Matches in Nanopublications for { ?s ?p ?o <http://bio2rdf.org/drugbank:DB00606_nanopub.RAns6h4OdV-HpT_vTdVKBC6n5b5YRkYS6kY-Amo7YBw8o#assertion>. }
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- drugbank:DB00606 type drugbank_vocabulary:Drug assertion.
- drugbank:DB00606 label "Cyclothiazide [drugbank:DB00606]" assertion.
- drugbank:DB00606 seeAlso DB00606 assertion.
- drugbank:DB00606 identifier "drugbank:DB00606" assertion.
- drugbank:DB00606 description "As a diuretic, cyclothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like cyclothiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of cyclothiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle. Cyclothiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. It is also indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension." assertion.
- drugbank:DB00606 title "Cyclothiazide" assertion.
- drugbank:DB00606 bio2rdf_vocabulary:identifier "DB00606" assertion.
- drugbank:DB00606 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB00606 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB00606" assertion.
- drugbank:DB00606 bio2rdf_vocabulary:x-identifiers.org DB00606 assertion.
- drugbank:DB00606 drugbank_vocabulary:drugbank-id "APRD00895" assertion.
- drugbank:DB00606 drugbank_vocabulary:drugbank-id "DB00606" assertion.
- drugbank:DB00606 drugbank_vocabulary:drugbank-id "EXPT01082" assertion.
- drugbank:DB00606 drugbank_vocabulary:x-cas cas:2259-96-3 assertion.
- drugbank:DB00606 drugbank_vocabulary:x-chemspider chemspider:2807 assertion.
- drugbank:DB00606 drugbank_vocabulary:x-pdb pdb:CYZ assertion.
- drugbank:DB00606 drugbank_vocabulary:x-pubchemcompound pubchem.compound:2910 assertion.
- drugbank:DB00606 drugbank_vocabulary:x-pubchemsubstance pubchem.substance:46508269 assertion.
- drugbank:DB00606 drugbank_vocabulary:x-atc atc:C03AA09 assertion.
- drugbank:DB00606 drugbank_vocabulary:x-chebi chebi:31448 assertion.
- drugbank:DB00606 drugbank_vocabulary:x-kegg kegg:C12685 assertion.
- drugbank:DB00606 drugbank_vocabulary:x-kegg kegg:D01256 assertion.
- drugbank:DB00606 drugbank_vocabulary:x-pharmgkb pharmgkb:PA449168 assertion.
- drugbank:DB00606 drugbank_vocabulary:x-bindingdb bindingdb:50192229 assertion.