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- drugbank:DB00022 type drugbank_vocabulary:Drug assertion.
- drugbank:DB00022 label "Peginterferon alfa-2b [drugbank:DB00022]" assertion.
- drugbank:DB00022 seeAlso DB00022 assertion.
- drugbank:DB00022 seeAlso peginterferon-alfa-2b.html assertion.
- drugbank:DB00022 seeAlso peginterferon.htm assertion.
- drugbank:DB00022 identifier "drugbank:DB00022" assertion.
- drugbank:DB00022 description "Peginterferon alfa-2b is a covalent conjugate of recombinant alfa-2b interferon with monomethoxy polyethylene glycol (PEG). The average molecular weight of the PEG portion of the molecule is 12,000 daltons. The average molecular weight of the PEG-Intron molecule is approximately 31,000 daltons. The specific activity of peginterferon alfa-2b is approximately 0.7 x 108 IU/mg protein. Interferon alfa-2b is a water-soluble protein with a molecular weight of 19,271 daltons produced by recombinant DNA techniques. It is obtained from the bacterial fermentation of a strain of <i>Escherichia coli</i> bearing a genetically engineered plasmid containing an interferon gene from human leukocytes. The PEG strand protects the molecule in vivo from proteolytic breakdown, substantially increases its in vivo half-life, and reduces immunogenicity by wrapping around and physically hindering access to the protein portion of the molecule." assertion.
- drugbank:DB00022 title "Peginterferon alfa-2b" assertion.
- drugbank:DB00022 bio2rdf_vocabulary:identifier "DB00022" assertion.
- drugbank:DB00022 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB00022 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB00022" assertion.
- drugbank:DB00022 bio2rdf_vocabulary:x-identifiers.org DB00022 assertion.
- drugbank:DB00022 drugbank_vocabulary:drugbank-id "BIOD00048" assertion.
- drugbank:DB00022 drugbank_vocabulary:drugbank-id "BTD00048" assertion.
- drugbank:DB00022 drugbank_vocabulary:drugbank-id "DB00022" assertion.
- drugbank:DB00022 drugbank_vocabulary:x-cas cas:99210-65-8 assertion.
- drugbank:DB00022 drugbank_vocabulary:x-ahfs ahfs:08:18.20 assertion.
- drugbank:DB00022 drugbank_vocabulary:x-atc atc:L03AB10 assertion.
- drugbank:DB00022 drugbank_vocabulary:x-dpd dpd:2242966 assertion.
- drugbank:DB00022 drugbank_vocabulary:x-pharmgkb pharmgkb:PA164784024 assertion.
- drugbank:DB00022 drugbank_vocabulary:x-wikipedia wikipedia:Peginterferon_alfa-2b assertion.
- drugbank:DB00022 drugbank_vocabulary:x-ndc ndc:0085-1323-01 assertion.
- drugbank:DB00022 drugbank_vocabulary:x-uniprot uniprot:P01563 assertion.