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- drugbank:DB00038 type drugbank_vocabulary:Drug assertion.
- drugbank:DB00038 label "Oprelvekin [drugbank:DB00038]" assertion.
- drugbank:DB00038 seeAlso DB00038 assertion.
- drugbank:DB00038 seeAlso oprelvekin.html assertion.
- drugbank:DB00038 seeAlso oprelvek.htm assertion.
- drugbank:DB00038 identifier "drugbank:DB00038" assertion.
- drugbank:DB00038 description "Oprelvekin, the active ingredient in Neumega® is recombinant Interleukin eleven, which is produced in Escherichia coli (E. coli) by recombinant DNA technology. The protein has a molecular mass of approximately 19,000 daltons, and is non-glycosylated. The polypeptide is 177 amino acids in length (the natural IL-11 has 178). This alteration has not resulted in measurable differences in bioactivity either in vitro or in vivo. The primary hematopoietic activity of Neumega® is stimulation of megakaryocytopoiesis and thrombopoiesis. In mice and nonhuman primate studies Neumega® has shown potent thrombopoietic activity in compromised hematopoiesis, including moderately to severely myelosuppressed animals. In these studies, Neumega® improved platelet nadirs and accelerated platelet recoveries compared to controls. In animal studies Oprelvekin also has non-hematopoetic activities. This includes the regulation of intestinal epithelium growth (enhanced healing of gastrointestinal lesions), the inhibition of adipogenesis, the induction of acute phase protein synthesis (e.g., fibrinogen), and inhibition of macrophageal released pro-inflammatory cytokines." assertion.
- drugbank:DB00038 title "Oprelvekin" assertion.
- drugbank:DB00038 bio2rdf_vocabulary:identifier "DB00038" assertion.
- drugbank:DB00038 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB00038 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB00038" assertion.
- drugbank:DB00038 bio2rdf_vocabulary:x-identifiers.org DB00038 assertion.
- drugbank:DB00038 drugbank_vocabulary:drugbank-id "BIOD00021" assertion.
- drugbank:DB00038 drugbank_vocabulary:drugbank-id "BTD00021" assertion.
- drugbank:DB00038 drugbank_vocabulary:drugbank-id "DB00038" assertion.
- drugbank:DB00038 drugbank_vocabulary:x-cas cas:145941-26-0 assertion.
- drugbank:DB00038 drugbank_vocabulary:x-atc atc:L03AC02 assertion.
- drugbank:DB00038 drugbank_vocabulary:x-pharmgkb pharmgkb:PA164747991 assertion.
- drugbank:DB00038 drugbank_vocabulary:x-wikipedia wikipedia:Oprelvekin assertion.
- drugbank:DB00038 drugbank_vocabulary:x-ndc ndc:58394-004-01 assertion.
- drugbank:DB00038 drugbank_vocabulary:x-genbank genbank:M57765 assertion.
- drugbank:DB00038 drugbank_vocabulary:x-uniprot uniprot:P20809 assertion.