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- drugbank:DB00843 type drugbank_vocabulary:Drug assertion.
- drugbank:DB00843 label "Donepezil [drugbank:DB00843]" assertion.
- drugbank:DB00843 seeAlso DB00843 assertion.
- drugbank:DB00843 seeAlso donepezil.html assertion.
- drugbank:DB00843 seeAlso donepezil.htm assertion.
- drugbank:DB00843 identifier "drugbank:DB00843" assertion.
- drugbank:DB00843 description "Donepezil (Aricept), is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine. Donepezil is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, donepezil's effect may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact. Donepezil has been tested in other cognitive disorders including Lewy body dementia and Vascular dementia, but it is not currently approved for these indications. Donepezil has also been studied in patients with Mild Cognitive Impairment, schizophrenia, attention deficit disorder, post-coronary bypass cognitive impairment, cognitive impairment associated with multiple sclerosis, and Down syndrome." assertion.
- drugbank:DB00843 title "Donepezil" assertion.
- drugbank:DB00843 bio2rdf_vocabulary:identifier "DB00843" assertion.
- drugbank:DB00843 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB00843 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB00843" assertion.
- drugbank:DB00843 bio2rdf_vocabulary:x-identifiers.org DB00843 assertion.
- drugbank:DB00843 drugbank_vocabulary:drugbank-id "APRD00039" assertion.
- drugbank:DB00843 drugbank_vocabulary:drugbank-id "DB00843" assertion.
- drugbank:DB00843 drugbank_vocabulary:x-cas cas:120014-06-4 assertion.
- drugbank:DB00843 drugbank_vocabulary:x-chemspider chemspider:3040 assertion.
- drugbank:DB00843 drugbank_vocabulary:x-pubchemcompound pubchem.compound:3152 assertion.
- drugbank:DB00843 drugbank_vocabulary:x-pubchemsubstance pubchem.substance:46504803 assertion.
- drugbank:DB00843 drugbank_vocabulary:x-ahfs ahfs:12:04.00 assertion.
- drugbank:DB00843 drugbank_vocabulary:x-atc atc:N06DA02 assertion.
- drugbank:DB00843 drugbank_vocabulary:x-chebi chebi:53289 assertion.
- drugbank:DB00843 drugbank_vocabulary:x-dpd dpd:2232044 assertion.
- drugbank:DB00843 drugbank_vocabulary:x-kegg kegg:D00670 assertion.
- drugbank:DB00843 drugbank_vocabulary:x-pharmgkb pharmgkb:PA449394 assertion.
- drugbank:DB00843 drugbank_vocabulary:x-wikipedia wikipedia:Donepezil assertion.
- drugbank:DB00843 drugbank_vocabulary:x-bindingdb bindingdb:8960 assertion.
- drugbank:DB00843 drugbank_vocabulary:x-ndc ndc:62856-851-30 assertion.