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- drugbank:DB00862 type drugbank_vocabulary:Drug assertion.
- drugbank:DB00862 label "Vardenafil [drugbank:DB00862]" assertion.
- drugbank:DB00862 seeAlso DB00862 assertion.
- drugbank:DB00862 seeAlso vardenafil.html assertion.
- drugbank:DB00862 seeAlso lev1688.shtml assertion.
- drugbank:DB00862 seeAlso levitra.htm assertion.
- drugbank:DB00862 identifier "drugbank:DB00862" assertion.
- drugbank:DB00862 description "Vardenafil (Levitra) is an oral therapy for the treatment of erectile dysfunction. It is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). Penile erection is a hemodynamic process initiated by the relaxation of smooth muscle in the corpus cavernosum and its associated arterioles. During sexual stimulation, nitric oxide is released from nerve endings and endothelial cells in the corpus cavernosum. Nitric oxide activates the enzyme guanylate cyclase resulting in increased synthesis of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the corpus cavernosum. The cGMP in turn triggers smooth muscle relaxation, allowing increased blood flow into the penis, resulting in erection. The tissue concentration of cGMP is regulated by both the rates of synthesis and degradation via phosphodiesterases (PDEs). The most abundant PDE in the human corpus cavernosum is the cGMPspecific phosphodiesterase type 5 (PDE5); therefore, the inhibition of PDE5 enhances erectile function by increasing the amount of cGMP." assertion.
- drugbank:DB00862 title "Vardenafil" assertion.
- drugbank:DB00862 bio2rdf_vocabulary:identifier "DB00862" assertion.
- drugbank:DB00862 bio2rdf_vocabulary:namespace "drugbank" assertion.
- drugbank:DB00862 bio2rdf_vocabulary:uri "http://bio2rdf.org/drugbank:DB00862" assertion.
- drugbank:DB00862 bio2rdf_vocabulary:x-identifiers.org DB00862 assertion.
- drugbank:DB00862 drugbank_vocabulary:drugbank-id "APRD00699" assertion.
- drugbank:DB00862 drugbank_vocabulary:drugbank-id "DB00862" assertion.
- drugbank:DB00862 drugbank_vocabulary:x-cas cas:224785-90-4 assertion.
- drugbank:DB00862 drugbank_vocabulary:x-chemspider chemspider:99300 assertion.
- drugbank:DB00862 drugbank_vocabulary:x-pubchemcompound pubchem.compound:110634 assertion.
- drugbank:DB00862 drugbank_vocabulary:x-pubchemsubstance pubchem.substance:46506777 assertion.
- drugbank:DB00862 drugbank_vocabulary:x-ahfs ahfs:24:12.12 assertion.
- drugbank:DB00862 drugbank_vocabulary:x-atc atc:G04BE09 assertion.
- drugbank:DB00862 drugbank_vocabulary:x-dpd dpd:2250462 assertion.
- drugbank:DB00862 drugbank_vocabulary:x-kegg kegg:D09989 assertion.
- drugbank:DB00862 drugbank_vocabulary:x-pharmgkb pharmgkb:PA10229 assertion.
- drugbank:DB00862 drugbank_vocabulary:x-wikipedia wikipedia:Vardenafil assertion.
- drugbank:DB00862 drugbank_vocabulary:x-bindingdb bindingdb:14776 assertion.
- drugbank:DB00862 drugbank_vocabulary:x-ndc ndc:0085-1923-01 assertion.