously expressed mammalian ABC half transporter, apolipoprotein A4, nuclear receptor binding factor-2, CD81, hypothetical protein (HSPC014) and one unidentified gene" provenance.
- _4 value "The decrease in eNOS expression was signaled in large part through a p38 MAPK-dependent mechanism." provenance.
- _5 value "The decrease in eNOS expression was signaled in large part through a p38 MAPK-dependent mechanism." provenance.
- _4 value "we showed that increased extracellular tonicity promotes increased type A natriuretic peptide receptor (NPR-A) expression through a p38 MAPKbeta pathway" provenance.
- _5 value "Modified assertion" provenance.
- _5 value "Eleven different protein phosphatases, many previously suggested to be involved in ERK2 regulation, were compared, including tyrosine-specific phosphatases (PTP1B, CD45, and HePTP), dual specificity MAPK phosphatases (VHR, MKP3, and MKP5), and Ser/Thr protein phosphatases (PP1, PP2A, PP2B, PP2C alpha, and lambda PP). The results provide biochemical evidence that protein phosphatases display exquisite specificity in their substrate recognition and implicate HePTP, MKP3, and PP2A as ERK2 phosphatases. The results provide biochemical evidence that protein phosphatases display exquisite specificity in their substrate recognition and implicate HePTP, MKP3, and PP2A as ERK2 phosphatases. " provenance.
- _5 value "Eleven different protein phosphatases, many previously suggested to be involved in ERK2 regulation, were compared, including tyrosine-specific phosphatases (PTP1B, CD45, and HePTP), dual specificity MAPK phosphatases (VHR, MKP3, and MKP5), and Ser/Thr protein phosphatases (PP1, PP2A, PP2B, PP2C alpha, and lambda PP). The results provide biochemical evidence that protein phosphatases display exquisite specificity in their substrate recognition and implicate HePTP, MKP3, and PP2A as ERK2 phosphatases. The results provide biochemical evidence that protein phosphatases display exquisite specificity in their substrate recognition and implicate HePTP, MKP3, and PP2A as ERK2 phosphatases. " provenance.
- _5 value "The dual phosphorylation of Thr-183 and Tyr-185 in ERK2 is catalyzed by MAPK/ERK kinase 1 (MEK1)." provenance.
- _6 value "The dual phosphorylation of Thr-183 and Tyr-185 in ERK2 is catalyzed by MAPK/ERK kinase 1 (MEK1)." provenance.
- _3 value "VN also interacts with two-chain high molecular weight kininogen (HKa), particularly its His-Gly-Lys-rich domain 5, and both HKa and PAI-1 are antiadhesive factors that have been shown to compete for binding to VN." provenance.
- _5 value "Our results demonstrate that expression of wt p53 but not mutant p53 significantly reduced tyrosine phosphorylation of Stat3 and inhibited Stat3 DNA binding activity in both DU145 and Tsu prostate cancer cell lines that express constitutively active Stat3." provenance.
- _6 value "Our results demonstrate that expression of wt p53 but not mutant p53 significantly reduced tyrosine phosphorylation of Stat3 and inhibited Stat3 DNA binding activity in both DU145 and Tsu prostate cancer cell lines that express constitutively active Stat3." provenance.
- _4 value "Expression of the immediate early protein tristetraprolin (TTP) is induced by numerous stimuli, including tumor necrosis factor-alpha (TNFalpha)." provenance.
- _3 value "TTP, TIS11b, and TIS11d each also induce apoptosis through the mitochondrial pathway analogously to certain oncogenes, suggesting that they influence growth or survival signals." provenance.
- _3 value "TTP, TIS11b, and TIS11d each also induce apoptosis through the mitochondrial pathway analogously to certain oncogenes, suggesting that they influence growth or survival signals." provenance.
- _4 value "By comparing S100A8 and S100A9 mRNA levels in wild type and c-Fos deficient mice (c-fos(-/-)) we found that expression is negatively regulated by c-Fos/AP-1." provenance.
- _5 value "From Full Paper Introduction PKB is involved in numerous cell processes...this includes supression of apoptosis, at least in part through its ability to phosphorylate the pro-apoptotic protein BAD." provenance.
- _5 value "Furthermore, ATP-citrate lyase was phosphorylated in vitro by recombinant protein kinase B on the same site. Taken together, these results demonstrate that serine 454 of ATP-citrate lyase is a novel and major in vivo substrate for protein kinase B." provenance.
- _5 value "PKB also plays an important role in the stimulaiton of glycogen synthase by insulin via the phosphoryaltion and inactivation of glycogen synthase kinase-3" provenance.
- _5 value "PKB also plays an important role in the stimulaiton of glycogen synthase by insulin via the phosphoryaltion and inactivation of glycogen synthase kinase-3" provenance.
- _3 value "We show that peroxiredoxins I and II are present in the cytoplasm of pancreatic islet cells as well as in insulinoma cell lines beta TC6-F7 and INS-1. Peroxiredoxins I and II were up-regulated by all stress agents used." provenance.
- _3 value "We show that peroxiredoxins I and II are present in the cytoplasm of pancreatic islet cells as well as in insulinoma cell lines beta TC6-F7 and INS-1. Peroxiredoxins I and II were up-regulated by all stress agents used." provenance.
- _3 value "E2 decreased N-cadherin and beta-catenin levels and induced a redistribution of p120ctn to the cytoplasm." provenance.
- _3 value "E2 decreased N-cadherin and beta-catenin levels and induced a redistribution of p120ctn to the cytoplasm." provenance.