Matches in Nanopublications for { ?s ?p ?o <http://bio2rdf.org/drugbank:DB00381_nanopub.RAtvrq1Bon5ZLMOxTDzRKQyetXm6mhwWy69ymFZ2f-rmc#assertion>. }
Showing items 1 to 27 of
27
with 100 items per page.
- drugbank:DB00381 type drugbank_vocabulary:Drug assertion.
- drugbank:DB00381 label "Amlodipine [drugbank:DB00381]" assertion.
- drugbank:DB00381 seeAlso DB00381 assertion.
- drugbank:DB00381 seeAlso amlodipine.html assertion.
- drugbank:DB00381 seeAlso rx-mono.aspx?contentFileName=nor1306.html&contentName=Norvasc&contentId=538 assertion.
- drugbank:DB00381 seeAlso amlod2.htm assertion.
- drugbank:DB00381 identifier "drugbank:DB00381" assertion.
- drugbank:DB00381 description "Amlodipine is a long-acting 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, amlodipine prevents calcium-dependent myocyte contraction and vasoconstriction. A second proposed mechanism for the drug’s vasodilatory effects involves pH-dependent inhibition of calcium influx via inhibition of smooth muscle carbonic anhydrase. Some studies have shown that amlodipine also exerts inhibitory effects on voltage-gated N-type calcium channels. N-type calcium channels located in the central nervous system may be involved in nociceptive signaling and pain sensation. Amlodipine is used to treat hypertension and chronic stable angina." assertion.
- drugbank:DB00381 title "Amlodipine" assertion.
- drugbank:DB00381 bio2rdf_vocabulary:identifier "DB00381" assertion.
- drugbank:DB00381 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB00381 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB00381" assertion.
- drugbank:DB00381 bio2rdf_vocabulary:x-identifiers.org DB00381 assertion.
- drugbank:DB00381 drugbank_vocabulary:drugbank-id "APRD00520" assertion.
- drugbank:DB00381 drugbank_vocabulary:drugbank-id "DB00381" assertion.
- drugbank:DB00381 drugbank_vocabulary:x-cas cas:88150-42-9 assertion.
- drugbank:DB00381 drugbank_vocabulary:x-chemspider chemspider:2077 assertion.
- drugbank:DB00381 drugbank_vocabulary:x-pubchemcompound pubchem.compound:2162 assertion.
- drugbank:DB00381 drugbank_vocabulary:x-pubchemsubstance pubchem.substance:46507214 assertion.
- drugbank:DB00381 drugbank_vocabulary:x-ahfs ahfs:24:28.08 assertion.
- drugbank:DB00381 drugbank_vocabulary:x-atc atc:C08CA01 assertion.
- drugbank:DB00381 drugbank_vocabulary:x-chebi chebi:2668 assertion.
- drugbank:DB00381 drugbank_vocabulary:x-dpd dpd:878936 assertion.
- drugbank:DB00381 drugbank_vocabulary:x-kegg kegg:C06825 assertion.
- drugbank:DB00381 drugbank_vocabulary:x-pharmgkb pharmgkb:PA448388 assertion.
- drugbank:DB00381 drugbank_vocabulary:x-wikipedia wikipedia:Amlodipine assertion.
- drugbank:DB00381 drugbank_vocabulary:x-ndc ndc:53808-0200-1 assertion.